{"id":"https://openalex.org/W2129459102","doi":"https://doi.org/10.1158/1078-0432.ccr-04-0436","title":"Phase I Study of Tirapazamine Plus Cisplatin/Etoposide and Concurrent Thoracic Radiotherapy in Limited-Stage Small Cell Lung Cancer (S0004)","display_name":"Phase I Study of Tirapazamine Plus Cisplatin/Etoposide and Concurrent Thoracic Radiotherapy in Limited-Stage Small Cell Lung Cancer (S0004)","publication_year":2004,"publication_date":"2004-08-15","ids":{"openalex":"https://openalex.org/W2129459102","doi":"https://doi.org/10.1158/1078-0432.ccr-04-0436","mag":"2129459102","pmid":"https://pubmed.ncbi.nlm.nih.gov/15328179"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-04-0436","doi":"https://doi.org/10.1158/1078-0432.ccr-04-0436","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-04-0436","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/10/16/5418/1918664/zdf01604005418.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/clincancerres/article-pdf/10/16/5418/1918664/zdf01604005418.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013860869","display_name":"Quynh\u2010Thu Le","orcid":"https://orcid.org/0000-0002-3682-1439","observed_orcids":["https://orcid.org/0000-0002-3682-1439"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quynh-Thu Le","raw_affiliation_strings":["1Stanford University, Stanford, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Stanford University, Stanford, California;","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108618276","display_name":"Jason McCoy","orcid":"https://orcid.org/0009-0006-1136-555X","observed_orcids":["https://orcid.org/0009-0006-1136-555X"]},"institutions":[{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason McCoy","raw_affiliation_strings":["2Southwest Oncology Group Statistical Center, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Southwest Oncology Group Statistical Center, Seattle, Washington;","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027304240","display_name":"Stephen K. Williamson","orcid":"https://orcid.org/0000-0003-4118-1242","observed_orcids":["https://orcid.org/0000-0003-4118-1242"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Williamson","raw_affiliation_strings":["3University of Kansas Medical Center, Kansas City, Kansas;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109933388","display_name":"Janice K. Ryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice Ryu","raw_affiliation_strings":["4University of California, Davis, Sacramento, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of California, Davis, Sacramento, California;","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109156278","display_name":"Laurie E. Gaspar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie E. Gaspar","raw_affiliation_strings":["5University of Colorado Health Science Center, Denver, Colorado;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Colorado Health Science Center, Denver, Colorado;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063441489","display_name":"Martin Joseph Edelman","orcid":"https://orcid.org/0000-0002-3752-0726","observed_orcids":["https://orcid.org/0000-0002-3752-0726"]},"institutions":[{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J. Edelman","raw_affiliation_strings":["6University of Maryland Greenebaum Cancer Center, Baltimore, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6University of Maryland Greenebaum Cancer Center, Baltimore, Maryland;","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064449830","display_name":"Shaker R. Dakhil","orcid":"https://orcid.org/0000-0002-6261-5882","observed_orcids":["https://orcid.org/0000-0002-6261-5882"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaker R. Dakhil","raw_affiliation_strings":["7Wichita Community Clinical Oncology Program, Wichita, Kansas;","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Wichita Community Clinical Oncology Program, Wichita, Kansas;","institution_ids":[]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085722656","display_name":"Stanley D. Sides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanley D. Sides","raw_affiliation_strings":["8St. Louis Community Clinical Oncology Program, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8St. Louis Community Clinical Oncology Program, St. Louis, Missouri","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103408877","display_name":"John J. Crowley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Crowley","raw_affiliation_strings":["2Southwest Oncology Group Statistical Center, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Southwest Oncology Group Statistical Center, Seattle, Washington;","institution_ids":["https://openalex.org/I4210165553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036091074","display_name":"David R. Gandara","orcid":"https://orcid.org/0000-0003-1784-048X","observed_orcids":["https://orcid.org/0000-0003-1784-048X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Gandara","raw_affiliation_strings":["4University of California, Davis, Sacramento, California;","Hematology and Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of California, Davis, Sacramento, California;","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Hematology and Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7592,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.83767927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"16","first_page":"5418","last_page":"5424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirapazamine","display_name":"tirapazamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/limited-stage-small-cell-lung-cancer","display_name":"limited-stage small cell lung cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/concurrent-chemoradiotherapy","display_name":"concurrent chemoradiotherapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/thoracic-radiotherapy","display_name":"thoracic radiotherapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/esophagitis","display_name":"esophagitis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.753000020980835},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/consolidation-therapy","display_name":"consolidation therapy","score":0.718999981880188},{"id":"https://openalex.org/keywords/prophylactic-cranial-irradiation","display_name":"prophylactic cranial irradiation","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7681256532669067},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6734400391578674},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.6553691625595093},{"id":"https://openalex.org/C2776313096","wikidata":"https://www.wikidata.org/wiki/Q3529346","display_name":"Tirapazamine","level":4,"score":0.6422644257545471},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.5718600153923035},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.5488763451576233},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4622146487236023},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.43572449684143066},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4298385977745056},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42417508363723755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.396684467792511},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3863667845726013},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3575960099697113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077704","descriptor_name":"Tirapazamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004941","descriptor_name":"Esophagitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-04-0436","doi":"https://doi.org/10.1158/1078-0432.ccr-04-0436","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-04-0436","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/10/16/5418/1918664/zdf01604005418.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:15328179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15328179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-04-0436","doi":"https://doi.org/10.1158/1078-0432.ccr-04-0436","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-04-0436","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/10/16/5418/1918664/zdf01604005418.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1077722570","display_name":"Southwest Oncology Group","funder_award_id":"U10CA004919","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G117886320","display_name":null,"funder_award_id":"CA22-433","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1202672505","display_name":null,"funder_award_id":"CA-58861","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1235982543","display_name":null,"funder_award_id":"CA-58658","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1268312386","display_name":null,"funder_award_id":"CA52654","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1439713495","display_name":"Columbus Community Clinical Oncology Program (Columbus CCOP)","funder_award_id":"U10CA035261","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1646027999","display_name":null,"funder_award_id":"CA-35261","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1794831901","display_name":null,"funder_award_id":"CA76132","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1911575068","display_name":null,"funder_award_id":"CA37981","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1958973285","display_name":null,"funder_award_id":"CA 20319","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2064543036","display_name":null,"funder_award_id":"CA-32102","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2139361903","display_name":"Scott & White Community Clinical Oncology Program","funder_award_id":"U10CA074647","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2397742718","display_name":null,"funder_award_id":"CA35119","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2745671310","display_name":null,"funder_award_id":"CA04919","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3065506811","display_name":"SOUTHWEST ONCOLOGY GROUP STATISTICAL CENTER","funder_award_id":"2u10ca038926-25","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3126600779","display_name":null,"funder_award_id":"CA 74647","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3334379738","display_name":null,"funder_award_id":"CA35128","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3350348941","display_name":null,"funder_award_id":"CA46441","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3497039781","display_name":null,"funder_award_id":"CA 63845","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4094841028","display_name":null,"funder_award_id":"CA67575","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G413878341","display_name":null,"funder_award_id":"CA-12644","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4281693517","display_name":"Southwest Oncology Group","funder_award_id":"U10CA020319","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5910506932","display_name":"UPSTATE CAROLINA COMMUNITY CLINICAL ONCOLOGY PROGRAM","funder_award_id":"U10CA035119","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6034396093","display_name":"SOUTHWEST ONCOLOGY GROUP","funder_award_id":"U10CA058658","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6109875642","display_name":null,"funder_award_id":"CA35431","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6134390630","display_name":"Southwest Oncology Group Treatment Grant","funder_award_id":"U10CA032102","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6143619056","display_name":"SOUTHWEST ONCOLOGY GROUP","funder_award_id":"U10CA022433","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6241345348","display_name":"Gulf Coast MBCCOP","funder_award_id":"U10CA052654","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6793431733","display_name":"SOUTHWEST ONCOLOGY GROUP STUDIES","funder_award_id":"U10CA012644","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7287383305","display_name":"LSUHSC Minority-Based Community Clinical Oncology Program","funder_award_id":"U10CA063845","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7509275415","display_name":"Community Clinical Oncology Program","funder_award_id":"U10CA035431","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G763325562","display_name":null,"funder_award_id":"CA 38926","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8468409242","display_name":"ST Louis-Cape Girardeau CCOP","funder_award_id":"U10CA035128","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8591831923","display_name":"SOUTHWEST ONCOLOGY GROUP (UTAH)","funder_award_id":"U10CA058861","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8722571841","display_name":"SOUTHWEST ONCOLOGY GROUP","funder_award_id":"U10CA037981","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G967989025","display_name":"Montana Cancer Consortium CCOP","funder_award_id":"U10CA067575","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G999571701","display_name":"Southwest Oncology Group/University of California, Davis","funder_award_id":"U10CA046441","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129459102.pdf","grobid_xml":"https://content.openalex.org/works/W2129459102.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W193937562","https://openalex.org/W1523500414","https://openalex.org/W1682474579","https://openalex.org/W1684733013","https://openalex.org/W1868704956","https://openalex.org/W1885320430","https://openalex.org/W1905406155","https://openalex.org/W1920090590","https://openalex.org/W1935482218","https://openalex.org/W1973865448","https://openalex.org/W1974993444","https://openalex.org/W1979317247","https://openalex.org/W1985883143","https://openalex.org/W1986794774","https://openalex.org/W1990497183","https://openalex.org/W1997518044","https://openalex.org/W2008347666","https://openalex.org/W2010286218","https://openalex.org/W2014017843","https://openalex.org/W2018210528","https://openalex.org/W2021907624","https://openalex.org/W2036789410","https://openalex.org/W2046155840","https://openalex.org/W2046492464","https://openalex.org/W2062410878","https://openalex.org/W2064248272","https://openalex.org/W2067686632","https://openalex.org/W2084979429","https://openalex.org/W2101038194","https://openalex.org/W2105024669","https://openalex.org/W2107806932","https://openalex.org/W2120683750","https://openalex.org/W2120826482","https://openalex.org/W2139248078","https://openalex.org/W2143124651","https://openalex.org/W2143779010","https://openalex.org/W2153965661","https://openalex.org/W2160012348","https://openalex.org/W2160585366","https://openalex.org/W2167541208","https://openalex.org/W2256738179","https://openalex.org/W2271870719","https://openalex.org/W2275341372","https://openalex.org/W2323020638","https://openalex.org/W2341745217","https://openalex.org/W2416789205","https://openalex.org/W2419492009"],"related_works":["https://openalex.org/W2157903728","https://openalex.org/W2259832400","https://openalex.org/W2101038194","https://openalex.org/W1973067758","https://openalex.org/W1868704956","https://openalex.org/W2380357034","https://openalex.org/W2156188896","https://openalex.org/W2290692009","https://openalex.org/W2027279621","https://openalex.org/W7097331123"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"the":[3,58,98,123,129,194,207,217,222,231,240],"feasibility":[4],"and":[5,35,84,147,166,182,193,227],"a":[6,113,133],"recommended":[7],"phase":[8,155],"II":[9],"dose":[10,52,212],"of":[11,29,32,60,76,79,107,136,171,219,224,239,246],"tirapazamine":[12,80,101,209,220,247],"when":[13],"combined":[14],"with":[15,50,111,160,215],"chemoradiotherapy":[16,27,126],"in":[17,57,119,164,169,248],"limited-stage":[18],"small":[19],"cell":[20],"lung":[21],"cancer":[22],"(LSCLC).":[23],"EXPERIMENTAL":[24],"DESIGN:":[25],"Concurrent":[26],"consisted":[28,75],"two":[30,77,175],"cycles":[31,78],"cisplatin,":[33,83],"etoposide,":[34],"once-daily":[36],"radiation":[37],"to":[38,54],"61":[39],"Gy.":[40],"Tirapazamine":[41],"(260":[42],"mg/m2)":[43],"was":[44,156,191,197,204],"given":[45],"1":[46],"h":[47],"before":[48],"cisplatin":[49],"planned":[51],"escalation":[53],"330":[55],"mg/m2":[56,100],"absence":[59],"dose-limiting":[61,202],"toxicity,":[62],"defined":[63],"as":[64],">":[65],"or":[66,71],"=33%":[67],"esophagitis":[68,139],"(grade":[69],"3":[70],"above).":[72],"Consolidation":[73],"therapy":[74],"(330":[81],"mg/m2),":[82],"etoposide.":[85],"Complete":[86],"responders":[87],"received":[88],"prophylactic":[89],"cranial":[90],"irradiation.":[91],"RESULTS:":[92],"Thirty":[93],"patients":[94],"were":[95,174],"enrolled":[96],"at":[97,206],"260":[99],"dose.":[102],"All":[103],"had":[104],"performance":[105],"status":[106],"0-1.":[108],"By":[109],"comparison":[110],"S9713,":[112,216],"predecessor":[114],"Southwest":[115],"Oncology":[116],"Group":[117],"study":[118,245],"LSCLC":[120,249],"that":[121],"used":[122],"same":[124],"concurrent":[125],"without":[127],"tirapazamine,":[128],"present":[130],"trial":[131],"showed":[132],"higher":[134],"rate":[135,190],"grade":[137,161],"3-4":[138],"(34%":[140,144],"versus":[141,145,151],"22%),":[142],"vomiting":[143],"23%),":[146],"febrile":[148,167,228],"neutropenia":[149,163,168],"(7%":[150],"2%).":[152],"The":[153,187],"consolidation":[154],"relatively":[157],"well":[158],"tolerated,":[159],"4":[162],"44%":[165],"5%":[170],"patients.":[172],"There":[173],"treatment-related":[176],"deaths:":[177],"one":[178,183],"from":[179,184],"neutropenic":[180],"fever":[181],"respiratory":[185],"infection.":[186],"overall":[188,232],"response":[189],"80%,":[192],"median":[195],"survival":[196],"22":[198],"months.":[199],"CONCLUSIONS:":[200],"Protocol-defined":[201],"toxicity":[203,233],"observed":[205,241],"initial":[208],"dose,":[210],"precluding":[211],"escalation.":[213],"Compared":[214],"addition":[218],"increased":[221],"incidence":[223],"vomiting,":[225],"neutropenia,":[226,229],"although":[230],"profile":[234],"remained":[235],"acceptable.":[236],"In":[237],"view":[238],"favorable":[242],"survival,":[243],"further":[244],"is":[250],"warranted.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}