{"id":"https://openalex.org/W2129227455","doi":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","title":"Familial Amyloid Polyneuropathy: Receptor for Advanced Glycation End Products-Dependent Triggering of Neuronal Inflammatory and Apoptotic Pathways","display_name":"Familial Amyloid Polyneuropathy: Receptor for Advanced Glycation End Products-Dependent Triggering of Neuronal Inflammatory and Apoptotic Pathways","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2129227455","doi":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","mag":"2129227455","pmid":"https://pubmed.ncbi.nlm.nih.gov/11567048","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6762914"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.21-19-07576.2001","doi":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/19/7576.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jneurosci.org/content/jneuro/21/19/7576.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034241498","display_name":"M\u00f3nica Mendes Sousa","orcid":"https://orcid.org/0000-0002-4524-2260","observed_orcids":["https://orcid.org/0000-0002-4524-2260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00f3nica Mendes Sousa","raw_affiliation_strings":["Institute for Cellular and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cellular and Molecular Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522158","display_name":"Shi Du Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shi Du Yan","raw_affiliation_strings":["Departments of Pathology, Surgery, and Physiology and Cellular Biophysics, Columbia University, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Surgery, and Physiology and Cellular Biophysics, Columbia University, New York, New York 10032,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046903959","display_name":"Rui Fernandes","orcid":"https://orcid.org/0000-0002-9535-368X","observed_orcids":["https://orcid.org/0000-0002-9535-368X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Fernandes","raw_affiliation_strings":["Institute for Cellular and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cellular and Molecular Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110241068","display_name":"Ant\u00f3nio Guimar\u00e3es","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127365","display_name":"Hospital de Santo Ant\u00f3nio","ror":"https://ror.org/02m9pj861","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210127365"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio Guimar\u00e3es","raw_affiliation_strings":["Hospital Geral de Santo Ant\u00f3nio, Porto 4150-180, Portugal, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Geral de Santo Ant\u00f3nio, Porto 4150-180, Portugal, and","institution_ids":["https://openalex.org/I4210127365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025321778","display_name":"David Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Stern","raw_affiliation_strings":["Departments of Pathology, Surgery, and Physiology and Cellular Biophysics, Columbia University, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Surgery, and Physiology and Cellular Biophysics, Columbia University, New York, New York 10032,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021195219","display_name":"Maria Jo\u00e3o Saraiva","orcid":"https://orcid.org/0000-0002-3360-6899","observed_orcids":["https://orcid.org/0000-0002-3360-6899"]},"institutions":[{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Jo\u00e3o Saraiva","raw_affiliation_strings":["Institute for Cellular and Molecular Biology,","Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Porto 4099-003, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cellular and Molecular Biology,","institution_ids":[]},{"raw_affiliation_string":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Porto 4099-003, Portugal","institution_ids":["https://openalex.org/I4405263123"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.2883,"has_fulltext":true,"cited_by_count":213,"citation_normalized_percentile":{"value":0.98197956,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"21","issue":"19","first_page":"7576","last_page":"7586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-amyloid-polyneuropathy","display_name":"hereditary transthyretin amyloidosis","score":1.0},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.7289999723434448},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.949999988079071},{"id":"https://openalex.org/keywords/tyrosine-nitration","display_name":"tyrosine nitration","score":0.9660000205039978},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neurotrophin-3","display_name":"neurotrophin-3","score":0.9309999942779541},{"id":"https://openalex.org/keywords/peripheral-nerve-dysfunction","display_name":"peripheral nerve dysfunction","score":0.578000009059906},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6426352858543396},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.5506680011749268},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.4833671450614929},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48215314745903015},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.470714271068573},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.46805447340011597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43479686975479126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40991729497909546},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36442673206329346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3165016770362854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3010505437850952},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.24001428484916687},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.15886539220809937}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013497","descriptor_name":"Sural Nerve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013497","descriptor_name":"Sural Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017772","descriptor_name":"Amyloid Neuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017772","descriptor_name":"Amyloid Neuropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.21-19-07576.2001","doi":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/19/7576.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6762914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6762914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:11567048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11567048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.924.5668","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.924.5668","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://kuscholarworks.ku.edu/bitstream/handle/1808/14817/Yan_et_al_2001.pdf%3Bjsessionid%3DA2895E834354DB64CC7F04E89C5B2A1F?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:kuscholarworks.ku.edu:1808/14817","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1808/14817","pdf_url":null,"source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.21-19-07576.2001","doi":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-19-07576.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/19/7576.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6621341250","display_name":"Cellular Cofactors, Neuronal Stress & Rescue, Aging & Alzheimer Disease","funder_award_id":"P01AG017490","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8500255941","display_name":"AGING BRAIN--CEREBROVASCULAR MECHANISM &AMYLOID BETA","funder_award_id":"P01AG016223","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129227455.pdf","grobid_xml":"https://content.openalex.org/works/W2129227455.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1487900963","https://openalex.org/W1502047387","https://openalex.org/W1538561477","https://openalex.org/W1545799264","https://openalex.org/W1547594230","https://openalex.org/W1621971853","https://openalex.org/W1662308449","https://openalex.org/W1693283493","https://openalex.org/W1745634660","https://openalex.org/W1965275873","https://openalex.org/W1967729440","https://openalex.org/W1971805587","https://openalex.org/W1972850922","https://openalex.org/W1974280458","https://openalex.org/W1982652047","https://openalex.org/W1985918137","https://openalex.org/W2005640704","https://openalex.org/W2016370501","https://openalex.org/W2021413266","https://openalex.org/W2024559246","https://openalex.org/W2025980618","https://openalex.org/W2049160327","https://openalex.org/W2049167261","https://openalex.org/W2056590551","https://openalex.org/W2067613962","https://openalex.org/W2068884332","https://openalex.org/W2069559773","https://openalex.org/W2070117026","https://openalex.org/W2071675524","https://openalex.org/W2073516240","https://openalex.org/W2098587915","https://openalex.org/W2104938297","https://openalex.org/W2107406217","https://openalex.org/W2116164680","https://openalex.org/W2117196518","https://openalex.org/W2120990932","https://openalex.org/W2122065036","https://openalex.org/W2135482947","https://openalex.org/W2136511265","https://openalex.org/W2137399373","https://openalex.org/W2407285342","https://openalex.org/W2931764882","https://openalex.org/W4231159784","https://openalex.org/W4236122603","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2131103898","https://openalex.org/W2016370501","https://openalex.org/W2049838034","https://openalex.org/W1860691715","https://openalex.org/W93813214","https://openalex.org/W30870368","https://openalex.org/W2061022393","https://openalex.org/W2037490734","https://openalex.org/W2131597939","https://openalex.org/W2102395447"],"abstract_inverted_index":{"Familial":[0],"amyloid":[1,16],"polyneuropathy":[2],"(FAP)":[3],"is":[4,45,248],"a":[5,48,144],"neurodegenerative":[6],"disorder":[7],"associated":[8,46],"with":[9,47,63,75,198,235],"extracellular":[10],"deposition":[11],"of":[12,29,57,71,91,98,112,129,171,179,204,222,232,252,254],"mutant":[13],"transthyretin":[14],"(TTR)":[15],"fibrils,":[17],"particularly":[18],"in":[19,85,109,143,155,186,244,257],"the":[20,33,95,99,126,169,230],"peripheral":[21,53],"nervous":[22],"system.":[23],"We":[24,227],"have":[25],"hypothesized":[26],"that":[27,229],"binding":[28],"TTR":[30,199,233],"fibrils":[31,200,234],"to":[32,239,260],"receptor":[34],"for":[35],"advanced":[36],"glycation":[37],"end":[38],"products":[39],"(RAGE)":[40],"on":[41,190],"critical":[42],"cellular":[43,240],"targets":[44],"destructive":[49],"stress":[50,241],"response":[51],"underlying":[52],"nerve":[54,58,259],"dysfunction.":[55],"Analysis":[56],"biopsy":[59],"samples":[60],"from":[61,157],"patients":[62,159],"FAP":[64,158,187,258],"(n":[65,78],"=":[66,79],"16)":[67],"at":[68,94,208],"different":[69],"stages":[70,97],"disease":[72,100],"(0-3),":[73],"compared":[74],"age-matched":[76],"controls":[77],"4),":[80],"by":[81,217],"semiquantitative":[82],"immunohistology":[83],"and":[84,106,118,125,151,184,194,206,212,224,242],"situ":[86],"hybridization":[87],"showed":[88],"increased":[89,152],"levels":[90],"RAGE,":[92],"beginning":[93],"earliest":[96],"(FAP":[101],"0;":[102],"p":[103,122,137],"<":[104,123,138,161],"0.02)":[105,124],"especially":[107],"localized":[108],"axons.":[110],"Upregulation":[111],"proinflammatory":[113],"cytokines":[114,205],"(tumor":[115],"necrosis":[116],"factor-alpha":[117],"interleukin-1beta)":[119],"(approximately":[120],"threefold;":[121],"inducible":[127],"form":[128],"nitric":[130],"oxide":[131],"synthase":[132],"(iNOS)":[133],"(":[134],"approximately":[135],"2.5-fold;":[136],"0.04)":[139],"was":[140,176],"also":[141],"observed":[142],"distribution":[145],"overlapping":[146],"RAGE":[147,236],"expression.":[148],"Tyrosine":[149],"nitration":[150],"activated":[153],"caspase-3":[154,223],"axons":[156],"(p":[160],"0.03)":[162],"were":[163],"apparent.":[164],"Although":[165],"these":[166],"data":[167],"suggest":[168],"presence":[170],"ongoing":[172],"neuronal":[173],"stress,":[174],"there":[175,247],"no":[177],"upregulation":[178],"neurotrophins":[180],"(nerve":[181],"growth":[182],"factor":[183],"neurotrophin-3)":[185],"nerves.":[188],"Studies":[189],"cultured":[191],"neuronal-like,":[192],"Schwann,":[193],"endothelial":[195],"cells":[196,256],"incubated":[197],"displayed":[201],"RAGE-dependent":[202],"expression":[203],"iNOS":[207],"early":[209],"times":[210],"(6":[211],"12":[213],"hr,":[214],"respectively),":[215],"followed":[216],"later":[218],"(24":[219],"hr)":[220],"activation":[221],"DNA":[225],"fragmentation.":[226],"propose":[228],"interaction":[231],"may":[237],"contribute":[238],"toxicity":[243],"FAP.":[245],"Furthermore,":[246],"an":[249],"apparent":[250],"lack":[251],"responsiveness":[253],"Schwann":[255],"provide":[261],"neurotrophic":[262],"factors.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
