{"id":"https://openalex.org/W2129309985","doi":"https://doi.org/10.1200/jco.2004.01.0660","title":"Phase I Clinical and Pharmacokinetic Study of Flavopiridol in Children With Refractory Solid Tumors: A Children's Oncology Group Study","display_name":"Phase I Clinical and Pharmacokinetic Study of Flavopiridol in Children With Refractory Solid Tumors: A Children's Oncology Group Study","publication_year":2005,"publication_date":"2005-12-17","ids":{"openalex":"https://openalex.org/W2129309985","doi":"https://doi.org/10.1200/jco.2004.01.0660","mag":"2129309985","pmid":"https://pubmed.ncbi.nlm.nih.gov/16361620"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.01.0660","doi":"https://doi.org/10.1200/jco.2004.01.0660","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.01.0660","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085057434","display_name":"James A. Whitlock","orcid":"https://orcid.org/0000-0002-7887-0634","observed_orcids":["https://orcid.org/0000-0002-7887-0634"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Whitlock","raw_affiliation_strings":["From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1299406639","https://openalex.org/I1330342723","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090325707","display_name":"Mark Krailo","orcid":"https://orcid.org/0000-0002-7608-0698","observed_orcids":["https://orcid.org/0000-0002-7608-0698"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Krailo","raw_affiliation_strings":["From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1299406639","https://openalex.org/I1330342723","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027416118","display_name":"Joel M. Reid","orcid":"https://orcid.org/0000-0003-2872-3123","observed_orcids":["https://orcid.org/0000-0003-2872-3123"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel M. Reid","raw_affiliation_strings":["From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1299406639","https://openalex.org/I1330342723","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054921029","display_name":"Stacie Ruben","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacie L. Ruben","raw_affiliation_strings":["From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1299406639","https://openalex.org/I1330342723","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066722006","display_name":"Matthew M. Ames","orcid":"https://orcid.org/0000-0003-3652-209X","observed_orcids":["https://orcid.org/0000-0003-3652-209X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew M. Ames","raw_affiliation_strings":["From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1299406639","https://openalex.org/I1330342723","https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Owen","raw_affiliation_strings":["From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1299406639","https://openalex.org/I1330342723","https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019914745","display_name":"Gregory H. Reaman","orcid":"https://orcid.org/0000-0002-6698-4503","observed_orcids":["https://orcid.org/0000-0002-6698-4503"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Reaman","raw_affiliation_strings":["From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Vanderbilt Children's Hospital, Nashville, TN; University of Southern California Keck School of Medicine, Los Angeles; Children's Oncology Group, Arcadia, CA; Mayo Clinic and Foundation, Rochester, MN; Children's Hospital\u2013King's Daughters, Norfolk, VA; Children's National Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1299406639","https://openalex.org/I1330342723","https://openalex.org/I1336742384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7529,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.67910206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"23","issue":"36","first_page":"9179","last_page":"9186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.33059999346733093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.33059999346733093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1737000048160553,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavopiridol","display_name":"flavopiridol","score":1.0},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.902999997138977},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.7789999842643738},{"id":"https://openalex.org/keywords/refractory-solid-tumors","display_name":"refractory solid tumors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9179999828338623},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plasma-clearance","display_name":"plasma clearance","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.87156081199646},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7754301428794861},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6729152798652649},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6651242971420288},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6558589935302734},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5095605850219727},{"id":"https://openalex.org/C2777334693","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Maximum tolerated dose","level":3,"score":0.4562872052192688},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42020362615585327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4139835238456726},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.01.0660","doi":"https://doi.org/10.1200/jco.2004.01.0660","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.01.0660","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:16361620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16361620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W286443710","https://openalex.org/W1527674890","https://openalex.org/W1527712367","https://openalex.org/W1664986701","https://openalex.org/W1777669545","https://openalex.org/W1831621090","https://openalex.org/W2016552601","https://openalex.org/W2016987929","https://openalex.org/W2029080338","https://openalex.org/W2051256348","https://openalex.org/W2086056059","https://openalex.org/W2103091073","https://openalex.org/W2107020701","https://openalex.org/W2109458089","https://openalex.org/W2115276278","https://openalex.org/W2130005679","https://openalex.org/W2131549312","https://openalex.org/W2141972206","https://openalex.org/W2144240156","https://openalex.org/W2150439521","https://openalex.org/W2155762742","https://openalex.org/W2162517036","https://openalex.org/W2170302386","https://openalex.org/W2177166422","https://openalex.org/W2595798132","https://openalex.org/W2596875443"],"related_works":["https://openalex.org/W2144240156","https://openalex.org/W1777669545","https://openalex.org/W2016987929","https://openalex.org/W2249636576","https://openalex.org/W2058177773","https://openalex.org/W2136682666","https://openalex.org/W2129496457","https://openalex.org/W3081465473","https://openalex.org/W2527377099","https://openalex.org/W2124742698"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"the":[3,11,90,155,158,193],"dose-limiting":[4,87,129],"toxicities,":[5],"maximum-tolerated":[6,91,122,186],"dose,":[7],"and":[8,89,103,133,149,192,218],"pharmacokinetics":[9],"of":[10,79,112,147,157,188,216],"cyclin-dependent":[12],"kinase":[13],"inhibitor":[14],"flavopiridol":[15,109,173,189],"(NSC":[16],"649890)":[17],"when":[18,56,204],"administered":[19,41,205],"as":[20,42,206],"a":[21,43,83,207],"1-hour":[22,44,159,208],"infusion":[23,46,209],"over":[24,117],"3":[25,49,118,211],"consecutive":[26,50,119,212],"days":[27,51,100],"to":[28,114,167,181,222],"children":[29,107],"with":[30],"recurrent":[31],"or":[32,55,59,63],"refractory":[33],"solid":[34],"tumors.":[35],"PATIENTS":[36],"AND":[37],"METHODS:":[38],"Flavopiridol":[39,95],"was":[40,71,76,124,138,176,201],"intravenous":[45],"daily":[47],"for":[48,198,210],"every":[52],"21":[53],"days,":[54],"hematologic":[57],"toxicity":[58,66,88],"any":[60],"grade":[61],"2":[62],"greater":[64],"nonhematologic":[65],"resolved.":[67],"The":[68,121,127,171,185],"starting":[69],"dose":[70,92,123,162,187,197],"37.5":[72,113,165],"mg/m2/d.":[73,126],"Dose":[74],"escalation":[75,163],"in":[77,82,140,190,224],"cohorts":[78],"three":[80],"patients":[81],"standard":[84],"fashion":[85],"until":[86],"were":[93,97,131,152,220],"determined.":[94],"levels":[96],"measured":[98],"on":[99],"1,":[101],"2,":[102],"3.":[104],"RESULTS:":[105],"Twenty-five":[106],"received":[108],"at":[110,154],"doses":[111],"80":[115,168],"mg/m2/day":[116,203],"days.":[120,213],"62.5":[125,202],"primary":[128],"toxicities":[130,215],"neutropenia":[132,217],"diarrhea.":[134],"No":[135],"antitumor":[136],"effect":[137],"observed":[139],"this":[141],"population.":[142],"Mean":[143],"peak":[144],"plasma":[145,174],"concentrations":[146],"3.71":[148],"9.11":[150],"micromol/L":[151],"achieved":[153],"end":[156],"infusion,":[160],"following":[161],"from":[164],"mg/m2":[166],"mg/m2,":[169],"respectively.":[170],"median":[172],"clearance":[175],"8.0":[177],"L/h/m2":[178],"(range,":[179],"2.6":[180],"17.1":[182],"L/h/m2).":[183],"CONCLUSION:":[184],"children,":[191],"recommended":[194],"phase":[195],"II":[196],"pediatric":[199],"studies,":[200],"Dose-limiting":[214],"diarrhea":[219],"similar":[221],"those":[223],"adult":[225],"studies.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}