{"id":"https://openalex.org/W2129907434","doi":null,"title":"Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on histological alterations and insulin resistance of non alcoholic fatty liver disease.","display_name":"Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on histological alterations and insulin resistance of non alcoholic fatty liver disease.","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2129907434","mag":"2129907434","pmid":"https://pubmed.ncbi.nlm.nih.gov/19961041"},"language":"en","primary_location":{"id":"pmid:19961041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19961041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110131905","display_name":"R. Aller","orcid":"https://orcid.org/0000-0002-6795-4541","observed_orcids":["https://orcid.org/0000-0002-6795-4541"]},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R Aller","raw_affiliation_strings":["Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076005842","display_name":"Daniel Antonio de Luis","orcid":"https://orcid.org/0000-0002-1745-9315","observed_orcids":["https://orcid.org/0000-0002-1745-9315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A De Luis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070661110","display_name":"Luis Ignacio Fern\u00e1ndez-Salazar","orcid":"https://orcid.org/0000-0002-9951-7979","observed_orcids":["https://orcid.org/0000-0002-9951-7979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Fernandez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083607803","display_name":"Fernando Calle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Calle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045260182","display_name":"Benito Velayos","orcid":"https://orcid.org/0000-0002-2489-6003","observed_orcids":["https://orcid.org/0000-0002-2489-6003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Velayos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007905745","display_name":"Olatz Izaola","orcid":"https://orcid.org/0000-0003-1201-4875","observed_orcids":["https://orcid.org/0000-0003-1201-4875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Izaola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067155686","display_name":"Manuel Gonzalez Sagrado","orcid":"https://orcid.org/0000-0001-9878-3776","observed_orcids":["https://orcid.org/0000-0001-9878-3776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gonzalez Sagrado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037511818","display_name":"Rosa Conde","orcid":"https://orcid.org/0000-0002-6636-5729","observed_orcids":["https://orcid.org/0000-0002-6636-5729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Conde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107897441","display_name":"Jos\u00e9 Manuel Dom\u00ednguez Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Gonzalez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3914,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.68228514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"5","first_page":"357","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-binding-protein-2","display_name":"fatty acid binding protein 2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fabp2","display_name":"FABP2","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ala54thr-polymorphism","display_name":"Ala54Thr polymorphism","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8949999809265137},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/portal-inflammation","display_name":"portal inflammation","score":0.527999997138977},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8690000176429749},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":0.7400000095367432},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.906000018119812},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8258689641952515},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.770659327507019},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7498400211334229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7427853345870972},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.6795414090156555},{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.6225036978721619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5284043550491333},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5246760249137878},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5186854600906372},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.44994181394577026},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.41928452253341675},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.4184056520462036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3310443162918091},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2736234664916992},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.19207140803337097},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12675020098686218},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11211502552032471},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06875047087669373}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000886","descriptor_name":"Anthropometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19961041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19961041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2129907434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19961041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W191809857","https://openalex.org/W1964863934","https://openalex.org/W1968827381","https://openalex.org/W1969295126","https://openalex.org/W1983000656","https://openalex.org/W1983506346","https://openalex.org/W1995000970","https://openalex.org/W2001545151","https://openalex.org/W2005340562","https://openalex.org/W2025160818","https://openalex.org/W2038150403","https://openalex.org/W2048204846","https://openalex.org/W2050385934","https://openalex.org/W2051227936","https://openalex.org/W2064121454","https://openalex.org/W2076862430","https://openalex.org/W2080187994","https://openalex.org/W2081895528","https://openalex.org/W2103906591","https://openalex.org/W2109555667","https://openalex.org/W2132408300","https://openalex.org/W2160234571","https://openalex.org/W2164118055","https://openalex.org/W2167940070","https://openalex.org/W2253667517","https://openalex.org/W2402255398"],"related_works":["https://openalex.org/W2181895336","https://openalex.org/W2079697014","https://openalex.org/W2021028926","https://openalex.org/W2100094677","https://openalex.org/W2182909111","https://openalex.org/W2182216307","https://openalex.org/W7038658372","https://openalex.org/W2107331237","https://openalex.org/W1964307596","https://openalex.org/W2064346294"],"abstract_inverted_index":{"A":[0,4,107,225],"transition":[1],"G":[2],"to":[3,23,47,114],"at":[5,104],"codon":[6],"54":[7,22],"of":[8,34,43,51,62,76,124,136,230,253,261,275],"fatty":[9,64],"acid":[10,19,28],"binding":[11],"protein":[12],"type":[13,174,188,208,212],"2":[14],"(FABP2)":[15],"produces":[16],"an":[17,215],"amino":[18,27],"substitution":[20,29],"(Ala":[21],"Thr":[24],"54).":[25],"This":[26],"was":[30,46,141,146,220,235],"associated":[31],"with":[32,73,127,158,214,279],"modifications":[33],"insulin":[35,39,69,288],"resistance,":[36],"adipokines":[37,292],"and":[38,68,98,119,151,162,176,201,290],"concentrations.":[40],"The":[41,143],"aim":[42],"this":[44,82],"study":[45,269],"evaluate":[48],"the":[49,55,59,74,152,170,194,267,272],"influence":[50],"Ala54Thr":[52,137,274],"polymorphism":[53,140,273],"in":[54,206,222,232,250,277],"FABP2":[56,138],"gene":[57,139],"on":[58],"histological":[60,251,284],"alterations":[61],"non-alcoholic":[63],"liver":[65,283],"disease":[66],"(NAFLD)":[67],"resistance.":[70],"Thirty":[71],"subjects":[72],"presence":[75],"biopsy-proven":[77],"NAFLD":[78,280],"were":[79,102,133,204,239,245],"enrolled":[80],"for":[81],"study.":[83],"Glucose,":[84],"Insulin,":[85],"Insulin":[86],"resistance":[87,289],"(HOMA),":[88],"total":[89],"cholesterol,":[90],"LDL-cholesterol,":[91],"HDL-cholesterol,":[92],"triglycerides,":[93],"resistin,":[94],"leptin,":[95],"adiponectin,":[96],"interleukin-6":[97],"TNF-alfa":[99],"serum":[100,291],"levels":[101,229],"measured":[103],"basal":[105],"time.":[106],"tetrapolar":[108],"bioimpedance,":[109],"BMI,":[110],"waist":[111,113],"circumference,":[112],"hip":[115],"ratio,":[116],"blood":[117],"pressure":[118],"a":[120],"prospective":[121],"serial":[122],"assessment":[123],"nutritional":[125],"intake":[126,219],"3":[128],"days":[129],"written":[130],"food":[131],"records":[132],"examined.":[134],"Genotype":[135],"studied.":[142],"mean":[144,153],"age":[145],"41.6":[147],"+/-":[148,156],"11":[149],"years":[150],"BMI":[154],"29.2":[155],"6.6":[157],"24":[159],"males":[160],"(80%)":[161],"6":[163],"females":[164],"(20%).":[165],"Fifteen":[166],"patients":[167,179,278],"(50%)":[168,178],"had":[169],"genotype":[171,191],"Ala54/Ala54":[172],"(wild":[173],"group)":[175],"15":[177],"Ala54/Thr54":[180],"(13":[181],"patients)":[182,186],"or":[183,256,259,263],"Thr54/Thr54":[184],"(2":[185],"(mutant":[187],"group).":[189],"Both":[190],"groups":[192],"have":[193],"similar":[195,221],"anthropometric":[196],"parameters.":[197],"Serum":[198],"aspartate":[199],"aminotransferase":[200],"alcaline":[202],"phosfatase":[203],"higher":[205],"wild":[207],"group":[209,234],"than":[210],"mutant":[211,233],"group,":[213],"unclear":[216],"explanation.":[217],"Dietary":[218],"both":[223,287],"groups.":[224],"non-statistical":[226],"significant":[227],"low":[228],"adiponectin":[231],"observed.":[236],"No":[237],"differences":[238,247],"detected":[240],"among":[241],"other":[242],"adipokines.":[243],"There":[244],"no":[246],"between":[248],"genotypes":[249],"results":[252],"inflammation":[254],"(portal":[255],"lobular":[257],"inflammation)":[258],"grade":[260],"steatosis":[262],"fibrosis.":[264],"In":[265],"conclusion,":[266],"present":[268],"demonstrates":[270],"that":[271],"FABP":[276],"doesn't":[281],"predict":[282],"changes,":[285],"nor":[286],"variations.":[293]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}