{"id":"https://openalex.org/W2129658196","doi":"https://doi.org/10.1002/bdra.20149","title":"Commercial animal feed: Variability in estrogenic activity and effects on body weight in mice","display_name":"Commercial animal feed: Variability in estrogenic activity and effects on body weight in mice","publication_year":2005,"publication_date":"2005-06-15","ids":{"openalex":"https://openalex.org/W2129658196","doi":"https://doi.org/10.1002/bdra.20149","mag":"2129658196","pmid":"https://pubmed.ncbi.nlm.nih.gov/15959886"},"language":"en","primary_location":{"id":"doi:10.1002/bdra.20149","doi":"https://doi.org/10.1002/bdra.20149","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.20149","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111413501","display_name":"Frederick S. vom Saal","orcid":"https://orcid.org/0000-0002-0488-3264","observed_orcids":["https://orcid.org/0000-0002-0488-3264"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frederick S. vom Saal","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri--Columbia, Columbia, Missouri 65211, USA. VomsaalF@missouri.edu","Division of Biological Sciences, University of Missouri\u2013Columbia, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri--Columbia, Columbia, Missouri 65211, USA. VomsaalF@missouri.edu","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri\u2013Columbia, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028994823","display_name":"Catherine A. Richter","orcid":"https://orcid.org/0000-0001-7322-4206","observed_orcids":["https://orcid.org/0000-0001-7322-4206"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine A. Richter","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri\u2013Columbia, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri\u2013Columbia, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002856239","display_name":"Jiude Mao","orcid":"https://orcid.org/0000-0003-0594-0571","observed_orcids":["https://orcid.org/0000-0003-0594-0571"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiude Mao","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri\u2013Columbia, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri\u2013Columbia, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114008048","display_name":"Wade V. Welshons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wade V. Welshons","raw_affiliation_strings":["Department of Veterinary Biomedical Sciences, University of Missouri\u2013Columbia, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, University of Missouri\u2013Columbia, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111413501"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":null,"apc_paid":null,"fwci":0.9922,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.73940086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"73","issue":"7","first_page":"474","last_page":"475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogenic-activity","display_name":"estrogenic activity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.8579999804496765},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.6850000023841858},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.5669999718666077},{"id":"https://openalex.org/keywords/developmental-programming","display_name":"developmental programming","score":0.3790000081062317},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.6639999747276306},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.5189999938011169},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5740000009536743},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.46799999475479126},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.4269999861717224},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.4699999988079071},{"id":"https://openalex.org/keywords/polycarbonate-plastics","display_name":"polycarbonate plastics","score":0.5009999871253967},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.35600000619888306},{"id":"https://openalex.org/keywords/epigenetic-development","display_name":"epigenetic development","score":0.5609999895095825},{"id":"https://openalex.org/keywords/glucose-insulin-interaction","display_name":"glucose-insulin interaction","score":0.4099999964237213},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7450709939002991},{"id":"https://openalex.org/C2781397067","wikidata":"https://www.wikidata.org/wiki/Q423989","display_name":"Diethylstilbestrol","level":3,"score":0.7427101135253906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7230868339538574},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6817578077316284},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6217674612998962},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5919040441513062},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5825056433677673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5367357134819031},{"id":"https://openalex.org/C2778656385","wikidata":"https://www.wikidata.org/wiki/Q414986","display_name":"Estrone","level":3,"score":0.5286655426025391},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5136889815330505},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.46630609035491943},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4315624237060547},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.42561689019203186},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4162443280220032},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.21584069728851318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15910467505455017},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14483585953712463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0749019980430603},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098826","descriptor_name":"Bisphenol A Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004054","descriptor_name":"Diethylstilbestrol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004054","descriptor_name":"Diethylstilbestrol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bdra.20149","doi":"https://doi.org/10.1002/bdra.20149","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.20149","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},{"id":"pmid:15959886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15959886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research. Part A, Clinical and molecular teratology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1543950566","https://openalex.org/W1969377280","https://openalex.org/W1982546336","https://openalex.org/W2000180814","https://openalex.org/W2044598637","https://openalex.org/W2075654456","https://openalex.org/W2096601431","https://openalex.org/W2105005092","https://openalex.org/W2113576333","https://openalex.org/W2156158367","https://openalex.org/W2288241310","https://openalex.org/W3130950488"],"related_works":["https://openalex.org/W7099920317","https://openalex.org/W2156796416","https://openalex.org/W4236169059","https://openalex.org/W1968614586","https://openalex.org/W2165471176","https://openalex.org/W2135752342","https://openalex.org/W2409286701","https://openalex.org/W2519824322","https://openalex.org/W2076203191","https://openalex.org/W2021775938"],"abstract_inverted_index":{"Mammalian":[0],"embryonic":[1],"development":[2,52,69],"is":[3,103,212,239,342,356,381,409,568,572,608,712,792],"epigenetic":[4],"in":[5,42,75,120,123,126,221,224,272,279,307,318,358,404,437,481,507,512,520,541,556,577,638,720,728,745,756,778,782,785,800,838,886],"that":[6,105,173,198,242,339,357,380,411,467,496,504,567,573,615,657,692,713,738,769],"hormonal":[7],"signals":[8],"control":[9],"not":[10,329,343,484,583,643],"only":[11,774],"the":[12,19,25,33,61,80,130,181,206,213,240,249,273,280,308,332,369,384,390,412,432,448,487,536,550,673,696,724,740,749,801,812,817,847,867,873],"timing":[13],"of":[14,21,27,35,53,60,63,82,96,133,158,180,205,251,275,325,368,387,414,435,442,450,472,489,499,527,538,544,552,569,588,618,636,678,695,710,726,742,751,803,805,814,819,852,869,891],"gene":[15],"expression":[16],"but":[17],"set":[18],"activity":[20,62,263,744],"genes":[22],"and":[23,29,48,84,194,258,264,284,312,366,407,760,821,875,896,900],"thus":[24,420,732],"functioning":[26],"organs":[28,54],"homeostatic":[30,76],"systems":[31],"for":[32,586,699,828,849],"remainder":[34],"life":[36,186],"(Newbold":[37],"et":[38,99,145,228,232,295,350,704,788,808],"al.,":[39,100,146,229,233,296,351,705,789,809],"2004).":[40,352],"Variation":[41],"endogenous":[43],"hormones,":[44],"such":[45,78,476,599,604,879],"as":[46,79,453,477,535,605,621,646,739,856,880],"estradiol":[47,109,159],"testosterone,":[49],"which":[50,211,607,791],"regulate":[51],"(vom":[55,530],"Saal,":[56,531,762],"1989),":[57],"or":[58,160,458,648,675],"disruption":[59],"these":[64,292,451,658,681],"hormones":[65],"by":[66,331,345],"chemicals":[67,163,430,444,452,619,659,682,715,854,871],"during":[68,106,165,184,775,835],"can":[70,89,151,515,601,660,716],"lead":[71,516],"to":[72,155,177,201,216,236,289,395,447,470,486,517,595,624,627,671,685,771,833,842,861,883,888],"permanent":[73],"changes":[74,88],"systems,":[77],"regulation":[81,818],"fat":[83,522,529,554,820],"body":[85,115,124,521,528,553,822,898],"weight.":[86],"These":[87],"have":[90,196,494,736,767,882],"profound":[91],"effects":[92,150,413,424,436,466,488,662,688,813,831,851,890],"on":[93,114,383,417,425,559,690,816,872,894],"a":[94,299,374,378,518,525,545,609,779,795],"variety":[95],"diseases":[97],"(Barker":[98],"1993).":[101],"There":[102],"evidence":[104,495],"postnatal":[107,225],"life,":[108],"has":[110,171,445,464,860],"an":[111,121,222,305,401],"inhibitory":[112],"effect":[113,324,341],"fat,":[116],"because":[117],"ovariectomy":[118],"results":[119,220,777],"increase":[122,223,306],"weight":[125,823],"females;":[127],"mice":[128,139,175,557,758,786],"without":[129],"alpha":[131,674],"form":[132,677],"estrogen":[134,142,333,347,397,455,631,679,815],"receptors":[135,143,348,702],"are":[136,468,483,505,582,683,693,824],"heavier":[137],"than":[138,190,393,524,798],"with":[140,580,590,629,653,794],"normal":[141],"(Heine":[144],"2000).":[147,706],"However,":[148],"different":[149,616,634,665,853],"occur":[152],"when":[153],"exposure":[154,200,770,834,893],"elevated":[156],"levels":[157,179,587],"other":[161,474,876],"estrogenic":[162,207,429,443,500,539,591,611,714,743,870],"occurs":[164],"fetal":[166,185,199],"development.":[167],"Newbold":[168],"(this":[169],"symposium)":[170],"reported":[172,197,768],"female":[174],"exposed":[176],"low":[178,203],"drug":[182],"diethylstilbestrol":[183],"eventually":[187],"become":[188],"fatter":[189],"nonexposed":[191],"mice.":[192],"We":[193,735,765],"others":[195],"very":[202],"doses":[204],"chemical":[208],"bisphenol":[209,243,269,285,302,326,362,415,462,654,772],"A,":[210],"monomer":[214],"used":[215,511,576],"make":[217],"polycarbonate":[218],"plastic,":[219],"growth":[226,804,895],"(Howdeshell":[227],"1999;":[230],"Rubin":[231],"2001).":[234],"Related":[235],"this":[237,323,340,560],"finding":[238,355,614],"report":[241],"A":[244,270,286,303,327,363,416,463,655,707,773],"at":[245],"2":[246],"\u03bcg/ml":[247],"accelerated":[248],"conversion":[250],"mouse":[252],"3T3-L1":[253],"fibroblast":[254],"cells":[255],"into":[256,315,389,864],"adipocytes":[257,317],"also":[259,421,766,859],"increased":[260],"lipoprotein":[261],"lipase":[262],"triacylglycerol":[265],"accumulation.":[266],"Over":[267],"time,":[268],"resulted":[271],"presence":[274],"larger":[276],"lipid":[277],"droplets":[278],"differentiated":[281],"cells.":[282],"Insulin":[283],"interacted":[287],"synergistically":[288],"further":[290],"accelerate":[291],"processes":[293],"(Masuno":[294],"2002).":[297,810],"In":[298,491,593,667,845],"related":[300,354],"study,":[301],"stimulated":[304],"glucose":[309,313],"transporter":[310],"(GLUT-4)":[311],"uptake":[314],"3T3-F442A":[316],"cell":[319,391],"culture.":[320],"Of":[321],"interest,":[322],"was":[328],"inhibited":[330],"receptor":[334,456],"antagonist":[335],"ICI":[336],"182,780,":[337],"revealing":[338],"mediated":[344],"nuclear":[346,396,630],"(Sakurai":[349],"Another":[353],"pancreatic":[359],"\u03b2":[360],"cells,":[361],"stimulates":[364],"phosphorylation":[365],"activation":[367],"transcription":[370],"factor":[371],"CREB":[372,399],"within":[373],"few":[375],"minutes":[376],"via":[377],"mechanism":[379],"dependent":[382],"rapid":[385,423],"influx":[386],"calcium":[388],"rather":[392,523,797],"binding":[394,670],"receptors.":[398],"plays":[400],"important":[402],"role":[403],"adipocyte":[405,418],"differentiation,":[406],"it":[408],"possible":[410],"differentiation":[419,840],"involve":[422],"CREB.":[426],"Not":[427],"all":[428],"show":[431,656],"same":[433],"spectrum":[434],"target":[438,640],"tissues.":[439],"This":[440],"property":[441],"led":[446],"description":[449],"selective":[454],"modulators":[457],"SERMs.":[459],"Thus,":[460],"while":[461],"some":[465,542],"similar":[469,485],"those":[471,478,503],"estradiol,":[473],"effects,":[475],"described":[479],"above":[480,651],"adipocytes,":[482],"estradiol.":[490],"fact,":[492],"we":[493],"another":[497],"class":[498],"chemicals,":[501],"namely":[502],"present":[506],"commercial":[508,574],"animal":[509,547,746],"feeds":[510,575],"laboratory":[513,578],"experiments,":[514],"reduction":[519,781],"stimulation":[526],"unpublished":[532,763],"observation).":[533,764],"Specifically,":[534],"amount":[537,551,741,750],"contaminants":[540,589,600],"batches":[543],"casein-based":[546],"feed":[548,561,747],"increased,":[549],"decreased":[555],"maintained":[558],"throughout":[562],"life.":[563],"One":[564],"issue":[565,709],"here":[566],"considerable":[570],"concern":[571],"experiments":[579],"rodents":[581],"routinely":[584],"screened":[585],"activity.":[592],"addition":[594],"naturally":[596],"occurring":[597],"phytoestrogens,":[598],"include":[602],"mycotoxins,":[603],"zeralonone,":[606],"potent":[610],"chemical.":[612],"The":[613,650,826],"types":[617,635],"classified":[620,855],"\u201cestrogens,\u201d":[622],"due":[623,832],"their":[625],"ability":[626],"interact":[628],"receptors,":[632,680],"exert":[633,661,686],"activities":[637],"certain":[639],"tissues":[641],"should":[642],"be":[644,843,862,884],"viewed":[645],"surprising":[647],"contradictory.":[649],"findings":[652],"through":[663],"many":[664],"pathways.":[666],"addition,":[668,846],"after":[669],"either":[672],"beta":[676],"known":[684],"unique":[687,829,850],"depending":[689],"coregulators":[691],"part":[694],"transcriptional":[697],"apparatus":[698],"steroid":[700],"hormone":[701],"(Routhledge":[703],"final":[708],"interest":[711],"impact":[717],"nursing":[718,754,783],"performance":[719],"mammals.":[721],"Estrogen":[722],"inhibits":[723],"action":[725],"prolactin":[727],"mammary":[729],"gland":[730],"epithelium,":[731],"reducing":[733],"lactation.":[734],"found":[737],"increases,":[748],"time":[752],"spent":[753],"decreases":[755],"lactating":[757],"(Giosa":[759],"vom":[761],"pregnancy":[776],"subsequent":[780,897],"behavior":[784],"(Palanza":[787],"2002),":[790],"associated":[793],"decrease,":[796],"increase,":[799],"rate":[802],"offspring":[806],"(Honma":[807],"Clearly,":[811],"complex.":[825],"potential":[827,848],"developmental":[830,892],"critical":[836],"periods":[837],"tissue":[839],"needs":[841],"considered.":[844],"\u201cenvironmental":[857],"estrogens\u201d":[858],"taken":[863],"account.":[865],"Finally,":[866],"actions":[868],"brain":[874],"physiological":[877],"processes,":[878],"lactation,":[881],"considered":[885],"order":[887],"understand":[889],"composition":[899],"size.":[901]},"counts_by_year":[{"year":2018,"cited_by_count":14},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}