{"id":"https://openalex.org/W2129773935","doi":"https://doi.org/10.1002/ijc.21922","title":"Increasing cyclooxygenase\u20102 (cox\u20102) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl\u20102","display_name":"Increasing cyclooxygenase\u20102 (cox\u20102) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl\u20102","publication_year":2006,"publication_date":"2006-03-21","ids":{"openalex":"https://openalex.org/W2129773935","doi":"https://doi.org/10.1002/ijc.21922","mag":"2129773935","pmid":"https://pubmed.ncbi.nlm.nih.gov/16550596"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.21922","doi":"https://doi.org/10.1002/ijc.21922","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.21922","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.21922","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.21922","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028216611","display_name":"Daisuke Shimizu","orcid":"https://orcid.org/0000-0002-7669-2838","observed_orcids":["https://orcid.org/0000-0002-7669-2838","https://orcid.org/0009-0009-1961-361X","https://orcid.org/0009-0000-0087-6860"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Daisuke Shimizu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA","Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034221030","display_name":"Daniel Vallb\u00f6hmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Vallb\u00f6hmer","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053050318","display_name":"Hidekazu Kuramochi","orcid":"https://orcid.org/0000-0003-0875-7393","observed_orcids":["https://orcid.org/0000-0003-0875-7393"]},"institutions":[{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidekazu Kuramochi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazumi Uchida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazumi Uchida","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047601236","display_name":"Sylke Schneider\u2010Burrus","orcid":"https://orcid.org/0000-0002-9740-6845","observed_orcids":["https://orcid.org/0000-0002-9740-6845"]},"institutions":[{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylke Schneider","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036382531","display_name":"Parakrama T. Chandrasoma","orcid":"https://orcid.org/0000-0002-2168-9287","observed_orcids":["https://orcid.org/0000-0002-2168-9287"]},"institutions":[{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parakrama T. Chandrasoma","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069641755","display_name":"Hiroshi Shimada","orcid":"https://orcid.org/0000-0002-4049-6376","observed_orcids":["https://orcid.org/0000-0002-4049-6376"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Shimada","raw_affiliation_strings":["Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111655564","display_name":"Tom R. DeMeester","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom R. DeMeester","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071711204","display_name":"Kathleen D. Danenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen D. Danenberg","raw_affiliation_strings":["Response Genetics Inc., Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Response Genetics Inc., Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020843186","display_name":"Jeffrey H. Peters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey H. Peters","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022229732","display_name":"Steven R. DeMeester","orcid":"https://orcid.org/0000-0002-5480-8406","observed_orcids":["https://orcid.org/0000-0002-5480-8406"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R DeMeester","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111891836","display_name":"Peter V. Danenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter V. Danenberg","raw_affiliation_strings":["","Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111891836"],"corresponding_institution_ids":["https://openalex.org/I4210117038"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.71,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.89910932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"119","issue":"4","first_page":"765","last_page":"770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/intraepithelial-neoplasia","display_name":"intraepithelial neoplasia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7239999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/reflux-esophagitis","display_name":"reflux esophagitis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/esophageal-squamous-epithelium","display_name":"esophageal squamous epithelium","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7454487085342407},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.6065202951431274},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.5837000608444214},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.579342782497406},{"id":"https://openalex.org/C11242284","wikidata":"https://www.wikidata.org/wiki/Q4293202","display_name":"Microdissection","level":3,"score":0.5555548667907715},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5267022252082825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5243485569953918},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.5193370580673218},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48944559693336487},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45659032464027405},{"id":"https://openalex.org/C2776497702","wikidata":"https://www.wikidata.org/wiki/Q872095","display_name":"Intestinal metaplasia","level":3,"score":0.45554935932159424},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44959181547164917},{"id":"https://openalex.org/C2780323790","wikidata":"https://www.wikidata.org/wiki/Q2912193","display_name":"Esophageal disease","level":3,"score":0.4303857982158661},{"id":"https://openalex.org/C2909576783","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Reflux esophagitis","level":4,"score":0.4303287863731384},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.4238140881061554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3898656666278839},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37662604451179504},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3237554430961609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3090164065361023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17481577396392822},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.14478904008865356},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06115499138832092},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.21922","doi":"https://doi.org/10.1002/ijc.21922","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.21922","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.21922","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:16550596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16550596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.21922","doi":"https://doi.org/10.1002/ijc.21922","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.21922","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.21922","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6210022617","display_name":"Biomarkers for Barretts's Esophagus and Adenocarcinoma","funder_award_id":"5r01ca084424-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7894447482","display_name":null,"funder_award_id":"R01-CA84424-02","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129773935.pdf","grobid_xml":"https://content.openalex.org/works/W2129773935.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W89997462","https://openalex.org/W199331381","https://openalex.org/W300411342","https://openalex.org/W1484784716","https://openalex.org/W1518353833","https://openalex.org/W1550475263","https://openalex.org/W1625189041","https://openalex.org/W1685016018","https://openalex.org/W1966635863","https://openalex.org/W1975917574","https://openalex.org/W1983479821","https://openalex.org/W1992817357","https://openalex.org/W1998394615","https://openalex.org/W2001255763","https://openalex.org/W2011199617","https://openalex.org/W2015773464","https://openalex.org/W2016008430","https://openalex.org/W2022640628","https://openalex.org/W2023331812","https://openalex.org/W2025048412","https://openalex.org/W2030592858","https://openalex.org/W2030701541","https://openalex.org/W2041175997","https://openalex.org/W2042942606","https://openalex.org/W2043707891","https://openalex.org/W2045381322","https://openalex.org/W2046451894","https://openalex.org/W2050847440","https://openalex.org/W2056242354","https://openalex.org/W2062845635","https://openalex.org/W2064888367","https://openalex.org/W2075039358","https://openalex.org/W2078422697","https://openalex.org/W2083256941","https://openalex.org/W2089413828","https://openalex.org/W2122543246","https://openalex.org/W2123107307","https://openalex.org/W2123830992","https://openalex.org/W2127099586","https://openalex.org/W2128709694","https://openalex.org/W2136743029","https://openalex.org/W2141735368","https://openalex.org/W2145149010","https://openalex.org/W2146708145","https://openalex.org/W2148122132","https://openalex.org/W2154700985","https://openalex.org/W2156470937","https://openalex.org/W2159733409","https://openalex.org/W2162517111","https://openalex.org/W2164578725","https://openalex.org/W2167916471","https://openalex.org/W2169498043","https://openalex.org/W2170720478","https://openalex.org/W2192027448","https://openalex.org/W2318276166","https://openalex.org/W2431606324","https://openalex.org/W2912615547","https://openalex.org/W3142049460","https://openalex.org/W3144719512"],"related_works":["https://openalex.org/W2244890532","https://openalex.org/W2136743029","https://openalex.org/W2391580029","https://openalex.org/W2030592858","https://openalex.org/W2393911132","https://openalex.org/W283258552","https://openalex.org/W2349145881","https://openalex.org/W2046451894","https://openalex.org/W2022640628","https://openalex.org/W2354863865"],"abstract_inverted_index":{"Previous":[0],"studies":[1,24],"from":[2,65],"our":[3],"laboratory":[4],"and":[5,84,98,103,128,141,162],"others":[6],"have":[7],"suggested":[8],"that":[9,26],"increased":[10,144],"expression":[11,29,99,113],"of":[12,19,30,45,53,60,101,119,138],"cox-2":[13,27,102,142],"is":[14,178],"important":[15],"in":[16,41,57,145,187],"the":[17,31,51,58,120],"genesis":[18],"esophageal":[20,122],"adenocarcinoma.":[21,62],"In":[22],"vitro":[23],"suggest":[25],"regulates":[28],"anti-apoptotic":[32],"protein":[33],"bcl-2,":[34],"thus":[35],"possibly":[36],"accounting":[37],"for":[38],"reduced":[39],"apoptosis":[40],"carcinogenesis.":[42],"The":[43,89],"aim":[44],"this":[46],"study":[47],"was":[48,92],"to":[49,117,171],"investigate":[50],"relationship":[52],"these":[54,183],"2":[55],"genes":[56],"development":[59],"Barrett's-associated":[61],"Histologic":[63],"sections":[64],"endoscopic":[66],"biopsies":[67],"or":[68,135,174],"esophagectomy":[69],"specimens":[70],"were":[71,105,115,143],"classified":[72],"as":[73],"non-dysplastic":[74,146],"Barrett's":[75,134,147],"(n":[76,81,86,125,130],"=":[77,82,87,126,131,149,152,157,160],"30),":[78],"intraepithelial":[79,154],"neoplasia":[80,155],"12)":[83],"adenocarcinoma":[85,163],"48).":[88],"desired":[90],"tissue":[91],"isolated":[93],"by":[94,107],"laser":[95],"capture":[96],"microdissection":[97],"levels":[100,114],"bcl-2":[104,140],"measured":[106],"quantitative":[108],"real-time":[109],"PCR":[110],"(Taqman).":[111],"Gene":[112],"compared":[116,170],"samples":[118],"distal":[121],"squamous":[123,172],"epithelium":[124,173],"55)":[127],"reflux-esophagitis":[129],"25),":[132],"without":[133],"cancer.":[136],"Expression":[137],"both":[139],"(p":[148,156,164,189],"0.0077,":[150],"p":[151,159,167],"0.0037),":[153],"0.0053,":[158],"0.0220)":[161],"<":[165,168,190],"0.0001,":[166],"0.0001)":[169],"reflux-esophagitis.":[175],"Furthermore,":[176],"there":[177],"a":[179],"significant":[180],"correlation":[181],"between":[182],"two":[184],"genes,":[185],"especially":[186],"carcinoma":[188],"0.0001).":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}