{"id":"https://openalex.org/W2129193267","doi":"https://doi.org/10.1186/s12974-015-0384-7","title":"Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats","display_name":"Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats","publication_year":2015,"publication_date":"2015-09-02","ids":{"openalex":"https://openalex.org/W2129193267","doi":"https://doi.org/10.1186/s12974-015-0384-7","mag":"2129193267","pmid":"https://pubmed.ncbi.nlm.nih.gov/26337974","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4558969"},"language":"en","primary_location":{"id":"doi:10.1186/s12974-015-0384-7","doi":"https://doi.org/10.1186/s12974-015-0384-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-015-0384-7","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0384-7","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0384-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112072992","display_name":"Beatriz Oliveira Amorim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Beatriz O. Amorim","raw_affiliation_strings":["Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. beatriz.oamorim@gmail.com","Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. beatriz.oamorim@gmail.com","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017169924","display_name":"Luciene Covolan","orcid":"https://orcid.org/0000-0002-9751-6438","observed_orcids":["https://orcid.org/0000-0002-9751-6438"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Luciene Covolan","raw_affiliation_strings":["Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. lucovolan@gmail.com","Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. lucovolan@gmail.com","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001708226","display_name":"Elenn Soares Ferreira","orcid":"https://orcid.org/0000-0003-0828-3351","observed_orcids":["https://orcid.org/0000-0003-0828-3351"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elenn Ferreira","raw_affiliation_strings":["Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. elenn_ferreira@msn.com","Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. elenn_ferreira@msn.com","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000752180","display_name":"Jos\u00e9 Geraldo Brito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Geraldo Brito","raw_affiliation_strings":["Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. jgabrito@gmail.com","Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. jgabrito@gmail.com","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038672376","display_name":"Diego P. Nunes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Diego P. Nunes","raw_affiliation_strings":["Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. diegopannunzio@hotmail.com","Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. diegopannunzio@hotmail.com","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063788844","display_name":"David G. de Morais","orcid":"https://orcid.org/0000-0003-4171-9292","observed_orcids":["https://orcid.org/0000-0003-4171-9292"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"David G. de Morais","raw_affiliation_strings":["Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. baratchowisky@bol.com.br","Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, Rua Botucatu, 862 5 andar, 04023-062, S\u00e3o Paulo, Brazil. baratchowisky@bol.com.br","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Disciplina de Neurofisiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037267","display_name":"Jos\u00e9 N. N\u00f3brega","orcid":"https://orcid.org/0000-0001-5655-6073","observed_orcids":["https://orcid.org/0000-0001-5655-6073"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 N. Nobrega","raw_affiliation_strings":["Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada. j.nobrega@utoronto.ca","Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada. j.nobrega@utoronto.ca","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038533104","display_name":"Ant\u00f4nio M\u00e1rcio Rodrigues","orcid":"https://orcid.org/0000-0002-2678-9180","observed_orcids":["https://orcid.org/0000-0002-2678-9180"]},"institutions":[{"id":"https://openalex.org/I166595947","display_name":"Federal University of S\u00e3o Jo\u00e3o del-Rei","ror":"https://ror.org/03vrj4p82","country_code":"BR","type":"education","lineage":["https://openalex.org/I166595947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio M. Rodrigues","raw_affiliation_strings":["Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, S\u00e3o Jo\u00e3o del-Rei, MG, 36301-160, Brazil. amr@ufsj.edu.br","Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o Del Rei, S\u00e3o Jo\u00e3o Del Rei, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, S\u00e3o Jo\u00e3o del-Rei, MG, 36301-160, Brazil. amr@ufsj.edu.br","institution_ids":["https://openalex.org/I166595947"]},{"raw_affiliation_string":"Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o Del Rei, S\u00e3o Jo\u00e3o Del Rei, Brazil","institution_ids":["https://openalex.org/I166595947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024529604","display_name":"Ant\u00f4nio-Carlos G. de Almeida","orcid":"https://orcid.org/0000-0003-4893-338X","observed_orcids":["https://orcid.org/0000-0003-4893-338X"]},"institutions":[{"id":"https://openalex.org/I166595947","display_name":"Federal University of S\u00e3o Jo\u00e3o del-Rei","ror":"https://ror.org/03vrj4p82","country_code":"BR","type":"education","lineage":["https://openalex.org/I166595947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio Carlos G. deAlmeida","raw_affiliation_strings":["Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, S\u00e3o Jo\u00e3o del-Rei, MG, 36301-160, Brazil. acga@ufsj.edu.br","Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o Del Rei, S\u00e3o Jo\u00e3o Del Rei, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, S\u00e3o Jo\u00e3o del-Rei, MG, 36301-160, Brazil. acga@ufsj.edu.br","institution_ids":["https://openalex.org/I166595947"]},{"raw_affiliation_string":"Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o Del Rei, S\u00e3o Jo\u00e3o Del Rei, Brazil","institution_ids":["https://openalex.org/I166595947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058507775","display_name":"Clement Hamani","orcid":"https://orcid.org/0000-0002-7586-2487","observed_orcids":["https://orcid.org/0000-0002-7586-2487"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Clement Hamani","raw_affiliation_strings":["Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada. c.hamani@sympatico.ca","Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada. c.hamani@sympatico.ca","Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health Toronto Canada","Division of Neurosurgery, Toronto Western Hospital; University of Toronto; Toronto Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Canada. c.hamani@sympatico.ca","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada. c.hamani@sympatico.ca","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2799337515"]},{"raw_affiliation_string":"Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health Toronto Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital; University of Toronto; Toronto Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2799337515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017169924"],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":2.4022,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.88365284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"162","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.26170000433921814,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":1.0},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pilocarpine-induced-seizures","display_name":"pilocarpine-induced seizures","score":0.7379999756813049},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.6880000233650208},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.925000011920929},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/anterior-thalamic-nucleus","display_name":"anterior thalamic nuclei","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hippocampal-cell-death","display_name":"hippocampal cell death","score":0.8730000257492065},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.7172847986221313},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6094390153884888},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6028991341590881},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5952455997467041},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5849807262420654},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.489879310131073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48378679156303406},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46949175000190735},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4646795094013214},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42860543727874756},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2764125466346741},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1959257423877716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19082164764404297},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0982220470905304},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010862","descriptor_name":"Pilocarpine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12974-015-0384-7","doi":"https://doi.org/10.1186/s12974-015-0384-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-015-0384-7","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0384-7","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4558969","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4558969","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuroinflammation","raw_type":"Text"},{"id":"pmid:26337974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26337974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/84832","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/84832","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0c74f8e0-efc2-4c44-88cb-5d672a53b247/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12974-015-0384-7","doi":"https://doi.org/10.1186/s12974-015-0384-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-015-0384-7","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-015-0384-7","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1911138429","display_name":null,"funder_award_id":"2012/10764-5","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G2327195810","display_name":"Cellular effects of deep brain stimulation in anterior thalamus nucleus in experimental models of temporal lobe epilepsy","funder_award_id":"12/50950-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G4804253319","display_name":"Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools","funder_award_id":"11/50680-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129193267.pdf","grobid_xml":"https://content.openalex.org/works/W2129193267.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1558556156","https://openalex.org/W1743810548","https://openalex.org/W1947356649","https://openalex.org/W1975404558","https://openalex.org/W1977172001","https://openalex.org/W1986145208","https://openalex.org/W1991890089","https://openalex.org/W1992598009","https://openalex.org/W1996715557","https://openalex.org/W2015510501","https://openalex.org/W2031772506","https://openalex.org/W2033242795","https://openalex.org/W2040076525","https://openalex.org/W2044192677","https://openalex.org/W2057087642","https://openalex.org/W2059424196","https://openalex.org/W2062559281","https://openalex.org/W2069368135","https://openalex.org/W2072309637","https://openalex.org/W2081393436","https://openalex.org/W2081534285","https://openalex.org/W2118764957","https://openalex.org/W2128896459","https://openalex.org/W2135629133","https://openalex.org/W2141469601","https://openalex.org/W2154696007","https://openalex.org/W2159394210","https://openalex.org/W2163815564"],"related_works":["https://openalex.org/W2087760866","https://openalex.org/W2563552165","https://openalex.org/W7120493831","https://openalex.org/W3112217653","https://openalex.org/W3135390168","https://openalex.org/W2319628138","https://openalex.org/W2757065237","https://openalex.org/W3175323321","https://openalex.org/W2755396508","https://openalex.org/W4318027537"],"abstract_inverted_index":{"BACKGROUND:":[0],"Status":[1],"epilepticus":[2],"(SE)":[3],"is":[4,38],"a":[5],"severe":[6],"condition":[7],"that":[8,43,101],"may":[9],"lead":[10],"to":[11,39,123],"hippocampal":[12,93],"cell":[13,24],"loss":[14],"and":[15,29,47,72,97,118],"epileptogenesis.":[16],"Some":[17],"of":[18,34,81],"the":[19,35,41,89],"mechanisms":[20],"associated":[21],"with":[22,61],"SE-induced":[23],"death":[25],"are":[26],"excitotoxicity,":[27],"neuroinflammation,":[28],"apoptosis.":[30],"OBJECTIVE:":[31],"The":[32],"objective":[33],"present":[36],"study":[37],"test":[40],"hypothesis":[42],"DBS":[44,87,115],"has":[45,116],"anti-inflammatory":[46,117],"antiapoptotic":[48,119],"effects":[49,120],"when":[50,121],"applied":[51],"during":[52],"SE.":[53],"METHODS:":[54],"Rats":[55],"undergoing":[56,125],"pilocarpine-induced":[57],"SE":[58,103],"were":[59,76],"treated":[60],"anterior":[62],"thalamic":[63],"nucleus":[64],"(AN)":[65],"deep":[66],"brain":[67],"stimulation":[68],"(DBS).":[69],"Inflammatory":[70],"changes":[71],"caspase":[73,94],"3":[74,95],"activity":[75,96],"measured":[77],"within":[78],"1":[79],"week":[80],"treatment.":[82],"RESULTS:":[83],"In":[84],"pilocarpine-treated":[85],"rats,":[86],"countered":[88],"significant":[90],"increase":[91],"in":[92],"interleukin-6":[98],"(IL-6)":[99],"levels":[100],"follows":[102],"but":[104],"had":[105],"no":[106],"effect":[107],"on":[108],"tumor":[109],"necrosis":[110],"factor":[111],"\u03b1":[112],"(TNF\u03b1).":[113],"CONCLUSIONS:":[114],"given":[122],"animals":[124],"status.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}