{"id":"https://openalex.org/W2129346318","doi":null,"title":"The role of AMP kinase in diabetes.","display_name":"The role of AMP kinase in diabetes.","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W2129346318","mag":"2129346318","pmid":"https://pubmed.ncbi.nlm.nih.gov/17496363"},"language":"en","primary_location":{"id":"pmid:17496363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17496363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Indian journal of medical research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058627249","display_name":"Parimal Misra","orcid":"https://orcid.org/0000-0003-1613-7549","observed_orcids":["https://orcid.org/0000-0003-1613-7549"]},"institutions":[{"id":"https://openalex.org/I4210117495","display_name":"Dr. Reddy's Laboratories (India)","ror":"https://ror.org/01rkxa860","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210117495"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Parimal Misra","raw_affiliation_strings":["Discovery Biology, Dr Reddy's Laboratories Ltd. - Discovery Research, Hyderabad, India. parimal@drreddys.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Biology, Dr Reddy's Laboratories Ltd. - Discovery Research, Hyderabad, India. parimal@drreddys.com","institution_ids":["https://openalex.org/I4210117495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084443410","display_name":"Ranjan Chakrabarti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranjan Chakrabarti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2849,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.88859749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"125","issue":"3","first_page":"389","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9940000176429749},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9879999756813049},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/skeletal-muscle-contraction","display_name":"skeletal muscle contraction","score":0.7789999842643738},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.7710000276565552},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":1.0},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.902999997138977},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.9610000252723694},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7919999957084656},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.9053235054016113},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7115628719329834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6852825880050659},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.6258770227432251},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.5591964721679688},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5202268958091736},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.5052827000617981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4866405427455902},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4768577516078949},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47436413168907166},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.43287116289138794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36068296432495117},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2895619869232178},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2846528887748718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1998102366924286}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000263","descriptor_name":"Adenylate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:17496363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17496363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Indian journal of medical research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.509.2333","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.509.2333","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://icmr.nic.in/ijmr/2007/March/0313.pdf","raw_type":"text"},{"id":"mag:2129346318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17496363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W158023292","https://openalex.org/W1525701947","https://openalex.org/W1539328421","https://openalex.org/W1607014413","https://openalex.org/W1820085648","https://openalex.org/W1964606633","https://openalex.org/W1972762474","https://openalex.org/W1973749169","https://openalex.org/W1978661151","https://openalex.org/W1983890824","https://openalex.org/W2000296802","https://openalex.org/W2002189991","https://openalex.org/W2006705342","https://openalex.org/W2007656636","https://openalex.org/W2010188590","https://openalex.org/W2013149813","https://openalex.org/W2019691564","https://openalex.org/W2038227076","https://openalex.org/W2039167216","https://openalex.org/W2040605398","https://openalex.org/W2042706232","https://openalex.org/W2065034018","https://openalex.org/W2073361547","https://openalex.org/W2074303577","https://openalex.org/W2075496544","https://openalex.org/W2076174132","https://openalex.org/W2104713078","https://openalex.org/W2106324494","https://openalex.org/W2109607186","https://openalex.org/W2114339108","https://openalex.org/W2115379691","https://openalex.org/W2120852510","https://openalex.org/W2122328486","https://openalex.org/W2124536446","https://openalex.org/W2127007481","https://openalex.org/W2127295385","https://openalex.org/W2155534957","https://openalex.org/W2155653958","https://openalex.org/W2164134117","https://openalex.org/W2165750940","https://openalex.org/W2167843337","https://openalex.org/W2169469988","https://openalex.org/W2170880090","https://openalex.org/W2286784035"],"related_works":["https://openalex.org/W2108156859","https://openalex.org/W2368325397","https://openalex.org/W2160448209","https://openalex.org/W2112133879","https://openalex.org/W2007656636","https://openalex.org/W2007415406","https://openalex.org/W2023382073","https://openalex.org/W1838677832","https://openalex.org/W2386258825","https://openalex.org/W2058719833"],"abstract_inverted_index":{"Type":[0],"2":[1,203],"diabetes":[2,204],"is":[3,47,70,83,102,114],"characterized":[4],"by":[5,106,127],"abnormal":[6],"metabolism":[7],"of":[8,20,42,96,119,133,144,176,201],"glucose":[9,77,120,186],"and":[10,38,50,78,110,113,122,141,147,156,188,205],"fat,":[11],"due":[12],"in":[13,22,44,64,94,116,136,178],"part":[14],"to":[15,17,29],"resistance":[16],"the":[18,117,199],"actions":[19],"insulin":[21],"peripheral":[23],"tissues.":[24],"If":[25],"untreated":[26],"it":[27],"leads":[28],"several":[30],"complications":[31],"such":[32],"as":[33,72,88],"blindness,":[34],"kidney":[35],"failure,":[36],"neuropathy":[37],"amputations.":[39],"The":[40,81,149],"benefit":[41],"exercise":[43,66],"diabetic":[45,152],"patients":[46],"well":[48],"known":[49],"recent":[51],"research":[52],"indicates":[53],"that":[54,86,173],"AMP":[55],"activated":[56,93,104],"protein":[57],"kinase":[58],"(AMPK)":[59],"plays":[60],"a":[61,73,89],"major":[62],"role":[63],"this":[65,192],"related":[67],"effect.":[68],"AMPK":[69,82,101,134,177],"considered":[71],"master":[74],"switch":[75],"regulating":[76],"lipid":[79,189],"metabolism.":[80],"an":[84,194],"enzyme":[85,193],"works":[87],"fuel":[90],"gauge,":[91],"being":[92],"conditions":[95],"high":[97],"energy":[98],"phosphate":[99],"depletion.":[100],"also":[103],"robustly":[105],"skeletal":[107],"muscle":[108],"contraction":[109],"myocardial":[111],"ischaemia,":[112],"involved":[115],"stimulation":[118],"transport":[121],"fatty":[123,138],"acid":[124,139],"oxidation":[125,140],"produced":[126],"these":[128],"stimuli.":[129],"In":[130],"liver,":[131],"activation":[132,175],"results":[135],"enhanced":[137],"decreased":[142],"production":[143],"glucose,":[145],"cholesterol,":[146],"triglycerides.":[148],"two":[150],"leading":[151],"drugs":[153],"namely,":[154],"metformin":[155],"rosiglitazone,":[157],"show":[158],"their":[159],"metabolic":[160,207],"effects":[161],"partially":[162],"through":[163],"AMPK.":[164],"These":[165],"data,":[166],"along":[167],"with":[168,180],"evidence":[169],"from":[170],"studies":[171],"showing":[172],"chemical":[174],"vivo":[179],"5-aminoimidazole-4-carboxamide":[181],"ribonucleoside":[182],"(AICAR)":[183],"improves":[184],"blood":[185],"concentrations":[187],"profiles,":[190],"make":[191],"attractive":[195],"pharmacological":[196],"target":[197],"for":[198],"treatment":[200],"type":[202],"other":[206],"disorders.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}