{"id":"https://openalex.org/W2129486290","doi":"https://doi.org/10.1590/s0074-02762011000200006","title":"Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails","display_name":"Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2129486290","doi":"https://doi.org/10.1590/s0074-02762011000200006","mag":"2129486290","pmid":"https://pubmed.ncbi.nlm.nih.gov/21537673"},"language":"en","primary_location":{"id":"doi:10.1590/s0074-02762011000200006","doi":"https://doi.org/10.1590/s0074-02762011000200006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0074-02762011000200006","pdf_url":"https://www.scielo.br/j/mioc/a/WWrtys7dvR4XC7GBWt3t9Xt/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/mioc/a/WWrtys7dvR4XC7GBWt3t9Xt/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112185450","display_name":"Fl\u00e1via Fernanda B\u00fabula Couto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via FB Couto","raw_affiliation_strings":["Fiocruz,  Brasil","Fiocruz, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fiocruz,  Brasil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Fiocruz, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085607583","display_name":"Paulo Marcos Zech Coelho","orcid":"https://orcid.org/0000-0002-2443-8897","observed_orcids":["https://orcid.org/0000-0002-2443-8897"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Marcos Z Coelho","raw_affiliation_strings":["Fiocruz,  Brasil","Fiocruz, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fiocruz,  Brasil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Fiocruz, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103419387","display_name":"Neusa Ara\u00fajo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Neusa Ara\u00fajo","raw_affiliation_strings":["Fiocruz,  Brasil","Fiocruz, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fiocruz,  Brasil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Fiocruz, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109103782","display_name":"John Robert Kusel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John R Kusel","raw_affiliation_strings":["University of Glasgow,  UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Glasgow,  UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078008444","display_name":"Naftale Katz","orcid":"https://orcid.org/0000-0003-0764-7141","observed_orcids":["https://orcid.org/0000-0003-0764-7141"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Naftale Katz","raw_affiliation_strings":["Fiocruz,  Brasil","Fiocruz, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fiocruz,  Brasil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Fiocruz, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111967784","display_name":"Liana Konovaloff Jannotti-Passos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Liana K Jannotti-Passos","raw_affiliation_strings":["Fiocruz,  Brasil","Fiocruz, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fiocruz,  Brasil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Fiocruz, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052835730","display_name":"Ana Carolina Alves de Mattos","orcid":"https://orcid.org/0000-0003-1903-7615","observed_orcids":["https://orcid.org/0000-0003-1903-7615"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Carolina A Mattos","raw_affiliation_strings":["Fiocruz,  Brasil","Fiocruz, Belo Horizonte, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fiocruz,  Brasil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Fiocruz, Belo Horizonte, Brasil","institution_ids":["https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.618,"has_fulltext":true,"cited_by_count":128,"citation_normalized_percentile":{"value":0.92736466,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"106","issue":"2","first_page":"153","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":1.0},{"id":"https://openalex.org/keywords/praziquantel-resistance","display_name":"praziquantel resistance","score":0.9229999780654907},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.609000027179718},{"id":"https://openalex.org/keywords/biomphalaria-glabrata","display_name":"Biomphalaria glabrata","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cercarial-emergence","display_name":"cercarial emergence","score":0.5730000138282776},{"id":"https://openalex.org/keywords/antischistosomal-drugs","display_name":"antischistosomal drugs","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2776453879","wikidata":"https://www.wikidata.org/wiki/Q1835536","display_name":"Biomphalaria glabrata","level":5,"score":0.9687496423721313},{"id":"https://openalex.org/C2779744950","wikidata":"https://www.wikidata.org/wiki/Q424145","display_name":"Praziquantel","level":4,"score":0.873383641242981},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.847831130027771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7503116130828857},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5213761925697327},{"id":"https://openalex.org/C2775934075","wikidata":"https://www.wikidata.org/wiki/Q3075178","display_name":"Biomphalaria","level":5,"score":0.5044010877609253},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46235737204551697},{"id":"https://openalex.org/C2776908094","wikidata":"https://www.wikidata.org/wiki/Q572294","display_name":"Anthelmintic","level":2,"score":0.4437350630760193},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.43337365984916687},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.42523902654647827},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.39077505469322205},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.3239840865135193},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2337970733642578},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10169270634651184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0991707444190979}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000871","descriptor_name":"Anthelmintics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001700","descriptor_name":"Biomphalaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011223","descriptor_name":"Praziquantel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D021261","descriptor_name":"Parasitic Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1590/s0074-02762011000200006","doi":"https://doi.org/10.1590/s0074-02762011000200006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0074-02762011000200006","pdf_url":"https://www.scielo.br/j/mioc/a/WWrtys7dvR4XC7GBWt3t9Xt/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},{"id":"pmid:21537673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21537673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Memorias do Instituto Oswaldo Cruz","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S0074-02762011000200006","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000200006","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz v.106 n.2 2011","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/8643","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/8643","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:eprints.gla.ac.uk:141673","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/view/author/6896.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/58633","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/58633","pdf_url":"https://utoronto.scholaris.ca/bitstreams/c9e09f91-4f38-4520-b09c-8af955066b57/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:cria:bioline:oc:oc11025","doi":null,"is_oa":false,"landing_page_url":"http://www.bioline.org.br/abstract?id=oc11025","pdf_url":null,"source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 106 Num 2","raw_type":"AA"},{"id":"pmh:oai:americanae.aecid.es:2321168","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/8643","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:2722910","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000200006","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz v.106 n.2 2011","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arca.fiocruz.br:icict/8643","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1590/S0074-02762011000200006","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:50520bef791f4b16a5825cec4c9bc3a0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/50520bef791f4b16a5825cec4c9bc3a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 2, Pp 153-157 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/s0074-02762011000200006","doi":"https://doi.org/10.1590/s0074-02762011000200006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0074-02762011000200006","pdf_url":"https://www.scielo.br/j/mioc/a/WWrtys7dvR4XC7GBWt3t9Xt/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.49000000953674316,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129486290.pdf","grobid_xml":"https://content.openalex.org/works/W2129486290.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1527406256","https://openalex.org/W1549521886","https://openalex.org/W1964044900","https://openalex.org/W1970103123","https://openalex.org/W1993154684","https://openalex.org/W1997785544","https://openalex.org/W2004762054","https://openalex.org/W2006372569","https://openalex.org/W2006632538","https://openalex.org/W2008422077","https://openalex.org/W2011732903","https://openalex.org/W2029262108","https://openalex.org/W2039043474","https://openalex.org/W2053297447","https://openalex.org/W2054873814","https://openalex.org/W2055312895","https://openalex.org/W2059153155","https://openalex.org/W2067454999","https://openalex.org/W2067947294","https://openalex.org/W2074437097","https://openalex.org/W2085631553","https://openalex.org/W2093077524","https://openalex.org/W2106825249","https://openalex.org/W2124609435","https://openalex.org/W2155150012","https://openalex.org/W2158723210","https://openalex.org/W2172159150","https://openalex.org/W2177715039","https://openalex.org/W2188852273","https://openalex.org/W2341820741","https://openalex.org/W2411798922","https://openalex.org/W4294232824"],"related_works":["https://openalex.org/W2070199524","https://openalex.org/W2411798922","https://openalex.org/W7120558308","https://openalex.org/W1986598519","https://openalex.org/W2006300406","https://openalex.org/W6976989716","https://openalex.org/W2074665106","https://openalex.org/W2187144093","https://openalex.org/W2177715039","https://openalex.org/W7097828851"],"abstract_inverted_index":{"To":[0],"elucidate":[1],"the":[2,59,61,69,98,110,116,128,132,142,151,154,160,166,170,173,183],"mechanisms":[3],"of":[4,29,101,112,150,153,172,185,194],"antischistosoma":[5],"resistance,":[6],"drug-resistant":[7],"Schistosoma":[8],"mansoni":[9,198],"laboratory":[10],"isolates":[11],"are":[12],"essential.":[13],"We":[14],"developed":[15],"a":[16,53,138],"new":[17],"method":[18],"for":[19,48,192],"inducing":[20],"resistance":[21,195],"to":[22,75,127,147,180,196],"praziquantel":[23],"(PZQ)":[24],"using":[25],"successive":[26],"drug":[27],"treatments":[28],"Biomphalaria":[30],"glabrata":[31,39],"snails":[32,67,187],"infected":[33,114,186],"with":[34,44,52,85,115,120,131],"S.":[35,197],"mansoni.":[36],"Infected":[37],"B.":[38],"were":[40,73,83,176],"treated":[41,84,119],"three":[42],"times":[43],"100":[45],"mg/kg":[46,90,124],"PZQ":[47],"five":[49],"consecutive":[50],"days":[51,79,93],"one-week":[54],"interval":[55],"between":[56,141],"them.":[57],"After":[58],"treatment,":[60],"cercariae":[62],"(LE-PZQ)":[63],"produced":[64],"from":[65],"these":[66],"and":[68,122,159,203],"LE":[70,129,161],"strains":[71],"(susceptible)":[72],"used":[74],"infect":[76],"mice.":[77],"Forty-five":[78],"after":[80],"infection,":[81],"mice":[82,113],"200,":[86],"400":[87,123],"or":[88],"800":[89],"PZQ.":[91,181],"Thirty":[92],"post-treatment,":[94],"we":[95],"observed":[96],"that":[97],"mean":[99],"number":[100],"worms":[102,171],"recovered":[103],"by":[104],"perfusion":[105],"was":[106,137],"significantly":[107],"higher":[108],"in":[109,125,167],"group":[111],"LE-PZQ":[117,155,174],"isolate":[118,156,175],"200":[121],"comparison":[126],"strain":[130,162],"same":[133],"treatment.":[134],"Moreover,":[135],"there":[136],"significant":[139],"difference":[140],"ED50":[143],"(effective":[144],"dose":[145],"required":[146],"kill":[148],"50%":[149],"worms)":[152],"(362":[157],"mg/kg)":[158],"(68":[163],"mg/kg).":[164],"In":[165],"vitro":[168],"assays,":[169],"also":[177],"less":[178],"susceptible":[179],"Thus,":[182],"use":[184],"as":[188],"an":[189],"experimental":[190],"model":[191],"development":[193],"is":[199],"effective,":[200],"fast,":[201],"simple":[202],"cheap.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}