{"id":"https://openalex.org/W2129339746","doi":null,"title":"Nucleic acid enzymes: The fusion of self-assembly and conformational computing","display_name":"Nucleic acid enzymes: The fusion of self-assembly and conformational computing","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2129339746","mag":"2129339746"},"language":"en","primary_location":{"id":"pmh:oai:eprints.soton.ac.uk:267293","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/267293/1/RamlanEI09NucAcidEnz.pdf","pdf_url":"https://eprints.soton.ac.uk/267293/1/RamlanEI09NucAcidEnz.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014901980","display_name":"Effirul Ikhwan Ramlan","orcid":"https://orcid.org/0000-0002-8150-4782","observed_orcids":["https://orcid.org/0000-0002-8150-4782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Effirul Ikhwan Ramlan","raw_affiliation_strings":["School of Computing, Eng & Intel. Sys"],"raw_orcid":"https://orcid.org/0000-0002-8150-4782","affiliations":[{"raw_affiliation_string":"School of Computing, Eng & Intel. Sys","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004916607","display_name":"Klaus\u2010Peter Zauner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Klaus\u2010Peter Zauner","raw_affiliation_strings":["University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4265,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60968858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"2","first_page":"165","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.1080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid-enzymes","display_name":"nucleic acid enzymes","score":0.984000027179718},{"id":"https://openalex.org/keywords/self-assembly","display_name":"self-assembly","score":0.9490000009536743},{"id":"https://openalex.org/keywords/conformational-switch","display_name":"conformational switching","score":0.8939999938011169},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/functional-nucleic-acids","display_name":"functional nucleic acids","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oligonucleotides","display_name":"oligonucleotides","score":0.8339999914169312},{"id":"https://openalex.org/keywords/molecular-computing","display_name":"molecular computing","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.6947653293609619},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5776328444480896},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.4902782738208771},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.48923230171203613},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48042941093444824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3785679042339325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26435205340385437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17465180158615112},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11971724033355713},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:eprints.soton.ac.uk:267293","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/267293/1/RamlanEI09NucAcidEnz.pdf","pdf_url":"https://eprints.soton.ac.uk/267293/1/RamlanEI09NucAcidEnz.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.104.4164","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.104.4164","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://eprints.ecs.soton.ac.uk/14345/1/RamlanEI07NucAcidEnz.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.567.6559","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.567.6559","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://eprints.soton.ac.uk/267293/1/RamlanEI09NucAcidEnz.pdf","raw_type":"text"},{"id":"mag:2129339746","doi":null,"is_oa":false,"landing_page_url":"http://redir.eprints.ecs.soton.ac.uk/redir.php?uri=/17293/1/RamlanEI09NucAcidEnz.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S136297078","display_name":"International journal of unconventional computing","issn_l":"1548-7199","issn":["1548-7199","1548-7202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International journal of unconventional computing","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1491459594","https://openalex.org/W1519185585","https://openalex.org/W1543796220","https://openalex.org/W1569125732","https://openalex.org/W1571429155","https://openalex.org/W1575320848","https://openalex.org/W1581075644","https://openalex.org/W1587658095","https://openalex.org/W1592411342","https://openalex.org/W1628582474","https://openalex.org/W1767395388","https://openalex.org/W1881326155","https://openalex.org/W1966789782","https://openalex.org/W1966857768","https://openalex.org/W1967830783","https://openalex.org/W1977312644","https://openalex.org/W1977709085","https://openalex.org/W1980001941","https://openalex.org/W1980410097","https://openalex.org/W1980532649","https://openalex.org/W1981119631","https://openalex.org/W1983744996","https://openalex.org/W1983851388","https://openalex.org/W1984675364","https://openalex.org/W1986232581","https://openalex.org/W1988884185","https://openalex.org/W1988905886","https://openalex.org/W1988989917","https://openalex.org/W1992692415","https://openalex.org/W1996969492","https://openalex.org/W1997424362","https://openalex.org/W1998215345","https://openalex.org/W2006145675","https://openalex.org/W2011318772","https://openalex.org/W2012486340","https://openalex.org/W2015960673","https://openalex.org/W2017313617","https://openalex.org/W2026892967","https://openalex.org/W2028617936","https://openalex.org/W2034789630","https://openalex.org/W2041857964","https://openalex.org/W2044839241","https://openalex.org/W2046656599","https://openalex.org/W2047206115","https://openalex.org/W2052812744","https://openalex.org/W2054428590","https://openalex.org/W2057350364","https://openalex.org/W2057445069","https://openalex.org/W2059013890","https://openalex.org/W2062218409","https://openalex.org/W2066511094","https://openalex.org/W2069688986","https://openalex.org/W2072363537","https://openalex.org/W2073775872","https://openalex.org/W2074120916","https://openalex.org/W2074192320","https://openalex.org/W2075734969","https://openalex.org/W2077799438","https://openalex.org/W2079356995","https://openalex.org/W2080484952","https://openalex.org/W2084943154","https://openalex.org/W2086298020","https://openalex.org/W2090909297","https://openalex.org/W2092016699","https://openalex.org/W2096883982","https://openalex.org/W2104095017","https://openalex.org/W2104525153","https://openalex.org/W2107558880","https://openalex.org/W2112333437","https://openalex.org/W2116344248","https://openalex.org/W2116804174","https://openalex.org/W2118471196","https://openalex.org/W2119340328","https://openalex.org/W2122944508","https://openalex.org/W2123281294","https://openalex.org/W2129706781","https://openalex.org/W2134097743","https://openalex.org/W2135373808","https://openalex.org/W2138246818","https://openalex.org/W2145149786","https://openalex.org/W2160001814","https://openalex.org/W2168201395","https://openalex.org/W2169436912"],"related_works":["https://openalex.org/W2072166497","https://openalex.org/W839016702","https://openalex.org/W2310492366","https://openalex.org/W2107757039","https://openalex.org/W2024921693","https://openalex.org/W2981336092","https://openalex.org/W1970548295","https://openalex.org/W2952341282","https://openalex.org/W1481227091","https://openalex.org/W2153728540"],"abstract_inverted_index":{"Abstract.":[0],"Macromolecules":[1],"are":[2,46,75],"the":[3,52,57,69,99,102],"predominant":[4],"physical":[5],"substrate":[6],"sup-porting":[7],"information":[8,35,124],"processing":[9,65],"in":[10,22,43,85],"organisms.":[11],"Two":[12],"key":[13],"characteristics\u2014":[14],"conformational":[15,39,73,103],"dynamics":[16],"and":[17,38,45,72,101],"self-assembly":[18,37,71,100],"properties\u2014render":[19],"macro-molecules":[20],"unique":[21],"this":[23],"context.":[24],"Both":[25],"characteristics":[26],"have":[27],"been":[28],"investi-gated":[29],"for":[30,60,123],"technical":[31],"applications.":[32,91],"In":[33],"nature\u2019s":[34],"processors":[36],"switching":[40,74],"commonly":[41],"appear":[42],"combination":[44,70],"typically":[47],"realised":[48,81],"with":[49,105],"proteins.":[50],"At":[51],"current":[53],"state":[54],"of":[55,83],"biotech-nology":[56],"best":[58],"candidates":[59],"implementing":[61],"artifical":[62],"molecular":[63],"informa-tion":[64],"systems":[66],"that":[67],"utilise":[68],"functional":[76,120],"nucleic":[77,108,121],"acids.":[78],"The":[79,92],"increasingly":[80],"prevalence":[82],"oligonucleotides":[84],"intracellular":[86],"control":[87],"points":[88],"to-wards":[89],"potential":[90],"present":[93],"paper":[94],"reviews":[95],"approaches":[96],"to":[97,118],"integrating":[98],"paradigm":[104],"al-losterically":[106],"controlled":[107],"acid":[109],"enzymes.":[110],"It":[111],"also":[112],"introduces":[113],"a":[114],"new":[115],"com-putational":[116],"workflow":[117],"design":[119],"acids":[122]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
