{"id":"https://openalex.org/W2129559166","doi":"https://doi.org/10.1093/ndt/gfq580","title":"p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease","display_name":"p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease","publication_year":2010,"publication_date":"2010-09-29","ids":{"openalex":"https://openalex.org/W2129559166","doi":"https://doi.org/10.1093/ndt/gfq580","mag":"2129559166","pmid":"https://pubmed.ncbi.nlm.nih.gov/20884620"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfq580","doi":"https://doi.org/10.1093/ndt/gfq580","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfq580","pdf_url":"https://academic.oup.com/ndt/article-pdf/26/3/938/5206619/gfq580.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/ndt/article-pdf/26/3/938/5206619/gfq580.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063891318","display_name":"I\u2010Wen Wu","orcid":"https://orcid.org/0000-0001-8535-3582","observed_orcids":["https://orcid.org/0000-0001-8535-3582"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"I.-W. Wu","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044406571","display_name":"Kuang\u2010Hung Hsu","orcid":"https://orcid.org/0000-0003-2642-7689","observed_orcids":["https://orcid.org/0000-0003-2642-7689"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"K.-H. Hsu","raw_affiliation_strings":["Laboratory of Epidemiology, Department of Health Care Management, Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Epidemiology, Department of Health Care Management, Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101722519","display_name":"Cheng\u2010Chi Lee","orcid":"https://orcid.org/0000-0001-6451-3882","observed_orcids":["https://orcid.org/0000-0001-6451-3882","https://orcid.org/0000-0001-9617-335X"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.-C. Lee","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001923294","display_name":"Chiao\u2010Yin Sun","orcid":"https://orcid.org/0000-0001-7438-8042","observed_orcids":["https://orcid.org/0000-0001-7438-8042"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.-Y. Sun","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"H.-J. Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"H.-J. Hsu","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112749205","display_name":"C.-J. Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.-J. Tsai","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112005248","display_name":"Chin\u2010Yuan Tzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129488","display_name":"Cathay General Hospital","ror":"https://ror.org/03c8c9n80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129488"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.-Y. Tzen","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Cathay General Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Cathay General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210129488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y.-C. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Y.-C. Wang","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108517588","display_name":"C.-Y. Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.-Y. Lin","raw_affiliation_strings":["Children\u2019s Medical Center, China Medical University Hospital, Taiwan","Institute of Clinical Medical Science, China Medical University, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Medical Center, China Medical University Hospital, Taiwan","institution_ids":["https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Institute of Clinical Medical Science, China Medical University, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103110708","display_name":"Mai-Szu Wu","orcid":"https://orcid.org/0000-0002-5110-0568","observed_orcids":["https://orcid.org/0000-0002-5110-0568"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"M.-S. Wu","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5063891318"],"corresponding_institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":{"value":3474,"currency":"EUR","value_usd":3926},"fwci":8.396,"has_fulltext":true,"cited_by_count":510,"citation_normalized_percentile":{"value":0.97952444,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"26","issue":"3","first_page":"938","last_page":"947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indoxyl-sulfate","display_name":"indoxyl sulfate","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.8389999866485596},{"id":"https://openalex.org/keywords/uremic-toxins","display_name":"uremic toxins","score":0.9150000214576721},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8690000176429749},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate-decline","display_name":"estimated glomerular filtration rate decline","score":0.8930000066757202},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8992965817451477},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7951563596725464},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7293115854263306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6890091896057129},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5826712250709534},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.570315420627594},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5170769691467285},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4927697479724884},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.48110002279281616},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4481639862060547},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.42087456583976746},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3686733543872833},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.1331568956375122}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003408","descriptor_name":"Cresols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003408","descriptor_name":"Cresols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003408","descriptor_name":"Cresols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007200","descriptor_name":"Indican","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007200","descriptor_name":"Indican","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007200","descriptor_name":"Indican","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013463","descriptor_name":"Sulfuric Acid Esters","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013463","descriptor_name":"Sulfuric Acid Esters","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013463","descriptor_name":"Sulfuric Acid Esters","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/ndt/gfq580","doi":"https://doi.org/10.1093/ndt/gfq580","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfq580","pdf_url":"https://academic.oup.com/ndt/article-pdf/26/3/938/5206619/gfq580.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:20884620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20884620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3042976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3042976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nephrol Dial Transplant","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ndt/gfq580","doi":"https://doi.org/10.1093/ndt/gfq580","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfq580","pdf_url":"https://academic.oup.com/ndt/article-pdf/26/3/938/5206619/gfq580.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129559166.pdf","grobid_xml":"https://content.openalex.org/works/W2129559166.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W110530710","https://openalex.org/W1963597717","https://openalex.org/W1983663722","https://openalex.org/W2004230365","https://openalex.org/W2006980919","https://openalex.org/W2023191091","https://openalex.org/W2024714913","https://openalex.org/W2027358754","https://openalex.org/W2053272981","https://openalex.org/W2056929656","https://openalex.org/W2076072930","https://openalex.org/W2100893920","https://openalex.org/W2101431807","https://openalex.org/W2103677411","https://openalex.org/W2104974775","https://openalex.org/W2109083270","https://openalex.org/W2118561903","https://openalex.org/W2128347961","https://openalex.org/W2130134727","https://openalex.org/W2133991735","https://openalex.org/W2143628786","https://openalex.org/W2154690872","https://openalex.org/W2155101891","https://openalex.org/W2157799799","https://openalex.org/W2164334517","https://openalex.org/W2165452639","https://openalex.org/W2168987491","https://openalex.org/W2171540831","https://openalex.org/W2172120880","https://openalex.org/W2226147016","https://openalex.org/W4253946839","https://openalex.org/W4376544320"],"related_works":["https://openalex.org/W1948603161","https://openalex.org/W2909812024","https://openalex.org/W2411849704","https://openalex.org/W1564222293","https://openalex.org/W2387860588","https://openalex.org/W393698729","https://openalex.org/W2050789305","https://openalex.org/W2313598751","https://openalex.org/W4226212074","https://openalex.org/W2398053996"],"abstract_inverted_index":{"BACKGROUND:":[0],"Indoxyl":[1],"sulphate":[2,6],"(IS)":[3],"and":[4,18,36,58,76,103,121,152,212,222],"p-cresyl":[5],"(PCS)":[7],"are":[8],"uraemic":[9],"toxins":[10],"that":[11,143],"have":[12,27],"similar":[13],"protein":[14,178],"binding,":[15],"dialytic":[16],"clearance":[17],"proinflammatory":[19],"features.":[20],"However,":[21],"only":[22,183],"a":[23,64,106,126],"few":[24],"prospective":[25,48],"studies":[26],"evaluated":[28,51],"possible":[29],"associations":[30,53],"between":[31,54],"these":[32],"two":[33],"retained":[34],"solutes":[35],"renal":[37,61,81,100,119,150,186,218,232],"disease":[38,43,101],"progression":[39,62,82,97,120,151,233],"in":[40,63,86,203,227,234],"chronic":[41],"kidney":[42],"(CKD)":[44],"patients.":[45],"METHODS:":[46],"This":[47],"observational":[49],"study":[50],"independent":[52,155],"serum":[55,163,165,193,198,220],"total":[56],"IS":[57,77,181,194,221],"PCS":[59,75,145,199,223],"with":[60,80,149,185],"selected":[65],"cohort":[66],"of":[67,72,109,129,156,192,231,239],"patients":[68,235],"having":[69,236],"different":[70,237],"stages":[71,238],"CKD.":[73,240],"Baseline":[74],"were":[78,147],"correlated":[79],"[defined":[83],"as":[84,217],"decrements":[85],"estimated":[87],"glomerular":[88],"filtration":[89],"rate":[90],"(eGFR)":[91],">":[92],"50%":[93],"from":[94],"baseline":[95],"or":[96,175],"to":[98,210],"end-stage":[99],"(ESRD)]":[102],"death":[104],"during":[105],"follow-up":[107,128],"period":[108],"24":[110],"months.":[111,133],"RESULTS:":[112],"Of":[113],"268":[114],"patients,":[115],"35":[116],"(13.1%)":[117],"had":[118],"14":[122],"(5.2%)":[123],"died":[124],"after":[125],"mean":[127],"21":[130],"\u00b1":[131],"3":[132],"Univariate":[134],"Cox":[135],"regression":[136],"analysis":[137,141],"followed":[138],"by":[139],"multivariate":[140],"showed":[142],"high-serum":[144],"levels":[146,224],"associated":[148,184],"all-cause":[153],"mortality":[154],"age,":[157],"gender,":[158],"diabetes":[159],"status,":[160],"albumin":[161],"levels,":[162],"IS,":[164],"creatinine,":[166],"Ca":[167],"\u00d7":[168],"P":[169],"product,":[170],"intact":[171],"parathyroid":[172],"hormone,":[173],"haemoglobin":[174],"high-sensitivity":[176],"C-reactive":[177],"level.":[179],"Serum":[180],"was":[182,195,200],"progression;":[187],"however,":[188],"the":[189,204,229],"predictive":[190],"power":[191],"weakened":[196],"when":[197],"also":[201],"present":[202],"analytical":[205],"model.":[206],"CONCLUSIONS:":[207],"In":[208],"addition":[209],"traditional":[211],"uraemia-related":[213],"risk":[214,230],"factors":[215],"such":[216],"function,":[219],"may":[225],"help":[226],"predicting":[228]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":49},{"year":2020,"cited_by_count":38},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":57},{"year":2017,"cited_by_count":40},{"year":2016,"cited_by_count":33},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}