{"id":"https://openalex.org/W2129760055","doi":"https://doi.org/10.1128/aac.37.7.1426","title":"Pharmacokinetic interaction between rifampin and zidovudine","display_name":"Pharmacokinetic interaction between rifampin and zidovudine","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W2129760055","doi":"https://doi.org/10.1128/aac.37.7.1426","mag":"2129760055","pmid":"https://pubmed.ncbi.nlm.nih.gov/8363370","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/187988"},"language":"en","primary_location":{"id":"doi:10.1128/aac.37.7.1426","doi":"https://doi.org/10.1128/aac.37.7.1426","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.37.7.1426","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/187988","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021568119","display_name":"David Marinus Burger","orcid":"https://orcid.org/0000-0001-7279-2818","observed_orcids":["https://orcid.org/0000-0001-7279-2818"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D M Burger","raw_affiliation_strings":["Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109900774","display_name":"P. L. Meenhorst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P L Meenhorst","raw_affiliation_strings":["Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113785658","display_name":"Cornelis H.W. Koks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C H Koks","raw_affiliation_strings":["Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062227574","display_name":"Jos H. Beijnen","orcid":"https://orcid.org/0000-0003-0118-561X","observed_orcids":["https://orcid.org/0000-0003-0118-561X"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J H Beijnen","raw_affiliation_strings":["Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802065108"],"apc_list":null,"apc_paid":null,"fwci":4.3724,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.94549676,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"37","issue":"7","first_page":"1426","last_page":"1431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8360000252723694},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.7630000114440918},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7120000123977661},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2780216070","wikidata":"https://www.wikidata.org/wiki/Q198504","display_name":"Zidovudine","level":4,"score":0.9820747375488281},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7386234402656555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6484952569007874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.600287914276123},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5188111662864685},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.46335864067077637},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.4416264593601227},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.42403626441955566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.392686128616333},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.3288417458534241},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2383948266506195},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.16361498832702637},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.37.7.1426","doi":"https://doi.org/10.1128/aac.37.7.1426","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.37.7.1426","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11800","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/187988","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:187988","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/187988","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:8363370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8363370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Case Reports"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11800","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/187988","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1529226096","https://openalex.org/W1884263948","https://openalex.org/W1968777919","https://openalex.org/W1976696095","https://openalex.org/W1986185948","https://openalex.org/W1999388526","https://openalex.org/W2006545933","https://openalex.org/W2007366202","https://openalex.org/W2015284136","https://openalex.org/W2015284483","https://openalex.org/W2031183788","https://openalex.org/W2035447635","https://openalex.org/W2038850422","https://openalex.org/W2039994228","https://openalex.org/W2056029598","https://openalex.org/W2057071250","https://openalex.org/W2061026895","https://openalex.org/W2073267709","https://openalex.org/W2073645997","https://openalex.org/W2083960623","https://openalex.org/W2085979262","https://openalex.org/W2086068617","https://openalex.org/W2106758148","https://openalex.org/W2319699534","https://openalex.org/W2335699216","https://openalex.org/W2341862408","https://openalex.org/W4302768649"],"related_works":["https://openalex.org/W2122374426","https://openalex.org/W2435989539","https://openalex.org/W2016290897","https://openalex.org/W2018247727","https://openalex.org/W2072264989","https://openalex.org/W2047006594","https://openalex.org/W2125870553","https://openalex.org/W2019452982","https://openalex.org/W2032223070","https://openalex.org/W2125262622"],"abstract_inverted_index":{"A":[0],"potential":[1],"pharmacokinetic":[2],"interaction":[3],"between":[4],"rifampin":[5,44,172,185],"(Rimactan,":[6],"Rifadin)":[7],"and":[8,43,55,113,126,140,186],"zidovudine":[9,42,54,73,82,93,130,139,141,155,187],"(AZT,":[10],"Retrovir)":[11],"was":[12],"investigated":[13],"in":[14,94,100,110,165],"the":[15,61,133,174],"population":[16,80],"of":[17,50,53,72,81,92,129,150,154,160,171,176,184,192],"human":[18],"immunodeficiency":[19],"virus-infected":[20],"patients":[21,29,112,118],"at":[22],"our":[23],"hospital.":[24],"The":[25,117,152],"results":[26],"from":[27],"four":[28],"who":[30],"were":[31,74,98,108,143],"on":[32,173],"long-term":[33,181],"(>":[34],"or":[35],"=":[36],"6":[37],"months)":[38],"combination":[39,182],"therapy":[40,183],"with":[41,77,167],"are":[45,164],"presented.":[46],"In":[47,136],"all":[48,101,119],"cases":[49],"combined":[51],"use":[52],"rifampin,":[56],"a":[57,68,78,86,158],"lower":[58],"area":[59],"under":[60],"plasma":[62,124],"concentration-time":[63],"curve":[64],"(AUC)":[65],"and,":[66],"consequently,":[67],"higher":[69,122,127],"apparent":[70],"clearance":[71,191],"found,":[75],"compared":[76],"reference":[79],"users.":[83],"Patients":[84],"had":[85,120],"low":[87],"to":[88,189],"normal":[89,99],"maximum":[90],"concentration":[91],"plasma.":[95],"Elimination":[96],"half-lives":[97],"but":[102],"one":[103,137],"patient.":[104],"Zidovudine":[105],"glucuronide":[106,131,142],"concentrations":[107,125],"determined":[109],"three":[111,114],"control":[115,134],"subjects.":[116,135],"relatively":[121],"peak":[123],"AUCs":[128],"than":[132],"patient,":[138],"also":[144],"measured":[145],"2.5":[146],"months":[147],"after":[148],"discontinuation":[149],"rifampin.":[151],"AUC":[153],"increased":[156,190],"by":[157],"factor":[159],"2.":[161],"These":[162],"data":[163],"agreement":[166],"an":[168],"enzyme-inducing":[169],"effect":[170],"glucuronidation":[175],"zidovudine.":[177],"They":[178],"indicate":[179],"that":[180],"leads":[188],"zidovudine,":[193],"which":[194],"may":[195],"have":[196],"therapeutic":[197],"consequences.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}