{"id":"https://openalex.org/W21298418","doi":null,"title":"Molecular imaging of integrin \u03b1v\u03b26 expression in living subjects.","display_name":"Molecular imaging of integrin \u03b1v\u03b26 expression in living subjects.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W21298418","mag":"21298418","pmid":"https://pubmed.ncbi.nlm.nih.gov/24982819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074499"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4074499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Nucl Med Mol Imaging","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074499","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016563317","display_name":"Yue Wu","orcid":"https://orcid.org/0000-0001-7296-8182","observed_orcids":["https://orcid.org/0000-0001-7296-8182"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Wu","raw_affiliation_strings":["Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380518","display_name":"Fan Wang","orcid":"https://orcid.org/0000-0002-4166-5776","observed_orcids":["https://orcid.org/0000-0002-4166-5776"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Wang","raw_affiliation_strings":["Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022600083","display_name":"Zhaofei Liu","orcid":"https://orcid.org/0000-0001-8718-8154","observed_orcids":["https://orcid.org/0000-0001-8718-8154"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaofei Liu","raw_affiliation_strings":["Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center, Peking University Beijing 100191, China ; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":null,"apc_paid":null,"fwci":1.383,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.7779344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"4","first_page":"333","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alphavbeta6","display_name":"integrin \u03b1v\u03b26","score":0.9789999723434448},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.8270000219345093},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.9390000104904175},{"id":"https://openalex.org/keywords/single-photon-emission-computed-tomography","display_name":"single photon emission computed tomography","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.7279999852180481},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7919999957084656},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8361871838569641},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.7435418963432312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6688777208328247},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6107985973358154},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5835267305374146},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4521583914756775},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4500494599342346},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.41489699482917786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39844393730163574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3939324915409088},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.381314754486084},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35555964708328247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21985101699829102},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17405971884727478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1664828658103943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1513272523880005},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.15115880966186523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13181394338607788},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.12986531853675842},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08307516574859619}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4074499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Nucl Med Mol Imaging","raw_type":"Text"},{"id":"pmid:24982819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24982819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nuclear medicine and molecular imaging","raw_type":"Journal Article"},{"id":"mag:21298418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24982819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4074499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Nucl Med Mol Imaging","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W1215646","https://openalex.org/W81760698","https://openalex.org/W156283619","https://openalex.org/W1533970263","https://openalex.org/W1576773659","https://openalex.org/W1835561921","https://openalex.org/W1964103441","https://openalex.org/W1965400339","https://openalex.org/W1966022051","https://openalex.org/W1967675430","https://openalex.org/W1969139934","https://openalex.org/W1975158646","https://openalex.org/W1975569947","https://openalex.org/W1977721242","https://openalex.org/W1980484972","https://openalex.org/W1980768771","https://openalex.org/W1990832247","https://openalex.org/W1994185723","https://openalex.org/W1995212099","https://openalex.org/W1995884865","https://openalex.org/W1998975199","https://openalex.org/W2000512425","https://openalex.org/W2000799481","https://openalex.org/W2001093897","https://openalex.org/W2001535574","https://openalex.org/W2003008393","https://openalex.org/W2004255859","https://openalex.org/W2005289470","https://openalex.org/W2008997752","https://openalex.org/W2009306082","https://openalex.org/W2010183177","https://openalex.org/W2010223161","https://openalex.org/W2013040491","https://openalex.org/W2015303690","https://openalex.org/W2017818795","https://openalex.org/W2018822666","https://openalex.org/W2020651856","https://openalex.org/W2023595481","https://openalex.org/W2024098656","https://openalex.org/W2025047729","https://openalex.org/W2026742952","https://openalex.org/W2027925760","https://openalex.org/W2029000580","https://openalex.org/W2029851814","https://openalex.org/W2036216834","https://openalex.org/W2041149077","https://openalex.org/W2043680485","https://openalex.org/W2044570850","https://openalex.org/W2049399971","https://openalex.org/W2050921789","https://openalex.org/W2052917153","https://openalex.org/W2060179431","https://openalex.org/W2062876609","https://openalex.org/W2070904831","https://openalex.org/W2072664608","https://openalex.org/W2076271925","https://openalex.org/W2079016331","https://openalex.org/W2080454950","https://openalex.org/W2083875118","https://openalex.org/W2084776720","https://openalex.org/W2084896891","https://openalex.org/W2086768605","https://openalex.org/W2089870500","https://openalex.org/W2091972981","https://openalex.org/W2097187642","https://openalex.org/W2103126725","https://openalex.org/W2106528753","https://openalex.org/W2111455595","https://openalex.org/W2112195516","https://openalex.org/W2114122248","https://openalex.org/W2118042202","https://openalex.org/W2118086743","https://openalex.org/W2120343044","https://openalex.org/W2129156929","https://openalex.org/W2131119538","https://openalex.org/W2136274526","https://openalex.org/W2136853458","https://openalex.org/W2141502931","https://openalex.org/W2147000598","https://openalex.org/W2153284298","https://openalex.org/W2154154147","https://openalex.org/W2154356447","https://openalex.org/W2154962020","https://openalex.org/W2155139007","https://openalex.org/W2155827928","https://openalex.org/W2161626694","https://openalex.org/W2265877031","https://openalex.org/W2305885785","https://openalex.org/W2335752216","https://openalex.org/W2784065054","https://openalex.org/W4232957465","https://openalex.org/W7095721368","https://openalex.org/W7140253188"],"related_works":["https://openalex.org/W4388688621","https://openalex.org/W2366554797","https://openalex.org/W4316037813","https://openalex.org/W3032677747","https://openalex.org/W2667456464","https://openalex.org/W2155827928","https://openalex.org/W2802113124","https://openalex.org/W7122629488","https://openalex.org/W2584738204","https://openalex.org/W3215529771"],"abstract_inverted_index":{"Integrins,":[0],"a":[1,17,50,82],"family":[2,30],"of":[3,8,20,28,46,52,92,125,151],"cell":[4],"adhesion":[5],"molecules":[6],"composed":[7],"\u03b1":[9],"and":[10,23,37,73,78,89,105,119,153],"\u03b2":[11],"heterodimeric":[12],"subunits,":[13],"are":[14,136],"involved":[15],"in":[16,63,129,148],"wide":[18],"range":[19],"cell-extracellular":[21],"matrix":[22],"cell-cell":[24],"interactions.":[25],"The":[26],"study":[27],"integrin":[29,47,54,93,126,140],"members":[31],"as":[32],"targets":[33],"for":[34,85,100,115,143],"molecular":[35,86,110],"imaging":[36,91,124],"therapy":[38],"has":[39],"been":[40,113],"generally":[41],"limited":[42],"with":[43],"the":[44,53,149],"exception":[45],"\u03b1v\u03b23.":[48],"v\u03b26,":[49],"member":[51],"family,":[55],"is":[56,67],"expressed":[57],"at":[58],"low":[59],"or":[60],"undetectable":[61],"levels":[62],"normal":[64],"tissues,":[65],"but":[66],"widely":[68],"upregulated":[69],"during":[70],"many":[71],"pathological":[72],"physiological":[74],"processes,":[75],"especially":[76],"cancer":[77],"fibrosis,":[79],"making":[80],"it":[81],"promising":[83],"target":[84],"imaging.":[87],"Noninvasive":[88],"quantitative":[90],"v\u03b26":[94,127],"expression":[95,128],"would":[96],"be":[97],"very":[98],"useful":[99],"disease":[101],"diagnosis,":[102],"treatment":[103],"monitoring,":[104],"prognosis":[106],"assessment.":[107],"Although":[108],"various":[109],"probes":[111,142],"have":[112],"developed":[114],"positron":[116],"emission":[117,121],"tomography":[118,123],"single-photon":[120],"computed":[122],"preclinical":[130],"animal":[131],"models,":[132],"further":[133],"research":[134],"efforts":[135],"required":[137],"to":[138],"optimize":[139],"v\u03b26-targeting":[141],"future":[144],"potential":[145],"clinical":[146],"applications":[147],"fields":[150],"oncology":[152],"beyond.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
