{"id":"https://openalex.org/W2129507901","doi":"https://doi.org/10.1073/pnas.0915166107","title":"Identifying the amylome, proteins capable of forming amyloid-like fibrils","display_name":"Identifying the amylome, proteins capable of forming amyloid-like fibrils","publication_year":2010,"publication_date":"2010-02-03","ids":{"openalex":"https://openalex.org/W2129507901","doi":"https://doi.org/10.1073/pnas.0915166107","mag":"2129507901","pmid":"https://pubmed.ncbi.nlm.nih.gov/20133726","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840437"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0915166107","doi":"https://doi.org/10.1073/pnas.0915166107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0915166107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840437","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062412676","display_name":"Lukasz Goldschmidt","orcid":"https://orcid.org/0000-0002-2925-1159","observed_orcids":["https://orcid.org/0000-0002-2925-1159"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lukasz Goldschmidt","raw_affiliation_strings":["Howard Hughes Medical Institute, University of California Los Angeles\u2013Department of Energy Institute for Genomics and Proteomics, Los Angeles, CA 90095-1570; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California Los Angeles\u2013Department of Energy Institute for Genomics and Proteomics, Los Angeles, CA 90095-1570; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081187128","display_name":"Poh K. Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poh K. Teng","raw_affiliation_strings":["Howard Hughes Medical Institute, University of California Los Angeles\u2013Department of Energy Institute for Genomics and Proteomics, Los Angeles, CA 90095-1570; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California Los Angeles\u2013Department of Energy Institute for Genomics and Proteomics, Los Angeles, CA 90095-1570; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084176856","display_name":"Roland Riek","orcid":"https://orcid.org/0000-0002-6333-066X","observed_orcids":["https://orcid.org/0000-0002-6333-066X"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253565","display_name":"Laboratory of Physical Chemistry","ror":"https://ror.org/00v171g37","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253565"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roland Riek","raw_affiliation_strings":["Laboratory of Physical Chemistry, Eidgen\u00f6ssiche Technische Hochschule Zurich, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physical Chemistry, Eidgen\u00f6ssiche Technische Hochschule Zurich, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080439570","display_name":"David S Eisenberg","orcid":"https://orcid.org/0000-0003-2432-5419","observed_orcids":["https://orcid.org/0000-0003-2432-5419"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Eisenberg","raw_affiliation_strings":["Howard Hughes Medical Institute, University of California Los Angeles\u2013Department of Energy Institute for Genomics and Proteomics, Los Angeles, CA 90095-1570; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California Los Angeles\u2013Department of Energy Institute for Genomics and Proteomics, Los Angeles, CA 90095-1570; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":23.5477,"has_fulltext":false,"cited_by_count":801,"citation_normalized_percentile":{"value":0.9980571,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"107","issue":"8","first_page":"3487","last_page":"3492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.21699999272823334,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/steric-zipper","display_name":"steric zipper","score":0.8840000033378601},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.5630000233650208},{"id":"https://openalex.org/keywords/rnase-a","display_name":"ribonuclease A","score":0.7789999842643738},{"id":"https://openalex.org/keywords/genome-wide-analysis","display_name":"genome-wide analysis","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.646420955657959},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.5709958672523499},{"id":"https://openalex.org/C105782903","wikidata":"https://www.wikidata.org/wiki/Q6577686","display_name":"Zipper","level":2,"score":0.570225715637207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5566483736038208},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5307440757751465},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5059594511985779},{"id":"https://openalex.org/C147259501","wikidata":"https://www.wikidata.org/wiki/Q14864949","display_name":"Fibrillogenesis","level":3,"score":0.5052910447120667},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.48309850692749023},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.4645889103412628},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4199478328227997},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3722916841506958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30091428756713867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23717057704925537},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.15112271904945374},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.12478098273277283},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08837473392486572},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003461","descriptor_name":"Crystallography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0915166107","doi":"https://doi.org/10.1073/pnas.0915166107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0915166107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2840437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20133726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20133726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2840437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1772692214","https://openalex.org/W1963994022","https://openalex.org/W1967773653","https://openalex.org/W1971804606","https://openalex.org/W1971840315","https://openalex.org/W1972798313","https://openalex.org/W1976103641","https://openalex.org/W1976632394","https://openalex.org/W1979558885","https://openalex.org/W1994595152","https://openalex.org/W1997643376","https://openalex.org/W2001641653","https://openalex.org/W2004360551","https://openalex.org/W2005279391","https://openalex.org/W2008708467","https://openalex.org/W2014297210","https://openalex.org/W2027839322","https://openalex.org/W2046093999","https://openalex.org/W2055501963","https://openalex.org/W2056034415","https://openalex.org/W2058469726","https://openalex.org/W2080931778","https://openalex.org/W2085899859","https://openalex.org/W2087357689","https://openalex.org/W2116063507","https://openalex.org/W2117537971","https://openalex.org/W2121543180","https://openalex.org/W2134439639","https://openalex.org/W2135815512","https://openalex.org/W2136567909","https://openalex.org/W2144481414","https://openalex.org/W2154950066","https://openalex.org/W2155143852","https://openalex.org/W2162575609","https://openalex.org/W2163210644","https://openalex.org/W2168182168"],"related_works":["https://openalex.org/W1929407592","https://openalex.org/W4248979723","https://openalex.org/W2087357689","https://openalex.org/W2121543180","https://openalex.org/W2081264291","https://openalex.org/W2128547681","https://openalex.org/W2162575609","https://openalex.org/W2117537971","https://openalex.org/W2806366252","https://openalex.org/W2139418286"],"abstract_inverted_index":{"The":[0,140],"amylome":[1],"is":[2,31,72,116,142],"the":[3,17,26,32,35,53,64,77,98,104],"universe":[4],"of":[5,10,37,55,66,76,107],"proteins":[6,137],"that":[7,19,40,62,111,125,143],"are":[8,128],"capable":[9],"forming":[11],"amyloid-like":[12],"fibrils.":[13],"Here":[14],"we":[15,92],"investigate":[16],"factors":[18],"enable":[20],"a":[21,38,43,56,89,112],"protein":[22,36],"to":[23,25,80,148],"belong":[24],"amylome.":[27],"A":[28,87],"major":[29],"factor":[30,71],"presence":[33],"in":[34,130],"segment":[39,79],"can":[41],"form":[42,63,138],"tightly":[44],"complementary":[45],"interface":[46],"with":[47,82,154],"an":[48,67],"identical":[49],"segment,":[50],"which":[51],"permits":[52],"formation":[54],"steric":[57],"zipper-two":[58],"self-complementary":[59,78,126,150],"beta":[60],"sheets":[61],"spine":[65],"amyloid":[68],"fibril.":[69],"Another":[70],"sufficient":[73],"conformational":[74],"freedom":[75],"interact":[81],"other":[83],"molecules.":[84],"Using":[85],"RNase":[86],"as":[88],"model":[90],"system,":[91],"validate":[93],"our":[94],"fibrillogenic":[95],"predictions":[96],"by":[97],"3D":[99],"profile":[100],"method":[101],"based":[102],"on":[103],"crystal":[105],"structure":[106],"NNQQNY":[108],"and":[109],"demonstrate":[110],"specific":[113],"residue":[114],"order":[115],"required":[117],"for":[118],"fiber":[119],"formation.":[120],"Our":[121],"genome-wide":[122],"analysis":[123],"revealed":[124],"segments":[127,151],"found":[129],"almost":[131],"all":[132,136],"proteins,":[133],"yet":[134],"not":[135],"amyloids.":[139],"implication":[141],"chaperoning":[144],"effects":[145],"have":[146],"evolved":[147],"constrain":[149],"from":[152],"interaction":[153],"each":[155],"other.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":36},{"year":2025,"cited_by_count":34},{"year":2024,"cited_by_count":47},{"year":2023,"cited_by_count":45},{"year":2022,"cited_by_count":43},{"year":2021,"cited_by_count":56},{"year":2020,"cited_by_count":45},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":53},{"year":2017,"cited_by_count":54},{"year":2016,"cited_by_count":56},{"year":2015,"cited_by_count":46},{"year":2014,"cited_by_count":57},{"year":2013,"cited_by_count":57},{"year":2012,"cited_by_count":44}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
