{"id":"https://openalex.org/W2129456343","doi":"https://doi.org/10.1002/jso.2930510313","title":"Synergistic effects of intratumor administration of cis\u2010diamminedichloroplatinum(II) combined with local hyperthermia in melanoma bearing mice","display_name":"Synergistic effects of intratumor administration of cis\u2010diamminedichloroplatinum(II) combined with local hyperthermia in melanoma bearing mice","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W2129456343","doi":"https://doi.org/10.1002/jso.2930510313","mag":"2129456343","pmid":"https://pubmed.ncbi.nlm.nih.gov/1434645"},"language":"en","primary_location":{"id":"doi:10.1002/jso.2930510313","doi":"https://doi.org/10.1002/jso.2930510313","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.2930510313","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102916386","display_name":"Kaoru Kitamura","orcid":"https://orcid.org/0000-0003-1339-5198","observed_orcids":["https://orcid.org/0000-0003-1339-5198"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kaoru Kitamura","raw_affiliation_strings":["Department of Surgery II, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017461232","display_name":"Hiroyuki Kuwano","orcid":"https://orcid.org/0000-0003-1809-8483","observed_orcids":["https://orcid.org/0000-0003-1809-8483"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kuwano","raw_affiliation_strings":["Department of Surgery II, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101547881","display_name":"Hiroyuki Matsuda","orcid":"https://orcid.org/0000-0003-4662-7012","observed_orcids":["https://orcid.org/0000-0003-4662-7012"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Matsuda","raw_affiliation_strings":["Department of Surgery II, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039941002","display_name":"Yasushi Toh","orcid":"https://orcid.org/0000-0002-8808-0740","observed_orcids":["https://orcid.org/0000-0002-8808-0740","https://orcid.org/0000-0002-1568-7867"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Toh","raw_affiliation_strings":["Department of Surgery II, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110038701","display_name":"Hidetaka Masuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200314755","display_name":"Kyushu Dental University","ror":"https://ror.org/03bwzch55","country_code":"JP","type":"education","lineage":["https://openalex.org/I200314755"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetaka Masuda","raw_affiliation_strings":["Department of Surgery, Kyushu Dental College, Kitakyushu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyushu Dental College, Kitakyushu, Japan","institution_ids":["https://openalex.org/I200314755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113510006","display_name":"Keiz\u014d Sugimachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keizo Sugimachi","raw_affiliation_strings":["Department of Surgery II, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102916386"],"corresponding_institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":1.534,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.79319017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":94},"biblio":{"volume":"51","issue":"3","first_page":"188","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/local-hyperthermia","display_name":"local hyperthermia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8149999976158142},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intratumoral-chemotherapy","display_name":"intratumoral chemotherapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6420000195503235},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6840000152587891},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/regional-chemotherapy","display_name":"regional chemotherapy","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8552489280700684},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.6809635162353516},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5725803971290588},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5640217661857605},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.48918774724006653},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.48427242040634155},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.4565969407558441},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4398960769176483},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.426789790391922},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3685661554336548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2912343740463257},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21932637691497803},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1963595449924469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0750877857208252},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jso.2930510313","doi":"https://doi.org/10.1002/jso.2930510313","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.2930510313","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:1434645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1434645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of surgical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W147559484","https://openalex.org/W1495915090","https://openalex.org/W1500678300","https://openalex.org/W1549056640","https://openalex.org/W1588328820","https://openalex.org/W1664302441","https://openalex.org/W1940103704","https://openalex.org/W1968272364","https://openalex.org/W2005342711","https://openalex.org/W2035474885","https://openalex.org/W2048848435","https://openalex.org/W2058285926","https://openalex.org/W2067403798","https://openalex.org/W2067729477","https://openalex.org/W2076932382","https://openalex.org/W2094914855","https://openalex.org/W2102691587","https://openalex.org/W2103780593","https://openalex.org/W2118738894","https://openalex.org/W2123675284","https://openalex.org/W2124242608","https://openalex.org/W2158956051","https://openalex.org/W2398988088","https://openalex.org/W2404131865","https://openalex.org/W2415347863","https://openalex.org/W3041047318"],"related_works":["https://openalex.org/W2050960490","https://openalex.org/W2163587675","https://openalex.org/W2417396755","https://openalex.org/W2076932382","https://openalex.org/W389110339","https://openalex.org/W2076954987","https://openalex.org/W2102691587","https://openalex.org/W2398162724","https://openalex.org/W2079687612","https://openalex.org/W2114748064"],"abstract_inverted_index":{"The":[0,26,83,132],"synergistic":[1],"effect":[2],"of":[3,11,28,67,183],"local":[4,61,165],"hyperthermia":[5,166],"(LHT)":[6],"with":[7,21,101,148,164],"intratumor":[8],"injection":[9,160],"(i.t.)":[10,62,100],"cis-diamminedichloroplatinum":[12],"(II)":[13],"(DDP)":[14],"was":[15,35,49,103,115,136],"studied":[16],"using":[17],"a":[18,38,116,149],"rodent":[19],"model":[20],"implanted":[22],"B16":[23],"melanoma":[24],"tumors.":[25],"hindfoot":[27],"the":[29,33,94,153,168,173,181],"C57BL/6":[30],"mouse":[31],"bearing":[32],"tumor":[34,84],"placed":[36],"in":[37,72,80,93,105,110,120,126,139,145,152],"water":[39],"bath":[40],"at":[41,50,88],"42.5":[42],"+/-":[43,52],"0.2":[44],"degrees":[45,54],"C":[46],"(intratumor":[47],"temperature":[48],"42.3":[51],"0.1":[53],"C)":[55],"for":[56],"30":[57],"minutes":[58],"just":[59],"after":[60,91],"or":[63,180],"systemic":[64],"(intraperitoneal;i.p.)":[65],"administration":[66],"DDP":[68,97],"(1-3":[69],"mg/kg":[70,77,99],"once":[71],"experiment":[73,81,106,111,140,146],"I":[74,107,141],"and":[75,108,113,142,171],"1-3":[76],"three":[78],"times":[79],"II).":[82],"growth":[85],"ratio":[86],"(TGR)":[87],"7":[89],"days":[90,138,144],"treatment":[92],"group":[95],"given":[96,162],"3":[98],"LHT":[102],"1.1":[104],"0.5":[109],"II,":[112,147],"there":[114],"statistically":[117],"significant":[118,150],"difference":[119,151],"both":[121],"experiments":[122],"compared":[123],"to":[124],"findings":[125],"other":[127],"groups":[128],"(P":[129,155],"<":[130,156],"0.01).":[131],"mean":[133],"survival":[134],"time":[135],"42.1":[137],"50.2":[143],"latter":[154],"0.001).":[157],"Thus":[158],"regional":[159],"chemotherapy":[161],"concomitantly":[163],"promotes":[167],"anticancer":[169],"effects":[170],"improves":[172],"prognosis":[174],"without":[175],"either":[176],"severe":[177],"renal":[178],"injury":[179],"promotion":[182],"hematogenic":[184],"metastasis.":[185]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
