{"id":"https://openalex.org/W2129382918","doi":"https://doi.org/10.1152/physiolgenomics.90216.2008","title":"Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise","display_name":"Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise","publication_year":2008,"publication_date":"2008-11-26","ids":{"openalex":"https://openalex.org/W2129382918","doi":"https://doi.org/10.1152/physiolgenomics.90216.2008","mag":"2129382918","pmid":"https://pubmed.ncbi.nlm.nih.gov/19033545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646458"},"language":"en","primary_location":{"id":"doi:10.1152/physiolgenomics.90216.2008","doi":"https://doi.org/10.1152/physiolgenomics.90216.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.90216.2008","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646458","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040733201","display_name":"Ira J. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira J. Smith","raw_affiliation_strings":["Center for the Study of Aging, Veterans Affairs Medical Center, Durham, North Carolina","Division of Cardiovascular Medicine, Veterans Affairs Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Aging, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210139568"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061496543","display_name":"Kim M. Huffman","orcid":"https://orcid.org/0000-0003-4708-4734","observed_orcids":["https://orcid.org/0000-0003-4708-4734"]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim M. Huffman","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, Veterans Affairs Medical Center, Durham, North Carolina","Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210139568"]},{"raw_affiliation_string":"Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015468225","display_name":"Michael T. Durheim","orcid":"https://orcid.org/0000-0002-4186-5698","observed_orcids":["https://orcid.org/0000-0002-4186-5698"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Durheim","raw_affiliation_strings":["School of Medicine, Duke University Medical Center, Veterans Affairs Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Duke University Medical Center, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088050924","display_name":"Brian D. Duscha","orcid":"https://orcid.org/0000-0002-3257-6157","observed_orcids":["https://orcid.org/0000-0002-3257-6157"]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Duscha","raw_affiliation_strings":["Duke Center for Living, Veterans Affairs Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Center for Living, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017226394","display_name":"William E. Kraus","orcid":"https://orcid.org/0000-0003-1930-9684","observed_orcids":["https://orcid.org/0000-0003-1930-9684"]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Kraus","raw_affiliation_strings":["Division of Cardiovascular Medicine, Veterans Affairs Medical Center, Durham, North Carolina","Duke Center for Living, Veterans Affairs Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210139568"]},{"raw_affiliation_string":"Duke Center for Living, Veterans Affairs Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210139568"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5778,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81330209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"36","issue":"3","first_page":"149","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.3253999948501587,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.3253999948501587,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.09489999711513519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endurance-training","display_name":"endurance training","score":0.8510000109672546},{"id":"https://openalex.org/keywords/skeletal-muscle-lipid-metabolism","display_name":"skeletal muscle lipid metabolism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8500000238418579},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7070000171661377},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.953000009059906},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.652999997138977},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ppargamma-coactivator-1alpha","display_name":"PPAR\u03b3 coactivator-1\u03b1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/diacylglycerol-acyltransferase-1","display_name":"diacylglycerol acyltransferase 1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acid-ceramidase","display_name":"acid ceramidase","score":0.996999979019165},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.9900000095367432},{"id":"https://openalex.org/keywords/serine-palmitoyltransferase","display_name":"serine palmitoyltransferase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lipogenic-genes","display_name":"lipogenic genes","score":0.6869999766349792},{"id":"https://openalex.org/keywords/middle-aged-adults","display_name":"middle-aged adults","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7810821533203125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7706506252288818},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7090230584144592},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6515380144119263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6443566679954529},{"id":"https://openalex.org/C2777062983","wikidata":"https://www.wikidata.org/wiki/Q21126841","display_name":"Adipose triglyceride lipase","level":4,"score":0.5806550979614258},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.5587636828422546},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.25086796283721924},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2373797595500946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17838504910469055}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051048","descriptor_name":"Diacylglycerol O-Acyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051048","descriptor_name":"Diacylglycerol O-Acyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1152/physiolgenomics.90216.2008","doi":"https://doi.org/10.1152/physiolgenomics.90216.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.90216.2008","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2646458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646458","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiol Genomics","raw_type":"Text"},{"id":"pmid:19033545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19033545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological genomics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.7834","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.7834","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://physiolgenomics.physiology.org/content/early/2008/11/25/physiolgenomics.90216.2008.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.3892","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.3892","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://physiolgenomics.physiology.org/content/36/3/149.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2646458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646458","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiol Genomics","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3987394949","display_name":"Peripheral Effects of Exercise on Cardiovascular Health","funder_award_id":"R01HL057354","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000889663","display_name":"Behavior and Physiology in Aging","funder_award_id":"T32AG000029","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1789862167","https://openalex.org/W1967737207","https://openalex.org/W1977797609","https://openalex.org/W1981033063","https://openalex.org/W1984413737","https://openalex.org/W1990943826","https://openalex.org/W2009318817","https://openalex.org/W2060063228","https://openalex.org/W2067950835","https://openalex.org/W2074327931","https://openalex.org/W2087773356","https://openalex.org/W2097505907","https://openalex.org/W2099337292","https://openalex.org/W2100779832","https://openalex.org/W2103453276","https://openalex.org/W2105244824","https://openalex.org/W2106693109","https://openalex.org/W2108462699","https://openalex.org/W2114452637","https://openalex.org/W2122036452","https://openalex.org/W2124259065","https://openalex.org/W2127262263","https://openalex.org/W2130850001","https://openalex.org/W2130919437","https://openalex.org/W2131149701","https://openalex.org/W2133290655","https://openalex.org/W2135525732","https://openalex.org/W2136520694","https://openalex.org/W2137574569","https://openalex.org/W2137842897","https://openalex.org/W2138480902","https://openalex.org/W2142416266","https://openalex.org/W2152024683","https://openalex.org/W2154768987","https://openalex.org/W2167485048","https://openalex.org/W2168588760","https://openalex.org/W2171699473","https://openalex.org/W2171977696","https://openalex.org/W2417001068"],"related_works":["https://openalex.org/W173374815","https://openalex.org/W7098177766","https://openalex.org/W2099337292","https://openalex.org/W2009318817","https://openalex.org/W1571850259","https://openalex.org/W4411329428","https://openalex.org/W2005342581","https://openalex.org/W814238211","https://openalex.org/W2626199106","https://openalex.org/W7100316817"],"abstract_inverted_index":{"Endurance":[0],"exercise":[1],"(EE)":[2],"leads":[3,44],"to":[4,34,45,74,141,171],"beneficial":[5],"alterations":[6,46,195],"in":[7,12,47,56,81,143,160,167,173,196,224,230],"skeletal":[8,57,118],"muscle":[9,58,119,144],"lipid":[10,53,100,201],"metabolism":[11,54,101,202],"overweight":[13,60,210],"and":[14,61,65,87,95,108,123,156,186,211,215],"obese":[15,62,212],"individuals;":[16],"however,":[17],"the":[18,30,36,48,76,128,174,178,197,200],"mechanisms":[19],"of":[20,29,51,59,70,92,131,134,138,177,199],"these":[21,222],"improvements":[22],"are":[23,206],"poorly":[24],"understood.":[25],"The":[26,89],"primary":[27],"goal":[28],"current":[31],"investigation":[32],"was":[33,73],"test":[35],"hypothesis":[37,77],"that":[38,78,193],"long-term":[39],"EE":[40,139,169],"training":[41],"(6":[42],"mo)":[43],"mRNA":[49,82,90,159,175,225],"abundance":[50,91,198],"key":[52],"enzymes":[55],"middle-aged":[63,213],"women":[64,86,214],"men.":[66,88,164,216],"A":[67],"secondary":[68],"aim":[69],"this":[71],"study":[72],"investigate":[75],"exercise-mediated":[79],"adaptations":[80,223],"levels":[83,226],"differ":[84],"between":[85,209],"representative":[93,106],"lipogenic":[94,107,179],"lipolytic":[96,109],"genes":[97,203],"from":[98,117],"major":[99],"pathways,":[102],"as":[103,105],"well":[104],"transcription":[110],"factors,":[111],"were":[112],"determined":[113],"by":[114],"real-time":[115],"PCR":[116],"biopsies":[120],"collected":[121],"before":[122],"approximately":[124],"24":[125],"h":[126],"after":[127],"final":[129],"bout":[130],"6":[132],"mo":[133],"EE.":[135],"Six":[136],"months":[137],"led":[140,170],"increases":[142],"lipoprotein":[145],"lipase,":[146],"peroxisome":[147],"proliferator-activated":[148],"receptor-gamma":[149],"coactivator-1alpha,":[150],"carnitine":[151],"palmitoyltransferase-1":[152],"beta,":[153],"diacylglycerol":[154],"acyltransferase-1,":[155],"acid":[157],"ceramidase":[158],"women,":[161],"but":[162],"not":[163],"In":[165],"contrast,":[166],"men,":[168],"reductions":[172],"content":[176],"factors":[180],"sterol":[181],"regulatory":[182],"element":[183],"binding":[184],"protein-1c":[185],"serine":[187],"palmitoyl":[188],"transferase.":[189],"These":[190],"data":[191],"suggest":[192],"EE-mediated":[194],"studied":[204],"here":[205],"fundamentally":[207],"different":[208],"Future":[217],"studies":[218],"should":[219],"determine":[220],"whether":[221],"translate":[227],"into":[228],"changes":[229],"protein":[231],"function.":[232]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}