{"id":"https://openalex.org/W2129409686","doi":"https://doi.org/10.1074/jbc.m109.054338","title":"Role of Wnt-5a in the Determination of Human Mesenchymal Stem Cells into Preadipocytes","display_name":"Role of Wnt-5a in the Determination of Human Mesenchymal Stem Cells into Preadipocytes","publication_year":2009,"publication_date":"2009-12-24","ids":{"openalex":"https://openalex.org/W2129409686","doi":"https://doi.org/10.1074/jbc.m109.054338","mag":"2129409686","pmid":"https://pubmed.ncbi.nlm.nih.gov/20032469"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.054338","doi":"https://doi.org/10.1074/jbc.m109.054338","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.054338","pdf_url":"http://www.jbc.org/article/S002192581937783X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581937783X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048293747","display_name":"Roman Bilkovski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roman Bilkovski","raw_affiliation_strings":["Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany","Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany","Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070227503","display_name":"Dominik Maria Schulte","orcid":"https://orcid.org/0000-0002-4622-6051","observed_orcids":["https://orcid.org/0000-0002-4622-6051"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik M. Schulte","raw_affiliation_strings":["Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113591160","display_name":"Frank Oberhauser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Oberhauser","raw_affiliation_strings":["Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032647334","display_name":"Matthias Gomolka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Gomolka","raw_affiliation_strings":["Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062919315","display_name":"Michael Udelhoven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Udelhoven","raw_affiliation_strings":["Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091200940","display_name":"Moritz M. Hettich","orcid":"https://orcid.org/0000-0003-1613-7848","observed_orcids":["https://orcid.org/0000-0003-1613-7848"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Moritz M. Hettich","raw_affiliation_strings":["Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110750072","display_name":"Bernhard Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard Roth","raw_affiliation_strings":["Department of Neonatology, Children's Hospital, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, Children's Hospital, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048118430","display_name":"Axel Heidenreich","orcid":"https://orcid.org/0000-0002-2511-3664","observed_orcids":["https://orcid.org/0000-0002-2511-3664"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Heidenreich","raw_affiliation_strings":["Department of Urology, University of Aachen, Pauwelsstrasse 30, 52074 Aachen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Aachen, Pauwelsstrasse 30, 52074 Aachen","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035910603","display_name":"Christian  Alexander Gutschow","orcid":"https://orcid.org/0000-0001-6171-4427","observed_orcids":["https://orcid.org/0000-0001-6171-4427"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Gutschow","raw_affiliation_strings":["Department of General and Abdominal Surgery, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Abdominal Surgery, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111833104","display_name":"Wilhelm Krone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wilhelm Krone","raw_affiliation_strings":["Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany","Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084869561","display_name":"Matthias Laudes","orcid":"https://orcid.org/0000-0002-7846-955X","observed_orcids":["https://orcid.org/0000-0002-7846-955X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Laudes","raw_affiliation_strings":["Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II and Centre of Molecular Medicine, University of Cologne, Kerpener Strasse 62, 50937 K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084869561"],"corresponding_institution_ids":["https://openalex.org/I180923762"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.3289,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.92003823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"285","issue":"9","first_page":"6170","last_page":"6178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/preadipocytes","display_name":"preadipocytes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.968999981880188},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.8270000219345093},{"id":"https://openalex.org/keywords/non-canonical-wnt-signaling","display_name":"non-canonical Wnt signaling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/multipotency","display_name":"multipotency","score":0.6620000004768372},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.8975250720977783},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8760258555412292},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8347663283348083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6668030023574829},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.45902734994888306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45161205530166626},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.448879212141037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4425332248210907},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.43311607837677},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27724093198776245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25941866636276245}],"mesh":[{"descriptor_ui":"D000071818","descriptor_name":"Wnt-5a Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071818","descriptor_name":"Wnt-5a Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071818","descriptor_name":"Wnt-5a Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m109.054338","doi":"https://doi.org/10.1074/jbc.m109.054338","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.054338","pdf_url":"http://www.jbc.org/article/S002192581937783X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:20032469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20032469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2048965","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2825412","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2825412","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2825412","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:publications.rwth-aachen.de:184769","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/184769","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The journal of biological chemistry : JBC 285(9), 6170-6178 (2010). doi:10.1074/jbc.M109.054338","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.054338","doi":"https://doi.org/10.1074/jbc.m109.054338","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.054338","pdf_url":"http://www.jbc.org/article/S002192581937783X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129409686.pdf","grobid_xml":"https://content.openalex.org/works/W2129409686.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W179583434","https://openalex.org/W1494249446","https://openalex.org/W1941626479","https://openalex.org/W1965079305","https://openalex.org/W1965766281","https://openalex.org/W1966401884","https://openalex.org/W1966650637","https://openalex.org/W1974530613","https://openalex.org/W1983609530","https://openalex.org/W1990851733","https://openalex.org/W1994367371","https://openalex.org/W1994586809","https://openalex.org/W1997432717","https://openalex.org/W2002341492","https://openalex.org/W2002481407","https://openalex.org/W2004856977","https://openalex.org/W2005347754","https://openalex.org/W2007215297","https://openalex.org/W2008527819","https://openalex.org/W2009244520","https://openalex.org/W2010221831","https://openalex.org/W2010506107","https://openalex.org/W2012334457","https://openalex.org/W2012880157","https://openalex.org/W2013200752","https://openalex.org/W2013205339","https://openalex.org/W2022505715","https://openalex.org/W2025744983","https://openalex.org/W2025991178","https://openalex.org/W2028256918","https://openalex.org/W2029194147","https://openalex.org/W2038017431","https://openalex.org/W2040169444","https://openalex.org/W2043129312","https://openalex.org/W2051844485","https://openalex.org/W2053780981","https://openalex.org/W2062356630","https://openalex.org/W2062730435","https://openalex.org/W2067096633","https://openalex.org/W2067542470","https://openalex.org/W2069496596","https://openalex.org/W2072087746","https://openalex.org/W2078600768","https://openalex.org/W2079819294","https://openalex.org/W2082122713","https://openalex.org/W2084771679","https://openalex.org/W2086267795","https://openalex.org/W2087959682","https://openalex.org/W2092494241","https://openalex.org/W2096571949","https://openalex.org/W2097899015","https://openalex.org/W2103347314","https://openalex.org/W2104668978","https://openalex.org/W2105054202","https://openalex.org/W2106613179","https://openalex.org/W2106837751","https://openalex.org/W2110330424","https://openalex.org/W2112121424","https://openalex.org/W2113619226","https://openalex.org/W2114912181","https://openalex.org/W2116465977","https://openalex.org/W2119284420","https://openalex.org/W2122803804","https://openalex.org/W2123039189","https://openalex.org/W2128801342","https://openalex.org/W2131525837","https://openalex.org/W2137483556","https://openalex.org/W2137508766","https://openalex.org/W2137911781","https://openalex.org/W2138924822","https://openalex.org/W2141108067","https://openalex.org/W2143768875","https://openalex.org/W2144291299","https://openalex.org/W2144511462","https://openalex.org/W2147830182","https://openalex.org/W2149340540","https://openalex.org/W2157229547","https://openalex.org/W2158315345","https://openalex.org/W2158963518","https://openalex.org/W2163270865","https://openalex.org/W2164012871","https://openalex.org/W2166254889","https://openalex.org/W2168536185","https://openalex.org/W2168581752","https://openalex.org/W2168730320","https://openalex.org/W2278906020","https://openalex.org/W2342149286","https://openalex.org/W2412060960"],"related_works":["https://openalex.org/W2084245009","https://openalex.org/W3145437501","https://openalex.org/W2118126928","https://openalex.org/W2141824926","https://openalex.org/W2626142573","https://openalex.org/W2116726599","https://openalex.org/W2908320623","https://openalex.org/W2921972886","https://openalex.org/W2113286739","https://openalex.org/W3217615580"],"abstract_inverted_index":{"Increasing":[0],"adipocyte":[1],"size":[2],"as":[3,5],"well":[4],"numbers":[6],"is":[7,61,227],"important":[8,152],"in":[9,59,89,141,153,162,202,210,245,250],"the":[10,29,40,49,57,86,90,154,211],"development":[11],"of":[12,31,42,51,102,159,205,213,220,233,238],"obesity":[13],"and":[14,39,71,78,99,105,118,235],"type":[15],"2":[16],"diabetes,":[17],"with":[18,144],"adipocytes":[19,117],"being":[20],"generated":[21],"from":[22],"mesenchymal":[23,32,104],"precursor":[24],"cells.":[25,47],"This":[26],"process":[27,50],"includes":[28],"determination":[30,58,91,155,247],"stem":[33],"cells":[34],"(MSC)":[35],"into":[36,44,85,116,248],"preadipocytes":[37],"(PA)":[38],"differentiation":[41,52],"PA":[43,74,120,129,145,249],"mature":[45],"fat":[46],"Although":[48],"has":[53],"been":[54],"highly":[55],"investigated,":[56],"humans":[60],"poorly":[62],"understood.":[63],"In":[64],"this":[65,206],"study,":[66],"we":[67],"compared":[68,143],"human":[69,72,160],"MSC":[70,111,142,161,234],"committed":[73],"on":[75],"a":[76,189,243],"cellular":[77],"molecular":[79,190],"level":[80],"to":[81,114,124,171,195,229],"gain":[82],"further":[83,216],"insights":[84],"regulatory":[87],"mechanisms":[88],"process.":[92,156],"Both":[93],"cell":[94],"types":[95],"showed":[96,137],"similar":[97],"morphology":[98],"expression":[100,136,215],"patterns":[101],"common":[103],"hematopoietic":[106],"surface":[107],"markers.":[108],"However,":[109],"although":[110,174],"were":[112,121],"able":[113,123],"differentiate":[115],"osteocytes,":[119],"only":[122],"undergo":[125,172],"adipogenesis,":[126],"indicating":[127,217],"that":[128,147,225,236],"lost":[130],"their":[131,169,246],"multipotency":[132],"during":[133],"determination.":[134],"WNT-5a":[135,148,166,186,192,226,239],"significantly":[138],"higher":[139],"levels":[140],"suggesting":[146],"down-regulation":[149],"might":[150],"be":[151],"Indeed,":[157],"incubation":[158],"medium":[163],"containing":[164],"neutralizing":[165],"antibodies":[167],"abolished":[168],"ability":[170],"osteogenesis,":[173],"adipogenesis":[175],"was":[176,182,193],"still":[177],"possible.":[178],"An":[179],"opposite":[180],"effect":[181],"achieved":[183],"using":[184],"recombinant":[185],"protein.":[187],"On":[188],"level,":[191],"found":[194],"promote":[196],"c-Jun":[197],"N-terminal":[198],"kinase-dependent":[199],"intracellular":[200],"signaling":[201,240],"MSC.":[203],"Activation":[204],"noncanonical":[207],"pathway":[208],"resulted":[209],"induction":[212],"osteopontin":[214],"pro-osteogenic":[218],"effects":[219],"WNT-5a.":[221],"Our":[222],"data":[223],"suggest":[224],"necessary":[228],"maintain":[230],"osteogenic":[231],"potential":[232],"inhibition":[237],"therefore":[241],"plays":[242],"role":[244],"humans.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}