{"id":"https://openalex.org/W2129245826","doi":"https://doi.org/10.1081/dct-100100129","title":"IN VITRO INHIBITION OF CARCINOGEN-INDUCED MUTAGENICITY BYCASSIA OCCIDENTALISANDEMBLICA OFFICINALIS","display_name":"IN VITRO INHIBITION OF CARCINOGEN-INDUCED MUTAGENICITY BYCASSIA OCCIDENTALISANDEMBLICA OFFICINALIS","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2129245826","doi":"https://doi.org/10.1081/dct-100100129","mag":"2129245826","pmid":"https://pubmed.ncbi.nlm.nih.gov/10959548"},"language":"en","primary_location":{"id":"doi:10.1081/dct-100100129","doi":"https://doi.org/10.1081/dct-100100129","is_oa":false,"landing_page_url":"https://doi.org/10.1081/dct-100100129","pdf_url":null,"source":{"id":"https://openalex.org/S17820993","display_name":"Drug and Chemical Toxicology","issn_l":"0148-0545","issn":["0148-0545","1525-6014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and Chemical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056645750","display_name":"Nidhi Sharma","orcid":"https://orcid.org/0000-0002-1302-7099","observed_orcids":["https://orcid.org/0000-0002-1302-7099"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nidhi Sharma","raw_affiliation_strings":["Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India","Department of Medical Elementology & Toxicology; Jamia Hamdard (Hamdard University); New Delhi 110 062 India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India","institution_ids":["https://openalex.org/I19716509"]},{"raw_affiliation_string":"Department of Medical Elementology & Toxicology; Jamia Hamdard (Hamdard University); New Delhi 110 062 India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008950160","display_name":"Prashant Trikha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Trikha","raw_affiliation_strings":["Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079917691","display_name":"Mohammad Athar","orcid":"https://orcid.org/0000-0001-5829-7992","observed_orcids":["https://orcid.org/0000-0001-5829-7992"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. Athar","raw_affiliation_strings":["Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070981650","display_name":"Sheikh Raisuddin","orcid":"https://orcid.org/0000-0003-0913-8906","observed_orcids":["https://orcid.org/0000-0003-0913-8906"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Raisuddin","raw_affiliation_strings":["Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Elementology & Toxicology, Jamia Hamdard (Hamdard University), New Delhi, 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19716509"],"apc_list":null,"apc_paid":null,"fwci":1.3363,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.79844696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"3","first_page":"477","last_page":"484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cassia-occidentalis","display_name":"Cassia occidentalis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/phyllanthus-emblica","display_name":"Phyllanthus emblica","score":1.0},{"id":"https://openalex.org/keywords/antimutagenic-activity","display_name":"antimutagenic activity","score":0.9070000052452087},{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.6610000133514404},{"id":"https://openalex.org/keywords/ames-test","display_name":"Ames test","score":0.7210000157356262},{"id":"https://openalex.org/keywords/salmonella-typhimurium-ta98","display_name":"Salmonella typhimurium TA98","score":0.8960000276565552},{"id":"https://openalex.org/keywords/salmonella-typhimurium-ta100","display_name":"Salmonella typhimurium TA100","score":0.9940000176429749},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/rat-liver-s9","display_name":"rat liver S9","score":0.7239999771118164},{"id":"https://openalex.org/keywords/anticarcinogenic-activity","display_name":"anticarcinogenic activity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C2775939860","wikidata":"https://www.wikidata.org/wiki/Q162882","display_name":"Cassia","level":4,"score":0.837912380695343},{"id":"https://openalex.org/C117632636","wikidata":"https://www.wikidata.org/wiki/Q30912","display_name":"Ames test","level":4,"score":0.7408912181854248},{"id":"https://openalex.org/C40758303","wikidata":"https://www.wikidata.org/wiki/Q212936","display_name":"Aflatoxin","level":2,"score":0.6899983882904053},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.555145800113678},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5442079305648804},{"id":"https://openalex.org/C2781422964","wikidata":"https://www.wikidata.org/wiki/Q12529398","display_name":"Antimutagen","level":4,"score":0.5057229995727539},{"id":"https://openalex.org/C2780886089","wikidata":"https://www.wikidata.org/wiki/Q7079617","display_name":"Officinalis","level":2,"score":0.46703287959098816},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.46482163667678833},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.4500647783279419},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.4187206029891968},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3974061608314514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38113677501678467},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3598862290382385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3518715500831604},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.35011711716651917},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.32829156517982483},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.22646641731262207},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1611419916152954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0652385950088501},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.054873883724212646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002366","descriptor_name":"Cassia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016587","descriptor_name":"Antimutagenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D019665","descriptor_name":"Euphorbiaceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1081/dct-100100129","doi":"https://doi.org/10.1081/dct-100100129","is_oa":false,"landing_page_url":"https://doi.org/10.1081/dct-100100129","pdf_url":null,"source":{"id":"https://openalex.org/S17820993","display_name":"Drug and Chemical Toxicology","issn_l":"0148-0545","issn":["0148-0545","1525-6014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and Chemical Toxicology","raw_type":"journal-article"},{"id":"pmid:10959548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10959548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and chemical toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313289","display_name":"Lady Tata Memorial Trust","ror":"https://ror.org/019yg2621"},{"id":"https://openalex.org/F4320323504","display_name":"Tata Trusts","ror":"https://ror.org/057kjcb31"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W131161169","https://openalex.org/W365713858","https://openalex.org/W1560631690","https://openalex.org/W1580040909","https://openalex.org/W1966781584","https://openalex.org/W1974193608","https://openalex.org/W1974348959","https://openalex.org/W1990183284","https://openalex.org/W1992308402","https://openalex.org/W2003994745","https://openalex.org/W2008677397","https://openalex.org/W2009368303","https://openalex.org/W2015387809","https://openalex.org/W2027879058","https://openalex.org/W2029520384","https://openalex.org/W2030839789","https://openalex.org/W2045544648","https://openalex.org/W2054057912","https://openalex.org/W2077764388","https://openalex.org/W2089160912","https://openalex.org/W2103546065","https://openalex.org/W2106825564","https://openalex.org/W2129074579","https://openalex.org/W2146046312","https://openalex.org/W2164887780","https://openalex.org/W2172322214","https://openalex.org/W2778118850"],"related_works":["https://openalex.org/W2106825564","https://openalex.org/W2005879123","https://openalex.org/W2068996773","https://openalex.org/W2046263539","https://openalex.org/W1974193608","https://openalex.org/W49140092","https://openalex.org/W2051550656","https://openalex.org/W1971928044","https://openalex.org/W784281939","https://openalex.org/W2349367214"],"abstract_inverted_index":{"Aqueous":[0],"extracts":[1],"of":[2,19,47],"Cassia":[3],"occidentalis":[4],"Linn.":[5],"(Leguminoceae)":[6],"and":[7,23,39,51,104],"Emblica":[8],"officinalis":[9,68],"Gaertn.":[10],"(Euphorbiaceae)":[11],"were":[12],"screened":[13],"for":[14],"effectiveness":[15],"in":[16,26],"inhibiting":[17],"mutagenicity":[18],"aflatoxin":[20],"B1":[21],"(AFB1)":[22],"benzo[a]pyrene":[24],"(B[a]P)":[25],"the":[27,43],"Ames":[28],"test.":[29],"Antimutagenicity":[30],"was":[31,55],"evaluated":[32],"using":[33],"Salmonella":[34],"typhimurium":[35],"strains":[36],"TA":[37,40],"98":[38],"100.":[41],"In":[42],"assay,":[44],"metabolic":[45,110],"activation":[46],"AFB1":[48],"(0.5":[49],"microg/plate)":[50,54],"B[a]P":[52],"(1":[53],"mediated":[56,80],"by":[57],"rat":[58],"liver":[59],"S9":[60],"preparation.":[61],"Although":[62],"both":[63],"plants":[64,100],"inhibited":[65],"mutagenicity,":[66],"E.":[67],"had":[69],"more":[70],"inhibitory":[71,88],"effect":[72],"than":[73],"C.":[74],"occidentalis.":[75],"Their":[76,87],"action":[77,89],"is":[78],"possibly":[79],"through":[81],"interactions":[82],"with":[83,94],"microsomal":[84],"activating":[85],"enzymes.":[86],"on":[90],"chromosomal":[91],"aberrations":[92],"together":[93],"present":[95],"results":[96],"suggest":[97],"that":[98],"these":[99],"have":[101],"potent":[102],"antimutagenic":[103],"anticarcinogenic":[105],"activities":[106],"against":[107],"mutagens":[108],"requiring":[109],"activation.":[111]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
