{"id":"https://openalex.org/W2129583379","doi":"https://doi.org/10.5936/csbj.201210022","title":"BIOPROCESS SYSTEMS ENGINEERING: TRANSFERRING TRADITIONAL PROCESS ENGINEERING PRINCIPLES TO INDUSTRIAL BIOTECHNOLOGY","display_name":"BIOPROCESS SYSTEMS ENGINEERING: TRANSFERRING TRADITIONAL PROCESS ENGINEERING PRINCIPLES TO INDUSTRIAL BIOTECHNOLOGY","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2129583379","doi":"https://doi.org/10.5936/csbj.201210022","mag":"2129583379","pmid":"https://pubmed.ncbi.nlm.nih.gov/24688682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3962201"},"language":"en","primary_location":{"id":"doi:10.5936/csbj.201210022","doi":"https://doi.org/10.5936/csbj.201210022","is_oa":true,"landing_page_url":"https://doi.org/10.5936/csbj.201210022","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2001037014600787/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2001037014600787/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055339529","display_name":"Michalis Koutinas","orcid":"https://orcid.org/0000-0002-5371-4280","observed_orcids":["https://orcid.org/0000-0002-5371-4280"]},"institutions":[{"id":"https://openalex.org/I163151358","display_name":"Cyprus University of Technology","ror":"https://ror.org/05qt8tf94","country_code":"CY","type":"education","lineage":["https://openalex.org/I163151358"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Michalis Koutinas","raw_affiliation_strings":["Department of Environmental Science and Technology, Cyprus University of Technology, 95 Irinis Street, 3041, Limassol, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Science and Technology, Cyprus University of Technology, 95 Irinis Street, 3041, Limassol, Cyprus","institution_ids":["https://openalex.org/I163151358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052291616","display_name":"Alexandros Kiparissides","orcid":"https://orcid.org/0000-0003-2923-2481","observed_orcids":["https://orcid.org/0000-0003-2923-2481"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexandros Kiparissides","raw_affiliation_strings":["Centre for Process Systems Engineering, Department of Chemical Engineering, South Kensington Campus, Imperial College London, SW7 2AZ, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Process Systems Engineering, Department of Chemical Engineering, South Kensington Campus, Imperial College London, SW7 2AZ, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115598076","display_name":"Efstratios N. Pistikopoulos","orcid":"https://orcid.org/0000-0001-6220-818X","observed_orcids":["https://orcid.org/0000-0001-6220-818X","https://orcid.org/0000-0001-6581-509X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Efstratios N. Pistikopoulos","raw_affiliation_strings":["Centre for Process Systems Engineering, Department of Chemical Engineering, South Kensington Campus, Imperial College London, SW7 2AZ, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Process Systems Engineering, Department of Chemical Engineering, South Kensington Campus, Imperial College London, SW7 2AZ, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048473531","display_name":"Athanasios Mantalaris","orcid":"https://orcid.org/0000-0001-6183-0292","observed_orcids":["https://orcid.org/0000-0001-6183-0292","https://orcid.org/0000-0002-8592-8304"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Athanasios Mantalaris","raw_affiliation_strings":["Centre for Process Systems Engineering, Department of Chemical Engineering, South Kensington Campus, Imperial College London, SW7 2AZ, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Process Systems Engineering, Department of Chemical Engineering, South Kensington Campus, Imperial College London, SW7 2AZ, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048473531"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":{"value":3230,"currency":"USD","value_usd":3230},"fwci":0.2361,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.20038196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"4","first_page":"e201210022","last_page":"e201210022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process-systems-engineering","display_name":"process systems engineering","score":0.8560000061988831},{"id":"https://openalex.org/keywords/industrial-biotechnology","display_name":"industrial biotechnology","score":0.984000027179718},{"id":"https://openalex.org/keywords/mathematical-modelling-of-biological-systems","display_name":"mathematical modelling of biological systems","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mechanistic-model","display_name":"mechanistic model","score":0.8059999942779541},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/microbial-growth-kinetics","display_name":"microbial growth kinetics","score":0.878000020980835},{"id":"https://openalex.org/keywords/model-based-control","display_name":"model-based control","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bioprocess-optimization","display_name":"bioprocess optimization","score":0.9279999732971191},{"id":"https://openalex.org/keywords/regulatory-networks","display_name":"regulatory networks","score":0.5600000023841858},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.4440000057220459},{"id":"https://openalex.org/keywords/bioprocess-design","display_name":"bioprocess design","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.7939397096633911},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.7768229246139526},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.6142631769180298},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5629783868789673},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5577930808067322},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.4964931607246399},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4841480851173401},{"id":"https://openalex.org/C61664519","wikidata":"https://www.wikidata.org/wiki/Q864734","display_name":"Bioprocess engineering","level":2,"score":0.43964821100234985},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.43277472257614136},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.39476659893989563},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3400248885154724},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.23977446556091309},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2362249791622162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18027982115745544},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":11,"locations":[{"id":"doi:10.5936/csbj.201210022","doi":"https://doi.org/10.5936/csbj.201210022","is_oa":true,"landing_page_url":"https://doi.org/10.5936/csbj.201210022","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2001037014600787/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2952211","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3962201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3962201","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3962201","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comput Struct Biotechnol J","raw_type":"Text"},{"id":"pmid:24688682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24688682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and structural biotechnology journal","raw_type":"Journal Article"},{"id":"pmh:lr::4178::23218313::oai:localhost:10596/5699","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10596/5699","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://bibliotecavirtual.unad.edu.co:2069/science/article/pii/S2001037014600787","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:12920eaf3c6c4d21bb64cb49dff0cd8a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/12920eaf3c6c4d21bb64cb49dff0cd8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Structural Biotechnology Journal, Vol 3, Iss 4 (2012)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7ed57299522541f1b2de0cfd37145b66","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7ed57299522541f1b2de0cfd37145b66","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Structural Biotechnology Journal, Vol 3, Iss 4, p e201210022 (2012)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1466901","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1466901/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Struct Biotechnol J , 3 , Article e201210022. (2012)","raw_type":"Article"},{"id":"pmh:oai:ktisis.cut.ac.cy:20.500.14279/3306","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14279/3306","pdf_url":null,"source":{"id":"https://openalex.org/S4306400897","display_name":"Ktisis at Cyprus University of Technology (Cyprus University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163151358","host_organization_name":"Cyprus University of Technology","host_organization_lineage":["https://openalex.org/I163151358"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:ktisis.cut.ac.cy:Publications/10488/3722","doi":null,"is_oa":false,"landing_page_url":"http://ktisis.cut.ac.cy/handle/10488/3722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400897","display_name":"Ktisis at Cyprus University of Technology (Cyprus University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163151358","host_organization_name":"Cyprus University of Technology","host_organization_lineage":["https://openalex.org/I163151358"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:localhost:10596/5699","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10596/5699","pdf_url":null,"source":{"id":"https://openalex.org/S4306401253","display_name":"Institutional Repository of the National University Open and Distance UNAD (Universidad Nacional Abierta y a Distancia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145466","host_organization_name":"Universidad Nacional Abierta y a Distancia","host_organization_lineage":["https://openalex.org/I4210145466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bibliotecavirtual.unad.edu.co:2069/science/article/pii/S2001037014600787","raw_type":"Articulo"}],"best_oa_location":{"id":"doi:10.5936/csbj.201210022","doi":"https://doi.org/10.5936/csbj.201210022","is_oa":true,"landing_page_url":"https://doi.org/10.5936/csbj.201210022","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2001037014600787/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2317771059","display_name":null,"funder_award_id":"BB/F003560/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4880427383","display_name":"Mathematical modelling and experiment design for hypothesis testing and model validation for PSEUDOMONAS PUTIDA (Partner 11 of SYSMO)","funder_award_id":"BB/F003560/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129583379.pdf","grobid_xml":"https://content.openalex.org/works/W2129583379.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W29018479","https://openalex.org/W993219267","https://openalex.org/W1270599943","https://openalex.org/W1501815954","https://openalex.org/W1502529406","https://openalex.org/W1573602524","https://openalex.org/W1574470162","https://openalex.org/W1581582023","https://openalex.org/W1642162696","https://openalex.org/W1645305843","https://openalex.org/W1963522244","https://openalex.org/W1964257826","https://openalex.org/W1965409125","https://openalex.org/W1966293504","https://openalex.org/W1971044068","https://openalex.org/W1971711803","https://openalex.org/W1973162672","https://openalex.org/W1973851828","https://openalex.org/W1976789958","https://openalex.org/W1981096637","https://openalex.org/W1982469741","https://openalex.org/W1983555294","https://openalex.org/W1985288140","https://openalex.org/W1985654700","https://openalex.org/W1986562649","https://openalex.org/W1988540551","https://openalex.org/W1996629685","https://openalex.org/W2000836282","https://openalex.org/W2003195392","https://openalex.org/W2009326360","https://openalex.org/W2014167093","https://openalex.org/W2016937028","https://openalex.org/W2017862866","https://openalex.org/W2018011810","https://openalex.org/W2021486592","https://openalex.org/W2031106655","https://openalex.org/W2034645234","https://openalex.org/W2035278103","https://openalex.org/W2039243040","https://openalex.org/W2041985017","https://openalex.org/W2043129236","https://openalex.org/W2043175094","https://openalex.org/W2049167322","https://openalex.org/W2050350037","https://openalex.org/W2052355054","https://openalex.org/W2053813135","https://openalex.org/W2056305771","https://openalex.org/W2058221907","https://openalex.org/W2065163714","https://openalex.org/W2066233746","https://openalex.org/W2072863458","https://openalex.org/W2078355959","https://openalex.org/W2080760786","https://openalex.org/W2082948758","https://openalex.org/W2094781659","https://openalex.org/W2098824895","https://openalex.org/W2099150180","https://openalex.org/W2105639755","https://openalex.org/W2118764014","https://openalex.org/W2123945540","https://openalex.org/W2126176298","https://openalex.org/W2127366503","https://openalex.org/W2134280223","https://openalex.org/W2137018402","https://openalex.org/W2142750990","https://openalex.org/W2143517204","https://openalex.org/W2144683622","https://openalex.org/W2151696328","https://openalex.org/W2152719599","https://openalex.org/W2161446862","https://openalex.org/W2163630217","https://openalex.org/W2164883237","https://openalex.org/W2166132142","https://openalex.org/W2170189276","https://openalex.org/W2419380513","https://openalex.org/W2507060499","https://openalex.org/W2797140162","https://openalex.org/W4246052834","https://openalex.org/W6703695517"],"related_works":["https://openalex.org/W2048206488","https://openalex.org/W6999716864","https://openalex.org/W2577910460","https://openalex.org/W1606280580","https://openalex.org/W1537422369","https://openalex.org/W4298838187","https://openalex.org/W120027252","https://openalex.org/W2053813135","https://openalex.org/W2793935304","https://openalex.org/W6908778464"],"abstract_inverted_index":{"The":[0,130],"complexity":[1],"of":[2,15,25,63,70,73,80,97,142,154],"the":[3,7,12,18,38,61,68,77,81,95,110,140,151],"regulatory":[4],"network":[5],"and":[6,28,52,56,90,120,124,147,156],"interactions":[8],"that":[9,100],"occur":[10],"in":[11,20,87,105,127],"intracellular":[13],"environment":[14],"microorganisms":[16],"highlight":[17,122],"importance":[19],"developing":[21],"tractable":[22],"mechanistic":[23,98],"models":[24,72,99],"cellular":[26],"functions":[27],"systematic":[29],"approaches":[30,43,149],"for":[31,49,67,102,139],"modelling":[32,131],"biological":[33,54,74],"systems.":[34],"To":[35],"this":[36],"end,":[37],"existing":[39],"process":[40],"systems":[41,55],"engineering":[42],"can":[44],"serve":[45],"as":[46],"a":[47,64],"vehicle":[48],"understanding,":[50],"integrating":[51],"designing":[53],"processes.":[57],"Here,":[58],"we":[59,121],"review":[60],"application":[62,86],"holistic":[65],"approach":[66],"development":[69],"mathematical":[71,128],"systems,":[75],"from":[76],"initial":[78],"conception":[79],"model":[82],"to":[83,108,115],"its":[84],"final":[85],"model-based":[88],"control":[89],"optimisation.":[91],"We":[92],"also":[93],"discuss":[94],"use":[96],"account":[101],"gene":[103],"regulation,":[104],"an":[106],"attempt":[107],"advance":[109],"empirical":[111],"expressions":[112],"traditionally":[113],"used":[114],"describe":[116],"micro-organism":[117],"growth":[118],"kinetics,":[119],"current":[123],"future":[125],"challenges":[126],"biology.":[129],"research":[132],"framework":[133],"discussed":[134],"herein":[135],"could":[136],"prove":[137],"beneficial":[138],"design":[141],"optimal":[143],"bioprocesses,":[144],"employing":[145],"rational":[146],"feasible":[148],"towards":[150],"efficient":[152],"production":[153],"chemicals":[155],"pharmaceuticals.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
