{"id":"https://openalex.org/W2129761653","doi":"https://doi.org/10.1186/1742-2094-4-25","title":"Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia","display_name":"Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia","publication_year":2007,"publication_date":"2007-10-10","ids":{"openalex":"https://openalex.org/W2129761653","doi":"https://doi.org/10.1186/1742-2094-4-25","mag":"2129761653","pmid":"https://pubmed.ncbi.nlm.nih.gov/17927823","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2100038"},"language":"en","primary_location":{"id":"doi:10.1186/1742-2094-4-25","doi":"https://doi.org/10.1186/1742-2094-4-25","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-4-25","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-4-25","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-4-25","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064044893","display_name":"Eduardo Candelario\u2010Jalil","orcid":"https://orcid.org/0000-0003-3631-1989","observed_orcids":["https://orcid.org/0000-0003-3631-1989"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Eduardo Candelario-Jalil","raw_affiliation_strings":["Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104 Freiburg, Germany. ecandelario-jalil@salud.unm.edu","Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, USA","Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104 Freiburg, Germany. ecandelario-jalil@salud.unm.edu","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, USA","institution_ids":["https://openalex.org/I4405255059"]},{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073191722","display_name":"Ant\u00f4nio Carlos Pinheiro de Oliveira","orcid":"https://orcid.org/0000-0003-3217-4294","observed_orcids":["https://orcid.org/0000-0003-3217-4294"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antonio C Pinheiro de Oliveira","raw_affiliation_strings":["Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073268257","display_name":"Sybille Gr\u00e4f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sybille Gr\u00e4f","raw_affiliation_strings":["Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013715586","display_name":"Harsharan S. Bhatia","orcid":"https://orcid.org/0000-0001-9912-8263","observed_orcids":["https://orcid.org/0000-0001-9912-8263"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harsharan S Bhatia","raw_affiliation_strings":["Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107863901","display_name":"Michael H\u00fcll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael H\u00fcll","raw_affiliation_strings":["Center for Geriatrics and Gerontology, University of Freiburg Medical School, Lehenerstrasse 88, D-79106, Freiburg, Germany","Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Geriatrics and Gerontology, University of Freiburg Medical School, Lehenerstrasse 88, D-79106, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019389835","display_name":"Eduardo Mu\u00f1\u00f3z","orcid":"https://orcid.org/0000-0001-8478-5842","observed_orcids":["https://orcid.org/0000-0001-8478-5842","https://orcid.org/0000-0002-9844-961X","https://orcid.org/0000-0003-4457-0817"]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Mu\u00f1oz","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular, Fisiolog\u00eda e Inmunolog\u00eda. Universidad de C\u00f3rdoba, Avda Men\u00e9ndez Pidal s/n, 14004, C\u00f3rdoba, Spain","Departamento de Biolog\u00eda Celular, Fisiolog\u00eda e Inmunolog\u00eda, Universidad de Cordoba, C\u00f3rdoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular, Fisiolog\u00eda e Inmunolog\u00eda. Universidad de C\u00f3rdoba, Avda Men\u00e9ndez Pidal s/n, 14004, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular, Fisiolog\u00eda e Inmunolog\u00eda, Universidad de Cordoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035925368","display_name":"Bernd L. Fiebich","orcid":"https://orcid.org/0000-0002-9261-6771","observed_orcids":["https://orcid.org/0000-0002-9261-6771"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bernd L Fiebich","raw_affiliation_strings":["Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","VivaCell Biotechnology GmbH, Ferdinand-Porsche-Str. 5, D-79211, Denzlingen, Germany","Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D-79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"VivaCell Biotechnology GmbH, Ferdinand-Porsche-Str. 5, D-79211, Denzlingen, Germany","institution_ids":[]},{"raw_affiliation_string":"Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035925368"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":8.8105,"has_fulltext":true,"cited_by_count":229,"citation_normalized_percentile":{"value":0.98382749,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9359999895095825},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.972000002861023},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.9539999961853027},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9509999752044678},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mpges-1","display_name":"mPGES-1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.7279999852180481},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7739999890327454},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.42100000381469727},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.6100000143051147},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8471872806549072},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7961620092391968},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7277512550354004},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6431578993797302},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.609437882900238},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5348258018493652},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5275017023086548},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5250199437141418},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5112021565437317},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.47721439599990845},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4197543263435364},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4138963222503662},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36743807792663574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2839365005493164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27067992091178894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26021134853363037},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24051403999328613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23990696668624878},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1742-2094-4-25","doi":"https://doi.org/10.1186/1742-2094-4-25","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-4-25","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-4-25","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2100038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2100038","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuroinflammation","raw_type":"Text"},{"id":"pmid:17927823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17927823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5e601bf76f1f42ccb72ec6fc29392a80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5e601bf76f1f42ccb72ec6fc29392a80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, Vol 4, Iss 1, p 25 (2007)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-2094-4-25","doi":"https://doi.org/10.1186/1742-2094-4-25","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-4-25","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-4-25","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129761653.pdf","grobid_xml":"https://content.openalex.org/works/W2129761653.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1512775573","https://openalex.org/W1517525911","https://openalex.org/W1526678238","https://openalex.org/W1557310960","https://openalex.org/W1560763587","https://openalex.org/W1563590122","https://openalex.org/W1588691619","https://openalex.org/W1676270203","https://openalex.org/W1800831454","https://openalex.org/W1809166631","https://openalex.org/W1945593562","https://openalex.org/W1964265093","https://openalex.org/W1966441204","https://openalex.org/W1967459697","https://openalex.org/W1974431794","https://openalex.org/W1977433941","https://openalex.org/W1979501382","https://openalex.org/W1979979472","https://openalex.org/W1986254047","https://openalex.org/W1993735050","https://openalex.org/W1994679263","https://openalex.org/W1996721832","https://openalex.org/W1996733510","https://openalex.org/W2003241128","https://openalex.org/W2004349171","https://openalex.org/W2008108455","https://openalex.org/W2016760563","https://openalex.org/W2019005658","https://openalex.org/W2019447370","https://openalex.org/W2027720504","https://openalex.org/W2029850313","https://openalex.org/W2032113087","https://openalex.org/W2033528375","https://openalex.org/W2037133338","https://openalex.org/W2038781543","https://openalex.org/W2040014429","https://openalex.org/W2041384877","https://openalex.org/W2043243971","https://openalex.org/W2054775930","https://openalex.org/W2056311398","https://openalex.org/W2056546282","https://openalex.org/W2058130980","https://openalex.org/W2060240527","https://openalex.org/W2061194161","https://openalex.org/W2061838477","https://openalex.org/W2063249182","https://openalex.org/W2064305999","https://openalex.org/W2068813982","https://openalex.org/W2070620348","https://openalex.org/W2070815033","https://openalex.org/W2070928409","https://openalex.org/W2071251759","https://openalex.org/W2081939036","https://openalex.org/W2086508570","https://openalex.org/W2089679897","https://openalex.org/W2089971537","https://openalex.org/W2096158347","https://openalex.org/W2098097762","https://openalex.org/W2100837269","https://openalex.org/W2101292609","https://openalex.org/W2101736298","https://openalex.org/W2102356176","https://openalex.org/W2111015407","https://openalex.org/W2121548571","https://openalex.org/W2126062115","https://openalex.org/W2134812217","https://openalex.org/W2136197942","https://openalex.org/W2141024716","https://openalex.org/W2145519598","https://openalex.org/W2147330842","https://openalex.org/W2150970599","https://openalex.org/W2151283331","https://openalex.org/W2153989172","https://openalex.org/W2154768453","https://openalex.org/W2155913937","https://openalex.org/W2156675756","https://openalex.org/W2157818382","https://openalex.org/W2159940930","https://openalex.org/W2166500242","https://openalex.org/W2167029659","https://openalex.org/W2169999439"],"related_works":["https://openalex.org/W2088667503","https://openalex.org/W1993735050","https://openalex.org/W2165353171","https://openalex.org/W2106673507","https://openalex.org/W2964944135","https://openalex.org/W2382665128","https://openalex.org/W1601505462","https://openalex.org/W2594333208","https://openalex.org/W1975845670","https://openalex.org/W2023074186"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuroinflammatory":[1],"responses":[2],"are":[3,18],"triggered":[4],"by":[5,131,204,275,327],"diverse":[6],"ethiologies":[7],"and":[8,41,67,105,125,185,196,241,260,317,323],"can":[9],"provide":[10],"either":[11],"beneficial":[12],"or":[13,162],"harmful":[14],"results.":[15],"Microglial":[16,150],"cells":[17,151],"the":[19,32,160,181,218,242,257,271,283,290,307,335],"major":[20],"cell":[21,140],"type":[22],"involved":[23],"in":[24,35,99,103,106,159,356,358],"neuroinflammation,":[25],"releasing":[26],"several":[27,36,357],"mediators,":[28],"which":[29,264,294],"contribute":[30],"to":[31,51,95,114,120,179,342,351],"neuronal":[33,97],"demise":[34],"diseases":[37],"including":[38],"cerebral":[39,145],"ischemia":[40],"neurodegenerative":[42],"disorders.":[43],"Attenuation":[44],"of":[45,57,82,110,147,157,164,167,183,193,210,215,244,249,262,273,285,306,361],"microglial":[46,139,344],"activation":[47],"has":[48,65,72],"been":[49,73],"shown":[50,75],"confer":[52],"protection":[53],"against":[54],"different":[55,100,165],"types":[56],"brain":[58,362],"injury.":[59,363],"Recent":[60],"evidence":[61],"suggests":[62],"that":[63,76,90,234,311,334,348],"resveratrol":[64,77,117,168,235,254,279,339],"anti-inflammatory":[66],"potent":[68,80],"antioxidant":[69],"properties.":[70],"It":[71],"also":[74],"is":[78,93,118,265,288,310,340],"a":[79,247,266],"inhibitor":[81,293],"cyclooxygenase":[83],"(COX)-1":[84],"activity.":[85],"Previous":[86],"findings":[87,332],"have":[88],"demonstrated":[89],"this":[91,111],"compound":[92],"able":[94,119,341],"reduce":[96,121,343],"injury":[98],"models,":[101],"both":[102],"vitro":[104],"vivo.":[107],"The":[108],"aim":[109],"study":[112,309],"was":[113,221],"examine":[115],"whether":[116],"prostaglandin":[122,198],"E2":[123],"(PGE2)":[124],"8-iso-prostaglandin":[126],"F2alpha":[127],"(8-iso-PGF2":[128],"alpha)":[129],"production":[130,182,326],"lipopolysaccharide":[132],"(LPS)-activated":[133],"primary":[134],"rat":[135],"microglia.":[136,329],"METHODS:":[137],"Primary":[138],"cultures":[141],"were":[142,152,177,202],"prepared":[143],"from":[144],"cortices":[146],"neonatal":[148],"rats.":[149],"stimulated":[153],"with":[154,212],"10":[155],"ng/ml":[156],"LPS":[158],"presence":[161],"absence":[163],"concentrations":[166],"(1-50":[169],"microM).":[170],"After":[171],"24":[172,208],"h":[173,209],"incubation,":[174],"culture":[175],"media":[176],"collected":[178],"measure":[180,248],"PGE2":[184,239,274,322],"8-iso-PGF2":[186,245,324],"alpha":[187,325],"using":[188,223],"enzyme":[189,268],"immunoassays.":[190],"Protein":[191],"levels":[192],"COX-1,":[194],"COX-2":[195,301],"microsomal":[197],"E":[199],"synthase-1":[200],"(mPGES-1)":[201],"studied":[203],"Western":[205],"blotting":[206],"after":[207],"incubation":[211],"LPS.":[213],"Expression":[214],"mPGES-1":[216,297],"at":[217],"mRNA":[219],"level":[220],"investigated":[222],"reverse":[224],"transcription-polymerase":[225],"chain":[226],"reaction":[227],"(RT-PCR)":[228],"analysis.":[229],"RESULTS:":[230],"Our":[231],"results":[232],"indicate":[233],"potently":[236,320],"reduced":[237,256,321],"LPS-induced":[238],"synthesis":[240,272],"formation":[243],"alpha,":[246],"free":[250],"radical":[251],"production.":[252],"Interestingly,":[253],"dose-dependently":[255],"expression":[258,284,298],"(mRNA":[259],"protein)":[261],"mPGES-1,":[263],"key":[267],"responsible":[269],"for":[270],"activated":[276],"microglia,":[277],"whereas":[278],"did":[280],"not":[281],"affect":[282],"COX-2.":[286],"Resveratrol":[287],"therefore":[289],"first":[291],"known":[292],"specifically":[295],"prevents":[296],"without":[299],"affecting":[300],"levels.":[302],"Another":[303],"important":[304],"observation":[305],"present":[308],"other":[312],"COX-1":[313],"selective":[314],"inhibitors":[315],"(SC-560":[316],"Valeroyl":[318],"Salicylate)":[319],"LPS-activated":[328],"CONCLUSION:":[330],"These":[331],"suggest":[333],"naturally":[336],"occurring":[337],"polyphenol":[338],"activation,":[345],"an":[346],"effect":[347],"might":[349],"help":[350],"explain":[352],"its":[353],"neuroprotective":[354],"effects":[355],"vivo":[359],"models":[360]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}