{"id":"https://openalex.org/W2129286961","doi":null,"title":"Analysis of nerve growth factor receptor expression in human neuroblastoma and neuroepithelioma cell lines.","display_name":"Analysis of nerve growth factor receptor expression in human neuroblastoma and neuroepithelioma cell lines.","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2129286961","mag":"2129286961","pmid":"https://pubmed.ncbi.nlm.nih.gov/2545334"},"language":"en","primary_location":{"id":"pmid:2545334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2545334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091237897","display_name":"David L. Baker","orcid":"https://orcid.org/0000-0002-0664-6780","observed_orcids":["https://orcid.org/0000-0002-0664-6780"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Baker","raw_affiliation_strings":["Division of Hematology-Oncology, Childrens Hospital of Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Childrens Hospital of Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074744495","display_name":"Usha Rani Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U R Reddy","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091386381","display_name":"David Pleasure","orcid":"https://orcid.org/0000-0002-9122-1268","observed_orcids":["https://orcid.org/0000-0002-9122-1268"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Pleasure","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066438872","display_name":"Crystal L. Thorpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C L Thorpe","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108635422","display_name":"Audrey E. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A E Evans","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108694880","display_name":"Pamela Sarah Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P S Cohen","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090059410","display_name":"Alonzo H. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A H Ross","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8183,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.95544817,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"49","issue":"15","first_page":"4142","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor-receptor","display_name":"nerve growth factor receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.7149999737739563},{"id":"https://openalex.org/keywords/neuroepithelioma","display_name":"neuroepithelioma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-surface-receptor-expression","display_name":"cell surface receptor expression","score":0.8119999766349792},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5740000009536743},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neuroblastoma-cell-lines","display_name":"neuroblastoma cell lines","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.779248833656311},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.7479197978973389},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.676160454750061},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5556111335754395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5347520112991333},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5053055882453918},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5034598708152771},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.4235127568244934},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3053414225578308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07219448685646057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05310395359992981},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.043462395668029785}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017475","descriptor_name":"Receptors, Nerve Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018241","descriptor_name":"Neuroectodermal Tumors, Primitive, Peripheral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2545334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2545334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2129286961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2545334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W265925562","https://openalex.org/W1032040594","https://openalex.org/W1493114553","https://openalex.org/W1547637982","https://openalex.org/W1565761678","https://openalex.org/W1680114508","https://openalex.org/W1732387600","https://openalex.org/W1775749144","https://openalex.org/W1853725381","https://openalex.org/W1864905496","https://openalex.org/W1894765306","https://openalex.org/W1910192122","https://openalex.org/W1975136926","https://openalex.org/W1977768398","https://openalex.org/W1980131968","https://openalex.org/W1980678647","https://openalex.org/W1989123060","https://openalex.org/W1996772672","https://openalex.org/W2003476408","https://openalex.org/W2011795445","https://openalex.org/W2024280594","https://openalex.org/W2042771387","https://openalex.org/W2054584972","https://openalex.org/W2063557187","https://openalex.org/W2063667918","https://openalex.org/W2067708781","https://openalex.org/W2070988380","https://openalex.org/W2083823071","https://openalex.org/W2121383450","https://openalex.org/W2123345036","https://openalex.org/W2126900820","https://openalex.org/W2134812217","https://openalex.org/W2144865486","https://openalex.org/W2148128479","https://openalex.org/W2153942882","https://openalex.org/W2153943744","https://openalex.org/W2154105002","https://openalex.org/W2154914569","https://openalex.org/W2164658118","https://openalex.org/W2328217679"],"related_works":["https://openalex.org/W2078759383","https://openalex.org/W2413050730","https://openalex.org/W2418740007","https://openalex.org/W2139184601","https://openalex.org/W2470378304","https://openalex.org/W1996914952","https://openalex.org/W2077156074","https://openalex.org/W1987961206","https://openalex.org/W2430873801","https://openalex.org/W2007207475"],"abstract_inverted_index":{"A":[0],"series":[1,222],"of":[2,13,38,53,122,177,197,223,237,239],"22":[3],"neuroepithelioma":[4,29,112,134,162,210],"and":[5,24,59,138,148,188,211,242],"neuroblastoma":[6,45,78,124,179,189,218],"cell":[7,30,33,46,54,65,113,125,135,163,180,185,190,219,225],"lines":[8,31,47,61,114,126,136,164,181,226],"were":[9,62,154,166,182],"screened":[10],"for":[11,109,119,133,168,209,217,234],"expression":[12,196,214,230,241],"nerve":[14],"growth":[15],"factor":[16],"receptor":[17],"(NGFR)":[18],"by":[19],"flow":[20],"cytometry,":[21],"Western":[22,99],"blotting,":[23,100,159],"Northern":[25,158],"blotting.":[26],"All":[27],"5":[28],"expressed":[32,81],"surface":[34,55,66],"NGFR,":[35],"with":[36,72,90],"30-69%":[37],"cells":[39,57],"NGFR":[40,84,105,172,198,204,213,229,240],"positive,":[41],"but":[42,116,174],"the":[43,101,169,194],"17":[44],"tested":[48,115,165],"had":[49,193],"a":[50,69,73,87,144,149,206],"smaller":[51],"percentage":[52],"NGFR-positive":[56],"(0-21%)":[58],"10":[60],"completely":[63],"lacking":[64],"NGFR.":[67],"SY5Y,":[68],"variant":[70,88],"line":[71,79,89,186,191],"neuronal":[74,243],"phenotype":[75,93],"derived":[76,95],"from":[77,96],"SKNSH,":[80],"much":[82],"more":[83],"than":[85],"SHEP,":[86],"an":[91],"epithelial-like":[92],"also":[94,155],"SKNSH.":[97],"By":[98,157],"Mr":[102,145,150],"approximately":[103,146,151],"69,000":[104],"band":[106,129,153],"was":[107,117,130],"detected":[108],"all":[110,160],"four":[111],"visible":[118],"only":[120,175],"8":[121,176],"15":[123,178],"tested.":[127],"The":[128],"most":[131],"intense":[132],"SKNMC":[137],"TC32.":[139],"For":[140],"these":[141],"two":[142],"lines,":[143],"56,000":[147],"60,000":[152],"detected.":[156],"three":[161],"positive":[167],"3.8":[170],"kilobase":[171],"mRNA,":[173],"positive.":[183],"Neuroepithelioma":[184],"TC32":[187],"GICAN":[192],"strongest":[195],"mRNA.":[199],"These":[200],"results":[201],"demonstrate":[202],"that":[203,212],"is":[205,215],"biological":[207],"marker":[208],"heterogeneous":[216],"lines.":[220],"This":[221],"neural":[224],"differing":[227],"in":[228],"will":[231],"be":[232],"useful":[233],"future":[235],"studies":[236],"regulation":[238],"differentiation.":[244]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
