{"id":"https://openalex.org/W2129727010","doi":"https://doi.org/10.1128/mcb.22.7.2111-2123.2002","title":"Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation","display_name":"Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2129727010","doi":"https://doi.org/10.1128/mcb.22.7.2111-2123.2002","mag":"2129727010","pmid":"https://pubmed.ncbi.nlm.nih.gov/11884599","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/133688"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.22.7.2111-2123.2002","doi":"https://doi.org/10.1128/mcb.22.7.2111-2123.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.22.7.2111-2123.2002","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/133688","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063875415","display_name":"William C. Hahn","orcid":"https://orcid.org/0000-0003-2840-9791","observed_orcids":["https://orcid.org/0000-0003-2840-9791"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Hahn","raw_affiliation_strings":["Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","2 Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"2 Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048863725","display_name":"Scott K. Dessain","orcid":"https://orcid.org/0000-0002-4331-6799","observed_orcids":["https://orcid.org/0000-0002-4331-6799"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott K. Dessain","raw_affiliation_strings":["Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114","Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","3 Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"3 Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049187047","display_name":"Mary W. Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary W. Brooks","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036795045","display_name":"Jessie E. King","orcid":"https://orcid.org/0009-0007-9142-7585","observed_orcids":["https://orcid.org/0009-0007-9142-7585"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie E. King","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008405453","display_name":"Brian Elenbaas","orcid":"https://orcid.org/0000-0002-7892-6028","observed_orcids":["https://orcid.org/0000-0002-7892-6028"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Elenbaas","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013582936","display_name":"David M. Sabatini","orcid":"https://orcid.org/0000-0002-1446-7256","observed_orcids":["https://orcid.org/0000-0002-1446-7256"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Sabatini","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081560191","display_name":"James A. DeCaprio","orcid":"https://orcid.org/0000-0002-0896-167X","observed_orcids":["https://orcid.org/0000-0002-0896-167X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. DeCaprio","raw_affiliation_strings":["Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012557712","display_name":"Robert A. Weinberg","orcid":"https://orcid.org/0000-0002-0895-3557","observed_orcids":["https://orcid.org/0000-0002-0895-3557"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A. Weinberg","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","4 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"4 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012557712"],"corresponding_institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":20.2978,"has_fulltext":false,"cited_by_count":626,"citation_normalized_percentile":{"value":0.99746259,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"22","issue":"7","first_page":"2111","last_page":"2123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simian-virus-40","display_name":"simian virus 40","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sv40-early-region","display_name":"SV40 early region","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/large-t-antigen","display_name":"large T antigen","score":0.890999972820282},{"id":"https://openalex.org/keywords/small-t-antigen","display_name":"small T antigen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.8619999885559082},{"id":"https://openalex.org/keywords/h-ras-oncogene","display_name":"H-ras oncogene","score":0.7509999871253967},{"id":"https://openalex.org/keywords/retinoblastoma-pathway","display_name":"retinoblastoma pathway","score":0.9139999747276306},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.9620000123977661},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.5799999833106995},{"id":"https://openalex.org/keywords/dna-tumor-viruses","display_name":"DNA tumor viruses","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8658214807510376},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.6027486324310303},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.5919227600097656},{"id":"https://openalex.org/C2775971809","wikidata":"https://www.wikidata.org/wiki/Q7395063","display_name":"SV40 large T antigen","level":4,"score":0.46529969573020935},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4607376456260681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44321560859680176},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4229084253311157},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41606777906417847},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39960044622421265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3759138584136963},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.3465951085090637},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3278023600578308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25137966871261597}],"mesh":[{"descriptor_ui":"D000957","descriptor_name":"Antigens, Viral, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000957","descriptor_name":"Antigens, Viral, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015689","descriptor_name":"Oncogene Protein p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015689","descriptor_name":"Oncogene Protein p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.22.7.2111-2123.2002","doi":"https://doi.org/10.1128/mcb.22.7.2111-2123.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.22.7.2111-2123.2002","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:133688","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/133688","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:11884599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11884599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.6164","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.6164","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/22/7/2111.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.996.5326","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.996.5326","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sabatinilab.wi.mit.edu/Sabatini%20papers/smallT_growth-MCB-2002.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:133688","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/133688","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5668053009","display_name":"New Models of Human Cancer","funder_award_id":"K01CA094223","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6018147714","display_name":"Papova Virus Transforming Mechanisms","funder_award_id":"P01CA050661","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8522539217","display_name":"Induced Differentiation to Deplete CSCs from Breast Cancer","funder_award_id":"R01CA078461","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8900337930","display_name":"RB-Related Proteins and Polyomavirus Large T antigen Transformation","funder_award_id":"R01CA063113","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G930853435","display_name":"PROGRESSION OF CHRONIC MYELOGENOUS LEUKEMIA","funder_award_id":"K08HL004463","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320311496","display_name":"Ludwig Institute for Cancer Research","ror":"https://ror.org/05qdwtz81"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W76421069","https://openalex.org/W183360374","https://openalex.org/W842785330","https://openalex.org/W1496421860","https://openalex.org/W1497210717","https://openalex.org/W1513463586","https://openalex.org/W1520658182","https://openalex.org/W1545398558","https://openalex.org/W1562223973","https://openalex.org/W1583419301","https://openalex.org/W1588072191","https://openalex.org/W1632349675","https://openalex.org/W1747055324","https://openalex.org/W1763110138","https://openalex.org/W1791349916","https://openalex.org/W1792657912","https://openalex.org/W1799167605","https://openalex.org/W1810419160","https://openalex.org/W1830988894","https://openalex.org/W1885554409","https://openalex.org/W1911118961","https://openalex.org/W1915392176","https://openalex.org/W1939404526","https://openalex.org/W1967017947","https://openalex.org/W1968325292","https://openalex.org/W1969219687","https://openalex.org/W1972392250","https://openalex.org/W1972490350","https://openalex.org/W1973886069","https://openalex.org/W1978775178","https://openalex.org/W1981943850","https://openalex.org/W1982622947","https://openalex.org/W1983475354","https://openalex.org/W1986808310","https://openalex.org/W1991494214","https://openalex.org/W2000971601","https://openalex.org/W2001304738","https://openalex.org/W2006659499","https://openalex.org/W2013880323","https://openalex.org/W2014231393","https://openalex.org/W2021029116","https://openalex.org/W2023335056","https://openalex.org/W2023418239","https://openalex.org/W2024619097","https://openalex.org/W2025791374","https://openalex.org/W2027345413","https://openalex.org/W2028125839","https://openalex.org/W2029124839","https://openalex.org/W2036495494","https://openalex.org/W2038287032","https://openalex.org/W2038638713","https://openalex.org/W2040717651","https://openalex.org/W2041083456","https://openalex.org/W2044014221","https://openalex.org/W2044119126","https://openalex.org/W2048518220","https://openalex.org/W2052912081","https://openalex.org/W2053956596","https://openalex.org/W2060155650","https://openalex.org/W2062228248","https://openalex.org/W2064125443","https://openalex.org/W2066893159","https://openalex.org/W2067445582","https://openalex.org/W2069904188","https://openalex.org/W2070012290","https://openalex.org/W2074455749","https://openalex.org/W2075009035","https://openalex.org/W2075808770","https://openalex.org/W2082518238","https://openalex.org/W2086603476","https://openalex.org/W2087404852","https://openalex.org/W2100550233","https://openalex.org/W2102692211","https://openalex.org/W2108482850","https://openalex.org/W2111600528","https://openalex.org/W2117824620","https://openalex.org/W2124380422","https://openalex.org/W2125169413","https://openalex.org/W2127237580","https://openalex.org/W2131670375","https://openalex.org/W2131675463","https://openalex.org/W2134482407","https://openalex.org/W2134871100","https://openalex.org/W2141711704","https://openalex.org/W2146574198","https://openalex.org/W2148090903","https://openalex.org/W2148235912","https://openalex.org/W2156299289","https://openalex.org/W2167036092","https://openalex.org/W2168565771","https://openalex.org/W2170718796","https://openalex.org/W2399052947","https://openalex.org/W2412012699"],"related_works":["https://openalex.org/W7095680692","https://openalex.org/W6987510169","https://openalex.org/W175862836","https://openalex.org/W7043770193","https://openalex.org/W2015379895","https://openalex.org/W2073061430","https://openalex.org/W2028083348","https://openalex.org/W1979051583","https://openalex.org/W2163708910","https://openalex.org/W138435273"],"abstract_inverted_index":{"While":[0],"it":[1],"is":[2],"clear":[3],"that":[4,13,31,68,115],"cancer":[5],"arises":[6],"from":[7,46],"the":[8,15,19,26,42,60,71,79,82,92,116,124,137,140,147,156,171,204,207,212],"accumulation":[9],"of":[10,21,29,41,53,62,70,91,126,139,167,174,181,206,214,223],"genetic":[11],"mutations":[12,30],"endow":[14],"malignant":[16],"cell":[17,35,63,187],"with":[18],"properties":[20],"uncontrolled":[22],"growth":[23,36],"and":[24,87,101,128,146,159,192,217],"proliferation,":[25,188],"precise":[27],"combinations":[28],"program":[32],"human":[33,97,168,215,237],"tumor":[34,48,161],"remain":[37],"unknown.":[38],"The":[39],"study":[40],"transforming":[43],"proteins":[44],"derived":[45],"DNA":[47],"viruses":[49],"in":[50,95,123,183,228],"experimental":[51],"models":[52],"transformation":[54,122,166,213],"has":[55],"provided":[56],"fundamental":[57],"insights":[58],"into":[59],"process":[61],"transformation.":[64],"We":[65],"recently":[66],"reported":[67],"coexpression":[69],"simian":[72],"virus":[73],"40":[74],"(SV40)":[75],"early":[76],"region":[77],"(ER),":[78],"gene":[80,94],"encoding":[81],"telomerase":[83],"catalytic":[84],"subunit":[85],"(hTERT),":[86],"an":[88],"oncogenic":[89,129],"allele":[90],"H-ras":[93,130],"normal":[96],"fibroblast,":[98],"kidney":[99],"epithelial,":[100],"mammary":[102],"epithelial":[103],"cells":[104,107,169,216],"converted":[105],"these":[106,201],"to":[108,120,196,219,231,234],"a":[109,221],"tumorigenic":[110,121,236],"state.":[111],"Here":[112],"we":[113],"show":[114],"SV40":[117,141,148,208],"ER":[118,209],"contributes":[119],"presence":[125],"hTERT":[127],"by":[131,178],"perturbing":[132],"three":[133],"intracellular":[134,224],"pathways":[135,225],"through":[136],"actions":[138],"large":[142],"T":[143],"antigen":[144,151],"(LT)":[145],"small":[149],"t":[150],"(ST).":[152],"LT":[153],"simultaneously":[154],"disables":[155],"retinoblastoma":[157],"(pRB)":[158],"p53":[160],"suppressor":[162],"pathways;":[163],"however,":[164],"complete":[165],"requires":[170],"additional":[172],"perturbation":[173],"protein":[175],"phosphatase":[176],"2A":[177],"ST.":[179],"Expression":[180],"ST":[182],"this":[184],"setting":[185],"stimulates":[186],"permits":[189],"anchorage-independent":[190],"growth,":[191],"confers":[193],"increased":[194],"resistance":[195],"nutrient":[197],"deprivation.":[198],"Taken":[199],"together,":[200],"observations":[202],"define":[203],"elements":[205],"required":[210],"for":[211],"begin":[218],"delineate":[220],"set":[222],"whose":[226],"disruption,":[227],"aggregate,":[229],"appears":[230],"be":[232],"necessary":[233],"generate":[235],"cells.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":34}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
