{"id":"https://openalex.org/W2129658335","doi":"https://doi.org/10.1124/dmd.107.014894","title":"Effect of Silibinin on the Pharmacokinetics of Pyrazinamide and Pyrazinoic Acid in Rats","display_name":"Effect of Silibinin on the Pharmacokinetics of Pyrazinamide and Pyrazinoic Acid in Rats","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W2129658335","doi":"https://doi.org/10.1124/dmd.107.014894","mag":"2129658335","pmid":"https://pubmed.ncbi.nlm.nih.gov/17540707"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.107.014894","doi":"https://doi.org/10.1124/dmd.107.014894","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.107.014894","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111813753","display_name":"Jhy-Wen Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jhy-Wen Wu","raw_affiliation_strings":["National Yang-Ming University, School of Medicine, Institute of Traditional Medicine, 155, Li-Nong Street Section 2, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Yang-Ming University, School of Medicine, Institute of Traditional Medicine, 155, Li-Nong Street Section 2, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013341045","display_name":"Tung\u2010Hu Tsai","orcid":"https://orcid.org/0000-0002-9007-2547","observed_orcids":["https://orcid.org/0000-0002-9007-2547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tung-Hu Tsai","raw_affiliation_strings":["Institute of Traditional Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4115,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.80995882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"35","issue":"9","first_page":"1603","last_page":"1610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silibinin","display_name":"silibinin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"pyrazinamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pyrazinoic-acid","display_name":"pyrazinoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.875},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hepatobiliary-excretion","display_name":"hepatobiliary excretion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/milk-thistle","display_name":"Silybum marianum","score":0.8090000152587891},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5730000138282776},{"id":"https://openalex.org/keywords/tuberculosis-chemotherapy","display_name":"tuberculosis chemotherapy","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2777130413","wikidata":"https://www.wikidata.org/wiki/Q425702","display_name":"Silibinin","level":2,"score":0.8672506809234619},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.834814727306366},{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.7788431644439697},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7094410061836243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45317935943603516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3991824984550476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17947238683700562},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.16239416599273682},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077385","descriptor_name":"Silybin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1124/dmd.107.014894","doi":"https://doi.org/10.1124/dmd.107.014894","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.107.014894","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmid:17540707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17540707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W40952352","https://openalex.org/W109228146","https://openalex.org/W130633592","https://openalex.org/W1257540794","https://openalex.org/W1553045097","https://openalex.org/W1829309082","https://openalex.org/W1849318309","https://openalex.org/W1893413863","https://openalex.org/W1970716479","https://openalex.org/W1975298037","https://openalex.org/W1980838143","https://openalex.org/W1982222906","https://openalex.org/W1983080992","https://openalex.org/W1999481211","https://openalex.org/W2003227142","https://openalex.org/W2006514190","https://openalex.org/W2009695102","https://openalex.org/W2016173021","https://openalex.org/W2026020954","https://openalex.org/W2039299190","https://openalex.org/W2057267277","https://openalex.org/W2066504688","https://openalex.org/W2080835467","https://openalex.org/W2083968585","https://openalex.org/W2102632252","https://openalex.org/W2109028417","https://openalex.org/W2142154255","https://openalex.org/W2157946922","https://openalex.org/W2168321453","https://openalex.org/W2224008834","https://openalex.org/W2235647666","https://openalex.org/W2239300707","https://openalex.org/W2264217721","https://openalex.org/W2438392818","https://openalex.org/W6644018741"],"related_works":["https://openalex.org/W1979426095","https://openalex.org/W2088392423","https://openalex.org/W2016173021","https://openalex.org/W2017577682","https://openalex.org/W2161400771","https://openalex.org/W560587886","https://openalex.org/W2153527385","https://openalex.org/W1993426734","https://openalex.org/W1981748458","https://openalex.org/W7100400961"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
