{"id":"https://openalex.org/W2129732298","doi":"https://doi.org/10.1002/jcp.24481","title":"Amsacrine suppresses matrix metalloproteinase\u20102 (MMP\u20102)/MMP\u20109 expression in human leukemia cells","display_name":"Amsacrine suppresses matrix metalloproteinase\u20102 (MMP\u20102)/MMP\u20109 expression in human leukemia cells","publication_year":2013,"publication_date":"2013-10-12","ids":{"openalex":"https://openalex.org/W2129732298","doi":"https://doi.org/10.1002/jcp.24481","mag":"2129732298","pmid":"https://pubmed.ncbi.nlm.nih.gov/24122234"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.24481","doi":"https://doi.org/10.1002/jcp.24481","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.24481","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067277053","display_name":"Wen\u2010Hsin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen\u2010Hsin Liu","raw_affiliation_strings":["Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan;","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028345523","display_name":"Ying\u2010Jung Chen","orcid":"https://orcid.org/0000-0001-8562-1268","observed_orcids":["https://orcid.org/0000-0001-8562-1268"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying\u2010Jung Chen","raw_affiliation_strings":["Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan;","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055393153","display_name":"Jen\u2010Hung Chien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102636","display_name":"Zuoying Armed Forces General Hospital","ror":"https://ror.org/017bd5k63","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210102636"]},{"id":"https://openalex.org/I4210118607","display_name":"Kaohsiung Armed Forces General Hospital","ror":"https://ror.org/026zpz859","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210118607"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jen\u2010Hung Chien","raw_affiliation_strings":["Department of Pediatrics, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210102636","https://openalex.org/I4210118607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035294253","display_name":"Long\u2010Sen Chang","orcid":"https://orcid.org/0000-0002-3204-5137","observed_orcids":["https://orcid.org/0000-0002-3204-5137"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Long\u2010Sen Chang","raw_affiliation_strings":["Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan","Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I142974352"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035294253"],"corresponding_institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":1.2092,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.77801258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"229","issue":"5","first_page":"588","last_page":"598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amsacrine","display_name":"amsacrine","score":1.0},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9940000176429749},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.625},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.9390000104904175},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9380000233650208},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.8040000200271606},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.8240000009536743},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9200000166893005},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.9075527787208557},{"id":"https://openalex.org/C2780500152","wikidata":"https://www.wikidata.org/wiki/Q2784004","display_name":"Amsacrine","level":4,"score":0.667944073677063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5713777542114258},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5327743291854858},{"id":"https://openalex.org/C2991819120","wikidata":"https://www.wikidata.org/wiki/Q13033749","display_name":"Matrix metalloproteinase 9","level":3,"score":0.5072764754295349},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.48562803864479065},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.47943347692489624},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4129226803779602},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.391803115606308},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3345497250556946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3216044008731842},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2827548086643219},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24347516894340515},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.171282559633255},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.05633482336997986},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.24481","doi":"https://doi.org/10.1002/jcp.24481","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.24481","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:24122234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24122234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1841429806","https://openalex.org/W1935046394","https://openalex.org/W1969133782","https://openalex.org/W1978035165","https://openalex.org/W1980831535","https://openalex.org/W1982319893","https://openalex.org/W1985390439","https://openalex.org/W1987302782","https://openalex.org/W1995986855","https://openalex.org/W2003500892","https://openalex.org/W2006510178","https://openalex.org/W2009297613","https://openalex.org/W2012703293","https://openalex.org/W2019679672","https://openalex.org/W2026111144","https://openalex.org/W2031019010","https://openalex.org/W2035191293","https://openalex.org/W2035198108","https://openalex.org/W2037163919","https://openalex.org/W2037680322","https://openalex.org/W2050012590","https://openalex.org/W2050568435","https://openalex.org/W2051381312","https://openalex.org/W2052022512","https://openalex.org/W2053957462","https://openalex.org/W2056441912","https://openalex.org/W2070186254","https://openalex.org/W2073259535","https://openalex.org/W2078212084","https://openalex.org/W2085872534","https://openalex.org/W2089715996","https://openalex.org/W2091285142","https://openalex.org/W2096564318","https://openalex.org/W2096763030","https://openalex.org/W2109143007","https://openalex.org/W2111023447","https://openalex.org/W2120643436","https://openalex.org/W2134407278","https://openalex.org/W2138539171","https://openalex.org/W2144434058","https://openalex.org/W2153709731","https://openalex.org/W2159849226","https://openalex.org/W2167214658","https://openalex.org/W2170661611"],"related_works":["https://openalex.org/W2534476060","https://openalex.org/W1982319893","https://openalex.org/W2103128092","https://openalex.org/W2088667932","https://openalex.org/W1965598402","https://openalex.org/W2078212084","https://openalex.org/W1570778910","https://openalex.org/W2107756707","https://openalex.org/W1841429806","https://openalex.org/W1982827713"],"abstract_inverted_index":{"This":[0],"study":[1],"explores":[2],"the":[3,75],"suppression":[4,164],"mechanism":[5],"of":[6,105,165],"amsacrine":[7,43,158],"(4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine":[8],"hydrochloride)":[9],"on":[10,58,145],"matrix":[11],"metalloproteinase-2":[12],"(MMP-2)":[13],"and":[14,30,39,50,69,81,93,150,168],"MMP-9":[15],"expression":[16,29],"in":[17,33,54,113,126,171],"human":[18,172],"leukemia":[19,55,173],"cells.":[20,41,56,116,152,174],"Amsacrine":[21],"attenuated":[22],"cell":[23],"invasion":[24],"with":[25],"decreased":[26],"MMP-2/MMP-9":[27,46,51,89,95,123,133,137,160],"protein":[28,106],"mRNA":[31,52,96,124,134,169],"levels":[32],"U937,":[34],"Jurkat,":[35,146],"HL-60,":[36,147],"K562,":[37,148],"KU812,":[38,149],"MEG-01":[40,151],"Moreover,":[42],"reduced":[44,74],"both":[45],"promoter":[47,90],"luciferase":[48,91],"activity":[49,92],"stability":[53,125,170],"Studies":[57],"amsacrine-treated":[59,114,127],"U937":[60,115],"cells":[61],"revealed":[62],"that":[63,157],"amsacrine-elicited":[64],"ROS":[65],"generation":[66],"induced":[67],"JNK":[68],"p38":[70,82,99],"MAPK":[71],"activation":[72,84,101],"but":[73],"phospho-ERK":[76],"level.":[77],"Amsacrine-induced":[78,136],"ERK":[79],"inactivation":[80],"MAPK/JNK":[83,100],"were":[85],"demonstrated":[86],"to":[87,103,142],"suppress":[88],"promote":[94],"decay,":[97],"respectively.":[98],"led":[102],"up-regulation":[104,144],"phosphatase":[107],"2A":[108],"catalytic":[109],"subunit":[110],"\u03b1":[111],"(PP2Ac\u03b1)":[112],"Okadaic":[117],"acid":[118],"(PP2A":[119],"inhibitor)":[120],"treatment":[121],"increased":[122,132],"cells,":[128],"whereas":[129],"PP2Ac\u03b1":[130,143],"over-expression":[131],"decay.":[135],"down-regulation":[138,161],"was":[139],"also":[140],"related":[141],"Collectively,":[153],"our":[154],"data":[155],"indicate":[156],"induces":[159],"via":[162],"simultaneous":[163],"genetic":[166],"transcription":[167]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
