{"id":"https://openalex.org/W2129494337","doi":null,"title":"Factors affecting bone growth.","display_name":"Factors affecting bone growth.","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W2129494337","mag":"2129494337","pmid":"https://pubmed.ncbi.nlm.nih.gov/25658073"},"language":"en","primary_location":{"id":"pmid:25658073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25658073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of orthopedics (Belle Mead, N.J.)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036133529","display_name":"Ioannis S. Gkiatas","orcid":"https://orcid.org/0000-0003-2541-5467","observed_orcids":["https://orcid.org/0000-0003-2541-5467"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Gkiatas","raw_affiliation_strings":["University of Ioannina, School of Medicine, Division of Orthopaedic Surgery, Ioannina, Greece. john.gkiatas@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina, School of Medicine, Division of Orthopaedic Surgery, Ioannina, Greece. john.gkiatas@gmail.com","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015978624","display_name":"Marios G. Lykissas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marios Lykissas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052939601","display_name":"Ioannis Kostas\u2010Agnantis","orcid":"https://orcid.org/0000-0001-7763-6937","observed_orcids":["https://orcid.org/0000-0001-7763-6937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioannis Kostas-Agnantis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072142500","display_name":"Anastasios V. Korompilias","orcid":"https://orcid.org/0000-0002-4246-0860","observed_orcids":["https://orcid.org/0000-0002-4246-0860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anastasios Korompilias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048212045","display_name":"Anna K. Batistatou","orcid":"https://orcid.org/0000-0003-4353-9535","observed_orcids":["https://orcid.org/0000-0003-4353-9535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Batistatou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112222676","display_name":"Alexandros E. Beris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandros Beris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1537,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.76692268,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"44","issue":"2","first_page":"61","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6298999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6298999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-growth","display_name":"bone growth","score":0.9929999709129333},{"id":"https://openalex.org/keywords/longitudinal-bone-growth","display_name":"longitudinal bone growth","score":0.8730000257492065},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bone-length","display_name":"bone length","score":0.527999997138977},{"id":"https://openalex.org/keywords/bone-width","display_name":"bone width","score":0.6700000166893005},{"id":"https://openalex.org/keywords/periosteal-apposition","display_name":"periosteal apposition","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.9900000095367432},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/environmental-factors","display_name":"environmental factors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/embryonic-bone-development","display_name":"embryonic bone development","score":0.7620000243186951},{"id":"https://openalex.org/keywords/bone-disorders","display_name":"bone disease","score":0.6420000195503235},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C2991750140","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone growth","level":2,"score":0.7419090867042542},{"id":"https://openalex.org/C2992191624","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone development","level":2,"score":0.6331232190132141},{"id":"https://openalex.org/C2780707029","wikidata":"https://www.wikidata.org/wiki/Q1512017","display_name":"Long bone","level":2,"score":0.5931529998779297},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5899009108543396},{"id":"https://openalex.org/C117866178","wikidata":"https://www.wikidata.org/wiki/Q321056","display_name":"Apposition","level":2,"score":0.5864307880401611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5698173642158508},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.45459654927253723},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.4185040593147278},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3225606083869934},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25556641817092896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2302255630493164}],"mesh":[{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25658073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25658073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of orthopedics (Belle Mead, N.J.)","raw_type":"Journal Article"},{"id":"mag:2129494337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25658073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W10384284","https://openalex.org/W75923715","https://openalex.org/W90213034","https://openalex.org/W157145421","https://openalex.org/W242131348","https://openalex.org/W1553594457","https://openalex.org/W1583699618","https://openalex.org/W1592656278","https://openalex.org/W1811612966","https://openalex.org/W1826914498","https://openalex.org/W1883420034","https://openalex.org/W1966641327","https://openalex.org/W1967485093","https://openalex.org/W1972673498","https://openalex.org/W1976018633","https://openalex.org/W1976282528","https://openalex.org/W1980620581","https://openalex.org/W1981000267","https://openalex.org/W1981350213","https://openalex.org/W1984325351","https://openalex.org/W1985712533","https://openalex.org/W1986161955","https://openalex.org/W1986455710","https://openalex.org/W1987440390","https://openalex.org/W1987708730","https://openalex.org/W1991424506","https://openalex.org/W1994718412","https://openalex.org/W1995467028","https://openalex.org/W1995499476","https://openalex.org/W1998954538","https://openalex.org/W2002174372","https://openalex.org/W2002482355","https://openalex.org/W2005227740","https://openalex.org/W2007762330","https://openalex.org/W2011011117","https://openalex.org/W2012076119","https://openalex.org/W2012388796","https://openalex.org/W2015220539","https://openalex.org/W2016411107","https://openalex.org/W2024394264","https://openalex.org/W2026084643","https://openalex.org/W2026201824","https://openalex.org/W2030381040","https://openalex.org/W2030693350","https://openalex.org/W2036851890","https://openalex.org/W2039225176","https://openalex.org/W2039911691","https://openalex.org/W2041808802","https://openalex.org/W2042932723","https://openalex.org/W2056493785","https://openalex.org/W2059342424","https://openalex.org/W2063055992","https://openalex.org/W2065578284","https://openalex.org/W2070539172","https://openalex.org/W2078981794","https://openalex.org/W2079051261","https://openalex.org/W2079360448","https://openalex.org/W2085375298","https://openalex.org/W2086690290","https://openalex.org/W2087733742","https://openalex.org/W2094797670","https://openalex.org/W2096523234","https://openalex.org/W2101469591","https://openalex.org/W2102702948","https://openalex.org/W2102894828","https://openalex.org/W2104692956","https://openalex.org/W2108568256","https://openalex.org/W2110341920","https://openalex.org/W2111134095","https://openalex.org/W2117005096","https://openalex.org/W2118962488","https://openalex.org/W2121661142","https://openalex.org/W2126263274","https://openalex.org/W2130333682","https://openalex.org/W2135427479","https://openalex.org/W2135930613","https://openalex.org/W2137279952","https://openalex.org/W2139260705","https://openalex.org/W2145324507","https://openalex.org/W2148811260","https://openalex.org/W2149097749","https://openalex.org/W2150892354","https://openalex.org/W2152265702","https://openalex.org/W2152399703","https://openalex.org/W2159179001","https://openalex.org/W2160753380","https://openalex.org/W2161999633","https://openalex.org/W2163047938","https://openalex.org/W2163160988","https://openalex.org/W2168278579","https://openalex.org/W2168569369","https://openalex.org/W2168876853","https://openalex.org/W2169158043","https://openalex.org/W2264107189","https://openalex.org/W2292838389","https://openalex.org/W2325440446","https://openalex.org/W2326819552","https://openalex.org/W2336368099","https://openalex.org/W2415098380","https://openalex.org/W4235825625"],"related_works":["https://openalex.org/W2111134095","https://openalex.org/W2515420826","https://openalex.org/W2161723037","https://openalex.org/W7099699451","https://openalex.org/W2256409148","https://openalex.org/W40104388","https://openalex.org/W2468385426","https://openalex.org/W2189338709","https://openalex.org/W2972767136","https://openalex.org/W2281008785"],"abstract_inverted_index":{"Bone":[0,43,88],"growth":[1,17,21,24,75,89,115],"and":[2,12,51,120,139,143],"development":[3],"are":[4],"products":[5],"of":[6,10,62,130],"the":[7,20,36,59,109,117,122],"complex":[8,132],"interactions":[9],"genetic":[11,96],"environmental":[13],"factors.":[14,53],"Longitudinal":[15],"bone":[16,72,74,86,114,126,141],"depends":[18],"on":[19],"plate.":[22],"The":[23],"plate":[25],"has":[26,78],"5":[27],"different":[28,32],"zones-each":[29],"with":[30],"a":[31,65],"functional":[33],"role-and":[34],"is":[35,45,92,134],"final":[37,60],"target":[38],"organ":[39],"for":[40],"longitudinal":[41,85],"growth.":[42,87,127],"length":[44,61],"affected":[46],"by":[47,95],"several":[48],"systemic,":[49],"local,":[50],"mechanical":[52,99],"All":[54],"these":[55],"regulation":[56],"systems":[57],"control":[58,125],"bones":[63],"in":[64,76,90,136],"complicated":[66],"way.":[67],"Despite":[68],"its":[69],"significance":[70],"to":[71],"stability,":[73],"width":[77,91],"not":[79],"been":[80],"studied":[81],"as":[82,84],"extensively":[83],"also":[93],"controlled":[94],"factors,":[97],"but":[98],"loading":[100],"regulates":[101],"periosteal":[102],"apposition.":[103],"In":[104],"this":[105,131],"article,":[106],"we":[107],"review":[108],"most":[110],"recent":[111],"data":[112],"regarding":[113],"from":[116],"embryonic":[118],"age":[119],"analyze":[121],"factors":[123],"that":[124],"An":[128],"understanding":[129],"system":[133],"important":[135],"identifying":[137],"metabolic":[138],"developmental":[140],"diseases":[142],"fracture":[144],"risk.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
