{"id":"https://openalex.org/W2129649561","doi":"https://doi.org/10.1046/j.1365-2958.2002.03224.x","title":"Saccharomyces cerevisiae C1D is implicated in both non\u2010homologous DNA end joining and homologous recombination","display_name":"Saccharomyces cerevisiae C1D is implicated in both non\u2010homologous DNA end joining and homologous recombination","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2129649561","doi":"https://doi.org/10.1046/j.1365-2958.2002.03224.x","mag":"2129649561","pmid":"https://pubmed.ncbi.nlm.nih.gov/12421302"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2958.2002.03224.x","doi":"https://doi.org/10.1046/j.1365-2958.2002.03224.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.2002.03224.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.bilkent.edu.tr/bitstreams/c691d45a-6b2d-48a4-a244-98f3dc076f21/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014321367","display_name":"Tuba Erdemir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tuba Erdemir","raw_affiliation_strings":["Bikent University, Molecular Biology and Genetics Department, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bikent University, Molecular Biology and Genetics Department, Ankara, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064144570","display_name":"Bilada Bilican","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I50863359","display_name":"Marie Curie","ror":"https://ror.org/02aqv1x10","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I50863359"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bilada Bilican","raw_affiliation_strings":["Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK","institution_ids":["https://openalex.org/I50863359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069774679","display_name":"Tolga \u00c7a\u011fatay","orcid":"https://orcid.org/0000-0003-0256-7636","observed_orcids":["https://orcid.org/0000-0003-0256-7636"]},"institutions":[{"id":"https://openalex.org/I168864056","display_name":"Bilkent University","ror":"https://ror.org/02vh8a032","country_code":"TR","type":"education","lineage":["https://openalex.org/I168864056"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tolga Cagatay","raw_affiliation_strings":["Bilkent University, Molecular Biology and Genetics Department, 06533, Bilkent, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bilkent University, Molecular Biology and Genetics Department, 06533, Bilkent, Ankara, Turkey","institution_ids":["https://openalex.org/I168864056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002433296","display_name":"Colin R. Goding","orcid":"https://orcid.org/0000-0002-1614-3909","observed_orcids":["https://orcid.org/0000-0002-1614-3909"]},"institutions":[{"id":"https://openalex.org/I50863359","display_name":"Marie Curie","ror":"https://ror.org/02aqv1x10","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I50863359"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin R. Goding","raw_affiliation_strings":["Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK","institution_ids":["https://openalex.org/I50863359"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048373642","display_name":"Ugur Yavuzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168864056","display_name":"Bilkent University","ror":"https://ror.org/02vh8a032","country_code":"TR","type":"education","lineage":["https://openalex.org/I168864056"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ugur Yavuzer","raw_affiliation_strings":["Bilkent University, Molecular Biology and Genetics Department, 06533, Bilkent, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bilkent University, Molecular Biology and Genetics Department, 06533, Bilkent, Ankara, Turkey","institution_ids":["https://openalex.org/I168864056"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048373642"],"corresponding_institution_ids":["https://openalex.org/I168864056"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.844,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.84965874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"4","first_page":"947","last_page":"957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9509999752044678},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9350000023841858},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":1.0},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dna-dependent-protein-kinase","display_name":"DNA-dependent protein kinase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/trax","display_name":"TRAX","score":0.7319999933242798},{"id":"https://openalex.org/keywords/translin","display_name":"translin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/p53-dependent-apoptosis","display_name":"p53-dependent apoptosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.734000027179718},{"id":"https://openalex.org/keywords/temperature-response","display_name":"temperature sensitivity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.851742684841156},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.8154864311218262},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.7102869153022766},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6523718237876892},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6452096104621887},{"id":"https://openalex.org/C135300049","wikidata":"https://www.wikidata.org/wiki/Q5426559","display_name":"FLP-FRT recombination","level":5,"score":0.6447896957397461},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6120873093605042},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.49566495418548584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4873238503932953},{"id":"https://openalex.org/C82040048","wikidata":"https://www.wikidata.org/wiki/Q7049125","display_name":"Non-allelic homologous recombination","level":5,"score":0.48211145401000977},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.46845221519470215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4494136571884155},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4436371326446533},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4165993928909302},{"id":"https://openalex.org/C101434241","wikidata":"https://www.wikidata.org/wiki/Q211675","display_name":"Genetic recombination","level":4,"score":0.4061471223831177},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3950815200805664},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.29527658224105835}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2958.2002.03224.x","doi":"https://doi.org/10.1046/j.1365-2958.2002.03224.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2958.2002.03224.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},{"id":"pmid:12421302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12421302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.bilkent.edu.tr:11693/24568","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11693/24568","pdf_url":"https://repository.bilkent.edu.tr/bitstreams/c691d45a-6b2d-48a4-a244-98f3dc076f21/download","source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Microbiology","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:repository.bilkent.edu.tr:11693/24568","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11693/24568","pdf_url":"https://repository.bilkent.edu.tr/bitstreams/c691d45a-6b2d-48a4-a244-98f3dc076f21/download","source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Microbiology","raw_type":"Article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323792","display_name":"Bilkent \u00dcniversitesi","ror":"https://ror.org/02vh8a032"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129649561.pdf","grobid_xml":"https://content.openalex.org/works/W2129649561.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1480404031","https://openalex.org/W1481821763","https://openalex.org/W1513743142","https://openalex.org/W1526043578","https://openalex.org/W1543815058","https://openalex.org/W1938372995","https://openalex.org/W1947782487","https://openalex.org/W1965242104","https://openalex.org/W1965336663","https://openalex.org/W1979587131","https://openalex.org/W1981255217","https://openalex.org/W1989726078","https://openalex.org/W2000912535","https://openalex.org/W2007558376","https://openalex.org/W2007919127","https://openalex.org/W2011232618","https://openalex.org/W2012126331","https://openalex.org/W2014722055","https://openalex.org/W2018078716","https://openalex.org/W2056555295","https://openalex.org/W2056644985","https://openalex.org/W2058971004","https://openalex.org/W2066979886","https://openalex.org/W2080402528","https://openalex.org/W2093600654","https://openalex.org/W2094245955","https://openalex.org/W2109316537","https://openalex.org/W2130728712","https://openalex.org/W2132347126","https://openalex.org/W2133491083","https://openalex.org/W2144550200","https://openalex.org/W2157451489","https://openalex.org/W2187946756","https://openalex.org/W2324910603","https://openalex.org/W2474783910"],"related_works":["https://openalex.org/W1978054036","https://openalex.org/W1981934737","https://openalex.org/W2324050605","https://openalex.org/W2121432854","https://openalex.org/W1938372995","https://openalex.org/W2041753976","https://openalex.org/W1860536703","https://openalex.org/W1627029737","https://openalex.org/W7000829452","https://openalex.org/W1990972868"],"abstract_inverted_index":{"C1D":[0,37,64,76,106,122],"is":[1,19,110,182],"a":[2,51,135,158],"gamma-irradiation":[3],"inducible":[4],"nuclear":[5],"matrix":[6],"protein":[7,15],"that":[8,18,36,60,74,107,126,139,167,180],"interacts":[9],"with":[10,41,49],"and":[11,29,43,59,95,138,151,188],"activates":[12],"the":[13,22,25,45,87,102,119,127,130,192],"DNA-dependent":[14],"kinase":[16],"(DNA-PK)":[17],"essential":[20],"for":[21,101,191],"repair":[23,94,193],"of":[24,47,63,82,89,105,129,194],"DNA":[26,56,93,147,153,195],"double-strand":[27,196],"breaks":[28],"V(D)J":[30],"recombination.":[31,96,176],"Recently,":[32],"it":[33],"was":[34],"demonstrated":[35],"can":[38,65],"also":[39,172],"interact":[40],"TRAX":[42,48],"prevent":[44],"association":[46],"Translin,":[50],"factor":[52],"known":[53],"to":[54],"bind":[55],"break-point":[57],"junctions,":[58],"over":[61],"expression":[62],"induce":[66],"p53-dependent":[67],"apoptosis.":[68],"Taken":[69],"together,":[70],"these":[71],"findings":[72],"suggest":[73],"mammalian":[75],"could":[77],"be":[78],"involved":[79,91],"in":[80,92,134,145,161,174,184],"maintenance":[81],"genome":[83],"integrity":[84],"by":[85],"regulating":[86],"activity":[88],"proteins":[90],"To":[97],"obtain":[98],"direct":[99],"evidence":[100],"biological":[103],"function":[104],"we":[108,116,165],"show":[109,166],"highly":[111],"conserved":[112],"between":[113],"diverse":[114],"species,":[115],"have":[117],"analysed":[118],"Saccharomyces":[120],"cerevisiae":[121],"homologue.":[123],"We":[124],"report":[125],"disruption":[128],"YC1D":[131,181],"gene":[132],"results":[133,178],"temperature":[136],"sensitivity":[137],"yc1d":[140,168],"mutant":[141,169],"strains":[142,170],"exhibit":[143],"defects":[144],"non-homologous":[146],"end":[148],"joining":[149],"(NHEJ)":[150],"accurate":[152],"repair.":[154],"In":[155],"addition,":[156],"using":[157],"novel":[159],"plasmid-based":[160],"vivo":[162],"recombination":[163,187],"assay,":[164],"are":[171],"defective":[173],"homologous":[175,186],"These":[177],"indicate":[179],"implicated":[183],"both":[185],"NHEJ":[189],"pathways":[190],"breaks.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
