{"id":"https://openalex.org/W2129328610","doi":"https://doi.org/10.1186/1742-2094-3-17","title":"Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy.","display_name":"Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2129328610","doi":"https://doi.org/10.1186/1742-2094-3-17","mag":"2129328610","pmid":"https://pubmed.ncbi.nlm.nih.gov/16872492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1559596"},"language":"en","primary_location":{"id":"doi:10.1186/1742-2094-3-17","doi":"https://doi.org/10.1186/1742-2094-3-17","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-3-17","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-3-17","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-3-17","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012931516","display_name":"Pritam Das","orcid":"https://orcid.org/0000-0002-0227-2320","observed_orcids":["https://orcid.org/0000-0002-0227-2320"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pritam Das","raw_affiliation_strings":["Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA. das.pritam@mayo.edu","Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA. das.pritam@mayo.edu","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043993264","display_name":"Lisa A. Smithson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A Smithson","raw_affiliation_strings":["Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert W Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W Price","raw_affiliation_strings":["Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011381164","display_name":"Vallie M. Holloway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vallie M Holloway","raw_affiliation_strings":["Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009025157","display_name":"Yona Levites","orcid":"https://orcid.org/0000-0001-6925-4525","observed_orcids":["https://orcid.org/0000-0001-6925-4525"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yona Levites","raw_affiliation_strings":["Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082320489","display_name":"Paramita Chakrabarty","orcid":"https://orcid.org/0000-0002-6226-3776","observed_orcids":["https://orcid.org/0000-0002-6226-3776"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paramita Chakrabarty","raw_affiliation_strings":["Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058688886","display_name":"Todd Eliot Golde","orcid":"https://orcid.org/0000-0003-1867-7071","observed_orcids":["https://orcid.org/0000-0003-1867-7071"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Todd E Golde","raw_affiliation_strings":["Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neurosciences, Mayo Clinic College of Medicine, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012931516","https://openalex.org/A5058688886"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":1.1074,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.78327541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-1r1","display_name":"IL1R1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/amyloid-beta-immunotherapy","display_name":"amyloid-beta immunotherapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tg2576-mice","display_name":"Tg2576 mice","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7829999923706055},{"id":"https://openalex.org/keywords/anti-amyloid-monoclonal-antibodies","display_name":"anti-amyloid monoclonal antibodies","score":0.7599999904632568},{"id":"https://openalex.org/keywords/app-transgenic-mice","display_name":"APP transgenic mice","score":0.6779999732971191},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/passive-immunization","display_name":"passive immunization","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.694551944732666},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6523789763450623},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6364983320236206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5005130767822266},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48970893025398254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4542664587497711},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.415865957736969},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33080342411994934},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3164837658405304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2771488428115845}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1742-2094-3-17","doi":"https://doi.org/10.1186/1742-2094-3-17","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-3-17","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-3-17","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmid:16872492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16872492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a773b67c3bb2452888a998926762ff0d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a773b67c3bb2452888a998926762ff0d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, Vol 3, Iss 1, p 17 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-2094-3-17","doi":"https://doi.org/10.1186/1742-2094-3-17","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-3-17","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-3-17","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5824905723","display_name":"Immune-Mediated Mechanisms underlying CNS Abeta Clearance","funder_award_id":"R01AG018454","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129328610.pdf","grobid_xml":"https://content.openalex.org/works/W2129328610.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1491655932","https://openalex.org/W1528113046","https://openalex.org/W1567490604","https://openalex.org/W1586876258","https://openalex.org/W1597819025","https://openalex.org/W1608895167","https://openalex.org/W1623920471","https://openalex.org/W1693283493","https://openalex.org/W1824528611","https://openalex.org/W1824975628","https://openalex.org/W1942463334","https://openalex.org/W1959572425","https://openalex.org/W1966977299","https://openalex.org/W1967413976","https://openalex.org/W1967549235","https://openalex.org/W1968014528","https://openalex.org/W1974626393","https://openalex.org/W1977775233","https://openalex.org/W1991993391","https://openalex.org/W1992481658","https://openalex.org/W1993909442","https://openalex.org/W1994394172","https://openalex.org/W2000917982","https://openalex.org/W2001210466","https://openalex.org/W2002520289","https://openalex.org/W2005586302","https://openalex.org/W2009174342","https://openalex.org/W2012903551","https://openalex.org/W2024262813","https://openalex.org/W2026156322","https://openalex.org/W2050181337","https://openalex.org/W2057270928","https://openalex.org/W2058614488","https://openalex.org/W2065633693","https://openalex.org/W2066344383","https://openalex.org/W2067420120","https://openalex.org/W2069148454","https://openalex.org/W2076161632","https://openalex.org/W2077290313","https://openalex.org/W2078136106","https://openalex.org/W2082429191","https://openalex.org/W2090978805","https://openalex.org/W2096576951","https://openalex.org/W2101174761","https://openalex.org/W2110998913","https://openalex.org/W2112216133","https://openalex.org/W2126885422","https://openalex.org/W2133595485","https://openalex.org/W2145283772","https://openalex.org/W2149399096","https://openalex.org/W2153126018","https://openalex.org/W2157064933","https://openalex.org/W2160676126","https://openalex.org/W2164096164","https://openalex.org/W2170241219","https://openalex.org/W2171467864","https://openalex.org/W2171576082","https://openalex.org/W2291628530","https://openalex.org/W2402623008","https://openalex.org/W4240307828"],"related_works":["https://openalex.org/W7101221498","https://openalex.org/W2164535032","https://openalex.org/W1964219940","https://openalex.org/W2063909850","https://openalex.org/W3157473458","https://openalex.org/W4297888792","https://openalex.org/W2032611206","https://openalex.org/W1608895167","https://openalex.org/W2045590748","https://openalex.org/W2093221976"],"abstract_inverted_index":{"BACKGROUND:":[0],"Microglial":[1],"activation":[2,54,147,267],"has":[3],"been":[4],"proposed":[5],"to":[6,36,41,172,177,223],"facilitate":[7],"clearance":[8],"of":[9,48,62,81,90,199,219,239,251],"amyloid":[10,21],"beta":[11],"protein":[12,23],"(Abeta)":[13],"from":[14],"the":[15,46,60,71,88,101,129,167,203,237,240,249],"brain":[16],"following":[17],"Abeta":[18,64,85,120,135,143,200,214,246],"immunotherapy":[19,65],"in":[20,55,66,87,122,137,158,162,184,202,261,274],"precursor":[22],"(APP)":[24],"transgenic":[25],"mice.":[26,124,139,196,230],"Interleukin-1":[27],"receptor":[28,243],"1":[29],"knockout":[30,132],"(IL-1":[31],"R1-/-)":[32],"mice":[33,68,98,165,188,207,221,263],"are":[34,256],"reported":[35],"exhibit":[37],"blunted":[38],"inflammatory":[39,50],"responses":[40,51],"injury.":[42],"To":[43],"further":[44],"define":[45],"role":[47],"IL-1-mediated":[49],"and":[52,141,145],"microglial":[53,146,266],"this":[56],"paradigm,":[57],"we":[58,77,115],"examined":[59,78,127],"efficacy":[61,250,273],"passive":[63,252,275],"Tg2576":[67,97,123,195,229,262],"crossed":[69,99],"into":[70,100],"IL-1":[72,82,102,130,190,224,241],"R1-/-":[73,83,103,106,164,187,206],"background.":[74],"In":[75],"addition,":[76],"if":[79],"loss":[80],"modifies":[84,134],"deposition":[86,121,136,201,247],"absence":[89],"additional":[91],"manipulations.":[92],"METHODS:":[93],"We":[94,125,232],"passively":[95],"immunized":[96],"background":[104,133],"(APP/IL-1":[105],"mice)":[107],"with":[108,153,258],"an":[109],"anti-Abeta1-16":[110],"mAb":[111,155],"(mAb9,":[112],"IgG2a)":[113],"that":[114,236,264],"previously":[116],"showed":[117],"could":[118],"attenuate":[119],"also":[126],"whether":[128],"R1":[131,191,225,242],"untreated":[138,204],"Biochemical":[140],"immunohistochemical":[142],"loads":[144,215],"was":[148,156,169,181],"assessed.":[149],"RESULTS:":[150],"Passive":[151],"immunization":[152,168,180,276],"anti-Abeta":[154],"effective":[157,183],"reducing":[159],"plaque":[160,174],"load":[161],"APP/IL-1":[163,186,205],"when":[166],"started":[170],"prior":[171],"significant":[173],"deposition.":[175],"Similar":[176],"previous":[178],"studies,":[179],"not":[182,209,269],"older":[185],"or":[189,248],"sufficient":[192,226],"wild":[193,227],"type":[194,228],"Our":[197],"analysis":[198],"did":[208],"show":[210],"differences":[211],"on":[212],"biochemical":[213],"during":[216],"normal":[217],"aging":[218],"these":[220],"compared":[222],"CONCLUSION:":[231],"find":[233],"no":[234],"evidence":[235],"lack":[238],"influences":[244],"either":[245],"immunotherapy.":[253],"Such":[254],"results":[255],"consistent":[257],"other":[259],"studies":[260],"suggest":[265],"may":[268],"be":[270],"required":[271],"for":[272],"approaches.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}