{"id":"https://openalex.org/W2129287888","doi":"https://doi.org/10.1074/jbc.m109.034926","title":"A Lectin Isolated from Bananas Is a Potent Inhibitor of HIV Replication","display_name":"A Lectin Isolated from Bananas Is a Potent Inhibitor of HIV Replication","publication_year":2010,"publication_date":"2010-01-15","ids":{"openalex":"https://openalex.org/W2129287888","doi":"https://doi.org/10.1074/jbc.m109.034926","mag":"2129287888","pmid":"https://pubmed.ncbi.nlm.nih.gov/20080975","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2838287"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.034926","doi":"https://doi.org/10.1074/jbc.m109.034926","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.034926","pdf_url":"http://www.jbc.org/article/S0021925820872639/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820872639/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113547593","display_name":"Michael D. Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Swanson","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA","Program in Immunology, University of Michigan Medical Center, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Program in Immunology, University of Michigan Medical Center, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040744976","display_name":"Harry C. Winter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry C. Winter","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Irwin J. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irwin J. Goldstein","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075367506","display_name":"David M. Markovitz","orcid":"https://orcid.org/0000-0003-3547-0849","observed_orcids":["https://orcid.org/0000-0003-3547-0849"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Markovitz","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Michigan 48109","Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical Center, Ann Arbor, Michigan 48109","Program in Immunology, University of Michigan Medical Center, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical Center, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Program in Immunology, University of Michigan Medical Center, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075367506"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.853,"has_fulltext":true,"cited_by_count":215,"citation_normalized_percentile":{"value":0.97338746,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"285","issue":"12","first_page":"8646","last_page":"8655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jacalin-related-lectins","display_name":"jacalin-related lectins","score":0.9570000171661377},{"id":"https://openalex.org/keywords/banana-lectin","display_name":"banana lectin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/antiviral-lectin","display_name":"antiviral lectin","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.878000020980835},{"id":"https://openalex.org/keywords/virus-entry-inhibition","display_name":"viral entry inhibition","score":0.75},{"id":"https://openalex.org/keywords/hiv-1-tropism","display_name":"HIV-1 tropism","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hiv-1-subtypes","display_name":"HIV-1 subtypes","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sexual-transmission-prevention","display_name":"sexual transmission prevention","score":0.7200000286102295},{"id":"https://openalex.org/keywords/musa-acuminata","display_name":"Musa acuminata","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.7660344839096069},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.5986220240592957},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5973202586174011},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5715641379356384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5700700283050537},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5559543967247009},{"id":"https://openalex.org/C2778899366","wikidata":"https://www.wikidata.org/wiki/Q421369","display_name":"Maraviroc","level":3,"score":0.47599637508392334},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.468833863735199},{"id":"https://openalex.org/C106257327","wikidata":"https://www.wikidata.org/wiki/Q24788214","display_name":"C-type lectin","level":3,"score":0.462126225233078},{"id":"https://openalex.org/C189413060","wikidata":"https://www.wikidata.org/wiki/Q415443","display_name":"Mannan-binding lectin","level":3,"score":0.458293080329895},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4511815011501312},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41100722551345825},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4020507037639618},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3689391016960144},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3376510739326477},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32954680919647217},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.17954021692276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09821692109107971}],"mesh":[{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028521","descriptor_name":"Musa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m109.034926","doi":"https://doi.org/10.1074/jbc.m109.034926","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.034926","pdf_url":"http://www.jbc.org/article/S0021925820872639/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2838287","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2838287","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20080975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20080975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.034926","doi":"https://doi.org/10.1074/jbc.m109.034926","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.034926","pdf_url":"http://www.jbc.org/article/S0021925820872639/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1412571906","display_name":null,"funder_award_id":"pNL4-3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5838619354","display_name":"CXC Chemokines and HIV Pathogenesis","funder_award_id":"R01AI062248","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6511232711","display_name":null,"funder_award_id":"pNL4-3","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320316668","display_name":"Progenics Pharmaceuticals","ror":"https://ror.org/023ka9926"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129287888.pdf","grobid_xml":"https://content.openalex.org/works/W2129287888.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W622557290","https://openalex.org/W1532310879","https://openalex.org/W1558726519","https://openalex.org/W1601713328","https://openalex.org/W1659719610","https://openalex.org/W1794879226","https://openalex.org/W1837922397","https://openalex.org/W1908410208","https://openalex.org/W1918785437","https://openalex.org/W1922162046","https://openalex.org/W1946734657","https://openalex.org/W1953822958","https://openalex.org/W1967015252","https://openalex.org/W1975423946","https://openalex.org/W1983846378","https://openalex.org/W1988356694","https://openalex.org/W1988784338","https://openalex.org/W1991443329","https://openalex.org/W1996209447","https://openalex.org/W1996641092","https://openalex.org/W1997677784","https://openalex.org/W2000150042","https://openalex.org/W2000884295","https://openalex.org/W2005963291","https://openalex.org/W2020321808","https://openalex.org/W2020465880","https://openalex.org/W2026833019","https://openalex.org/W2032898755","https://openalex.org/W2037432907","https://openalex.org/W2047623219","https://openalex.org/W2051949274","https://openalex.org/W2066121768","https://openalex.org/W2069851285","https://openalex.org/W2076424086","https://openalex.org/W2077436109","https://openalex.org/W2078412328","https://openalex.org/W2079028174","https://openalex.org/W2081409099","https://openalex.org/W2085378807","https://openalex.org/W2085612023","https://openalex.org/W2086325331","https://openalex.org/W2087451026","https://openalex.org/W2087658228","https://openalex.org/W2092238090","https://openalex.org/W2100265029","https://openalex.org/W2102090534","https://openalex.org/W2106804406","https://openalex.org/W2109622775","https://openalex.org/W2117307765","https://openalex.org/W2120078856","https://openalex.org/W2121132802","https://openalex.org/W2126255146","https://openalex.org/W2133919255","https://openalex.org/W2134747757","https://openalex.org/W2136916161","https://openalex.org/W2137387290","https://openalex.org/W2138802639","https://openalex.org/W2141444589","https://openalex.org/W2143019707","https://openalex.org/W2146478787","https://openalex.org/W2146704167","https://openalex.org/W2147907754","https://openalex.org/W2148780186","https://openalex.org/W2153747683","https://openalex.org/W2154097024","https://openalex.org/W2156643487","https://openalex.org/W2159211632","https://openalex.org/W2161024777","https://openalex.org/W2163558461","https://openalex.org/W2168518636","https://openalex.org/W2170263132"],"related_works":["https://openalex.org/W7098873443","https://openalex.org/W12161065","https://openalex.org/W2605463633","https://openalex.org/W2083063417","https://openalex.org/W3010943873","https://openalex.org/W1972791406","https://openalex.org/W13104210","https://openalex.org/W2023788542","https://openalex.org/W2342154042","https://openalex.org/W2462974441"],"abstract_inverted_index":{"BanLec":[0,41,57,69,121,127,143,182,202,231],"is":[1,144,232],"a":[2,233],"jacalin-related":[3],"lectin":[4,14,96,212],"isolated":[5],"from":[6],"the":[7,48,78,100,108,111,130,138,160,164,173,189,246],"fruit":[8],"of":[9,47,64,107,120,163,167,175,201,249],"bananas,":[10],"Musa":[11],"acuminata.":[12],"This":[13],"binds":[15],"to":[16,81,122,146,188,205,216,244],"high":[17,131],"mannose":[18,132],"carbohydrate":[19],"structures,":[20],"including":[21],"those":[22],"found":[23],"on":[24,228],"viruses":[25],"containing":[26],"glycosylated":[27,49,190],"envelope":[28,51,102,192],"proteins":[29],"such":[30,209],"as":[31,151,210],"human":[32],"immunodeficiency":[33],"virus":[34,109],"type-1":[35],"(HIV-1).":[36],"Therefore,":[37],"we":[38],"hypothesized":[39],"that":[40,56,126,134,181,240],"might":[42],"inhibit":[43],"HIV-1":[44,50,62,101,148,184],"through":[45],"binding":[46,119,187],"protein,":[52],"gp120.":[53],"We":[54],"determined":[55],"inhibits":[58,183],"primary":[59],"and":[60,67,104,124,158,193,213,215,218],"laboratory-adapted":[61],"isolates":[63],"different":[65],"tropisms":[66],"subtypes.":[68],"possesses":[70],"potent":[71],"anti-HIV":[72,199,207,221],"activity,":[73],"with":[74],"IC(50)":[75],"values":[76],"in":[77,172,224],"low":[79],"nanomolar":[80],"picomolar":[82],"range.":[83],"The":[84,197],"mechanism":[85],"for":[86,236],"BanLec-mediated":[87],"antiviral":[88],"activity":[89,200],"was":[90],"investigated":[91],"by":[92,137,153,159,186],"determining":[93],"if":[94],"this":[95],"can":[97,128],"directly":[98],"bind":[99],"protein":[103],"block":[105,147],"entry":[106,150,156],"into":[110],"cell.":[112],"An":[113],"enzyme-linked":[114],"immunosorbent":[115],"assay":[116],"confirmed":[117],"direct":[118],"gp120":[123],"indicated":[125,152],"recognize":[129],"structures":[133],"are":[135],"recognized":[136],"monoclonal":[139],"antibody":[140],"2G12.":[141],"Furthermore,":[142],"able":[145],"cellular":[149,195],"temperature-sensitive":[154],"viral":[155,191],"studies":[157],"decreased":[161],"levels":[162],"strong-stop":[165],"product":[166],"early":[168],"reverse":[169],"transcription":[170],"seen":[171],"presence":[174],"BanLec.":[176],"Thus,":[177],"our":[178],"data":[179],"indicate":[180],"infection":[185],"blocking":[194],"entry.":[196],"relative":[198],"compared":[203],"favorably":[204],"other":[206],"lectins,":[208],"snowdrop":[211],"Griffithsin,":[214],"T-20":[217],"maraviroc,":[219],"two":[220],"drugs":[222],"currently":[223],"clinical":[225],"use.":[226],"Based":[227],"these":[229],"results,":[230],"potential":[234],"component":[235],"an":[237],"anti-viral":[238],"microbicide":[239],"could":[241],"be":[242],"used":[243],"prevent":[245],"sexual":[247],"transmission":[248],"HIV-1.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":17}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}