{"id":"https://openalex.org/W2129868577","doi":"https://doi.org/10.1080/09553008814552331","title":"Comparative Human Cellular Radiosensitivity: II. The Survival Following Gamma-irradiation of Unstimulated ( G 0 ) T-lymphocytes, T-lymphocyte Lines, Lymphoblastoid Cell Lines and Fibroblasts from Normal Donors, from Ataxia-telangiectasia Patients and from Ataxia-telangiectasia Heterozygotes","display_name":"Comparative Human Cellular Radiosensitivity: II. The Survival Following Gamma-irradiation of Unstimulated ( G 0 ) T-lymphocytes, T-lymphocyte Lines, Lymphoblastoid Cell Lines and Fibroblasts from Normal Donors, from Ataxia-telangiectasia Patients and from Ataxia-telangiectasia Heterozygotes","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2129868577","doi":"https://doi.org/10.1080/09553008814552331","mag":"2129868577","pmid":"https://pubmed.ncbi.nlm.nih.gov/2903890"},"language":"en","primary_location":{"id":"doi:10.1080/09553008814552331","doi":"https://doi.org/10.1080/09553008814552331","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553008814552331","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085760161","display_name":"Jane Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Cole","raw_affiliation_strings":["MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, U.K","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073072762","display_name":"C.F. Arlett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin F. Arlett","raw_affiliation_strings":["Centre for Medical Research, Sussex University, Falmer, Brighton, BN1 9RR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Research, Sussex University, Falmer, Brighton, BN1 9RR, U.K","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080116120","display_name":"Michael H.L. Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael H.L. Green","raw_affiliation_strings":["Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, Huntingdon, Cambs., PE18 6ES, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, Huntingdon, Cambs., PE18 6ES, U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005509014","display_name":"Susan A. Harcourt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susan A. Harcourt","raw_affiliation_strings":["MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, U.K","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111740359","display_name":"Anne Priestley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne Priestley","raw_affiliation_strings":["Centre for Medical Research, Sussex University, Falmer, Brighton, BN1 9RR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Research, Sussex University, Falmer, Brighton, BN1 9RR, U.K","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Leigh Henderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leigh Henderson","raw_affiliation_strings":["Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, Huntingdon, Cambs., PE18 6ES, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, Huntingdon, Cambs., PE18 6ES, U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039526311","display_name":"Helen Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen Cole","raw_affiliation_strings":["MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, U.K","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111463883","display_name":"S. Elizabeth James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Elizabeth James","raw_affiliation_strings":["Centre for Medical Research, Sussex University, Falmer, Brighton, BN1 9RR, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Research, Sussex University, Falmer, Brighton, BN1 9RR, U.K","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044134746","display_name":"Frances N. Richmond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frances Richmond","raw_affiliation_strings":["Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, Huntingdon, Cambs., PE18 6ES, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, Huntingdon, Cambs., PE18 6ES, U.K","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0795,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.97070837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"54","issue":"6","first_page":"929","last_page":"943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-radiosensitivity","display_name":"cellular radiosensitivity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.953000009059906},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.8305461406707764},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.6352763175964355},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.629511296749115},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5431645512580872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.501741886138916},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4881337583065033},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.4752200245857239},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4376617968082428},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40459680557250977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37956276535987854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1934056580066681},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19105571508407593},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08912578225135803},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007399","descriptor_name":"Interphase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/09553008814552331","doi":"https://doi.org/10.1080/09553008814552331","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553008814552331","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:2903890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2903890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.atira.dk:publications/fb6a702c-756d-4b0f-8120-e3e634359460","doi":null,"is_oa":false,"landing_page_url":"http://informahealthcare.com/doi/abs/10.1080/09553008814552331","pdf_url":null,"source":{"id":"https://openalex.org/S4306401758","display_name":"University of Brighton Repository (University of Brighton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71637028","host_organization_name":"University of Brighton","host_organization_lineage":["https://openalex.org/I71637028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W133789462","https://openalex.org/W618247855","https://openalex.org/W1524485065","https://openalex.org/W1582871837","https://openalex.org/W1591941252","https://openalex.org/W1963675229","https://openalex.org/W1965684447","https://openalex.org/W1979786912","https://openalex.org/W1992476889","https://openalex.org/W2012192362","https://openalex.org/W2012492678","https://openalex.org/W2014459040","https://openalex.org/W2041045166","https://openalex.org/W2044060290","https://openalex.org/W2061788727","https://openalex.org/W2062374903","https://openalex.org/W2075500972","https://openalex.org/W2085250590","https://openalex.org/W2090182749","https://openalex.org/W2109122112","https://openalex.org/W2139893623","https://openalex.org/W2147571613","https://openalex.org/W2157127637","https://openalex.org/W2210489517","https://openalex.org/W2210872362","https://openalex.org/W2221331257","https://openalex.org/W2335100379","https://openalex.org/W2416189626","https://openalex.org/W2424281967","https://openalex.org/W4206103575","https://openalex.org/W4244130264","https://openalex.org/W4255244349","https://openalex.org/W4255635114"],"related_works":["https://openalex.org/W2012192362","https://openalex.org/W2113725806","https://openalex.org/W1538093100","https://openalex.org/W2122359255","https://openalex.org/W2022807956","https://openalex.org/W79630052","https://openalex.org/W2894680115","https://openalex.org/W2366369935","https://openalex.org/W4251527248","https://openalex.org/W2417570882"],"abstract_inverted_index":{"We":[0],"have":[1,33,46],"measured":[2],"clonal":[3],"survival":[4,91],"following":[5],"gamma-irradiation":[6],"of":[7,14,19,25,111,121,191,200,210],"unstimulated":[8],"(G0)":[9],"T-lymphocytes":[10,74,135,235],"from":[11,37,48,52,56,62,75,139,189,236],"35":[12],"donors,":[13,51,171],"11":[15],"T-lymphocyte":[16,35,85],"cell":[17,22,98,156,184,196],"lines,":[18,23,86],"six":[20],"lymphoblastoid":[21,97],"and":[24,61,129,136],"nine":[26,49,63,125],"primary":[27,112,137],"fibroblast":[28],"strains":[29],"for":[30],"which":[31],"we":[32,45],"G0":[34,43,73,122,134,192,223,234],"material":[36],"the":[38,42,140,154,198,206],"same":[39,141],"donor.":[40],"Amongst":[41],"lymphocytes":[44],"results":[47,226],"normal":[50,76,170],"eight":[53],"cord":[54,241],"bloods,":[55],"seven":[57],"ataxia-telangiectasia":[58],"(A-T)":[59],"patients":[60],"A-T":[64,131,201,211],"heterozygotes.":[65],"Although":[66],"there":[67,148,162],"is":[68],"some":[69,164],"variation":[70],"between":[71],"samples,":[72],"donors":[77],"appear":[78,100],"to":[79,101,115,119,177],"be":[80,102,116,173,187],"slightly":[81,103,230],"more":[82,89,104],"radioresistant":[83],"than":[84,106],"with":[87,169,218,222],"a":[88,216,229],"shouldered":[90],"curve.":[92],"From":[93],"our":[94],"limited":[95],"sample,":[96],"lines":[99],"radiosensitive":[105],"T-lymphocytes.":[107,123,193,224],"The":[108],"overall":[109],"radiosensitivity":[110,152,181,232],"fibroblasts":[113,138],"appears":[114],"broadly":[117],"similar":[118,151],"that":[120,190],"In":[124,145,194],"instances,":[126],"five":[127,146],"A-Ts":[128],"four":[130,160],"heterozygotes,":[132,212],"both":[133],"donor":[142],"were":[143],"tested.":[144],"cases":[147,161],"was":[149,163,203,220],"closely":[150],"in":[153,159,175,182,233],"two":[155],"types,":[157],"but":[158,238],"discrepancy.":[165],"Further":[166],"work,":[167],"especially":[168],"will":[172],"required":[174],"order":[176],"establish":[178],"how":[179],"reliably":[180],"other":[183],"types":[185,197],"can":[186],"predicted":[188],"all":[195],"hypersensitivity":[199],"cells":[202],"confirmed.":[204],"Furthermore,":[205],"marginally":[207],"greater":[208],"sensitivity":[209],"when":[213],"compared":[214],"as":[215],"group":[217],"normals,":[219],"confirmed":[221],"Our":[225],"also":[227],"suggest":[228],"increased":[231],"some,":[237],"not":[239],"all,":[240],"blood":[242],"samples.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}