{"id":"https://openalex.org/W2129669616","doi":"https://doi.org/10.1073/pnas.82.2.526","title":"The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule.","display_name":"The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2129669616","doi":"https://doi.org/10.1073/pnas.82.2.526","mag":"2129669616","pmid":"https://pubmed.ncbi.nlm.nih.gov/3881766","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/397072"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.82.2.526","doi":"https://doi.org/10.1073/pnas.82.2.526","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.2.526","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC397072","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001063223","display_name":"Philip Mark Hogarth","orcid":"https://orcid.org/0000-0002-0360-7890","observed_orcids":["https://orcid.org/0000-0002-0360-7890"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P M Hogarth","raw_affiliation_strings":["University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030379","display_name":"Ian D. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"I D Walker","raw_affiliation_strings":["University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110169336","display_name":"Ian F. C. McKenzie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"I F McKenzie","raw_affiliation_strings":["University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T A Springer","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6081,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91075193,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"2","first_page":"526","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lymphocyte-function-associated-antigen-1","display_name":"CD11a/CD18","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antigenic-polymorphism","display_name":"antigenic polymorphism","score":0.6000000238418579},{"id":"https://openalex.org/keywords/alpha-beta-heterodimer","display_name":"alpha beta heterodimer","score":0.6449999809265137},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.6850000023841858},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cell-surface-expression","display_name":"cell surface expression","score":0.5230000019073486},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8730000257492065},{"id":"https://openalex.org/keywords/peptide-mapping","display_name":"peptide mapping","score":0.6349999904632568},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6942870616912842},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.6812077760696411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6450244784355164},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6400015354156494},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6026065945625305},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.5067387223243713},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4892275333404541},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.48749780654907227},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.48539623618125916},{"id":"https://openalex.org/C2778593620","wikidata":"https://www.wikidata.org/wiki/Q4042438","display_name":"Lymphocyte function-associated antigen 1","level":4,"score":0.4702928066253662},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.452776700258255},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.18730390071868896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1795787811279297}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007519","descriptor_name":"Isoantigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.82.2.526","doi":"https://doi.org/10.1073/pnas.82.2.526","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.2.526","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:64963","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC397072","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:397072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/397072","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3881766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3881766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:64963","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC397072","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W310637976","https://openalex.org/W1506365543","https://openalex.org/W1506397040","https://openalex.org/W1599569725","https://openalex.org/W1602540790","https://openalex.org/W1659855818","https://openalex.org/W1970654518","https://openalex.org/W1972276577","https://openalex.org/W1978240166","https://openalex.org/W1985932988","https://openalex.org/W2001035036","https://openalex.org/W2012348028","https://openalex.org/W2023318533","https://openalex.org/W2025486698","https://openalex.org/W2026923875","https://openalex.org/W2049099772","https://openalex.org/W2050355320","https://openalex.org/W2061345330","https://openalex.org/W2061477200","https://openalex.org/W2070437307","https://openalex.org/W2077702220","https://openalex.org/W2089967575","https://openalex.org/W2105074038","https://openalex.org/W2139203324","https://openalex.org/W2140799426","https://openalex.org/W2141906846","https://openalex.org/W2157885486","https://openalex.org/W2164358316","https://openalex.org/W2310464721","https://openalex.org/W2437415083","https://openalex.org/W2476079089","https://openalex.org/W4299134003"],"related_works":["https://openalex.org/W2086787667","https://openalex.org/W2075510528","https://openalex.org/W1984544136","https://openalex.org/W1501259863","https://openalex.org/W2146756090","https://openalex.org/W1659855818","https://openalex.org/W2056686246","https://openalex.org/W1585833237","https://openalex.org/W1574988996","https://openalex.org/W41691213"],"abstract_inverted_index":{"Serological":[0],"and":[1,26,38,40,55,64,77,89,99,107],"biochemical":[2],"studies":[3,102],"using":[4],"monoclonal":[5],"antibodies":[6,91],"have":[7,67],"demonstrated":[8],"that":[9,104],"the":[10,19,93,105,115],"Ly-15":[11],"cell":[12,46],"membrane":[13],"alloantigens":[14],"are":[15,111,114],"polymorphic":[16],"sites":[17],"on":[18,34,84],"lymphocyte":[20],"function-associated":[21],"antigen-1":[22],"(LFA-1)":[23],"molecule.":[24],"Ly-15.2":[25,54,63,106],"LFA-1":[27,56,65,108],"show":[28,103],"identical":[29,45,69],"tissue":[30],"distributions,":[31],"being":[32],"present":[33],"all":[35],"thymocytes,":[36],"lymphocytes,":[37],"neutrophils,":[39],"flow":[41],"cytofluorometric":[42],"analysis":[43],"indicated":[44],"surface":[47],"expression":[48],"of":[49,53,72],"these":[50],"molecules.":[51],"Identity":[52],"was":[57],"confirmed":[58],"by":[59],"immunochemical":[60],"analysis.":[61],"The":[62],"molecules":[66],"an":[68],"heterodimeric":[70],"structure":[71],"Mr":[73,78],"180,000":[74],"alpha":[75,109],"chain":[76],"94,000":[79],"beta":[80,116],"chain,":[81],"which":[82],"coelectrophorese":[83],"two-dimensional":[85],"NaDodSO4/PAGE.":[86],"Furthermore,":[87],"anti-Ly-15.2":[88],"anti-LFA-1":[90],"coprecipitate":[92],"same":[94],"molecule":[95],"from":[96],"thymocyte":[97],"lysates,":[98],"peptide":[100],"mapping":[101],"chains":[110],"identical,":[112],"as":[113],"chains.":[117]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}