{"id":"https://openalex.org/W21292166","doi":null,"title":"A short two-drug regimen prevents active TB.","display_name":"A short two-drug regimen prevents active TB.","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W21292166","mag":"21292166","pmid":"https://pubmed.ncbi.nlm.nih.gov/11365399"},"language":"en","primary_location":{"id":"pmid:11365399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11365399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies","raw_type":"Newspaper Article"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G Torres","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"G Torres","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"4","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-prevention","display_name":"tuberculosis prevention","score":0.949999988079071},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.4749999940395355},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"pyrazinamide","score":1.0},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.734000027179718},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.925000011920929},{"id":"https://openalex.org/keywords/hiv-tb-co-infection","display_name":"HIV/TB coinfection","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.9131754040718079},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.8541674017906189},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7899025082588196},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7312895059585571},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.5910837054252625},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5475918650627136},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5463547706604004},{"id":"https://openalex.org/C3019041143","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Active tuberculosis","level":4,"score":0.5174225568771362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43615010380744934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.363608717918396},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3609205186367035},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2609853446483612},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.23404625058174133},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11742249131202698}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11365399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11365399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies","raw_type":"Newspaper Article"},{"id":"mag:21292166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11365399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W151834247","https://openalex.org/W2079685435","https://openalex.org/W2122308238","https://openalex.org/W2034849841","https://openalex.org/W2008223866","https://openalex.org/W1488964125","https://openalex.org/W2020569170","https://openalex.org/W1675473273","https://openalex.org/W1965091152","https://openalex.org/W2103188931","https://openalex.org/W1970964125","https://openalex.org/W2007432423","https://openalex.org/W2133779882","https://openalex.org/W1598259199","https://openalex.org/W2103211563","https://openalex.org/W1980489179","https://openalex.org/W2099562375","https://openalex.org/W1992470956","https://openalex.org/W2087129510","https://openalex.org/W1449164337","https://openalex.org/W2023127046","https://openalex.org/W2000191183","https://openalex.org/W2109709152","https://openalex.org/W1964732867","https://openalex.org/W2131907269","https://openalex.org/W2123612435","https://openalex.org/W1755737437","https://openalex.org/W1504676920","https://openalex.org/W2002013777","https://openalex.org/W1991096314","https://openalex.org/W2154544847","https://openalex.org/W2080682083","https://openalex.org/W2079081359","https://openalex.org/W2013425130","https://openalex.org/W2093498871","https://openalex.org/W2078643939","https://openalex.org/W2070546979","https://openalex.org/W2128083349","https://openalex.org/W2037279684","https://openalex.org/W2086597706","https://openalex.org/W2122550753","https://openalex.org/W2102324590","https://openalex.org/W2050154932","https://openalex.org/W2075376480","https://openalex.org/W2073149987","https://openalex.org/W2167060626","https://openalex.org/W2084560720","https://openalex.org/W2073726493","https://openalex.org/W1985238694","https://openalex.org/W2130847860","https://openalex.org/W2134836290","https://openalex.org/W1992248892"],"related_works":["https://openalex.org/W2413227409","https://openalex.org/W2209100444","https://openalex.org/W2151990581","https://openalex.org/W2744081054","https://openalex.org/W1996730055","https://openalex.org/W4301902964","https://openalex.org/W2287511476","https://openalex.org/W1995411117","https://openalex.org/W2050414099","https://openalex.org/W2046071939"],"abstract_inverted_index":{"Study":[0],"results":[1],"presented":[2],"at":[3],"the":[4,33,90,103],"5th":[5],"Conference":[6],"on":[7],"Retroviruses":[8],"and":[9,55,63,107],"Opportunistic":[10],"Infections":[11],"showed":[12],"that":[13],"a":[14,27,44],"two-month":[15],"regimen":[16,29],"of":[17,30,35,49,92],"rifampin":[18,82],"with":[19,81],"pyrazinamide":[20],"proved":[21],"to":[22,59,78,83],"be":[23,99],"as":[24,26],"effective":[25],"twelve-month":[28],"isoniazid":[31],"in":[32,38,94],"prevention":[34,91],"tuberculosis":[36],"(TB)":[37],"HIV-positive":[39,41,95],"individuals.":[40],"individuals":[42,96],"have":[43],"ten":[45],"times":[46],"greater":[47,60],"chance":[48],"developing":[50],"TB":[51,56,93],"than":[52],"HIV-negative":[53],"individuals,":[54],"may":[57],"contribute":[58],"viral":[61],"loads":[62],"HIV":[64],"progression.":[65],"The":[66,87],"short-term":[67],"course":[68],"is":[69],"not":[70],"recommended":[71],"for":[72,89],"patients":[73],"using":[74],"protease":[75],"inhibitors":[76],"due":[77],"drug":[79],"interactions":[80],"treat":[84],"active":[85],"TB.":[86],"recommendations":[88],"will":[97],"probably":[98],"changed":[100],"when":[101],"all":[102],"data":[104],"are":[105],"analyzed":[106],"confirmed.":[108]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
