{"id":"https://openalex.org/W2129644952","doi":null,"title":"EFFECTS OF GLUTATHIONE PEROXIDASE 1, GLUTATHIONE PEROXIDASE 4 AND COPPER, ZINC-SUPEROXIDE DISMUTASE GENE KNOCKOUTS ON ENZYME ACTIVITIES, BODY SELENIUM AND RESISTANCE TO OXIDATIVE AND NITROSATIVE STRESSES","display_name":"EFFECTS OF GLUTATHIONE PEROXIDASE 1, GLUTATHIONE PEROXIDASE 4 AND COPPER, ZINC-SUPEROXIDE DISMUTASE GENE KNOCKOUTS ON ENZYME ACTIVITIES, BODY SELENIUM AND RESISTANCE TO OXIDATIVE AND NITROSATIVE STRESSES","publication_year":2005,"publication_date":"2005-08-03","ids":{"openalex":"https://openalex.org/W2129644952","mag":"2129644952"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/2127","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/2127","pdf_url":"https://hdl.handle.net/1813/2127","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1813/2127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028701792","display_name":"Michael S. Scimeca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael S. Scimeca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028701792"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-peroxidase-1","display_name":"glutathione peroxidase 1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":1.0},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.6600000262260437},{"id":"https://openalex.org/keywords/paraquat-poisoning","display_name":"paraquat poisoning","score":0.6690000295639038},{"id":"https://openalex.org/keywords/acetaminophen-toxicity","display_name":"acetaminophen toxicity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.871999979019165},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.4749999940395355},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6069999933242798},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.5509999990463257},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C203663253","wikidata":"https://www.wikidata.org/wiki/Q18026456","display_name":"GPX1","level":5,"score":0.8254544734954834},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.8123202323913574},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.7018851041793823},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6823517084121704},{"id":"https://openalex.org/C2781264002","wikidata":"https://www.wikidata.org/wiki/Q3724651","display_name":"Phospholipid-hydroperoxide glutathione peroxidase","level":5,"score":0.5432778596878052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5399700403213501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5106478333473206},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5064214468002319},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5020854473114014},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4948541522026062},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.4380648136138916},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.42241740226745605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3320941925048828},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23850104212760925}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ecommons.cornell.edu:1813/2127","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/2127","pdf_url":"https://hdl.handle.net/1813/2127","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},{"id":"mag:2129644952","doi":null,"is_oa":false,"landing_page_url":"http://ecommons.cornell.edu/bitstream/1813/2127/1/MS%20thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/2127","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/2127","pdf_url":"https://hdl.handle.net/1813/2127","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129644952.pdf","grobid_xml":"https://content.openalex.org/works/W2129644952.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W48783516","https://openalex.org/W103184443","https://openalex.org/W136131483","https://openalex.org/W183120241","https://openalex.org/W313018790","https://openalex.org/W1484563081","https://openalex.org/W1486579226","https://openalex.org/W1497318066","https://openalex.org/W1501074197","https://openalex.org/W1508162082","https://openalex.org/W1514161203","https://openalex.org/W1516659005","https://openalex.org/W1522996075","https://openalex.org/W1529637676","https://openalex.org/W1529804537","https://openalex.org/W1537948347","https://openalex.org/W1540141309","https://openalex.org/W1541765566","https://openalex.org/W1544230661","https://openalex.org/W1545965226","https://openalex.org/W1550853891","https://openalex.org/W1571132164","https://openalex.org/W1572963091","https://openalex.org/W1574656070","https://openalex.org/W1576198188","https://openalex.org/W1580766481","https://openalex.org/W1581203443","https://openalex.org/W1595015475","https://openalex.org/W1605318792","https://openalex.org/W1670885862","https://openalex.org/W1775749144","https://openalex.org/W1784516732","https://openalex.org/W1802486171","https://openalex.org/W1826455295","https://openalex.org/W1832691281","https://openalex.org/W1882553807","https://openalex.org/W1888475249","https://openalex.org/W1904507659","https://openalex.org/W1914835696","https://openalex.org/W1933984510","https://openalex.org/W1940436875","https://openalex.org/W1958778503","https://openalex.org/W1963549348","https://openalex.org/W1963874808","https://openalex.org/W1965137017","https://openalex.org/W1965534308","https://openalex.org/W1966342185","https://openalex.org/W1966597352","https://openalex.org/W1966920840","https://openalex.org/W1967052070","https://openalex.org/W1967684747","https://openalex.org/W1969391229","https://openalex.org/W1969846504","https://openalex.org/W1970928392","https://openalex.org/W1971864549","https://openalex.org/W1971891532","https://openalex.org/W1974017120","https://openalex.org/W1974231678","https://openalex.org/W1975500283","https://openalex.org/W1975892042","https://openalex.org/W1977229794","https://openalex.org/W1977858876","https://openalex.org/W1978038466","https://openalex.org/W1979997292","https://openalex.org/W1986665522","https://openalex.org/W1986926122","https://openalex.org/W1986993954","https://openalex.org/W1987171188","https://openalex.org/W1987338970","https://openalex.org/W1988998244","https://openalex.org/W1992412942","https://openalex.org/W1995744241","https://openalex.org/W1996049259","https://openalex.org/W1996236557","https://openalex.org/W1996641704","https://openalex.org/W1999563094","https://openalex.org/W1999933933","https://openalex.org/W2001505200","https://openalex.org/W2002209113","https://openalex.org/W2002449018","https://openalex.org/W2002467106","https://openalex.org/W2003337850","https://openalex.org/W2006313098","https://openalex.org/W2007202879","https://openalex.org/W2008430621","https://openalex.org/W2008613157","https://openalex.org/W2008820074","https://openalex.org/W2011198909","https://openalex.org/W2011338898","https://openalex.org/W2013135033","https://openalex.org/W2016373146","https://openalex.org/W2017649638","https://openalex.org/W2017906971","https://openalex.org/W2018685529","https://openalex.org/W2019032733","https://openalex.org/W2019920716","https://openalex.org/W2020418108","https://openalex.org/W2020444493","https://openalex.org/W2025939085","https://openalex.org/W2027043097","https://openalex.org/W2029376735","https://openalex.org/W2030331975","https://openalex.org/W2030395436","https://openalex.org/W2037617638","https://openalex.org/W2039610545","https://openalex.org/W2042412591","https://openalex.org/W2042662902","https://openalex.org/W2046100931","https://openalex.org/W2047672047","https://openalex.org/W2048283871","https://openalex.org/W2049016288","https://openalex.org/W2050204181","https://openalex.org/W2052396259","https://openalex.org/W2053712580","https://openalex.org/W2054262242","https://openalex.org/W2055055753","https://openalex.org/W2055112763","https://openalex.org/W2055420058","https://openalex.org/W2055479342","https://openalex.org/W2055557845","https://openalex.org/W2055615470","https://openalex.org/W2056273538","https://openalex.org/W2058329308","https://openalex.org/W2058566356","https://openalex.org/W2060194897","https://openalex.org/W2061506033","https://openalex.org/W2061820222","https://openalex.org/W2063860588","https://openalex.org/W2065621311","https://openalex.org/W2065699268","https://openalex.org/W2066639890","https://openalex.org/W2067816697","https://openalex.org/W2068630495","https://openalex.org/W2068972343","https://openalex.org/W2070742508","https://openalex.org/W2071527810","https://openalex.org/W2072978915","https://openalex.org/W2073278082","https://openalex.org/W2073679464","https://openalex.org/W2076055378","https://openalex.org/W2077811595","https://openalex.org/W2078744504","https://openalex.org/W2079736357","https://openalex.org/W2081645231","https://openalex.org/W2081748503","https://openalex.org/W2083980210","https://openalex.org/W2085010213","https://openalex.org/W2085826212","https://openalex.org/W2086122328","https://openalex.org/W2092279282","https://openalex.org/W2092317255","https://openalex.org/W2093873520","https://openalex.org/W2096386031","https://openalex.org/W2098651583","https://openalex.org/W2098890352","https://openalex.org/W2099286609","https://openalex.org/W2099659761","https://openalex.org/W2101537600","https://openalex.org/W2107095755","https://openalex.org/W2107919301","https://openalex.org/W2108396632","https://openalex.org/W2115971178","https://openalex.org/W2115975389","https://openalex.org/W2117102245","https://openalex.org/W2123572537","https://openalex.org/W2124898371","https://openalex.org/W2127568565","https://openalex.org/W2129314792","https://openalex.org/W2129843256","https://openalex.org/W2131052776","https://openalex.org/W2132658326","https://openalex.org/W2134140021","https://openalex.org/W2134363913","https://openalex.org/W2134586772","https://openalex.org/W2135057047","https://openalex.org/W2138138539","https://openalex.org/W2139850491","https://openalex.org/W2141819645","https://openalex.org/W2143833424","https://openalex.org/W2145560274","https://openalex.org/W2147418323","https://openalex.org/W2147806246","https://openalex.org/W2148072098","https://openalex.org/W2148207815","https://openalex.org/W2154204943","https://openalex.org/W2161859654","https://openalex.org/W2165072468","https://openalex.org/W2167519860","https://openalex.org/W2168433858","https://openalex.org/W2169556070","https://openalex.org/W2169958072","https://openalex.org/W2172132891","https://openalex.org/W2173725245","https://openalex.org/W2209831038","https://openalex.org/W2222772859","https://openalex.org/W2242530905","https://openalex.org/W2256231933","https://openalex.org/W2258452643","https://openalex.org/W2260997781","https://openalex.org/W2281817356","https://openalex.org/W2304301066","https://openalex.org/W2314050713","https://openalex.org/W2318551389","https://openalex.org/W2335646039","https://openalex.org/W2389931660","https://openalex.org/W2410912998","https://openalex.org/W2418393813","https://openalex.org/W4237383128","https://openalex.org/W4298997209"],"related_works":["https://openalex.org/W2095757171","https://openalex.org/W2033932776","https://openalex.org/W1992412942","https://openalex.org/W1974017120","https://openalex.org/W2115971178","https://openalex.org/W2301670026","https://openalex.org/W2126870338","https://openalex.org/W2790743137","https://openalex.org/W2147418323","https://openalex.org/W2129314792"],"abstract_inverted_index":{"This":[0],"thesis":[1],"addresses":[2],"two":[3,80],"studies,":[4],"1)":[5],"characterization":[6],"of":[7,20,23,79,93,105,143,165,167,192,255,276,283,303,365,371,457,565,635,648],"a":[8,57,73,122,175,234,281,377,563],"glutathione":[9,24,84],"peroxidase":[10,25],"4":[11,205],"(GPx4)":[12],"haploid":[13],"insufficient":[14],"(+/-)":[15],"mouse":[16],"and":[17,28,41,71,87,89,113,124,141,173,179,203,218,266,288,306,339,374,411,426,442,459,519,543,571,590,617,629],"2)":[18],"effects":[19,164,284],"different":[21,495],"levels":[22],"1":[26,34,161],"(GPx1)":[27],"Cu,":[29],"Zn":[30],"-":[31],"superoxide":[32,322],"dismutase":[33],"(SOD1)":[35],"gene":[36,369],"dosage":[37],"on":[38,248,285,527,638,651],"enzyme":[39,69,569],"_expression":[40,70],"responses":[42,364,566],"to":[43,63,98,127,135,222,296,311,326,382,507,567,576,596,609,614,640],"paraquat":[44],"(PQ),":[45],"diquat":[46],"(DQ)":[47],"and/or":[48],"acetaminophen":[49],"(AP)":[50],"toxicity.":[51,598],"These":[52],"studies":[53],"are":[54,96,308,351,562,574],"united":[55],"in":[56,72,101,102,214,240,261,271,300,314,331,337,376,394,455,510,555],"general":[58,416],"way":[59,76],"by":[60,77,408],"addressing":[61],"response":[62],"oxidative":[64,579],"stress":[65],"with":[66,174,187,367,450,505,540,546,606,626],"altered":[67],"antioxidant":[68,568],"more":[74,133],"specific":[75],"involvement":[78],"selenium":[81],"(Se)":[82],"containing":[83],"peroxidases":[85],"(GPx1":[86],"GPx4)":[88],"SOD1.":[90],"All":[91],"three":[92],"these":[94],"enzymes":[95],"believed":[97],"be":[99],"involved":[100],"vivo":[103,395],"metabolism":[104],"reactive":[106,354],"oxygen":[107],"species":[108,356],"(ROS).":[109],"GPx4":[110,131,145,212,286,588],"is":[111,125,132,147,155],"structurally":[112],"functionally":[114],"unique":[115],"among":[116],"selenoperoxidases":[117,140],"since":[118],"it":[119],"functions":[120],"as":[121],"monomer":[123],"able":[126],"metabolize":[128],"phospholipid":[129],"hydroperoxides.":[130],"resistant":[134],"Se":[136,242,249,289,592],"depletion":[137],"than":[138,229,484,645],"other":[139,262],"deletion":[142,166,275,585],"both":[144,372,440],"alleles":[146],"embryonic":[148],"lethal,":[149],"indicating":[150],"an":[151],"important":[152],"role":[153],"that":[154],"not":[156,293,493,572],"yet":[157],"fully":[158],"understood.":[159],"Experiment":[160,361,582,600],"examined":[162],"the":[163,193,315,383,392,633,646],"one":[168,277,452],"gpx4":[169,278,584],"allele":[170,279,422,436],"at":[171],"baseline":[172],"ROS":[176,194,313,332,384],"challenge.":[177],"GPx4+/-":[178,208,231,244],"wild-type":[180],"(WT":[181],"or":[182,197,258,264,343,346,391,462],"GPx4+/+)":[183],"mice":[184,209,232,340,366,449,480],"were":[185],"injected":[186],"24":[188,221],"mg/kg":[189,388,400],"body":[190,389,401],"weight":[191],"generator":[195,385,397],"PQ":[196,597],"phosphate":[198],"buffered":[199],"saline":[200],"(PBS)":[201],"control":[202,485,497],"sacrificed":[204],"h":[206,379,536,545],"later.":[207],"had":[210,233,245,464],"decreased":[211,423,466,618],"activity":[213,228,260,270,589,620],"lung,":[215],"liver,":[216],"kidney":[217],"testis,":[219],"from":[220,321,439,496],"39%":[223],"(P":[224,236,430,444,475,513],"<":[225,237,431,445,476,514],"0.05)":[226,238],"lower":[227],"WT.":[230],"34%":[235,508],"decrease":[239],"testis":[241,591],"concentration.":[243],"no":[246],"effect":[247,634,647],"concentration,":[250],"protein":[251,298],"carbonyl":[252],"formation":[253],"(measure":[254],"oxidized":[256],"protein)":[257],"GPx1":[259,307,324,342,375,434,460,511,619,622,649],"tissues":[263,302],"GPx3":[265],"alanine":[267],"aminotransferase":[268],"(ALT)":[269],"plasma.":[272],"In":[273,447,559,581,599],"summary,":[274,560],"demonstrated":[280],"range":[282],"activities":[287],"concentrations,":[290],"but":[291,470,488,552],"did":[292],"affect":[294],"susceptibilities":[295],"pro-oxidant-induced":[297],"oxidation":[299],"various":[301,368],"mice.":[304,558],"SOD1":[305,317,344,373,420,458,500,528,602,636],"often":[309],"considered":[310],"detoxify":[312],"cytosol.":[316],"produces":[318],"hydrogen":[319],"peroxide":[320],"which":[323],"reduces":[325],"water.":[327],"A":[328],"dramatic":[329],"increase":[330],"lethality":[333,642],"has":[334],"been":[335],"found":[336],"cells":[338],"lacking":[341],"(GPx1-/-":[345],"SOD1-/-)":[347],"whereas":[348],"GPx1-/-":[349],"hepatocytes":[350],"protected":[352],"against":[353,578],"nitrogen":[355],"(RNS)":[357],"induced":[358],"cell":[359],"death.":[360],"2":[362],"compared":[363],"dosages":[370],"72":[378],"survival":[380,468,473,490],"trial":[381],"DQ":[386,443,467,547,615,630],"(25":[387],"weight)":[390],"putative":[393],"RNS":[396],"AP":[398,441,472,541,610,628,641,652],"(600":[399],"weight).":[402],"Although":[403],"this":[404],"experiment":[405],"was":[406,492,502,553,604,624,643],"limited":[407],"sample":[409],"size":[410],"group":[412],"death":[413],"rates,":[414],"some":[415],"trends":[417],"emerged.":[418],"The":[419,433],"knockout":[421,435,501,603,623,637,650],"AP-induced":[424],"mortality":[425,429,438],"increased":[427,437,594,627],"DQ-induced":[428],"0.05).":[432,446,477],"combination,":[448],"only":[451],"functional":[453],"copy":[454,529],"total":[456],"(GPx1+/-|SOD1-/-":[461],"GPx1-/-|SOD1+/-)":[463],"significantly":[465,482,494],"time":[469,474,491],"unchanged":[471,554],"AP-treated":[478],"GPx1+/-|SOD1+/+":[479],"died":[481],"earlier":[483],"(<40":[486],"h)":[487],"GPx1+/-|SOD1+/-":[489],"(>72":[498],"h).":[499],"also":[503],"associated":[504,605,625],"28":[506],"decreases":[509],"activity,":[512],"0.05;":[515],"+/+":[516,523],"vs.":[517,524],"+/-":[518],"P":[520],"=":[521],"0.078":[522],"-/-),":[525],"depending":[526],"number).":[530],"Plasma":[531],"ALT":[532],"peaked":[533],"between":[534],"20-40":[535],"(11740":[537],"?":[538,550],"1074)":[539],"treatment":[542,548],"<20":[544],"(2129":[549],"537)":[551],"all":[556,573],"surviving":[557],"there":[561],"variety":[564],"knockouts":[570],"detrimental":[575],"defense":[577],"stress.":[580],"1,":[583],"reduced":[586],"tissue":[587],"without":[593],"susceptibility":[595,613],"2,":[601],"high":[607,612],"resistance":[608,639],"toxicity,":[611],"toxicity":[616],"while":[621],"mortality.":[631],"Overall,":[632],"greater":[644],"lethality.":[653]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
