{"id":"https://openalex.org/W2129907203","doi":null,"title":"Phosphatase Regulation of CFTR","display_name":"Phosphatase Regulation of CFTR","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2129907203","mag":"2129907203"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.liberty.edu:bio_chem_fac_pubs-1053","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54","pdf_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54","source":{"id":"https://openalex.org/S4306400581","display_name":"Digital Commons (Liberty University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67789559","host_organization_name":"Liberty University","host_organization_lineage":["https://openalex.org/I67789559"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications and Presentations","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056371233","display_name":"John W. Hanrahan","orcid":"https://orcid.org/0000-0001-9080-2039","observed_orcids":["https://orcid.org/0000-0001-9080-2039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John W. Hanrahan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9080-2039","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112178854","display_name":"Tang Zhu","orcid":"https://orcid.org/0000-0003-3237-0420","observed_orcids":["https://orcid.org/0000-0003-3237-0420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tang Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084422385","display_name":"L. Daniel Howell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Daniel Howell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.19923248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"cystic fibrosis transmembrane conductance regulator","score":0.9409999847412109},{"id":"https://openalex.org/keywords/phosphatase-regulation","display_name":"phosphatase regulation","score":0.699999988079071},{"id":"https://openalex.org/keywords/protein-phosphatase-2c","display_name":"protein phosphatase 2C","score":0.8169999718666077},{"id":"https://openalex.org/keywords/serine-threonine-protein-phosphatase","display_name":"serine/threonine phosphatase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/protein-dephosphorylation","display_name":"protein dephosphorylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/chloride-channel-regulation","display_name":"chloride channel regulation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.5849999785423279},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.734000027179718},{"id":"https://openalex.org/keywords/secretory-diarrhea","display_name":"secretory diarrhea","score":0.9150000214576721},{"id":"https://openalex.org/keywords/epithelial-ion-transport","display_name":"epithelial ion transport","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.8967462778091431},{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.7779179811477661},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6186686158180237},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.5977500677108765},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.5853992700576782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5585997700691223},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.46452081203460693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4608570635318756},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.454490602016449},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4410087466239929},{"id":"https://openalex.org/C21547065","wikidata":"https://www.wikidata.org/wiki/Q418243","display_name":"Acid phosphatase","level":3,"score":0.4276030659675598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39461326599121094},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34132301807403564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1430273950099945}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.liberty.edu:bio_chem_fac_pubs-1053","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54","pdf_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54","source":{"id":"https://openalex.org/S4306400581","display_name":"Digital Commons (Liberty University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67789559","host_organization_name":"Liberty University","host_organization_lineage":["https://openalex.org/I67789559"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications and Presentations","raw_type":"text"},{"id":"mag:2129907203","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.liberty.edu:bio_chem_fac_pubs-1053","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54","pdf_url":"https://digitalcommons.liberty.edu/bio_chem_fac_pubs/54","source":{"id":"https://openalex.org/S4306400581","display_name":"Digital Commons (Liberty University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67789559","host_organization_name":"Liberty University","host_organization_lineage":["https://openalex.org/I67789559"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications and Presentations","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129907203.pdf","grobid_xml":"https://content.openalex.org/works/W2129907203.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W148345225","https://openalex.org/W625068684","https://openalex.org/W1497015848","https://openalex.org/W1506485465","https://openalex.org/W1523858318","https://openalex.org/W1565516646","https://openalex.org/W1568241318","https://openalex.org/W1594802364","https://openalex.org/W1637411575","https://openalex.org/W1638694981","https://openalex.org/W1642473590","https://openalex.org/W1662090173","https://openalex.org/W1882996137","https://openalex.org/W1952616107","https://openalex.org/W1965144258","https://openalex.org/W1966010415","https://openalex.org/W1972608995","https://openalex.org/W1975980935","https://openalex.org/W1977341692","https://openalex.org/W1977984619","https://openalex.org/W1979922389","https://openalex.org/W1980775459","https://openalex.org/W1982446968","https://openalex.org/W1982625622","https://openalex.org/W1988832534","https://openalex.org/W1989009320","https://openalex.org/W1990261175","https://openalex.org/W1992273146","https://openalex.org/W1995579048","https://openalex.org/W1995690959","https://openalex.org/W1997376701","https://openalex.org/W1997664222","https://openalex.org/W1999383552","https://openalex.org/W2002759608","https://openalex.org/W2004394635","https://openalex.org/W2006460840","https://openalex.org/W2006856042","https://openalex.org/W2008924335","https://openalex.org/W2009337463","https://openalex.org/W2010255414","https://openalex.org/W2010577838","https://openalex.org/W2010691166","https://openalex.org/W2015761686","https://openalex.org/W2019099644","https://openalex.org/W2021595400","https://openalex.org/W2023292433","https://openalex.org/W2023681929","https://openalex.org/W2024369949","https://openalex.org/W2024984341","https://openalex.org/W2027085827","https://openalex.org/W2027207647","https://openalex.org/W2027894194","https://openalex.org/W2028171116","https://openalex.org/W2028834582","https://openalex.org/W2033335450","https://openalex.org/W2038638713","https://openalex.org/W2039589874","https://openalex.org/W2041799513","https://openalex.org/W2045675920","https://openalex.org/W2047233384","https://openalex.org/W2054208935","https://openalex.org/W2054522199","https://openalex.org/W2054996246","https://openalex.org/W2055433327","https://openalex.org/W2058127221","https://openalex.org/W2059778621","https://openalex.org/W2061780012","https://openalex.org/W2062950568","https://openalex.org/W2074598967","https://openalex.org/W2075967117","https://openalex.org/W2076091117","https://openalex.org/W2080310479","https://openalex.org/W2080832123","https://openalex.org/W2081358444","https://openalex.org/W2082746388","https://openalex.org/W2083493906","https://openalex.org/W2084675078","https://openalex.org/W2086065555","https://openalex.org/W2097794180","https://openalex.org/W2101638068","https://openalex.org/W2108807925","https://openalex.org/W2112998606","https://openalex.org/W2117962961","https://openalex.org/W2120907075","https://openalex.org/W2124137428","https://openalex.org/W2130592046","https://openalex.org/W2135187212","https://openalex.org/W2137221055","https://openalex.org/W2137346267","https://openalex.org/W2141240174","https://openalex.org/W2144387894","https://openalex.org/W2156594133","https://openalex.org/W2162618593","https://openalex.org/W2167437560","https://openalex.org/W2168062869","https://openalex.org/W2173634416","https://openalex.org/W2178456244","https://openalex.org/W2319884815","https://openalex.org/W2335805947","https://openalex.org/W2344483515","https://openalex.org/W2411839122","https://openalex.org/W2411884503","https://openalex.org/W2468161918","https://openalex.org/W2608746487"],"related_works":["https://openalex.org/W2027207647","https://openalex.org/W6996159480","https://openalex.org/W2120907075","https://openalex.org/W2047703509","https://openalex.org/W6987498599","https://openalex.org/W2319884815","https://openalex.org/W1523858318","https://openalex.org/W2167437560","https://openalex.org/W43175307","https://openalex.org/W2084675078"],"abstract_inverted_index":{"The":[0,87],"cystic":[1,211],"fibrosis":[2,212],"transmembrane":[3],"conductance":[4],"regulator":[5],"(CFTR)":[6],"chloride":[7],"channel":[8,44],"is":[9,63,92,109,115,155,203],"tightly":[10],"regulated":[11],"by":[12,25,65,112,128],"the":[13,43,76,80,95,145,148,174,180,201],"opposing":[14],"actions":[15],"of":[16,42,74,79,84,163,187,192],"protein":[17,26],"kinases":[18,27],"and":[19,23,30,99,108,120,178,195,213],"phosphatases.":[20,86],"Its":[21],"phosphorylation":[22],"activation":[24],"A":[28],"(PKA)":[29],"C":[31],"(PKC)":[32],"have":[33,197],"been":[34],"studied":[35],"in":[36,54,59,173],"some":[37],"detail":[38],"but":[39],"phosphatase":[40,68,89,146,172,181,202],"regulation":[41],"has":[45],"received":[46],"less":[47],"attention.":[48],"Several":[49],"phosphatases":[50],"may":[51,196],"control":[52],"CFTR":[53,119,193],"various":[55],"cell":[56],"types,":[57],"however":[58],"epithelia":[60],"most":[61],"deactivation":[62],"mediated":[64],"a":[66,156,164,169,204],"membrane-bound":[67],"with":[69,118,135],"functional":[70],"properties":[71],"resembling":[72],"those":[73],"PP2C,":[75],"prototypic":[77],"member":[78],"PPM":[81,175],"gene":[82],"family":[83],"serinelthreonine":[85],"PP2C-like":[88],"requires":[90],"Mg2+,":[91],"insensitive":[93],"to":[94,209],"inhibitors":[96],"okadaic":[97],"acid":[98],"calyculin":[100],"A,":[101],"does":[102],"not":[103],"require":[104],"Ca2+":[105],"or":[106,124,132,159,168],"calmodulin,":[107],"inhibited":[110],"non-specifically":[111],"phenylimidazothiazoles.":[113],"It":[114],"closely":[116],"associated":[117],"can":[121],"be":[122],"co-immunoprecipitated":[123],"co-purified":[125],"from":[126],"celllysates":[127],"affinity":[129],"chromatography":[130],"with,":[131],"without,":[133],"pretreatment":[134],"chemical":[136],"crosslinking":[137],"reagents.":[138],"Current":[139],"efforts":[140],"are":[141],"directed":[142],"towards":[143],"identifying":[144],"at":[147],"molecular":[149],"level;":[150],"i.e.,":[151],"determining":[152],"if":[153],"it":[154],"novel":[157],"isoform":[158],"alternatively":[160],"spliced":[161],"variant":[162],"known":[165],"PP2C":[166],"isoform,":[167],"new":[170,185],"membrane-targeted":[171],"family.":[176],"Identifying":[177],"characterizing":[179],"will":[182],"open":[183],"many":[184],"avenues":[186],"investigation":[188],"into":[189],"basic":[190],"aspects":[191],"regulation,":[194],"clinical":[198],"significance":[199],"since":[200],"potential":[205],"target":[206],"for":[207],"pharmacotherapies":[208],"treat":[210],"secretory":[214],"diarrhea.":[215]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}