{"id":"https://openalex.org/W2129449870","doi":"https://doi.org/10.1152/ajpendo.00259.2006","title":"Impaired insulin secretion in a mouse model of ataxia telangiectasia","display_name":"Impaired insulin secretion in a mouse model of ataxia telangiectasia","publication_year":2007,"publication_date":"2007-03-14","ids":{"openalex":"https://openalex.org/W2129449870","doi":"https://doi.org/10.1152/ajpendo.00259.2006","mag":"2129449870","pmid":"https://pubmed.ncbi.nlm.nih.gov/17356010"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00259.2006","doi":"https://doi.org/10.1152/ajpendo.00259.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00259.2006","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014612757","display_name":"Philip D.G. Miles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip D. Miles","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056657552","display_name":"Kai Treuner","orcid":"https://orcid.org/0009-0006-3443-3578","observed_orcids":["https://orcid.org/0009-0006-3443-3578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Treuner","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050185020","display_name":"Marc Latronica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Latronica","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091832115","display_name":"Jerrold M. Olefsky","orcid":"https://orcid.org/0000-0003-0392-1705","observed_orcids":["https://orcid.org/0000-0003-0392-1705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerrold M. Olefsky","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025279301","display_name":"Carrolee Barlow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrolee Barlow","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3201,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.91974865,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"293","issue":"1","first_page":"E70","last_page":"E74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":1.0},{"id":"https://openalex.org/keywords/atm-gene","display_name":"ATM gene","score":0.8199999928474426},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9290000200271606},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8090000152587891},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.7770000100135803},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7400000095367432},{"id":"https://openalex.org/keywords/atm-deficient-mice","display_name":"Atm-deficient mice","score":0.7369999885559082},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6299999952316284},{"id":"https://openalex.org/keywords/metabolic-function","display_name":"metabolic function","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.8453026413917542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7796968221664429},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7764986753463745},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5318386554718018},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.49066007137298584},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.45749199390411377},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4519323408603668},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.43904706835746765},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.43501532077789307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4158622622489929},{"id":"https://openalex.org/C2780833929","wikidata":"https://www.wikidata.org/wiki/Q1501412","display_name":"Glucose tolerance test","level":4,"score":0.41332823038101196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3768981397151947},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.34609612822532654},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3361991047859192},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.310525119304657},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11032941937446594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.077821284532547}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018149","descriptor_name":"Glucose Intolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.00259.2006","doi":"https://doi.org/10.1152/ajpendo.00259.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00259.2006","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:17356010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17356010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2676089267","display_name":null,"funder_award_id":"NS39601","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3362831738","display_name":null,"funder_award_id":"DK-33651","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4321362590","display_name":"Defining a Role for ATM in the Nervous System","funder_award_id":"R01NS039601","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W197358573","https://openalex.org/W1479769602","https://openalex.org/W1513662526","https://openalex.org/W1673747382","https://openalex.org/W1985113364","https://openalex.org/W2011089421","https://openalex.org/W2026387345","https://openalex.org/W2046589688","https://openalex.org/W2059347700","https://openalex.org/W2068412840","https://openalex.org/W2088359631","https://openalex.org/W2089664641","https://openalex.org/W2113054573","https://openalex.org/W2114319968","https://openalex.org/W2149926350","https://openalex.org/W2156833934","https://openalex.org/W2161174158","https://openalex.org/W2165991181","https://openalex.org/W2178375292","https://openalex.org/W2324837838","https://openalex.org/W2336907516","https://openalex.org/W4240846885"],"related_works":["https://openalex.org/W2179039968","https://openalex.org/W2106925712","https://openalex.org/W1968498684","https://openalex.org/W2290114860","https://openalex.org/W2065916701","https://openalex.org/W2024632192","https://openalex.org/W2317321657","https://openalex.org/W197358573","https://openalex.org/W2324837838","https://openalex.org/W2346625038"],"abstract_inverted_index":{"Ataxia":[0],"telangiectasia":[1],"(A-T)":[2],"is":[3],"an":[4],"autosomal":[5],"recessive":[6],"disease":[7],"caused":[8],"by":[9],"mutations":[10],"in":[11,26,75,117,124,136,151],"the":[12,27,34,49,55,71,146],"A-T":[13,53],"mutated":[14],"(ATM)":[15],"gene.":[16],"The":[17],"gene":[18],"encodes":[19],"a":[20,76,114,122,132],"serine/threonine":[21],"kinase":[22],"with":[23],"important":[24],"roles":[25],"cellular":[28],"response":[29],"to":[30,59],"DNA":[31],"damage,":[32],"including":[33],"activation":[35],"of":[36,42,52,73,79,149],"cell":[37],"cycle":[38],"checkpoints":[39],"and":[40,62,93,106,121,126,139],"induction":[41],"apoptosis.":[43],"Although":[44],"these":[45],"functions":[46],"might":[47],"explain":[48],"cancer":[50],"predisposition":[51],"patients,":[54],"molecular":[56],"mechanisms":[57],"leading":[58],"glucose":[60,91,99,119],"intolerance":[61],"diabetes":[63],"mellitus":[64],"(DM)":[65],"are":[66],"unknown.":[67],"We":[68],"have":[69],"investigated":[70],"pathogenesis":[72],"DM":[74,150],"mouse":[77],"model":[78],"A-T.":[80,152],"Here":[81],"we":[82],"show":[83,88,113],"that":[84],"young":[85],"Atm-deficient":[86],"mice":[87,112],"normal":[89,94],"fasting":[90],"levels":[92,120],"insulin":[95,104,125,143],"sensitivity.":[96],"However,":[97],"oral":[98],"tolerance":[100],"testing":[101],"revealed":[102],"delayed":[103],"secretion":[105,144],"resulting":[107],"transient":[108],"hyperglycemia.":[109],"Aged":[110],"Atm-/-":[111],"pronounced":[115],"increase":[116],"blood":[118],"decrease":[123],"C-peptide":[127],"levels.":[128],"Our":[129],"findings":[130],"support":[131],"role":[133],"for":[134],"ATM":[135],"metabolic":[137],"function":[138],"point":[140],"toward":[141],"impaired":[142],"as":[145],"primary":[147],"cause":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
