{"id":"https://openalex.org/W2129768655","doi":"https://doi.org/10.1039/b905145g","title":"Incorporation of excess gadolinium into human bone from medical contrast agents","display_name":"Incorporation of excess gadolinium into human bone from medical contrast agents","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2129768655","doi":"https://doi.org/10.1039/b905145g","mag":"2129768655","pmid":"https://pubmed.ncbi.nlm.nih.gov/21305156"},"language":"en","primary_location":{"id":"doi:10.1039/b905145g","doi":"https://doi.org/10.1039/b905145g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b905145g","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042442806","display_name":"Thomas H. Darrah","orcid":"https://orcid.org/0000-0002-7327-1720","observed_orcids":["https://orcid.org/0000-0002-7327-1720"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas H. Darrah","raw_affiliation_strings":["Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY 14627, USA. Thomas.Darrah@umb.edu","Department of Earth and Environmental Sciences, University of Rochester, Rochester, USA","Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston,Dorchester,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY 14627, USA. Thomas.Darrah@umb.edu","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Earth and Environmental Sciences, University of Rochester, Rochester, USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston,Dorchester,USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062617049","display_name":"Jennifer J. Prutsman-Pfeiffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer J. Prutsman-Pfeiffer","raw_affiliation_strings":["Department of Autopsy and Neuropathology, University of Rochester Medical Center, Rochester, NY 14624, USA","Department of Autopsy and Neuropathology, University of Rochester Medical Center,Rochester,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Autopsy and Neuropathology, University of Rochester Medical Center, Rochester, NY 14624, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"Department of Autopsy and Neuropathology, University of Rochester Medical Center,Rochester,USA","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111816597","display_name":"Robert J. Poreda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Poreda","raw_affiliation_strings":["Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY 14627, USA","Department of Earth & Environmental Sciences University of Rochester, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Earth & Environmental Sciences University of Rochester, Rochester, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Ellen Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ellen Campbell","raw_affiliation_strings":["Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY 14627, USA","Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston, Dorchester, MA 02125, USA","Department of Earth and Environmental Sciences, University of Rochester, Rochester, USA","Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston,Dorchester,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston, Dorchester, MA 02125, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Earth and Environmental Sciences, University of Rochester, Rochester, USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston,Dorchester,USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044743272","display_name":"Peter V. Hauschka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter V. Hauschka","raw_affiliation_strings":["Department of Orthopedic Surgery, Children\u2019s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA","Department of Orthopedic Surgery, Children\u2019s Hospital Boston, Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Children\u2019s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Children\u2019s Hospital Boston, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012267584","display_name":"Robyn E. Hannigan","orcid":"https://orcid.org/0000-0003-4782-1124","observed_orcids":["https://orcid.org/0000-0003-4782-1124"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn E. Hannigan","raw_affiliation_strings":["Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston, Dorchester, MA 02125, USA","Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston,Dorchester,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston, Dorchester, MA 02125, USA","institution_ids":["https://openalex.org/I33434090"]},{"raw_affiliation_string":"Department of Environmental, Earth and Ocean Sciences, University of Massachusetts at Boston,Dorchester,USA","institution_ids":["https://openalex.org/I33434090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042442806"],"corresponding_institution_ids":["https://openalex.org/I33434090","https://openalex.org/I5388228"],"apc_list":{"value":2653,"currency":"USD","value_usd":2653},"apc_paid":null,"fwci":1.6965,"has_fulltext":false,"cited_by_count":298,"citation_normalized_percentile":{"value":0.83065193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"1","issue":"6","first_page":"479","last_page":"479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.23019999265670776,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11740","display_name":"Geochemistry and Elemental Analysis","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1906","display_name":"Geochemistry and Petrology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium","display_name":"gadolinium","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gadolinium-based-contrast-agents","display_name":"gadolinium-based contrast agents","score":0.9580000042915344},{"id":"https://openalex.org/keywords/femoral-head","display_name":"femoral head","score":0.7940000295639038},{"id":"https://openalex.org/keywords/rare-earth-elements","display_name":"rare earth elements","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nephrogenic-systemic-fibrosis","display_name":"nephrogenic systemic fibrosis","score":0.890999972820282},{"id":"https://openalex.org/keywords/gadodiamide","display_name":"gadodiamide","score":0.8320000171661377},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.3799999952316284},{"id":"https://openalex.org/keywords/rare-earth-element-anomalies","display_name":"rare earth element anomalies","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.8596078157424927},{"id":"https://openalex.org/C2781027423","wikidata":"https://www.wikidata.org/wiki/Q677803","display_name":"Nephrogenic systemic fibrosis","level":3,"score":0.7843722701072693},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.6097456812858582},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5612512230873108},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5162932276725769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49544966220855713},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4898068606853485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3661801517009735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12347424030303955},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/b905145g","doi":"https://doi.org/10.1039/b905145g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b905145g","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},{"id":"pmid:21305156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21305156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics : integrated biometal science","raw_type":"Journal Article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/19633","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2292/19633","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W14041409","https://openalex.org/W15174121","https://openalex.org/W1495795226","https://openalex.org/W1569584988","https://openalex.org/W1971545309","https://openalex.org/W1973873044","https://openalex.org/W1978965889","https://openalex.org/W1979856671","https://openalex.org/W1979988962","https://openalex.org/W1986156067","https://openalex.org/W1990310567","https://openalex.org/W1991214552","https://openalex.org/W1991985237","https://openalex.org/W1993638883","https://openalex.org/W2000001293","https://openalex.org/W2001787548","https://openalex.org/W2002514019","https://openalex.org/W2003128797","https://openalex.org/W2010191338","https://openalex.org/W2013599864","https://openalex.org/W2019138482","https://openalex.org/W2019811781","https://openalex.org/W2020319537","https://openalex.org/W2024264467","https://openalex.org/W2029072716","https://openalex.org/W2030561313","https://openalex.org/W2038371833","https://openalex.org/W2040768064","https://openalex.org/W2047344596","https://openalex.org/W2049134111","https://openalex.org/W2053790124","https://openalex.org/W2054543250","https://openalex.org/W2054917280","https://openalex.org/W2056029027","https://openalex.org/W2059864970","https://openalex.org/W2062637658","https://openalex.org/W2064079094","https://openalex.org/W2066912277","https://openalex.org/W2069195769","https://openalex.org/W2086145083","https://openalex.org/W2090027766","https://openalex.org/W2103286976","https://openalex.org/W2103813652","https://openalex.org/W2107934382","https://openalex.org/W2110213842","https://openalex.org/W2116557384","https://openalex.org/W2121751309","https://openalex.org/W2121868299","https://openalex.org/W2129653665","https://openalex.org/W2136421454","https://openalex.org/W2143751651","https://openalex.org/W2150489367","https://openalex.org/W2150765327","https://openalex.org/W2156123988","https://openalex.org/W2157433411","https://openalex.org/W2159837057","https://openalex.org/W2164954578","https://openalex.org/W2413570053","https://openalex.org/W4235466046"],"related_works":["https://openalex.org/W3127115336","https://openalex.org/W3015195301","https://openalex.org/W2775202762","https://openalex.org/W2312938814","https://openalex.org/W3093413062","https://openalex.org/W4387003133","https://openalex.org/W7160254609","https://openalex.org/W7115825593","https://openalex.org/W2972997625","https://openalex.org/W4397041798"],"abstract_inverted_index":{"We":[0,82,144],"find":[1],"anomalously":[2],"high":[3,182],"gadolinium":[4],"(Gd)":[5],"concentrations":[6,91,101,183,198,262,292],"in":[7,30,56,61,78,92,102,157,241,259,308],"the":[8,138,151,177,197,205,228],"femoral":[9,94],"head":[10],"bones":[11],"of":[12,155,179,184,190,199,303,318,327],"patients":[13,35,103,222,266,284,295,323,332],"exposed":[14,221,285,341],"to":[15,33,38,65,107,149,204,209,225,286,342],"chelated":[16,31,242],"Gd,":[17,239],"commonly":[18],"used":[19],"as":[20,69],"a":[21,42],"contrast":[22,109,214,344],"agent":[23],"for":[24,220,250,322],"medical":[25,66],"imaging.":[26],"Gd":[27,52,59,84,100,114,120,156,194,211,217,261,269,276,287,291,320],"is":[28,63,248],"introduced":[29,240],"form":[32],"protect":[34],"from":[36,196,213],"exposure":[37,106],"toxic":[39],"free":[40],"Gd(3+),":[41],"calcium":[43],"antagonist":[44],"which":[45],"disrupts":[46],"cellular":[47],"processes.":[48],"Recent":[49],"studies":[50],"suggest":[51],"chelates":[53],"break":[54],"down":[55],"vivo,":[57],"and":[58,77,85,202,247,263,275,312,333,336],"accumulation":[60],"tissue":[62],"linked":[64],"conditions":[67],"such":[68],"nephrogenic":[70],"systemic":[71],"fibrosis":[72],"(NSF),":[73],"acute":[74],"kidney":[75],"failure,":[76],"some":[79],"cases":[80],"death.":[81],"measure":[83],"other":[86],"rare":[87],"earth":[88],"element":[89],"(REE)":[90],"35":[93],"heads":[95],"by":[96],"solution":[97],"based":[98],"ICP-MS.":[99],"with":[104,181,268,324],"documented":[105],"Gd-based":[108,343],"agents":[110],"(n":[111,141],"=":[112,118,124,129,142,273,280],"13:":[113],"DTPA-BMA":[115,270],"(Omniscan)":[116],"n":[117,123,128,272,279],"6;":[119],"HP-DO3A":[121,277],"(Prohance)":[122],"5;":[125],"unknown":[126],"type":[127],"4)":[130],"are":[131,340],"significantly":[132,289],"higher":[133],"(p":[134,296],"<":[135,297],"0.001)":[136],"than":[137,252,293],"control":[139,147,173,206],"group":[140,148,174,207],"17).":[143],"use":[145],"our":[146],"establish":[150],"'natural'":[152,229],"background":[153],"level":[154,230],"human":[158],"bone":[159,246,260,310,328],"(cortical":[160],"95%":[161,167],"CI:":[162,168,232],"0.023,":[163],"0.041":[164],"nmol/g;":[165],"trabecular":[166],"0.054,":[169],"0.107":[170],"nmol/g).":[171],"A":[172],"outlier":[175],"reveals":[176],"occurrence":[178],"individuals":[180],"all":[185],"REEs,":[186],"including":[187],"Gd.":[188],"Because":[189],"this,":[191],"we":[192],"calculate":[193],"anomalies":[195,264],"adjacent":[200],"REEs":[201],"normalize":[203],"mean":[208],"isolate":[210],"input":[212],"agents.":[215,345],"Normalized":[216],"anomalies,":[218],"(Gd/Gd*)(N),":[219],"range":[223],"up":[224],">800":[226],"times":[227],"(95%":[231],"124,":[233],"460).":[234],"Our":[235],"data":[236],"confirm":[237],"that":[238],"form,":[243],"incorporates":[244],"into":[245],"retained":[249],"more":[251],"8":[253],"years.":[254],"No":[255],"difference":[256],"was":[257],"observed":[258],"between":[265],"dosed":[267],"(Omniscan;":[271],"6)":[274],"(Prohance;":[278],"5).":[281],"Osteoporotic":[282],"fracture":[283],"have":[288],"lower":[290],"osteoarthritis":[294],"0.001).":[298],"This":[299],"indicates":[300],"different":[301],"mechanisms":[302],"metal":[304],"incorporation":[305],"and/or":[306],"retention":[307],"osteoporotic":[309],"tissues,":[311],"may":[313],"signal":[314],"an":[315],"increased":[316,325],"risk":[317],"endogenous":[319],"release":[321],"rates":[326],"resorption":[329],"(e.g.":[330],"osteoporosis":[331],"menopausal,":[334],"pregnant,":[335],"lactating":[337],"women)":[338],"who":[339]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}