{"id":"https://openalex.org/W2129357983","doi":"https://doi.org/10.1186/1559-0275-10-5","title":"Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer\u2019s disease and age-matched control brains","display_name":"Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer\u2019s disease and age-matched control brains","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2129357983","doi":"https://doi.org/10.1186/1559-0275-10-5","mag":"2129357983","pmid":"https://pubmed.ncbi.nlm.nih.gov/23635041","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3648498"},"language":"en","primary_location":{"id":"doi:10.1186/1559-0275-10-5","doi":"https://doi.org/10.1186/1559-0275-10-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1559-0275-10-5","pdf_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/1559-0275-10-5","source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/1559-0275-10-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082574883","display_name":"Ilijana Begcevic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ilijana Begcevic","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063893436","display_name":"Hari Kosanam","orcid":"https://orcid.org/0000-0002-1407-5906","observed_orcids":["https://orcid.org/0000-0002-1407-5906"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hari Kosanam","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042130704","display_name":"Eduardo Mart\u00ednez\u2010Morillo","orcid":"https://orcid.org/0000-0003-3339-1362","observed_orcids":["https://orcid.org/0000-0003-3339-1362"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eduardo Mart\u00ednez-Morillo","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068897391","display_name":"Apostolos Dimitromanolakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Apostolos Dimitromanolakis","raw_affiliation_strings":["Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077316921","display_name":"Phedias Diamandis","orcid":"https://orcid.org/0000-0001-5291-9068","observed_orcids":["https://orcid.org/0000-0001-5291-9068"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Phedias Diamandis","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091542550","display_name":"Uro\u0161 Kuzmanov","orcid":"https://orcid.org/0000-0002-3502-6986","observed_orcids":["https://orcid.org/0000-0002-3502-6986"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Uros Kuzmanov","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085508118","display_name":"Lili\u2010Naz Hazrati","orcid":"https://orcid.org/0000-0003-2715-1485","observed_orcids":["https://orcid.org/0000-0003-2715-1485"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lili-Naz Hazrati","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084226800","display_name":"Eleftherios P. Diamandis","orcid":"https://orcid.org/0000-0002-1589-820X","observed_orcids":["https://orcid.org/0000-0002-1589-820X","https://orcid.org/0009-0000-8901-2072"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Eleftherios P Diamandis","raw_affiliation_strings":["Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada","Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 60 Murray St., Box 32, Floor 6, Rm. L6-201, Toronto, ON, M5T 3L9, Canada","Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 60 Murray St., Box 32, Floor 6, Rm. L6-201, Toronto, ON, M5T 3L9, Canada","institution_ids":["https://openalex.org/I1291836623"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084226800"],"corresponding_institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I210557978"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.483,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.88567636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hippocampal-proteome","display_name":"hippocampal proteome","score":0.875},{"id":"https://openalex.org/keywords/disease-biomarkers","display_name":"disease biomarkers","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8450000286102295},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.578000009059906},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.847000002861023},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8730000257492065},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.6899999976158142},{"id":"https://openalex.org/keywords/protein-identification","display_name":"protein identification","score":0.33899998664855957},{"id":"https://openalex.org/keywords/alzheimer-s-disease-pathogenesis","display_name":"Alzheimer's disease pathogenesis","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8442608118057251},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7293975949287415},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7124502658843994},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6035738587379456},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5825111865997314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5650359988212585},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.523037314414978},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5208340287208557},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.46913501620292664},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41441044211387634},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3921701908111572},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.378306120634079},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2957232594490051},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2913989722728729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22986763715744019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21850436925888062},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0901932418346405}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1186/1559-0275-10-5","doi":"https://doi.org/10.1186/1559-0275-10-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1559-0275-10-5","pdf_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/1559-0275-10-5","source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2647543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3648498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23635041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23635041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical proteomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3648498","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3648498/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Proteomics","raw_type":"Text"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/83009","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/83009","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0b00d721-2922-4af4-bdf9-8158170f0e4a/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:escholarship.mcgill.ca:xp68kn95f","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.mcgill.ca/concern/articles/xp68kn95f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://clinicalproteomicsjournal.biomedcentral.com/","raw_type":"Article"},{"id":"pmh:oai:mcgill.scholaris.ca:20.500.14905/82560","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14905/82560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"https://vocabularies.coar-repositories.org/resource_types/c_6501/"}],"best_oa_location":{"id":"doi:10.1186/1559-0275-10-5","doi":"https://doi.org/10.1186/1559-0275-10-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1559-0275-10-5","pdf_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/1559-0275-10-5","source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129357983.pdf","grobid_xml":"https://content.openalex.org/works/W2129357983.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W15770206","https://openalex.org/W1500549861","https://openalex.org/W1563543424","https://openalex.org/W1966929153","https://openalex.org/W1967823816","https://openalex.org/W1981848544","https://openalex.org/W1982341565","https://openalex.org/W1991880332","https://openalex.org/W2002181764","https://openalex.org/W2013391120","https://openalex.org/W2017966763","https://openalex.org/W2018609434","https://openalex.org/W2034286717","https://openalex.org/W2037249816","https://openalex.org/W2056015216","https://openalex.org/W2072325753","https://openalex.org/W2076253751","https://openalex.org/W2085851888","https://openalex.org/W2097925533","https://openalex.org/W2131478918","https://openalex.org/W2132786485","https://openalex.org/W2143047857","https://openalex.org/W2149862198","https://openalex.org/W2295393683","https://openalex.org/W2582524520"],"related_works":["https://openalex.org/W2273521132","https://openalex.org/W2094738799","https://openalex.org/W2918874992","https://openalex.org/W4289313872","https://openalex.org/W3134260018","https://openalex.org/W2986407147","https://openalex.org/W4406051353","https://openalex.org/W7199390626","https://openalex.org/W2134286669","https://openalex.org/W2981094360"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alzheimer's":[1],"disease":[2,81],"(AD)":[3],"is":[4],"the":[5,23,32,40,83,114,227],"most":[6,191],"common":[7],"type":[8],"of":[9,16,20,37,96,103,113,172,180,192,205,226,235,244],"dementia":[10],"affecting":[11],"people":[12],"over":[13],"65":[14],"years":[15],"age.":[17],"The":[18,233],"hallmarks":[19],"AD":[21,68,141,151,159,174,236,249,257],"are":[22,39],"extracellular":[24],"deposits":[25],"known":[26],"as":[27,65,201,255],"amyloid":[28],"\u03b2":[29],"plaques":[30],"and":[31,47,53,86,93,106,140,152,160,177,214,237,251],"intracellular":[33],"neurofibrillary":[34],"tangles,":[35],"both":[36,138],"which":[38,78],"principal":[41],"players":[42],"involved":[43,247],"in":[44,62,82,119,150,155,188,216,248],"synaptic":[45],"loss":[46],"neuronal":[48],"cell":[49],"death.":[50],"Tau":[51],"protein":[52],"A\u03b2":[54],"fragment":[55],"1-42":[56],"have":[57],"been":[58],"investigated":[59],"so":[60],"far":[61],"cerebrospinal":[63,165],"fluid":[64,166],"a":[66,100,202,242],"potential":[67,203],"biomarkers.":[69,259],"However,":[70],"an":[71],"urgent":[72],"need":[73,209],"to":[74,210],"identify":[75],"novel":[76],"biomarkers":[77,207],"will":[79],"capture":[80],"early":[84],"stages":[85],"with":[87,164],"better":[88],"specificity":[89],"remains.":[90],"High-throughput":[91],"proteomic":[92,222],"pathway":[94],"analysis":[95,223],"hippocampal":[97,230],"tissue":[98],"provides":[99,224],"valuable":[101],"source":[102,204],"disease-related":[104],"proteins":[105,126,146,154,163,176,184,194,240,245],"biomarker":[107],"candidates,":[108],"since":[109],"it":[110],"represents":[111],"one":[112,225],"earliest":[115],"affected":[116],"brain":[117,142],"regions":[118],"AD.":[120],"RESULTS:":[121],"In":[122],"this":[123],"study":[124],"2954":[125],"were":[127,147,185,195],"identified":[128],"(with":[129],"at":[130],"least":[131],"2":[132],"peptides":[133],"for":[134],"1203":[135],"proteins)":[136],"from":[137],"control":[139,156,161,182,238],"tissues.":[143],"Overall,":[144],"204":[145,173],"exclusively":[148],"detected":[149],"600":[153,181],"samples.":[157,218],"Comparing":[158],"exclusive":[162],"(CSF)":[167],"literature-based":[168],"proteome,":[169],"40":[170],"out":[171,179],"related":[175,183,239],"106":[178],"also":[186,253],"present":[187],"CSF.":[189],"As":[190],"these":[193],"extracellular/secretory":[196],"origin,":[197],"we":[198],"consider":[199],"them":[200],"candidate":[206],"that":[208],"be":[211],"further":[212],"studied":[213],"verified":[215],"CSF":[217],"CONCLUSIONS:":[219],"Our":[220],"semiquantitative":[221],"largest":[228],"human":[229],"proteome":[231],"databases.":[232],"lists":[234],"represent":[241],"panel":[243],"potentially":[246],"pathogenesis":[250],"could":[252],"serve":[254],"prospective":[256],"diagnostic":[258]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
