{"id":"https://openalex.org/W2129377253","doi":"https://doi.org/10.1146/annurev-nutr-071813-105541","title":"Acyl-CoA Metabolism and Partitioning","display_name":"Acyl-CoA Metabolism and Partitioning","publication_year":2014,"publication_date":"2014-04-18","ids":{"openalex":"https://openalex.org/W2129377253","doi":"https://doi.org/10.1146/annurev-nutr-071813-105541","mag":"2129377253","pmid":"https://pubmed.ncbi.nlm.nih.gov/24819326","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5881898"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-nutr-071813-105541","doi":"https://doi.org/10.1146/annurev-nutr-071813-105541","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-nutr-071813-105541","pdf_url":null,"source":{"id":"https://openalex.org/S160110530","display_name":"Annual Review of Nutrition","issn_l":"0199-9885","issn":["0199-9885","1545-4312"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Nutrition","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5881898/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017540265","display_name":"Trisha Jean Grevengoed","orcid":"https://orcid.org/0000-0003-4433-3950","observed_orcids":["https://orcid.org/0000-0003-4433-3950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trisha J. Grevengoed","raw_affiliation_strings":["Department of Nutrition and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041040082","display_name":"Eric L. Klett","orcid":"https://orcid.org/0000-0002-8000-6810","observed_orcids":["https://orcid.org/0000-0002-8000-6810"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Klett","raw_affiliation_strings":["Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599;","Endocrinology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599;","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Endocrinology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021007054","display_name":"Rosalind Coleman","orcid":"https://orcid.org/0000-0003-4379-3824","observed_orcids":["https://orcid.org/0000-0003-4379-3824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalind A. Coleman","raw_affiliation_strings":["Department of Nutrition and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.849,"has_fulltext":false,"cited_by_count":462,"citation_normalized_percentile":{"value":0.88452088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"34","issue":"1","first_page":"1","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.3889000117778778,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-coa-metabolism","display_name":"acyl-CoA metabolism","score":0.9259999990463257},{"id":"https://openalex.org/keywords/fatty-acid-activation","display_name":"fatty acid activation","score":0.968999981880188},{"id":"https://openalex.org/keywords/metabolic-intermediates","display_name":"metabolic intermediates","score":0.5559999942779541},{"id":"https://openalex.org/keywords/triacylglycerol-biosynthesis","display_name":"triglyceride synthesis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/phospholipid-synthesis","display_name":"phospholipid synthesis","score":0.847000002861023},{"id":"https://openalex.org/keywords/cholesteryl-ester-synthesis","display_name":"cholesteryl ester synthesis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.7919999957084656},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C2779685201","wikidata":"https://www.wikidata.org/wiki/Q2699537","display_name":"Acyl-CoA","level":3,"score":0.7245738506317139},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6915183067321777},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.664204478263855},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6531945466995239},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5839296579360962},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.563381016254425},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5612958073616028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5459039807319641},{"id":"https://openalex.org/C2781113356","wikidata":"https://www.wikidata.org/wiki/Q4864654","display_name":"Metabolic intermediate","level":3,"score":0.4963281750679016},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.47119995951652527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3666648268699646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19261035323143005},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003066","descriptor_name":"Coenzyme A Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050612","descriptor_name":"Fatty Acid Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050612","descriptor_name":"Fatty Acid Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1146/annurev-nutr-071813-105541","doi":"https://doi.org/10.1146/annurev-nutr-071813-105541","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-nutr-071813-105541","pdf_url":null,"source":{"id":"https://openalex.org/S160110530","display_name":"Annual Review of Nutrition","issn_l":"0199-9885","issn":["0199-9885","1545-4312"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Nutrition","raw_type":"journal-article"},{"id":"pmid:24819326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24819326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/2190f861-a27f-4924-bfe1-74b68fa1ce07","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/2190f861-a27f-4924-bfe1-74b68fa1ce07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Grevengoed, T J, Klett, E L & Coleman, R A 2014, 'Acyl-CoA metabolism and partitioning', Annual Review of Nutrition, vol. 34, pp. 1-30. https://doi.org/10.1146/annurev-nutr-071813-105541","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5881898","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5881898/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Nutr","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5881898","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5881898/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Nutr","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1276034686","display_name":"Acyl-CoA Synthetase: Structure, Function and Regulation","funder_award_id":"R01DK059935","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1894279353","display_name":"Role of acyl-CoA synthetases in mouse pancreatic ??-cell function","funder_award_id":"K08DK090141","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":209,"referenced_works":["https://openalex.org/W13114764","https://openalex.org/W36236453","https://openalex.org/W123784549","https://openalex.org/W163794720","https://openalex.org/W195890107","https://openalex.org/W1479945388","https://openalex.org/W1509847058","https://openalex.org/W1529306244","https://openalex.org/W1530046934","https://openalex.org/W1540140680","https://openalex.org/W1570662124","https://openalex.org/W1587435244","https://openalex.org/W1591547152","https://openalex.org/W1594318336","https://openalex.org/W1644344232","https://openalex.org/W1700809695","https://openalex.org/W1763805809","https://openalex.org/W1776131825","https://openalex.org/W1819563916","https://openalex.org/W1934878529","https://openalex.org/W1965700049","https://openalex.org/W1966870955","https://openalex.org/W1967849676","https://openalex.org/W1970300511","https://openalex.org/W1970641718","https://openalex.org/W1972168184","https://openalex.org/W1973662608","https://openalex.org/W1974581269","https://openalex.org/W1976702450","https://openalex.org/W1977667620","https://openalex.org/W1978552062","https://openalex.org/W1979794194","https://openalex.org/W1980057782","https://openalex.org/W1980321222","https://openalex.org/W1980568044","https://openalex.org/W1981222875","https://openalex.org/W1982301089","https://openalex.org/W1983421509","https://openalex.org/W1986813347","https://openalex.org/W1987088213","https://openalex.org/W1987787422","https://openalex.org/W1987919833","https://openalex.org/W1988447693","https://openalex.org/W1990589135","https://openalex.org/W1991876528","https://openalex.org/W1992956691","https://openalex.org/W1994271130","https://openalex.org/W1994455967","https://openalex.org/W1995129162","https://openalex.org/W1997223805","https://openalex.org/W2000360891","https://openalex.org/W2000471969","https://openalex.org/W2000642937","https://openalex.org/W2000692520","https://openalex.org/W2001631164","https://openalex.org/W2002573790","https://openalex.org/W2005157714","https://openalex.org/W2006375647","https://openalex.org/W2006994587","https://openalex.org/W2009240157","https://openalex.org/W2009437300","https://openalex.org/W2011767986","https://openalex.org/W2012483858","https://openalex.org/W2012890116","https://openalex.org/W2013862513","https://openalex.org/W2015259264","https://openalex.org/W2017176768","https://openalex.org/W2018062124","https://openalex.org/W2019829898","https://openalex.org/W2020538044","https://openalex.org/W2021334001","https://openalex.org/W2021900382","https://openalex.org/W2022336683","https://openalex.org/W2022626924","https://openalex.org/W2023785133","https://openalex.org/W2025408537","https://openalex.org/W2025578932","https://openalex.org/W2025650515","https://openalex.org/W2026644276","https://openalex.org/W2027702041","https://openalex.org/W2027874598","https://openalex.org/W2029101691","https://openalex.org/W2031555775","https://openalex.org/W2031846075","https://openalex.org/W2033689828","https://openalex.org/W2036051146","https://openalex.org/W2037597845","https://openalex.org/W2037637049","https://openalex.org/W2037918439","https://openalex.org/W2039531356","https://openalex.org/W2041351622","https://openalex.org/W2042567485","https://openalex.org/W2044731074","https://openalex.org/W2045619830","https://openalex.org/W2046631083","https://openalex.org/W2049318107","https://openalex.org/W2051403503","https://openalex.org/W2051581852","https://openalex.org/W2052378749","https://openalex.org/W2053012302","https://openalex.org/W2053837499","https://openalex.org/W2054248098","https://openalex.org/W2054800964","https://openalex.org/W2055232941","https://openalex.org/W2057095795","https://openalex.org/W2057455189","https://openalex.org/W2059275312","https://openalex.org/W2059867106","https://openalex.org/W2060503560","https://openalex.org/W2060952287","https://openalex.org/W2061361921","https://openalex.org/W2064702379","https://openalex.org/W2065913635","https://openalex.org/W2066845483","https://openalex.org/W2066944932","https://openalex.org/W2069297347","https://openalex.org/W2069573236","https://openalex.org/W2070102104","https://openalex.org/W2073463418","https://openalex.org/W2073636275","https://openalex.org/W2075023203","https://openalex.org/W2075574260","https://openalex.org/W2076831564","https://openalex.org/W2077753425","https://openalex.org/W2078905435","https://openalex.org/W2079386976","https://openalex.org/W2081642846","https://openalex.org/W2082877035","https://openalex.org/W2084526009","https://openalex.org/W2086853859","https://openalex.org/W2087563317","https://openalex.org/W2091614510","https://openalex.org/W2091900359","https://openalex.org/W2091994022","https://openalex.org/W2092769513","https://openalex.org/W2093656658","https://openalex.org/W2093672729","https://openalex.org/W2094091679","https://openalex.org/W2095659152","https://openalex.org/W2096135945","https://openalex.org/W2099512289","https://openalex.org/W2100855877","https://openalex.org/W2102940990","https://openalex.org/W2103267495","https://openalex.org/W2104216656","https://openalex.org/W2104540277","https://openalex.org/W2105110220","https://openalex.org/W2106694937","https://openalex.org/W2110738761","https://openalex.org/W2111993410","https://openalex.org/W2112323767","https://openalex.org/W2112669923","https://openalex.org/W2113557359","https://openalex.org/W2113824754","https://openalex.org/W2115332847","https://openalex.org/W2115714968","https://openalex.org/W2116205530","https://openalex.org/W2117820310","https://openalex.org/W2119595824","https://openalex.org/W2120467074","https://openalex.org/W2124753768","https://openalex.org/W2125404675","https://openalex.org/W2127498339","https://openalex.org/W2128522314","https://openalex.org/W2129326001","https://openalex.org/W2130586614","https://openalex.org/W2132919883","https://openalex.org/W2133285158","https://openalex.org/W2133800593","https://openalex.org/W2133849172","https://openalex.org/W2134016419","https://openalex.org/W2135386829","https://openalex.org/W2136039410","https://openalex.org/W2137229556","https://openalex.org/W2138367727","https://openalex.org/W2138486337","https://openalex.org/W2139399016","https://openalex.org/W2139593118","https://openalex.org/W2141798047","https://openalex.org/W2143349038","https://openalex.org/W2148261607","https://openalex.org/W2148427109","https://openalex.org/W2149294491","https://openalex.org/W2151091815","https://openalex.org/W2152285341","https://openalex.org/W2153178365","https://openalex.org/W2154582742","https://openalex.org/W2158224682","https://openalex.org/W2158326572","https://openalex.org/W2158609797","https://openalex.org/W2159695068","https://openalex.org/W2159868923","https://openalex.org/W2160134374","https://openalex.org/W2160264312","https://openalex.org/W2164102960","https://openalex.org/W2164277931","https://openalex.org/W2165464486","https://openalex.org/W2165574517","https://openalex.org/W2178164598","https://openalex.org/W2182635476","https://openalex.org/W2187882718","https://openalex.org/W2209913555","https://openalex.org/W2235424783","https://openalex.org/W2267251168","https://openalex.org/W2336686047","https://openalex.org/W2340951843","https://openalex.org/W2411968291","https://openalex.org/W4232708467","https://openalex.org/W4299365787"],"related_works":["https://openalex.org/W2210368407","https://openalex.org/W1972669645","https://openalex.org/W1910630598","https://openalex.org/W2030878833","https://openalex.org/W1974020172","https://openalex.org/W2032611127","https://openalex.org/W1986813347","https://openalex.org/W2065597493","https://openalex.org/W4381595103","https://openalex.org/W2891325408"],"abstract_inverted_index":{"Long-chain":[0],"fatty":[1,22],"acyl-coenzyme":[2],"As":[3],"(CoAs)":[4],"are":[5,34,62,81,121],"critical":[6],"regulatory":[7],"molecules":[8],"and":[9,37,43,52,61,67,74,99,136,150],"metabolic":[10,50,79,97,129,148],"intermediates.":[11],"The":[12],"initial":[13],"step":[14],"in":[15,144],"their":[16],"synthesis":[17],"is":[18],"the":[19,90,102,109,128,137,145],"activation":[20],"of":[21,26,86,131,133,140,147],"acids":[23],"by":[24,83,114],"one":[25],"13":[27],"long-chain":[28],"acyl-CoA":[29,47,112,126,142],"synthetase":[30],"isoforms.":[31],"These":[32],"isoforms":[33],"regulated":[35],"independently":[36],"have":[38],"different":[39],"tissue":[40],"expression":[41],"patterns":[42],"subcellular":[44],"locations.":[45],"Their":[46,77],"products":[48],"regulate":[49],"enzymes":[51],"signaling":[53],"pathways,":[54],"become":[55],"oxidized":[56],"to":[57,123,125],"provide":[58],"cellular":[59],"energy,":[60],"incorporated":[63],"into":[64],"acylated":[65],"proteins":[66,87,119],"complex":[68],"lipids":[69],"such":[70],"as":[71,101],"triacylglycerol,":[72],"phospholipids,":[73],"cholesterol":[75],"esters.":[76],"differing":[78],"fates":[80],"determined":[82],"a":[84],"network":[85],"that":[88,120],"channel":[89],"acyl-CoAs":[91],"toward":[92],"or":[93],"away":[94],"from":[95],"specific":[96],"pathways":[98],"serve":[100],"basis":[103],"for":[104,111],"partitioning.":[105],"This":[106],"review":[107],"evaluates":[108],"evidence":[110],"partitioning":[113,143],"reviewing":[115],"experimental":[116],"data":[117],"on":[118],"believed":[122],"contribute":[124],"channeling,":[127],"consequences":[130],"loss":[132],"these":[134],"proteins,":[135],"potential":[138],"role":[139],"maladaptive":[141],"pathogenesis":[146],"disease":[149],"carcinogenesis.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":43},{"year":2024,"cited_by_count":59},{"year":2023,"cited_by_count":43},{"year":2022,"cited_by_count":71},{"year":2021,"cited_by_count":42},{"year":2020,"cited_by_count":59},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
