{"id":"https://openalex.org/W2129594776","doi":null,"title":"A mechanism study on propofol's action on middle latency auditory evoked potential by neurons in ventral partition of medial geniculate body in rats.","display_name":"A mechanism study on propofol's action on middle latency auditory evoked potential by neurons in ventral partition of medial geniculate body in rats.","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W2129594776","mag":"2129594776","pmid":"https://pubmed.ncbi.nlm.nih.gov/25010614"},"language":"en","primary_location":{"id":"pmid:25010614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25010614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037095781","display_name":"Q-Q Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q-Q Shi","raw_affiliation_strings":["Department of Anesthesiology, Children Hospital of Fudan University, Shanghai, China.drfanghao@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Children Hospital of Fudan University, Shanghai, China.drfanghao@163.com","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110683157","display_name":"Xiaotan Sun","orcid":"https://orcid.org/0009-0000-0320-3821","observed_orcids":["https://orcid.org/0009-0000-0320-3821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"H Fang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2186,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.79589502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"13","first_page":"1859","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/middle-latency-auditory-evoked-potentials","display_name":"middle latency auditory evoked potentials","score":0.984000027179718},{"id":"https://openalex.org/keywords/medial-geniculate-nucleus","display_name":"medial geniculate body","score":0.9580000042915344},{"id":"https://openalex.org/keywords/auditory-pathway","display_name":"auditory pathway","score":0.41200000047683716},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.5720000267028809},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nickel","display_name":"nickel","score":0.6859999895095825},{"id":"https://openalex.org/keywords/4-aminopyridine","display_name":"4-aminopyridine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/auditory-brainstem","display_name":"auditory brainstem","score":0.49900001287460327},{"id":"https://openalex.org/keywords/anesthetic-mechanisms","display_name":"anesthetic mechanisms","score":0.47600001096725464},{"id":"https://openalex.org/keywords/intralipid","display_name":"Intralipid","score":0.6449999809265137},{"id":"https://openalex.org/keywords/wave-latency","display_name":"wave latency","score":0.3709999918937683},{"id":"https://openalex.org/keywords/wave-amplitude","display_name":"wave amplitude","score":0.7889999747276306},{"id":"https://openalex.org/keywords/whole-cell-patch-clamp","display_name":"whole-cell patch clamp","score":0.7139999866485596},{"id":"https://openalex.org/keywords/stereotactic-injection","display_name":"stereotactic injection","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.9714697599411011},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6220372319221497},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6137405633926392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5283570885658264},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49429750442504883},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4725967049598694},{"id":"https://openalex.org/C2909708642","wikidata":"https://www.wikidata.org/wiki/Q3694103","display_name":"Medial geniculate body","level":4,"score":0.46992576122283936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4009855091571808},{"id":"https://openalex.org/C2775980177","wikidata":"https://www.wikidata.org/wiki/Q358512","display_name":"Inferior colliculus","level":3,"score":0.1753377616405487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13774943351745605},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005072","descriptor_name":"Evoked Potentials, Auditory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005829","descriptor_name":"Geniculate Bodies","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005829","descriptor_name":"Geniculate Bodies","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25010614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25010614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2129594776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25010614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1554288589","https://openalex.org/W1979019085","https://openalex.org/W1983187084","https://openalex.org/W1991978604","https://openalex.org/W1996176484","https://openalex.org/W1998209329","https://openalex.org/W2011362027","https://openalex.org/W2022929721","https://openalex.org/W2025312180","https://openalex.org/W2027402924","https://openalex.org/W2028201405","https://openalex.org/W2028494208","https://openalex.org/W2028498661","https://openalex.org/W2036790219","https://openalex.org/W2039107583","https://openalex.org/W2065857403","https://openalex.org/W2066715062","https://openalex.org/W2070021885","https://openalex.org/W2090674261","https://openalex.org/W2093126183","https://openalex.org/W2094846297","https://openalex.org/W2112805640","https://openalex.org/W2115310446","https://openalex.org/W2124384330","https://openalex.org/W2143630514","https://openalex.org/W2145114985","https://openalex.org/W2145980353","https://openalex.org/W2146819146","https://openalex.org/W2162707841","https://openalex.org/W2416947667"],"related_works":["https://openalex.org/W2401430044","https://openalex.org/W7096971118","https://openalex.org/W2058577133","https://openalex.org/W2171018562","https://openalex.org/W2356140350","https://openalex.org/W2320289399","https://openalex.org/W2487604594","https://openalex.org/W2079501761","https://openalex.org/W7057278991","https://openalex.org/W2068557617"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1,136],"investigate":[2],"the":[3,8,18,215,238,250,270,378,389,423],"effect":[4],"of":[5,21,56,59,99,103,126,174,205,228,240,260,272,340,365,392,409,426],"propofol":[6,60,153,158,163,169,376],"on":[7],"middle":[9],"latency":[10,227,259,307,317,355],"auditory":[11],"evoked":[12],"potentials":[13],"(MLAEP)":[14],"by":[15,97,115,144,421],"neurons":[16],"in":[17,26,202,207,219,252,278,285,295,304,310,320,330,351,358,388,396,407,411],"ventral":[19],"partition":[20],"medial":[22],"geniculate":[23],"body":[24],"(MGBv)":[25],"rats":[27,37,80,147,410],"and":[28,54,75,85,124,131,166,184,224,231,237,256,263,269,282,288,306,313,323,336,354,361,373,382,401,415,430],"study":[29],"their":[30],"mechanism.":[31],"MATERIALS":[32],"AND":[33],"METHODS:":[34],"Sprague-Dawley":[35],"(SD)":[36],"were":[38,70,81,134,148,176,293,302,349],"randomly":[39],"divided":[40,149],"into":[41,95,150],"7":[42],"groups":[43,55],"(n":[44],"=":[45],"6):":[46],"group":[47,51,220,253,279,286],"normal":[48,107],"saline":[49,108],"(NS),":[50],"intralipid":[52],"(I),":[53],"different":[57],"concentrations":[58],"(5.6,":[61],"16.8,":[62],"56,":[63],"168,":[64],"560":[65,374,402],"\u00b5mol/L)":[66],"(P1-P5).":[67],"These":[68],"animals":[69],"anesthetized":[71],"with":[72,83,91,214,249],"ether,":[73],"tracheostomized,":[74],"mechanically":[76],"ventilated.":[77],"After":[78,101,298,345],"anesthesia,":[79],"paralyzed":[82],"vecuronium":[84],"fixed.":[86],"A":[87],"recording":[88],"needle":[89],"electrode":[90],"drugs":[92],"was":[93,113,190,198,234,243,266,275,308,318,356],"inserted":[94],"MGBv":[96,208,408],"means":[98],"stereotaxis.":[100],"injection":[102,218,246],"0.2":[104],"\u00b5l":[105],"propofol,":[106,145,300,347],"or":[109],"intralipid,":[110],"correct":[111],"insertion":[112],"verified":[114],"MLAEP":[116,121,175,206,341,406],"response":[117],"to":[118,192],"standard":[119],"sound.":[120],"including":[122],"amplitudes":[123,292,328,348],"latencies":[125],"N0,":[127],"P0,":[128],"Na,":[129,229,261,311,321,359],"Pa,":[130,230,262,312,322,360],"Nb":[132,232,264,324],"waves":[133,204,265,301],"recorded.":[135],"identify":[137],"which":[138],"ion":[139,181,424],"channel":[140,182,425],"could":[141],"be":[142,419],"impacted":[143],"SD":[146],"Ni2+":[151,335],"plus":[152,157,162,168],"(A1":[154],"group),":[155,160],"Cd2+":[156],"(A2":[159],"4-AP":[161],"(A3":[164],"grouop),":[165],"TTX":[167],"(A4":[170],"group).":[171],"The":[172,226,258,363],"changes":[173,201,417],"recorded":[177],"between":[178],"injecting":[179],"4":[180],"blockers":[183],"propofol.":[185],"Whole-cell":[186],"patch":[187,366],"clamp":[188,367],"technique":[189],"used":[191],"confirm":[193],"these":[194,416],"variations.":[195],"RESULTS:":[196],"There":[197],"no":[199,343],"significant":[200],"all":[203],"after":[209,245,333],"drug":[210],"administration":[211],"as":[212,247,325,327],"compared":[213,248],"baselins":[216],"before":[217],"NS,":[221],"I,":[222],"P1,":[223],"P2.":[225],"wave":[233,242,274,296,339,352],"significantly":[235,267,276],"prolonged":[236],"amplitude":[239,271],"Pa":[241,273],"decreased":[244,294,350],"baseline":[251],"P3,":[254,280],"P4,":[255,281],"P5.":[257],"longer":[268],"lower":[277],"P5":[283],"than":[284],"NS":[287],"I.":[289],"With":[290,315],"TTX,":[291],"Na-Pa.":[297,331],"given":[299,334],"unchanged":[303,319],"Na-Pa":[305,353],"increased":[309,357],"Nb.":[314,362],"Cd2+,":[316],"well":[326],"decreasing":[329],"Nevertheless,":[332],"4-AP,":[337],"every":[338],"had":[342],"changes.":[344],"injected":[346],"results":[364],"showed":[368],"56":[369,397],"\u00b5mol/L,":[370,398],"168":[371,399],"\u00b5mol/L":[372,375,400,403],"inhibited":[377],"persistent":[379,427],"sodium":[380,428],"currents":[381,387,429],"high":[383,431],"voltaged":[384,432],"activated":[385,433],"calcium":[386,434],"brain":[390],"slices":[391],"rats.":[393],"CONCLUSIONS:":[394],"Propofol":[395],"can":[404],"inhibit":[405],"a":[412],"dose-dependent":[413],"manner":[414],"may":[418],"caused":[420],"blocking":[422],"currents.":[435]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}