{"id":"https://openalex.org/W2129285632","doi":"https://doi.org/10.1681/asn.2014010108","title":"High-Sensitivity Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and Risk of Incident Heart Failure in Patients with CKD","display_name":"High-Sensitivity Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and Risk of Incident Heart Failure in Patients with CKD","publication_year":2014,"publication_date":"2014-10-02","ids":{"openalex":"https://openalex.org/W2129285632","doi":"https://doi.org/10.1681/asn.2014010108","mag":"2129285632","pmid":"https://pubmed.ncbi.nlm.nih.gov/25278510","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4378105"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2014010108","doi":"https://doi.org/10.1681/asn.2014010108","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2014010108","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4378105","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085683611","display_name":"Nisha Bansal","orcid":"https://orcid.org/0000-0002-9583-8628","observed_orcids":["https://orcid.org/0000-0002-9583-8628"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nisha Bansal","raw_affiliation_strings":["University of Washington, Seattle, Washington; nbansal@nephrology.washington.edu","University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, Washington; nbansal@nephrology.washington.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090601106","display_name":"Amanda Hyre Anderson","orcid":"https://orcid.org/0000-0002-1454-4282","observed_orcids":["https://orcid.org/0000-0002-1454-4282"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Hyre Anderson","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643710","display_name":"Wei Peter Yang","orcid":"https://orcid.org/0000-0001-8984-4389","observed_orcids":["https://orcid.org/0000-0001-8984-4389"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Yang","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029186856","display_name":"Robert H. Christenson","orcid":"https://orcid.org/0000-0003-2612-9083","observed_orcids":["https://orcid.org/0000-0003-2612-9083"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Christenson","raw_affiliation_strings":["University of Maryland, School of Medicine, Baltimore, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine, Baltimore, Maryland;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071573513","display_name":"Christopher R. deFilippi","orcid":"https://orcid.org/0000-0002-0660-4943","observed_orcids":["https://orcid.org/0000-0002-0660-4943"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. deFilippi","raw_affiliation_strings":["University of Maryland, School of Medicine, Baltimore, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine, Baltimore, Maryland;","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059631475","display_name":"Rajat Deo","orcid":"https://orcid.org/0000-0002-8250-2607","observed_orcids":["https://orcid.org/0000-0002-8250-2607"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajat Deo","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109174911","display_name":"Daniel L. Dries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L. Dries","raw_affiliation_strings":["Yale University; New Haven Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University; New Haven Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026846209","display_name":"Alan S. Go","orcid":"https://orcid.org/0000-0001-9109-0811","observed_orcids":["https://orcid.org/0000-0001-9109-0811","https://orcid.org/0000-0001-5671-0763"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan S. Go","raw_affiliation_strings":["Kaiser Permanente Northern California, Oakland, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Northern California, Oakland, California","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421924","display_name":"Jiang He","orcid":"https://orcid.org/0000-0002-8286-9652","observed_orcids":["https://orcid.org/0000-0002-8286-9652","https://orcid.org/0000-0002-2060-0893"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiang He","raw_affiliation_strings":["Tulane University, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109934186","display_name":"John W. Kusek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John W. Kusek","raw_affiliation_strings":["National Institutes of Health, Bethesda, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, Maryland;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058217417","display_name":"James Phillip Lash","orcid":"https://orcid.org/0000-0002-6580-4080","observed_orcids":["https://orcid.org/0000-0002-6580-4080"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Lash","raw_affiliation_strings":["University of Illinois Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018412357","display_name":"Dominic S. Raj","orcid":"https://orcid.org/0000-0001-9647-083X","observed_orcids":["https://orcid.org/0000-0001-9647-083X"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominic Raj","raw_affiliation_strings":["The George Washington University Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George Washington University Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086540785","display_name":"Sylvia E. Rosas","orcid":"https://orcid.org/0000-0002-9903-4002","observed_orcids":["https://orcid.org/0000-0002-9903-4002"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvia Rosas","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008906136","display_name":"Myles Selig Wolf","orcid":"https://orcid.org/0000-0002-1127-1442","observed_orcids":["https://orcid.org/0000-0002-1127-1442"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myles Wolf","raw_affiliation_strings":["Northwestern University, Feinberg School of Medicine, Chicago, Illinois; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Feinberg School of Medicine, Chicago, Illinois; and","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462568","display_name":"Xiaoming Zhang","orcid":"https://orcid.org/0000-0001-8669-4530","observed_orcids":["https://orcid.org/0000-0001-8669-4530"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoming Zhang","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071585977","display_name":"Michael G. Shlipak","orcid":"https://orcid.org/0000-0002-9559-204X","observed_orcids":["https://orcid.org/0000-0002-9559-204X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Shlipak","raw_affiliation_strings":["University of California, San Francisco, California","University of California,#R#San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California,#R#San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016894949","display_name":"Harold I. Feldman","orcid":"https://orcid.org/0000-0003-4572-2608","observed_orcids":["https://orcid.org/0000-0003-4572-2608"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold I. Feldman","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5085683611","https://openalex.org/A5109934186"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":7.6854,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.9811503,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"26","issue":"4","first_page":"946","last_page":"956"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-sensitivity-troponin-t","display_name":"high-sensitivity troponin T","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9660000205039978},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/incident-heart-failure-risk","display_name":"incident heart failure risk","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cardiac-biomarkers","display_name":"cardiac biomarkers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/myocardial-stress","display_name":"myocardial stress","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cric-study","display_name":"CRIC study","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.8523684740066528},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.6903611421585083},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.684427797794342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.683444619178772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6688529849052429},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6272287964820862},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.4518038332462311},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.057930439710617065}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020107","descriptor_name":"Troponin T","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1681/asn.2014010108","doi":"https://doi.org/10.1681/asn.2014010108","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2014010108","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4378105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4378105","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},{"id":"pmid:25278510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25278510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4378105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4378105","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1355330398","display_name":null,"funder_award_id":"K24DK02651","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1651394900","display_name":"Clinical and Translational Science Institute","funder_award_id":"UL1RR024131","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1886927148","display_name":"Heart failure and atrial arrhythmias in CKD","funder_award_id":"R01DK103612","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2246312996","display_name":"Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury","funder_award_id":"K01DK092353","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2351969343","display_name":"Heart Failure Incidence and Progression in Renal Disease","funder_award_id":"R01DK066488","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2390485895","display_name":"Hispanic Chronic Renal Insufficiency Cohort(CRIC) Study","funder_award_id":"R01DK072231","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G243530825","display_name":null,"funder_award_id":"K24-DK002651","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2550829853","display_name":"Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study","funder_award_id":"U01DK060990","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3505631406","display_name":"General Clinical Research Center","funder_award_id":"M01RR016500","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3562949498","display_name":null,"funder_award_id":"K23-DK088865","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3620995393","display_name":"Mentored Patient Oriented Research in Mineral Metabolism","funder_award_id":"K24DK093723","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G36850890","display_name":null,"funder_award_id":"1DK066488","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3711858758","display_name":"Translational Research in Hypertension and Renal Biology","funder_award_id":"P30GM103337","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4509620513","display_name":"Blood Pressure in Advanced Chronic Kidney Disease","funder_award_id":"5k23dk088865-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5134606249","display_name":"FGF23 and Cardiovascular Disease in CKD","funder_award_id":"R01DK081374","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5807784960","display_name":"Center for Clinical and Translational Science","funder_award_id":"UL1RR029879","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6838483561","display_name":"Michigan Institute for Clinical and Health Research (MCHR)","funder_award_id":"UL1TR000433","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7161438706","display_name":"CKD the metabolic syndrome & cardiovascular illness","funder_award_id":"5k24dk002651-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7623314599","display_name":"Institute for Clinical and Translational Research","funder_award_id":"UL1TR000424","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7683699529","display_name":"Institutional Clinical and Translational Science Award","funder_award_id":"UL1TR000003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8441272977","display_name":"Clinical and Translational Science Collaborative of Cleveland","funder_award_id":"UL1TR000439","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000870431","display_name":"A pilot trial of an intervention to support initial type 2 diabetes selfmanagement among younger adults with children.","funder_award_id":"R01DK139225","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000874920","display_name":"Prospective renal insufficiency cohort evaluation: PRICE","funder_award_id":"U01DK060984","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000884021","display_name":"Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center","funder_award_id":"U01DK060902","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000893802","display_name":"Continuation of the University of Illinois Chicago CRIC Clinical Center","funder_award_id":"U01DK060980","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000904092","display_name":"Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center","funder_award_id":"U01DK061022","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000908582","display_name":"Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study","funder_award_id":"U01DK060963","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000909191","display_name":"Chronic Renal Insufficiency Cohort Limited competition continuation","funder_award_id":"U01DK061021","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000909344","display_name":"Chronic Renal Insufficiency Cohort (CRIC) Study","funder_award_id":"U01DK061028","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1489794112","https://openalex.org/W1976322287","https://openalex.org/W1980870383","https://openalex.org/W1986071500","https://openalex.org/W1999448954","https://openalex.org/W2009383000","https://openalex.org/W2009826381","https://openalex.org/W2015399721","https://openalex.org/W2016422315","https://openalex.org/W2017554373","https://openalex.org/W2018811948","https://openalex.org/W2035282793","https://openalex.org/W2038295319","https://openalex.org/W2043767297","https://openalex.org/W2049893341","https://openalex.org/W2056503496","https://openalex.org/W2060658849","https://openalex.org/W2073742622","https://openalex.org/W2076335162","https://openalex.org/W2077856938","https://openalex.org/W2079901425","https://openalex.org/W2080594749","https://openalex.org/W2084859385","https://openalex.org/W2095517160","https://openalex.org/W2098105324","https://openalex.org/W2101099004","https://openalex.org/W2101660928","https://openalex.org/W2107420262","https://openalex.org/W2112245414","https://openalex.org/W2112816524","https://openalex.org/W2113079363","https://openalex.org/W2113865982","https://openalex.org/W2114089832","https://openalex.org/W2114157611","https://openalex.org/W2129015099","https://openalex.org/W2129426962","https://openalex.org/W2129675891","https://openalex.org/W2131110345","https://openalex.org/W2135422127","https://openalex.org/W2137271727","https://openalex.org/W2137800496","https://openalex.org/W2140732936","https://openalex.org/W2143448016","https://openalex.org/W2145632027","https://openalex.org/W2146105386","https://openalex.org/W2148983669","https://openalex.org/W2151434193","https://openalex.org/W2157953504","https://openalex.org/W2160134719","https://openalex.org/W2167228964","https://openalex.org/W2408907312","https://openalex.org/W2605975631","https://openalex.org/W2990123797"],"related_works":["https://openalex.org/W3136182163","https://openalex.org/W2981468466","https://openalex.org/W3111541948","https://openalex.org/W2886898880","https://openalex.org/W4415722401","https://openalex.org/W4392930287","https://openalex.org/W4415474820","https://openalex.org/W4403831762","https://openalex.org/W7159571688","https://openalex.org/W3213411892"],"abstract_inverted_index":{"High-sensitivity":[0],"troponin":[1],"T":[2],"(hsTnT)":[3],"and":[4,42,101,122,136,213,242],"N-terminal":[5],"pro-B-type":[6],"natriuretic":[7],"peptide":[8],"(NT-proBNP)":[9],"strongly":[10,216],"predict":[11],"heart":[12],"failure":[13],"(HF)":[14],"in":[15,64,153,179,187,233,240],"the":[16,20,65,94,154,180,188],"general":[17],"population.":[18],"However,":[19],"interpretation":[21],"of":[22,24,29,75,79,84,96,99,116,164,198,225],"levels":[23,98,129,138],"these":[25,234],"biomarkers":[26,235],"as":[27],"predictors":[28],"HF":[30,48,85,105,165,199,220],"is":[31],"uncertain":[32],"among":[33,49,221],"patients":[34,50],"with":[35,46,51,62,103,146,177,218,227],"CKD.":[36,52,231],"Here,":[37],"we":[38,58],"investigated":[39],"whether":[40],"hsTnT":[41,100,128,212],"NT-proBNP":[43,102,137,182,214],"are":[44],"associated":[45,217],"incident":[47,104,219],"In":[53,210],"a":[54,160,194,222],"prospective":[55],"cohort":[56,224],"analysis,":[57],"studied":[59],"3483":[60],"people":[61],"CKD":[63],"Chronic":[66],"Renal":[67],"Insufficiency":[68],"Cohort":[69],"(CRIC)":[70],"Study":[71],"recruited":[72],"from":[73,131,140],"June":[74],"2003":[76],"to":[77,92,133,142,173,207,229,248],"August":[78],"2008":[80],"who":[81,148],"were":[82,215],"free":[83],"at":[86],"baseline.":[87],"We":[88],"used":[89],"Cox":[90],"regression":[91],"examine":[93],"association":[95],"baseline":[97],"after":[106],"adjustment":[107],"for":[108],"demographic":[109],"factors,":[110,114],"traditional":[111],"cardiovascular":[112],"risk":[113],"markers":[115],"kidney":[117],"disease,":[118],"pertinent":[119],"medication":[120],"use,":[121],"mineral":[123],"metabolism":[124],"markers.":[125],"At":[126],"baseline,":[127],"ranged":[130,139],"\u22645.0":[132],"738.7":[134],"pg/ml,":[135],"\u22645":[141],"35,000":[143],"pg/ml.":[144],"Compared":[145],"those":[147,178],"had":[149,159],"undetectable":[150],"hsTnT,":[151],"participants":[152,186],"highest":[155,189],"quartile":[156],"(>26.5":[157],"pg/ml)":[158,192],"significantly":[161],"higher":[162,196],"rate":[163,197],"(hazard":[166,200],"ratio,":[167,201],"4.77;":[168],"95%":[169,203],"confidence":[170,204],"interval,":[171,205],"2.49":[172],"9.14).":[174],"Similarly,":[175],"compared":[176],"lowest":[181],"quintile":[183,190],"(<47.6":[184],"pg/ml),":[185],"(>433.0":[191],"experienced":[193],"substantially":[195],"9.57;":[202],"4.40":[206],"20.83)":[208],"[corrected].":[209],"conclusion,":[211],"diverse":[223],"individuals":[226],"mild":[228],"severe":[230],"Elevations":[232],"may":[236],"indicate":[237],"subclinical":[238],"changes":[239],"volume":[241],"myocardial":[243],"stress":[244],"that":[245],"subsequently":[246],"contribute":[247],"clinical":[249],"HF.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}