{"id":"https://openalex.org/W2129700402","doi":"https://doi.org/10.1073/pnas.83.9.3037","title":"Sequence of a cDNA clone encoding the polysialic acid-rich and cytoplasmic domains of the neural cell adhesion molecule N-CAM.","display_name":"Sequence of a cDNA clone encoding the polysialic acid-rich and cytoplasmic domains of the neural cell adhesion molecule N-CAM.","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W2129700402","doi":"https://doi.org/10.1073/pnas.83.9.3037","mag":"2129700402","pmid":"https://pubmed.ncbi.nlm.nih.gov/3458261","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/323442"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.83.9.3037","doi":"https://doi.org/10.1073/pnas.83.9.3037","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.83.9.3037","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/323442","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111725108","display_name":"John J. Hemperly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Hemperly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534658","display_name":"Ben A. Murray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Murray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110126312","display_name":"Gerald M. Edelman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Edelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108513198","display_name":"Bruce A. Cunningham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B A Cunningham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.162,"has_fulltext":false,"cited_by_count":171,"citation_normalized_percentile":{"value":0.98684211,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"83","issue":"9","first_page":"3037","last_page":"3041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.08209999650716782,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.9660000205039978},{"id":"https://openalex.org/keywords/n-cam","display_name":"N-CAM","score":0.9959999918937683},{"id":"https://openalex.org/keywords/polysialic-acid","display_name":"polysialic acid","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cdna-sequence","display_name":"cDNA sequence","score":0.7749999761581421},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cytoplasmic-domain","display_name":"cytoplasmic domain","score":0.8709999918937683},{"id":"https://openalex.org/keywords/membrane-spanning-segments","display_name":"membrane-spanning segments","score":0.8399999737739563},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2778993516","wikidata":"https://www.wikidata.org/wiki/Q7226934","display_name":"Polysialic acid","level":5,"score":0.9045466184616089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6775119304656982},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.6165830492973328},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5860514044761658},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.4966748356819153},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4927108585834503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44788193702697754},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.4441242218017578},{"id":"https://openalex.org/C122871604","wikidata":"https://www.wikidata.org/wiki/Q2248886","display_name":"Neural cell adhesion molecule","level":4,"score":0.43753480911254883},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4007660746574402},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.32058653235435486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2964801788330078},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17446038126945496}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.83.9.3037","doi":"https://doi.org/10.1073/pnas.83.9.3037","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.83.9.3037","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:323442","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/323442","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3458261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3458261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:2341091442","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/26970","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:323442","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/323442","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1802618880","display_name":"Chick cell surface glycoproteins in embryogenesis","funder_award_id":"R01HD016550","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3194718259","display_name":"INTERACTION AND ENERGY TRANSFER IN BIOLOGICAL SYSTEMS","funder_award_id":"5r01am004256-26","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4645447296","display_name":null,"funder_award_id":"HD09635","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1480181846","https://openalex.org/W1516340190","https://openalex.org/W1540302946","https://openalex.org/W1601687245","https://openalex.org/W1653543413","https://openalex.org/W1966193561","https://openalex.org/W1967421456","https://openalex.org/W1968082000","https://openalex.org/W1970181764","https://openalex.org/W1970674812","https://openalex.org/W1975304761","https://openalex.org/W1997029893","https://openalex.org/W2013089703","https://openalex.org/W2014689788","https://openalex.org/W2029195137","https://openalex.org/W2037050570","https://openalex.org/W2040772756","https://openalex.org/W2046378363","https://openalex.org/W2055627347","https://openalex.org/W2056039107","https://openalex.org/W2070141228","https://openalex.org/W2080282290","https://openalex.org/W2087344385","https://openalex.org/W2087700563","https://openalex.org/W2098610794","https://openalex.org/W2119135079","https://openalex.org/W2127500378","https://openalex.org/W2136556760","https://openalex.org/W2138270253","https://openalex.org/W2138466097","https://openalex.org/W2152825059","https://openalex.org/W2175994423","https://openalex.org/W2218538343","https://openalex.org/W2220912830","https://openalex.org/W2411136849","https://openalex.org/W2615388883","https://openalex.org/W7095998816"],"related_works":["https://openalex.org/W2341091442","https://openalex.org/W2100671089","https://openalex.org/W2067495948","https://openalex.org/W2004222109","https://openalex.org/W2012222242","https://openalex.org/W2088803561","https://openalex.org/W2070141228","https://openalex.org/W2409319046","https://openalex.org/W1018379079","https://openalex.org/W2081341596"],"abstract_inverted_index":{"Purified":[0],"fractions":[1],"of":[2,52,65,81,90,109,141,176,190],"the":[3,39,45,62,76,82,115,127,150,155,162,168,177,204],"neural":[4],"cell-adhesion":[5],"molecule":[6],"N-CAM":[7,84,157,191],"from":[8,55,75],"embryonic":[9],"chicken":[10],"brain":[11],"contain":[12],"two":[13,46],"similar":[14],"polypeptides":[15,47,181],"(Mr,":[16],"160,000":[17],"and":[18,31,78,118,167,179],"130,000),":[19],"each":[20],"containing":[21],"an":[22],"amino-terminal":[23],"external":[24],"binding":[25],"region,":[26,30],"a":[27,32,56,66,119,139,195],"carbohydrate-rich":[28],"central":[29],"carboxyl-terminal":[33],"region":[34],"that":[35,44,70,123],"is":[36],"associated":[37],"with":[38,198,203],"cell.":[40],"Previous":[41],"studies":[42],"indicate":[43],"arise":[48],"by":[49,87,192],"alternative":[50],"splicing":[51],"mRNAs":[53],"transcribed":[54],"single":[57,120],"gene.":[58],"We":[59,159],"report":[60],"here":[61],"3556-nucleotide":[63],"sequence":[64,97,122],"cDNA":[67],"clone":[68],"(pEC208)":[69],"encodes":[71],"964":[72],"amino":[73,146],"acids":[74,147],"carbohydrate":[77],"cell-associated":[79],"domains":[80,175],"larger":[83,151],"polypeptide":[85,110,166],"followed":[86],"664":[88],"nucleotides":[89],"3'":[91],"untranslated":[92],"sequence.":[93],"The":[94,130,173],"predicted":[95],"protein":[96],"contains":[98],"attachment":[99],"sites":[100],"for":[101,187],"polysialic":[102],"acid-containing":[103],"oligosaccharides,":[104],"four":[105],"tandem":[106],"homologous":[107],"regions":[108],"resembling":[111],"those":[112],"seen":[113],"in":[114,149,154,194],"immunoglobulin":[116],"superfamily,":[117],"hydrophobic":[121],"appears":[124],"to":[125,135,144,184],"be":[126,185],"membrane-spanning":[128],"segment.":[129],"cytoplasmic":[131],"domain":[132],"carboxyl":[133],"terminal":[134],"this":[136],"segment":[137],"includes":[138],"block":[140],"approximately":[142],"equal":[143],"250":[145],"present":[148],"but":[152],"not":[153],"smaller":[156],"polypeptide.":[158,172],"designate":[160],"these":[161],"ld":[163,178],"(large":[164],"domain)":[165,171],"sd":[169,180],"(small":[170],"intracellular":[174],"are":[182],"likely":[183],"critical":[186],"cell-surface":[188],"modulation":[189],"interacting":[193],"differential":[196],"fashion":[197],"other":[199],"intrinsic":[200],"proteins":[201],"or":[202],"cytoskeleton.":[205]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}