{"id":"https://openalex.org/W2129240736","doi":"https://doi.org/10.1016/j.juro.2007.01.068","title":"Risk of Prostate Cancer for Young Men With a Prostate Specific Antigen Less Than Their Age Specific Median","display_name":"Risk of Prostate Cancer for Young Men With a Prostate Specific Antigen Less Than Their Age Specific Median","publication_year":2007,"publication_date":"2007-04-15","ids":{"openalex":"https://openalex.org/W2129240736","doi":"https://doi.org/10.1016/j.juro.2007.01.068","mag":"2129240736","pmid":"https://pubmed.ncbi.nlm.nih.gov/17437803"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2007.01.068","doi":"https://doi.org/10.1016/j.juro.2007.01.068","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2007.01.068","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031483568","display_name":"Stacy Loeb","orcid":"https://orcid.org/0000-0003-3933-9207","observed_orcids":["https://orcid.org/0000-0003-3933-9207"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy Loeb","raw_affiliation_strings":["Department of Urology, Georgetown University School of Medicine, Washington, D. C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Georgetown University School of Medicine, Washington, D. C","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108660894","display_name":"Robert B. Nadler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert B. Nadler","raw_affiliation_strings":["Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109236192","display_name":"Kimberly A. Roehl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly A. Roehl","raw_affiliation_strings":["Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110024513","display_name":"Jo Ann V. Antenor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jo Ann V. Antenor","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065869555","display_name":"William J. Cat\u00e0lona","orcid":"https://orcid.org/0009-0004-2926-5114","observed_orcids":["https://orcid.org/0009-0004-2926-5114"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Catalona","raw_affiliation_strings":["Department of Surgery/Urology, Washington University School of Medicine, St. Louis, Missouri","Department of Urology, Georgetown University School of Medicine, Washington, D. C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery/Urology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Urology, Georgetown University School of Medicine, Washington, D. C","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.7496,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84814902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"177","issue":"5","first_page":"1745","last_page":"1748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.8730000257492065},{"id":"https://openalex.org/keywords/young-men","display_name":"young men","score":0.7929999828338623},{"id":"https://openalex.org/keywords/psa-velocity","display_name":"PSA velocity","score":0.75},{"id":"https://openalex.org/keywords/prostate-cancer-screening","display_name":"prostate cancer screening","score":0.671999990940094},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8709999918937683},{"id":"https://openalex.org/keywords/biopsy-threshold","display_name":"biopsy threshold","score":0.5400000214576721},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.6290000081062317},{"id":"https://openalex.org/keywords/black-men","display_name":"Black men","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9019843339920044},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8288230299949646},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.8220454454421997},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7255069613456726},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5784193277359009},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.516751229763031},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.509199321269989},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4836348295211792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.463184118270874},{"id":"https://openalex.org/C2775941076","wikidata":"https://www.wikidata.org/wiki/Q7250979","display_name":"Prostate cancer screening","level":5,"score":0.44411927461624146},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4386886656284332},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.43200021982192993},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3905339539051056},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14163824915885925}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.juro.2007.01.068","doi":"https://doi.org/10.1016/j.juro.2007.01.068","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2007.01.068","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:17437803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17437803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1992694633","https://openalex.org/W2004345073","https://openalex.org/W2042748219","https://openalex.org/W2044210477","https://openalex.org/W2061129859","https://openalex.org/W2063614609","https://openalex.org/W2070845688","https://openalex.org/W2108391240","https://openalex.org/W2112689533","https://openalex.org/W2143858821","https://openalex.org/W2161637485","https://openalex.org/W2413314156"],"related_works":["https://openalex.org/W2042748219","https://openalex.org/W2110504486","https://openalex.org/W2147707434","https://openalex.org/W2133577475","https://openalex.org/W1981611851","https://openalex.org/W2044210477","https://openalex.org/W2320124102","https://openalex.org/W2106519742","https://openalex.org/W2171061866","https://openalex.org/W2134956576"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"previously":[2],"reported":[3],"that":[4,21],"the":[5,45,65,76,135,149,176,204,251,263,274,297],"median":[6,79,157,207,254,300],"prostate":[7,24,40,57,88,102,130,151,167,187,198,210,228,246,260,269],"specific":[8,25,58,78,103,131,152,168,199,206,211,247,253,270,299],"antigen":[9,26,59,104,132,169,200,212,248,271],"for":[10,47,69,178,286],"men":[11,51,70,113,194,290],"40":[12,94,239],"to":[13,95,120,240,278],"49":[14,96,241],"years":[15,97,242],"old":[16,98,243],"is":[17,32,80],"0.7":[18,28,63,108,173],"ng/ml":[19,31,109,174,217],"and":[20,29,139,180,224,282],"a":[22,35,56,72,86,100,121,146,156,181,196,209,245,256,267],"baseline":[23,101,150,197,268],"between":[27],"2.5":[30],"associated":[33],"with":[34,55,71,99,164,186,195,227,244,291],"14.6-fold":[36],"increased":[37],"risk":[38,118,258,287,304],"of":[39,50,148,159,193,259],"cancer.":[41,188],"Although":[42],"this":[43],"suggests":[44],"need":[46],"close":[48],"followup":[49,158],"in":[52,129,262,273],"their":[53],"40s":[54],"level":[60,73,105,170,201],"greater":[61,191,202,214,293],"than":[62,75,107,172,203,215,250,296],"ng/ml,":[64],"appropriate":[66],"screening":[67,90],"strategy":[68],"less":[74,106,171,249,295],"age":[77,205,231,252,298],"unclear.":[81],"MATERIALS":[82],"AND":[83],"METHODS:":[84],"From":[85],"large":[87],"cancer":[89,136,229,261],"study":[91],"581":[92],"participants":[93],"were":[110,114,143,225],"identified.":[111],"All":[112],"classified":[115],"as":[116,145],"high":[117],"due":[119],"positive":[122],"family":[123],"history":[124],"and/or":[125],"black":[126],"heritage.":[127],"Changes":[128],"over":[133],"time,":[134],"detection":[137],"rate":[138],"pathological":[140],"tumor":[141],"features":[142],"examined":[144],"function":[147],"antigen.":[153],"RESULTS:":[154],"At":[155],"13":[160],"months":[161],"2":[162],"patients":[163],"an":[165],"initial":[166],"reached":[175],"threshold":[177],"biopsy,":[179],"single":[182],"patient":[183],"was":[184,283],"diagnosed":[185,226],"A":[189],"significantly":[190],"proportion":[192],"had":[208,301],"velocity":[213],"0.75":[216],"per":[218],"year":[219],"(9%":[220],"vs":[221,234],"3%,":[222],"p=0.009)":[223],"before":[230],"50":[232],"(4.6%":[233],"0.16%,":[235],"p<0.0001).":[236],"CONCLUSIONS:":[237],"Men":[238],"have":[255],"low":[257],"short":[264],"term.":[265],"Performing":[266],"measurement":[272],"fifth":[275],"decade":[276],"led":[277],"few":[279],"additional":[280],"biopsies,":[281],"extremely":[284],"useful":[285],"stratification":[288],"since":[289],"levels":[292],"or":[294],"strikingly":[302],"different":[303],"profiles.":[305]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}