{"id":"https://openalex.org/W2129659130","doi":"https://doi.org/10.1590/2359-3997000000003","title":"Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus","display_name":"Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W2129659130","doi":"https://doi.org/10.1590/2359-3997000000003","mag":"2129659130","pmid":"https://pubmed.ncbi.nlm.nih.gov/25926108"},"language":"en","primary_location":{"id":"doi:10.1590/2359-3997000000003","doi":"https://doi.org/10.1590/2359-3997000000003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/2359-3997000000003","pdf_url":"https://www.scielo.br/j/aem/a/dwQpsDsxvctbMjzQNbQ5GXg/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2738297940","display_name":"Archives of Endocrinology and Metabolism","issn_l":"2359-3997","issn":["2359-3997","2359-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","medline","poland-40","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312184","host_organization_name":"Brazilian Society of Endocrinology and Metabolism","host_organization_lineage":["https://openalex.org/P4310312184"],"host_organization_lineage_names":["Brazilian Society of Endocrinology and Metabolism"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/aem/a/dwQpsDsxvctbMjzQNbQ5GXg/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071829222","display_name":"Ta\u00eds Silveira Assmann","orcid":"https://orcid.org/0000-0001-9114-8243","observed_orcids":["https://orcid.org/0000-0001-9114-8243"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ta\u00eds Silveira Assmann","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073886333","display_name":"Let\u00edcia de Almeida Brondani","orcid":"https://orcid.org/0000-0003-0837-2645","observed_orcids":["https://orcid.org/0000-0003-0837-2645"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Let\u00edcia de Almeida Brondani","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034430577","display_name":"Ana Paula Bou\u00e7as","orcid":"https://orcid.org/0000-0002-1563-1513","observed_orcids":["https://orcid.org/0000-0002-1563-1513"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Paula Bou\u00e7as","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064782627","display_name":"Lu\u00eds Henrique Santos Canani","orcid":"https://orcid.org/0000-0002-1813-4491","observed_orcids":["https://orcid.org/0000-0002-1813-4491"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Henrique Canani","raw_affiliation_strings":["UFRGS,  Brazil","[UFRGS, Porto Alegre, RS, Brazil]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UFRGS,  Brazil","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"[UFRGS, Porto Alegre, RS, Brazil]","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059043028","display_name":"Daisy Crispim","orcid":"https://orcid.org/0000-0001-5095-9269","observed_orcids":["https://orcid.org/0000-0001-5095-9269"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Daisy Crispim","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul,  Brazil; UFRGS,  Brazil","institution_ids":["https://openalex.org/I130442723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059043028"],"corresponding_institution_ids":["https://openalex.org/I130442723"],"apc_list":null,"apc_paid":null,"fwci":0.3731,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.36753041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"59","issue":"1","first_page":"4","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.9909999966621399},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/enterovirus","display_name":"enterovirus","score":0.703000009059906},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.9079999923706055},{"id":"https://openalex.org/keywords/viral-triggers-of-autoimmunity","display_name":"viral triggers of autoimmunity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.8169999718666077},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/autoimmune-beta-cell-destruction","display_name":"autoimmune beta-cell destruction","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.7896610498428345},{"id":"https://openalex.org/C134474686","wikidata":"https://www.wikidata.org/wiki/Q21111069","display_name":"MDA5","level":5,"score":0.639363169670105},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5424696803092957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5407590270042419},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.5017664432525635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4943428039550781},{"id":"https://openalex.org/C2779120600","wikidata":"https://www.wikidata.org/wiki/Q1138287","display_name":"Coxsackievirus","level":4,"score":0.460659921169281},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4549625813961029},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.3921854496002197},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3673563003540039},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3381332755088806},{"id":"https://openalex.org/C2777888124","wikidata":"https://www.wikidata.org/wiki/Q519796","display_name":"Enterovirus","level":3,"score":0.30491071939468384},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2797180116176605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27892303466796875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.266153484582901},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2296212613582611},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17673861980438232},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.17146062850952148},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15585416555404663}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004770","descriptor_name":"Enterovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004770","descriptor_name":"Enterovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1590/2359-3997000000003","doi":"https://doi.org/10.1590/2359-3997000000003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/2359-3997000000003","pdf_url":"https://www.scielo.br/j/aem/a/dwQpsDsxvctbMjzQNbQ5GXg/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2738297940","display_name":"Archives of Endocrinology and Metabolism","issn_l":"2359-3997","issn":["2359-3997","2359-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","medline","poland-40","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312184","host_organization_name":"Brazilian Society of Endocrinology and Metabolism","host_organization_lineage":["https://openalex.org/P4310312184"],"host_organization_lineage_names":["Brazilian Society of Endocrinology and Metabolism"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:25926108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25926108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S2359-39972015000100004","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000100004","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Endocrinology and Metabolism v.59 n.1 2015","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2494269","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000100004","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Endocrinology and Metabolism v.59 n.1 2015","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:81499d98180a4d0fb71b68ac256b0ea0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/81499d98180a4d0fb71b68ac256b0ea0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Endocrinology and Metabolism, Vol 59, Iss 1, Pp 4-12","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7516544","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Toll-like_receptor_3_TLR3_and_the_development_of_type_1_diabetes_mellitus/7516544","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.7516544","doi":"https://doi.org/10.6084/m9.figshare.7516544","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.7516544","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.7516544.v1","doi":"https://doi.org/10.6084/m9.figshare.7516544.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.7516544.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"mag:2741508865","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Daisy_Crispim/publication/275667541_Toll-like_receptor_3_(TLR3)_and_the_development_of_type_1_diabetes_mellitus/links/555b4b2408ae91e75e76422e.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1590/2359-3997000000003","doi":"https://doi.org/10.1590/2359-3997000000003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/2359-3997000000003","pdf_url":"https://www.scielo.br/j/aem/a/dwQpsDsxvctbMjzQNbQ5GXg/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2738297940","display_name":"Archives of Endocrinology and Metabolism","issn_l":"2359-3997","issn":["2359-3997","2359-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","medline","poland-40","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312184","host_organization_name":"Brazilian Society of Endocrinology and Metabolism","host_organization_lineage":["https://openalex.org/P4310312184"],"host_organization_lineage_names":["Brazilian Society of Endocrinology and Metabolism"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Endocrinology and Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322177","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38"},{"id":"https://openalex.org/F4320322502","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","ror":"https://ror.org/05k49za97"},{"id":"https://openalex.org/F4320324374","display_name":"Funda\u00e7\u00e3o Instituto de Pesquisas Econ\u00f4micas","ror":"https://ror.org/00ngrh496"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129659130.pdf","grobid_xml":"https://content.openalex.org/works/W2129659130.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1558251373","https://openalex.org/W1558806530","https://openalex.org/W1965869838","https://openalex.org/W1971260005","https://openalex.org/W1972882603","https://openalex.org/W1981433429","https://openalex.org/W1981895613","https://openalex.org/W1986178107","https://openalex.org/W1992199206","https://openalex.org/W1994942139","https://openalex.org/W1995744610","https://openalex.org/W2004256935","https://openalex.org/W2004312418","https://openalex.org/W2007388120","https://openalex.org/W2013583403","https://openalex.org/W2013601771","https://openalex.org/W2014077667","https://openalex.org/W2015875235","https://openalex.org/W2018249504","https://openalex.org/W2020996714","https://openalex.org/W2022500617","https://openalex.org/W2023746601","https://openalex.org/W2027685458","https://openalex.org/W2031819338","https://openalex.org/W2032172495","https://openalex.org/W2033673252","https://openalex.org/W2039287908","https://openalex.org/W2042433863","https://openalex.org/W2043012291","https://openalex.org/W2043107413","https://openalex.org/W2043204562","https://openalex.org/W2047759625","https://openalex.org/W2048833964","https://openalex.org/W2049309853","https://openalex.org/W2053274278","https://openalex.org/W2072664252","https://openalex.org/W2076361525","https://openalex.org/W2078219613","https://openalex.org/W2088350742","https://openalex.org/W2089118531","https://openalex.org/W2089934054","https://openalex.org/W2091554591","https://openalex.org/W2092281246","https://openalex.org/W2095720372","https://openalex.org/W2095935768","https://openalex.org/W2107497518","https://openalex.org/W2107575481","https://openalex.org/W2109261259","https://openalex.org/W2114216755","https://openalex.org/W2114637517","https://openalex.org/W2116880362","https://openalex.org/W2117047223","https://openalex.org/W2121656093","https://openalex.org/W2123988383","https://openalex.org/W2124071345","https://openalex.org/W2126552441","https://openalex.org/W2127380424","https://openalex.org/W2132216352","https://openalex.org/W2148387062","https://openalex.org/W2149901735","https://openalex.org/W2154239819","https://openalex.org/W2155706758","https://openalex.org/W2157339124","https://openalex.org/W2157928864","https://openalex.org/W2159273584","https://openalex.org/W2520432709","https://openalex.org/W4241151929","https://openalex.org/W4246077736","https://openalex.org/W6648189787","https://openalex.org/W7096217783"],"related_works":["https://openalex.org/W2741508865","https://openalex.org/W2027284335","https://openalex.org/W2185454062","https://openalex.org/W119578581","https://openalex.org/W2107575481","https://openalex.org/W3039657489","https://openalex.org/W2100060444","https://openalex.org/W1981895613","https://openalex.org/W2018221483","https://openalex.org/W1986449294"],"abstract_inverted_index":{"Type":[0],"1":[1],"diabetes":[2],"mellitus":[3],"(T1DM)":[4],"is":[5,69,151],"a":[6,152],"chronic,":[7],"progressive":[8],"autoimmune":[9,32],"disease":[10],"characterized":[11],"by":[12,114],"metabolic":[13],"decompensation":[14],"often":[15],"leading":[16],"to":[17,24,36,120,170],"dehydration":[18],"and":[19,77,82,141],"ketoacidosis.":[20],"Viral":[21],"agents":[22],"seem":[23],"play":[25],"an":[26,92,105],"important":[27,106],"role":[28,107,173],"in":[29,60,108,178],"triggering":[30],"the":[31,37,48,56,64,70,96,109,121,124,148,156,163,166,172,175,179],"destruction":[33],"that":[34,101],"leads":[35],"development":[38,157,180],"of":[39,58,63,66,79,95,118,126,144,158,165,174,181],"T1DM.":[40,159,182],"Among":[41],"several":[42],"viral":[43,67,80,115],"strains":[44],"investigated":[45],"so":[46],"far,":[47],"enterovirus":[49],"family":[50,100],"has":[51],"been":[52],"consistently":[53],"associated":[54],"with":[55],"onset":[57],"T1DM":[59],"humans.":[61],"One":[62],"mediators":[65],"damage":[68],"double-stranded":[71],"RNA":[72,81],"(dsRNA)":[73],"generated":[74],"during":[75],"replication":[76],"transcription":[78],"DNA.":[83],"The":[84],"Toll-like":[85],"receptor":[86,94],"3":[87],"(TLR3)":[88],"gene":[89,150,177],"codes":[90],"for":[91,155],"endoplasmic":[93],"pattern-recognition":[97],"receptors":[98],"(PRRs)":[99],"recognizes":[102],"dsRNA,":[103],"plays":[104],"innate":[110],"immune":[111],"response":[112],"triggered":[113],"infection.":[116],"Binding":[117],"dsRNA":[119],"TLR3":[122,149,176],"triggers":[123],"release":[125],"proinflammatory":[127],"cytokines,":[128],"such":[129],"as":[130],"interferons,":[131],"which":[132],"exhibit":[133],"potent":[134],"antiviral":[135],"action;":[136],"thus,":[137],"protecting":[138],"uninfected":[139],"cells":[140],"inducing":[142],"apoptosis":[143],"infected":[145],"ones.":[146],"Therefore,":[147],"good":[153],"candidate":[154],"Within":[160],"this":[161],"context,":[162],"objective":[164],"present":[167],"review":[168],"was":[169],"address":[171]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}