{"id":"https://openalex.org/W2129390724","doi":"https://doi.org/10.1158/1078-0432.ccr-11-2087","title":"Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non\u2013Small Cell Lung Cancer Patients","display_name":"Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non\u2013Small Cell Lung Cancer Patients","publication_year":2012,"publication_date":"2012-01-15","ids":{"openalex":"https://openalex.org/W2129390724","doi":"https://doi.org/10.1158/1078-0432.ccr-11-2087","mag":"2129390724","pmid":"https://pubmed.ncbi.nlm.nih.gov/22252258","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3373176"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-11-2087","doi":"https://doi.org/10.1158/1078-0432.ccr-11-2087","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-11-2087","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3373176","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Klaus W. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klaus W. Wagner","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082365305","display_name":"Yuanqing Ye","orcid":"https://orcid.org/0000-0001-5708-8961","observed_orcids":["https://orcid.org/0000-0001-5708-8961"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanqing Ye","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684204","display_name":"Jie Ming Lin","orcid":"https://orcid.org/0000-0002-0150-0264","observed_orcids":["https://orcid.org/0000-0002-0150-0264"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Lin","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049826084","display_name":"Ara Asadur Vaporciyan","orcid":"https://orcid.org/0000-0002-2060-3584","observed_orcids":["https://orcid.org/0000-0002-2060-3584"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ara A. Vaporciyan","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027152610","display_name":"Jack A. Roth","orcid":"https://orcid.org/0000-0002-8955-1313","observed_orcids":["https://orcid.org/0000-0002-8955-1313"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack A. Roth","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066957198","display_name":"Xifeng Wu","orcid":"https://orcid.org/0000-0001-5174-3769","observed_orcids":["https://orcid.org/0000-0001-5174-3769"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xifeng Wu","raw_affiliation_strings":["Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Division of Cancer Medicine, and Departments of 2Epidemiology and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066957198"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":3.2393,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.92348834,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"2","first_page":"585","last_page":"592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.14180000126361847,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/early-stage-lung-cancer","display_name":"early-stage lung cancer","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7919999957084656},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8809999823570251},{"id":"https://openalex.org/keywords/epigenetic-genes","display_name":"epigenetic genes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.8980000019073486},{"id":"https://openalex.org/keywords/methyl-cpg-binding-proteins","display_name":"methyl-CpG binding proteins","score":0.9440000057220459},{"id":"https://openalex.org/keywords/o6-methylguanine-dna-methyltransferase","display_name":"O6-methylguanine-DNA methyltransferase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9390000104904175},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.759091854095459},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6384985446929932},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6071428060531616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6021230220794678},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.509425938129425},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.49096181988716125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4875568747520447},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45232897996902466},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.43516767024993896},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.43414732813835144},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4267582893371582},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.38854551315307617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32415997982025146},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29516464471817017},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21723824739456177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18913161754608154},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.11718213558197021},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015257","descriptor_name":"DNA-Cytosine Methylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-11-2087","doi":"https://doi.org/10.1158/1078-0432.ccr-11-2087","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-11-2087","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:22252258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22252258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2378712","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3373176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3373176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3373176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2378712","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3373176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3423162581","display_name":"Research Training in Academic Medical Oncology","funder_award_id":"T32CA009666","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4737797335","display_name":"Lung Cancer Chemoradiation: Predictors of Survival","funder_award_id":"R01CA111646","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5746294","display_name":"Targeting Lung Cancer Vulnerabilities","funder_award_id":"P50CA070907","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6692776045","display_name":"Epigenetic miRNA, SNP Signatures, and their Functions in Lung Cancer Outcomes","funder_award_id":"R01CA176568","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W166525381","https://openalex.org/W2036427175","https://openalex.org/W2067727760","https://openalex.org/W2084001490","https://openalex.org/W2115157373","https://openalex.org/W2121277505","https://openalex.org/W2132165198","https://openalex.org/W2135525589","https://openalex.org/W2143372384","https://openalex.org/W2147560440","https://openalex.org/W2150688669","https://openalex.org/W2166246430","https://openalex.org/W2168150041","https://openalex.org/W6607900426"],"related_works":["https://openalex.org/W2300486941","https://openalex.org/W2072860556","https://openalex.org/W3046180555","https://openalex.org/W2081260992","https://openalex.org/W1537598859","https://openalex.org/W2147560440","https://openalex.org/W2244969468","https://openalex.org/W4410948204","https://openalex.org/W2125679632","https://openalex.org/W2982085550"],"abstract_inverted_index":{"PURPOSE:":[0],"Early-stage":[1],"non-small":[2],"cell":[3],"lung":[4,59],"cancer":[5,60,89],"(NSCLC)":[6],"is":[7,32],"potentially":[8],"curable,":[9],"however,":[10],"many":[11],"patients":[12,93,138,146,181,191,227],"develop":[13],"recurrent":[14],"disease.":[15],"Therefore,":[16],"identification":[17],"of":[18,28,40,47,58,75,158,167,178,199,207,216,242],"biomarkers":[19,224],"that":[20,132,155,174],"can":[21],"be":[22,122,219],"used":[23,220],"to":[24,54,121,225,247],"predict":[25,245],"patient's":[26],"risk":[27,57,166,177],"recurrence":[29,90,179],"and":[30,42,85,150,209,238],"survival":[31],"critical.":[33],"Genetic":[34],"polymorphisms":[35,38],"or":[36,97,108],"single-nucleotide":[37],"(SNP)":[39],"DNA-":[41],"histone-modifying":[43],"genes,":[44,82],"particularly":[45],"those":[46],"O(6)-methylguanine":[48],"DNA-methyltransferase":[49],"(MGMT),":[50],"have":[51],"been":[52],"linked":[53],"an":[55],"increased":[56],"as":[61,63,221],"well":[62],"treatment":[64],"outcomes":[65,204],"in":[66,78,91,137,145,180,190],"other":[67],"tumors.":[68],"EXPERIMENTAL":[69],"DESIGN:":[70],"We":[71,117,128,169],"assessed":[72],"the":[73,135,156,163,176,239],"association":[74],"165":[76],"SNPs":[77,120,131,173,201,243],"selected":[79],"epigenetic":[80],"enzyme":[81],"DNA":[83],"methyltransferases,":[84],"methyl-CpG-binding":[86],"proteins":[87],"with":[88,94,101,125,134,140,148,183,193,205,228],"467":[92],"stage":[95,229],"I":[96,230],"II":[98],"NSCLC":[99],"treated":[100,139,147,182,192],"either":[102],"surgery":[103,109,141,149,184,194],"alone":[104,142],"(N":[105,113],"=":[106,114],"340)":[107],"plus":[110,185],"(neo)-adjuvant":[111],"chemotherapy":[112,160,187],"127).":[115],"RESULTS:":[116],"found":[118],"several":[119],"strongly":[123],"correlated":[124,133],"tumor":[126],"recurrence.":[127,168],"identified":[129,171],"10":[130,172],"outcome":[136],"but":[143,188],"not":[144,189],"adjuvant":[151,186,236,248],"chemotherapy,":[152,237],"which":[153],"suggested":[154],"addition":[157],"platinum-based":[159],"could":[161,233],"reverse":[162],"high":[164],"genetic":[165],"also":[170],"predicted":[175,203],"alone.":[195],"The":[196,213],"cumulative":[197],"effect":[198],"these":[200],"significantly":[202],"P-values":[206],"10(-9)":[208],"10(-6),":[210],"respectively.":[211],"CONCLUSIONS:":[212],"first":[214],"set":[215,241],"genotypes":[217],"may":[218],"novel":[222],"predictive":[223],"identify":[226],"NSCLC,":[231],"who":[232],"benefit":[234],"from":[235],"second":[240],"might":[244],"response":[246],"chemotherapy.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
