{"id":"https://openalex.org/W2129465046","doi":"https://doi.org/10.1093/cvr/cvp047","title":"MinK-dependent internalization of the IKs potassium channel","display_name":"MinK-dependent internalization of the IKs potassium channel","publication_year":2009,"publication_date":"2009-02-07","ids":{"openalex":"https://openalex.org/W2129465046","doi":"https://doi.org/10.1093/cvr/cvp047","mag":"2129465046","pmid":"https://pubmed.ncbi.nlm.nih.gov/19202166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682613"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvp047","doi":"https://doi.org/10.1093/cvr/cvp047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvp047","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/82/3/430/17390738/cvp047.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cardiovascres/article-pdf/82/3/430/17390738/cvp047.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078869493","display_name":"Xianghua Xu","orcid":"https://orcid.org/0000-0001-5244-6707","observed_orcids":["https://orcid.org/0000-0001-5244-6707"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianghua Xu","raw_affiliation_strings":["Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057453629","display_name":"Vikram A. Kanda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram A. Kanda","raw_affiliation_strings":["Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052927480","display_name":"Eun Joo Choi","orcid":"https://orcid.org/0000-0002-7002-3932","observed_orcids":["https://orcid.org/0000-0002-7002-3932"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eun Choi","raw_affiliation_strings":["Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003377808","display_name":"Gianina Panaghie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianina Panaghie","raw_affiliation_strings":["Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032931552","display_name":"Torsten Kai Roepke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Torsten K. Roepke","raw_affiliation_strings":["Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007962149","display_name":"Stephen A. Gaeta","orcid":"https://orcid.org/0000-0001-8641-1481","observed_orcids":["https://orcid.org/0000-0001-8641-1481"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A. Gaeta","raw_affiliation_strings":["Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035862691","display_name":"David J. Christini","orcid":"https://orcid.org/0000-0003-0852-2922","observed_orcids":["https://orcid.org/0000-0003-0852-2922"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Christini","raw_affiliation_strings":["Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544733","display_name":"Daniel J. Lerner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. Lerner","raw_affiliation_strings":["CV Ingenuity, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CV Ingenuity, San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062051181","display_name":"Geoffrey Winston Abbott","orcid":"https://orcid.org/0000-0003-4552-496X","observed_orcids":["https://orcid.org/0000-0003-4552-496X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoffrey W. Abbott","raw_affiliation_strings":["Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, Starr 463, 520 East 70th Street, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062051181"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":2.0112,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.86170008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"82","issue":"3","first_page":"430","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.1378999948501587,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mink","display_name":"mink","score":0.7099999785423279},{"id":"https://openalex.org/keywords/kcnq1","display_name":"KCNQ1","score":0.996999979019165},{"id":"https://openalex.org/keywords/iks-current","display_name":"IKs current","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dynamin-2","display_name":"dynamin 2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/channel-stoichiometry","display_name":"channel stoichiometry","score":0.625},{"id":"https://openalex.org/keywords/ion-channel-gating-kinetics","display_name":"channel gating kinetics","score":0.7789999842643738},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2776104367","wikidata":"https://www.wikidata.org/wiki/Q5891451","display_name":"Homomeric","level":4,"score":0.8954373002052307},{"id":"https://openalex.org/C2780754187","wikidata":"https://www.wikidata.org/wiki/Q17700","display_name":"Mink","level":2,"score":0.7710899114608765},{"id":"https://openalex.org/C156407911","wikidata":"https://www.wikidata.org/wiki/Q420160","display_name":"Dynamin","level":4,"score":0.6279393434524536},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5693976879119873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5187326073646545},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5159526467323303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5116346478462219},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.5115467309951782},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.43492391705513},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3926522433757782},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3536263108253479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33925896883010864},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.3059208393096924},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.2012728750705719},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11280027031898499},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.10447180271148682},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002966","descriptor_name":"Clathrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051657","descriptor_name":"KCNQ1 Potassium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/cvr/cvp047","doi":"https://doi.org/10.1093/cvr/cvp047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvp047","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/82/3/430/17390738/cvp047.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2682613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682613","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Res","raw_type":"Text"},{"id":"pmid:19202166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19202166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"},{"id":"pmh:oai:null:20.500.12648/15825","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12648/15825","pdf_url":null,"source":{"id":"https://openalex.org/S4306400078","display_name":"SUNY Digital Repository Support (State University of New York System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63190737","host_organization_name":"University at Buffalo, State University of New York","host_organization_lineage":["https://openalex.org/I63190737"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"438","raw_type":"Article/Review"}],"best_oa_location":{"id":"doi:10.1093/cvr/cvp047","doi":"https://doi.org/10.1093/cvr/cvp047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvp047","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/82/3/430/17390738/cvp047.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4945016434","display_name":"K+ Channel Trafficking and Modulation by Mink and MiRP1","funder_award_id":"R01HL079275","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5004515454","display_name":null,"funder_award_id":"HL-079275","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8798105863","display_name":"Weill Cornell/Rockefeller/Sloan Kettering MST Program","funder_award_id":"T32GM007739","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129465046.pdf","grobid_xml":"https://content.openalex.org/works/W2129465046.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1689798268","https://openalex.org/W1904293285","https://openalex.org/W1949421724","https://openalex.org/W1970407380","https://openalex.org/W1971065575","https://openalex.org/W1979815209","https://openalex.org/W1983137097","https://openalex.org/W1988930233","https://openalex.org/W1989899477","https://openalex.org/W1990737080","https://openalex.org/W1999601435","https://openalex.org/W2002422701","https://openalex.org/W2002444558","https://openalex.org/W2010009765","https://openalex.org/W2010038788","https://openalex.org/W2014104254","https://openalex.org/W2022414157","https://openalex.org/W2024732013","https://openalex.org/W2026740840","https://openalex.org/W2040081725","https://openalex.org/W2042310717","https://openalex.org/W2050291058","https://openalex.org/W2059995944","https://openalex.org/W2065288202","https://openalex.org/W2067698573","https://openalex.org/W2072096539","https://openalex.org/W2073677053","https://openalex.org/W2078381702","https://openalex.org/W2104605409","https://openalex.org/W2105006553","https://openalex.org/W2114636835","https://openalex.org/W2114911095","https://openalex.org/W2117216522","https://openalex.org/W2119067306","https://openalex.org/W2123262667","https://openalex.org/W2124381514","https://openalex.org/W2134042326","https://openalex.org/W2142133653","https://openalex.org/W2152136740","https://openalex.org/W2155455801","https://openalex.org/W2163240506","https://openalex.org/W2164450517","https://openalex.org/W2171548189","https://openalex.org/W2178812731"],"related_works":["https://openalex.org/W1964210830","https://openalex.org/W4241247103","https://openalex.org/W2121976505","https://openalex.org/W3080229138","https://openalex.org/W2012151855","https://openalex.org/W2971596681","https://openalex.org/W2006933437","https://openalex.org/W1904293285","https://openalex.org/W3004754612","https://openalex.org/W2913929806"],"abstract_inverted_index":{"AIMS:":[0],"KCNQ1-MinK":[1,146,189],"potassium":[2],"channel":[3,58,229,246],"complexes":[4],"(4alpha:2beta":[5],"stoichiometry)":[6],"generate":[7],"IKs,":[8],"the":[9,166,206],"slowly":[10],"activating":[11],"human":[12,42],"cardiac":[13,70],"ventricular":[14,89],"repolarization":[15],"current.":[16],"The":[17,209],"MinK":[18,36,86,134,167,212],"ancillary":[19],"subunit":[20,230],"slows":[21],"KCNQ1":[22,33,45,84,129,151,218],"activation,":[23],"eliminates":[24],"its":[25,29],"inactivation,":[26],"and":[27,78,80,85,91,118,135,138,158,174,180,219,235],"increases":[28],"unitary":[30],"conductance.":[31],"However,":[32],"transcripts":[34,37],"outnumber":[35],"five":[38],"to":[39,124,139,155,182,192,241],"one":[40],"in":[41,83,143,171],"ventricles,":[43],"suggesting":[44],"also":[46,239],"forms":[47],"other":[48,242],"heteromeric":[49],"or":[50,132],"even":[51],"homomeric":[52,150,193],"channels":[53,142,190],"there.":[54],"Mechanisms":[55],"governing":[56],"which":[57],"types":[59],"prevail":[60],"have":[61],"not":[62,149],"previously":[63],"been":[64],"reported,":[65],"despite":[66],"their":[67],"significance:":[68],"normal":[69],"rhythm":[71],"requires":[72],"tight":[73],"control":[74],"of":[75],"IKs":[76,141],"density":[77,234],"kinetics,":[79],"inherited":[81],"mutations":[82],"can":[87],"cause":[88],"fibrillation":[90],"sudden":[92],"death.":[93],"Here,":[94],"we":[95],"describe":[96],"a":[97,221],"novel":[98],"mechanism":[99,223],"for":[100,176,217,224],"this":[101],"control.":[102],"METHODS":[103],"AND":[104],"RESULTS:":[105],"Whole-cell":[106],"patch-clamping,":[107],"confocal":[108],"immunofluorescence":[109],"microscopy,":[110],"antibody":[111],"feeding,":[112,114,117],"biotin":[113],"fluorescent":[115],"transferrin":[116],"protein":[119],"biochemistry":[120],"techniques":[121],"were":[122,153],"applied":[123],"COS-7":[125],"cells":[126],"heterologously":[127],"expressing":[128],"with":[130],"wild-type":[131],"mutant":[133],"dynamin":[136,159],"2":[137],"native":[140],"guinea-pig":[144],"myocytes.":[145],"complexes,":[147],"but":[148,198],"channels,":[152],"found":[154],"undergo":[156],"clathrin-":[157],"2-dependent":[160],"internalization":[161],"(DDI).":[162],"Three":[163],"sites":[164],"on":[165],"intracellular":[168],"C-terminus":[169],"were,":[170],"concert,":[172],"necessary":[173],"sufficient":[175],"DDI.":[177],"Gating":[178],"kinetics":[179],"sensitivity":[181],"XE991":[183],"indicated":[184],"that":[185],"DDI":[186,204],"decreased":[187],"cell-surface":[188],"relative":[191],"KCNQ1,":[194],"decreasing":[195],"whole-cell":[196],"current":[197,233],"increasing":[199],"net":[200,226],"activation":[201],"rate;":[202],"inhibiting":[203],"did":[205],"reverse.":[207],"CONCLUSION:":[208],"data":[210],"redefine":[211],"as":[213],"an":[214],"endocytic":[215],"chaperone":[216],"present":[220],"dynamic":[222],"controlling":[225],"surface":[227],"Kv":[228,245],"composition-and":[231],"thus":[232],"gating":[236],"kinetics-that":[237],"may":[238],"apply":[240],"alpha-beta":[243],"type":[244],"complexes.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
