{"id":"https://openalex.org/W2129346144","doi":"https://doi.org/10.1128/mcb.00331-09","title":"A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo","display_name":"A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2129346144","doi":"https://doi.org/10.1128/mcb.00331-09","mag":"2129346144","pmid":"https://pubmed.ncbi.nlm.nih.gov/19720742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772748"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.00331-09","doi":"https://doi.org/10.1128/mcb.00331-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00331-09","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772748","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041281073","display_name":"Yoji Andrew Minamishima","orcid":"https://orcid.org/0000-0001-7995-9318","observed_orcids":["https://orcid.org/0000-0001-7995-9318"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoji Andrew Minamishima","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019401898","display_name":"Javid J. Moslehi","orcid":"https://orcid.org/0000-0001-5443-4312","observed_orcids":["https://orcid.org/0000-0001-5443-4312"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javid Moslehi","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","Division of Cardiovascular Medicine, Department of Medicine","2 Division of Cardiovascular Medicine, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"2 Division of Cardiovascular Medicine, Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019306613","display_name":"Robert F. Padera","orcid":"https://orcid.org/0000-0002-4571-5494","observed_orcids":["https://orcid.org/0000-0002-4571-5494"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert F. Padera","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054412365","display_name":"Roderick Terry Bronson","orcid":"https://orcid.org/0000-0003-3725-2511","observed_orcids":["https://orcid.org/0000-0003-3725-2511"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roderick T. Bronson","raw_affiliation_strings":["Rodent Histopathology Core, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rodent Histopathology Core, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052626419","display_name":"Ronglih Liao","orcid":"https://orcid.org/0000-0002-9598-9020","observed_orcids":["https://orcid.org/0000-0002-9598-9020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronglih Liao","raw_affiliation_strings":["Division of Cardiovascular Medicine, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088456751","display_name":"William G. Kaelin","orcid":"https://orcid.org/0000-0002-0574-4856","observed_orcids":["https://orcid.org/0000-0002-0574-4856"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William G. Kaelin","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","Howard Hughes Medical Institute, Chevy Chase, Maryland 20815","5 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, Maryland 20815","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"5 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088456751"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"],"apc_list":null,"apc_paid":null,"fwci":4.4981,"has_fulltext":false,"cited_by_count":159,"citation_normalized_percentile":{"value":0.95029123,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"29","issue":"21","first_page":"5729","last_page":"5741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phd3","display_name":"PHD3","score":0.9359999895095825},{"id":"https://openalex.org/keywords/prolyl-hydroxylase","display_name":"prolyl hydroxylase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hif-alpha","display_name":"hypoxia-inducible factor alpha","score":0.75},{"id":"https://openalex.org/keywords/von-hippel-lindau-protein","display_name":"von Hippel-Lindau protein","score":0.9559999704360962},{"id":"https://openalex.org/keywords/phd2","display_name":"PHD2","score":0.6589999794960022},{"id":"https://openalex.org/keywords/hypoxia-response","display_name":"hypoxia response","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/premature-mortality","display_name":"premature mortality","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tissue-specific-gene-regulation","display_name":"tissue-specific gene regulation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/prolyl-hydroxylase-inhibitors","display_name":"prolyl hydroxylase inhibitors","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8010109663009644},{"id":"https://openalex.org/C12387725","wikidata":"https://www.wikidata.org/wiki/Q937024","display_name":"Phenocopy","level":4,"score":0.6790255308151245},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.658272922039032},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.630470335483551},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.622577428817749},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.5449825525283813},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5427236557006836},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5407806038856506},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4627203345298767},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45100346207618713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35937270522117615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3114497661590576},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29228904843330383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2566560208797455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11300551891326904},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10273516178131104},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006334","descriptor_name":"Heart Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011086","descriptor_name":"Polycythemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011086","descriptor_name":"Polycythemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011086","descriptor_name":"Polycythemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011393","descriptor_name":"Procollagen-Proline Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051794","descriptor_name":"Von Hippel-Lindau Tumor Suppressor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064799","descriptor_name":"Hypoxia-Inducible Factor-Proline Dioxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.00331-09","doi":"https://doi.org/10.1128/mcb.00331-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00331-09","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2772748","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772748","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:19720742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19720742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb2000_2009-3058","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2000_2009/2059","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2000 - 2009","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2772748","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772748","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320309165","display_name":"FibroGen","ror":"https://ror.org/03sxe1905"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1501467249","https://openalex.org/W1574172480","https://openalex.org/W1965209932","https://openalex.org/W1965827991","https://openalex.org/W1975984062","https://openalex.org/W1976752846","https://openalex.org/W1977249513","https://openalex.org/W1986005575","https://openalex.org/W1988377666","https://openalex.org/W1992933063","https://openalex.org/W1994937827","https://openalex.org/W1996356693","https://openalex.org/W2005729255","https://openalex.org/W2005800951","https://openalex.org/W2005868568","https://openalex.org/W2011810742","https://openalex.org/W2016160962","https://openalex.org/W2017575850","https://openalex.org/W2019521269","https://openalex.org/W2021932335","https://openalex.org/W2023259982","https://openalex.org/W2027052432","https://openalex.org/W2030334534","https://openalex.org/W2041492515","https://openalex.org/W2042216712","https://openalex.org/W2042742511","https://openalex.org/W2052201224","https://openalex.org/W2056714071","https://openalex.org/W2058021996","https://openalex.org/W2059951197","https://openalex.org/W2060104085","https://openalex.org/W2060113755","https://openalex.org/W2062805420","https://openalex.org/W2070254655","https://openalex.org/W2072526492","https://openalex.org/W2087214757","https://openalex.org/W2089692551","https://openalex.org/W2092566326","https://openalex.org/W2095793094","https://openalex.org/W2096040409","https://openalex.org/W2097654747","https://openalex.org/W2102692211","https://openalex.org/W2105230781","https://openalex.org/W2106590335","https://openalex.org/W2106756627","https://openalex.org/W2117236885","https://openalex.org/W2118019127","https://openalex.org/W2130456602","https://openalex.org/W2138137672","https://openalex.org/W2141042647","https://openalex.org/W2144103034","https://openalex.org/W2145023430","https://openalex.org/W2161071327","https://openalex.org/W2166932492","https://openalex.org/W2169448152"],"related_works":["https://openalex.org/W2016160962","https://openalex.org/W2166932492","https://openalex.org/W2087214757","https://openalex.org/W1971272556","https://openalex.org/W4388284629","https://openalex.org/W2046600832","https://openalex.org/W2047969741","https://openalex.org/W2960626844","https://openalex.org/W2072526492","https://openalex.org/W2081174130"],"abstract_inverted_index":{"Hypoxia-inducible":[0],"factor":[1],"(HIF),":[2],"consisting":[3],"of":[4,18,104,115,137,161,184],"a":[5,10,15,33,72,101],"labile":[6],"alpha":[7,22],"subunit":[8],"and":[9,90,99,129,139,151,174,178],"stable":[11],"beta":[12],"subunit,":[13],"is":[14,57],"master":[16],"regulator":[17],"hypoxia-responsive":[19],"mRNAs.":[20],"HIF":[21,53,60,84,163],"undergoes":[23],"oxygen-dependent":[24],"prolyl":[25,54,169,186],"hydroxylation,":[26],"which":[27,122,133],"marks":[28],"it":[29],"for":[30,126,147,181],"polyubiquitination":[31],"by":[32,59],"complex":[34],"containing":[35],"the":[36,42,51,83,105,113,119,130,134,159,182],"von":[37],"Hippel-Lindau":[38],"protein":[39],"(pVHL).":[40],"Among":[41],"three":[43],"Phd":[44],"family":[45],"members,":[46],"Phd2":[47,97,116,127,138],"appears":[48],"to":[49,121,132,145,166],"be":[50],"primary":[52],"hydroxylase.":[55],"Phd3":[56,80,123,140],"induced":[58],"and,":[61],"based":[62],"on":[63],"findings":[64,156],"from":[65],"in":[66,71,94,108,152,168,176],"vitro":[67],"studies,":[68],"may":[69],"participate":[70],"HIF-regulatory":[73],"feedback":[74],"loop.":[75],"Here,":[76],"we":[77],"report":[78],"that":[79,158],"loss":[81,114,128,136,143],"exacerbates":[82],"activation,":[85],"hepatic":[86],"steatosis,":[87],"dilated":[88],"cardiomyopathy,":[89],"premature":[91],"mortality":[92],"observed":[93],"mice":[95,109],"lacking":[96,110],"alone":[98],"produces":[100],"closer":[102],"phenocopy":[103],"changes":[106,167],"seen":[107],"pVHL":[111,142],"than":[112],"alone.":[117],"Importantly,":[118],"degree":[120,131],"can":[124],"compensate":[125],"combined":[135],"resembles":[141],"appear":[144],"differ":[146],"different":[148,153,162],"HIF-responsive":[149],"genes":[150,165],"tissues.":[154],"These":[155],"highlight":[157],"responses":[160],"target":[164],"hydroxylase":[170,187],"activity":[171],"differ,":[172],"quantitatively":[173],"qualitatively,":[175],"vivo":[177],"have":[179],"implications":[180],"development":[183],"paralog-specific":[185],"inhibitors":[188],"as":[189],"therapeutic":[190],"agents.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
