{"id":"https://openalex.org/W2129173045","doi":"https://doi.org/10.1128/mcb.11.3.1718-1723.1991","title":"Rapamycin Sensitivity in Saccharomyces cerevisiae Is Mediated by a Peptidyl-Prolyl cis-trans Isomerase Related to Human FK506-Binding Protein","display_name":"Rapamycin Sensitivity in Saccharomyces cerevisiae Is Mediated by a Peptidyl-Prolyl cis-trans Isomerase Related to Human FK506-Binding Protein","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2129173045","doi":"https://doi.org/10.1128/mcb.11.3.1718-1723.1991","mag":"2129173045","pmid":"https://pubmed.ncbi.nlm.nih.gov/1996117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/369480"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.11.3.1718-1723.1991","doi":"https://doi.org/10.1128/mcb.11.3.1718-1723.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.11.3.1718-1723.1991","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC369480","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054033391","display_name":"Yigal Koltin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Koltin","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036331253","display_name":"Leo F. Faucette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Faucette","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111432825","display_name":"Derk J. Bergsma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Bergsma","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002157510","display_name":"Mark A. Levy","orcid":"https://orcid.org/0000-0003-0515-6402","observed_orcids":["https://orcid.org/0000-0003-0515-6402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Levy","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063469423","display_name":"Robert Cafferkey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Cafferkey","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033166820","display_name":"Paul L. Koser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Koser","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103465098","display_name":"Randall K. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R K Johnson","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111858645","display_name":"George P. Livi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G P Livi","raw_affiliation_strings":["Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.2332,"has_fulltext":false,"cited_by_count":248,"citation_normalized_percentile":{"value":0.98589644,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"11","issue":"3","first_page":"1718","last_page":"1723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fkbp","display_name":"FKBP","score":0.8149999976158142},{"id":"https://openalex.org/keywords/peptidyl-prolyl-cis-trans-isomerase","display_name":"peptidyl-prolyl isomerase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8899999856948853},{"id":"https://openalex.org/keywords/rapamycin-resistance","display_name":"rapamycin resistance","score":0.7760000228881836},{"id":"https://openalex.org/keywords/rbp1","display_name":"RBP1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cyclophilin","display_name":"cyclophilin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/macrolide-immunosuppressants","display_name":"macrolide immunosuppressants","score":0.7990000247955322},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.6520000100135803},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C133956753","wikidata":"https://www.wikidata.org/wiki/Q583864","display_name":"FKBP","level":2,"score":0.9574261903762817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8283078670501709},{"id":"https://openalex.org/C2776326521","wikidata":"https://www.wikidata.org/wiki/Q3774751","display_name":"Cyclophilin","level":3,"score":0.7711329460144043},{"id":"https://openalex.org/C2910677434","wikidata":"https://www.wikidata.org/wiki/Q426411","display_name":"Peptidylprolyl isomerase","level":4,"score":0.7205472588539124},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6714663505554199},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.590988278388977},{"id":"https://openalex.org/C2781098309","wikidata":"https://www.wikidata.org/wiki/Q426411","display_name":"Prolyl isomerase","level":5,"score":0.5321335792541504},{"id":"https://openalex.org/C2910190745","wikidata":"https://www.wikidata.org/wiki/Q5122112","display_name":"Cis-trans-Isomerases","level":5,"score":0.46729758381843567},{"id":"https://openalex.org/C2781264208","wikidata":"https://www.wikidata.org/wiki/Q118026","display_name":"Isomerase","level":3,"score":0.4404323697090149},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41997548937797546},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36430150270462036},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.3051806092262268},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2909970283508301},{"id":"https://openalex.org/C154472170","wikidata":"https://www.wikidata.org/wiki/Q18030556","display_name":"PIN1","level":4,"score":0.14318934082984924}],"mesh":[{"descriptor_ui":"D000591","descriptor_name":"Amino Acid Isomerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000591","descriptor_name":"Amino Acid Isomerases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011090","descriptor_name":"Polyenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019696","descriptor_name":"Peptidylprolyl Isomerase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022021","descriptor_name":"Tacrolimus Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/mcb.11.3.1718-1723.1991","doi":"https://doi.org/10.1128/mcb.11.3.1718-1723.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.11.3.1718-1723.1991","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.11.3.1718","doi":"https://doi.org/10.1128/mcb.11.3.1718","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.11.3.1718","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:233917","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC369480","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:1996117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1996117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:369480","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC369480/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.816.7727","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.816.7727","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/11/3/1718.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:233917","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC369480","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1517480469","https://openalex.org/W1533596330","https://openalex.org/W1537782690","https://openalex.org/W1539977736","https://openalex.org/W1806205354","https://openalex.org/W1841455434","https://openalex.org/W1863217888","https://openalex.org/W1885152112","https://openalex.org/W1971177037","https://openalex.org/W1976129849","https://openalex.org/W1976726113","https://openalex.org/W1978879981","https://openalex.org/W1982929789","https://openalex.org/W2001881651","https://openalex.org/W2006584848","https://openalex.org/W2011952922","https://openalex.org/W2015407598","https://openalex.org/W2024448132","https://openalex.org/W2027095809","https://openalex.org/W2040790875","https://openalex.org/W2040830056","https://openalex.org/W2046276016","https://openalex.org/W2050869281","https://openalex.org/W2052562460","https://openalex.org/W2052741482","https://openalex.org/W2056959896","https://openalex.org/W2062120260","https://openalex.org/W2070305157","https://openalex.org/W2074898216","https://openalex.org/W2087226653","https://openalex.org/W2089869923","https://openalex.org/W2115073295","https://openalex.org/W2128635872","https://openalex.org/W2134887033","https://openalex.org/W2283538748","https://openalex.org/W2335433921","https://openalex.org/W2411154019","https://openalex.org/W2418598064","https://openalex.org/W2517054293","https://openalex.org/W2626632314","https://openalex.org/W2782175582"],"related_works":["https://openalex.org/W2100186022","https://openalex.org/W2086969670","https://openalex.org/W2024431372","https://openalex.org/W2001701470","https://openalex.org/W4254477335","https://openalex.org/W1599851165","https://openalex.org/W1989389781","https://openalex.org/W2063013559","https://openalex.org/W2165393736","https://openalex.org/W1978879981"],"abstract_inverted_index":{"Rapamycin":[0],"is":[1,152],"a":[2,74,110,115,134,155,158,165,201,238],"macrolide":[3],"antifungal":[4],"agent":[5],"with":[6,171],"structural":[7],"similarity":[8],"to":[9,17,47,52,69,107,147,192,196,223],"FK506.":[10],"It":[11],"exhibits":[12],"potent":[13],"immunosuppressive":[14],"properties":[15],"analogous":[16],"those":[18],"of":[19,37,73,76,92,112,129,168,200,228],"both":[20,220],"FK506":[21,27,55,96,213],"and":[22,28,56,61,67,95,103,124,132,194,212,244],"cyclosporin":[23],"A":[24],"(CsA).":[25],"Unlike":[26],"CsA,":[29,217],"however,":[30],"rapamycin":[31,94,119,148,211,235],"does":[32],"not":[33,215],"inhibit":[34],"the":[35,86,145,224,242],"transcription":[36],"early":[38],"T-cell":[39,53],"activation":[40],"genes,":[41],"including":[42],"interleukin-2,":[43],"but":[44,214],"instead":[45],"appears":[46],"block":[48],"downstream":[49],"events":[50],"leading":[51],"activation.":[54],"CsA":[57],"receptor":[58],"proteins":[59],"(FKBP":[60],"cyclophilin,":[62],"respectively)":[63],"have":[64],"been":[65],"identified":[66],"shown":[68,195],"be":[70],"distinct":[71],"members":[72],"class":[75],"enzymes":[77],"that":[78,138,144,219],"possess":[79],"peptidyl-prolyl":[80,198],"cis-trans":[81],"isomerase":[82],"(PPIase)":[83],"activity.":[84],"Despite":[85],"apparent":[87],"differences":[88],"in":[89,101,120,149,188,231],"their":[90],"mode":[91],"action,":[93],"act":[97],"as":[98],"reciprocal":[99],"antagonists":[100],"vivo":[102],"compete":[104],"for":[105,118],"binding":[106],"FKBP.":[108],"As":[109],"means":[111],"rapidly":[113],"identifying":[114],"target":[116],"protein":[117,162,184],"vivo,":[121],"we":[122,174],"selected":[123],"genetically":[125],"characterized":[126],"rapamycin-resistant":[127,232],"mutants":[128,233],"Saccharomyces":[130],"cerevisiae":[131],"isolated":[133],"yeast":[135,150,243],"genomic":[136],"fragment":[137],"confers":[139],"drug":[140],"sensitivity.":[141],"We":[142],"demonstrate":[143],"resonse":[146],"cells":[151],"mediated":[153],"by":[154,210,216],"gene":[156,177],"encoding":[157],"114-amino-acid,":[159],"approximately":[160],"13-kDa":[161],"which":[163],"has":[164],"high":[166],"degree":[167],"sequence":[169],"homology":[170],"human":[172,229,245],"FKBP;":[173],"designated":[175],"this":[176],"RBP1":[178,183],"(for":[179],"rapamycin-binding":[180],"protein).":[181],"The":[182],"(RBP)":[185],"was":[186,207],"expressed":[187],"Escherichia":[189],"coli,":[190],"purified":[191],"homogeneity,":[193],"catalyze":[197],"isomerization":[199],"synthetic":[202],"peptide":[203],"substrate.":[204],"PPIase":[205],"activity":[206],"completely":[208],"inhibited":[209],"indicating":[218,237],"macrolides":[221],"bind":[222],"recombinant":[225],"protein.":[226],"Expression":[227],"FKBP":[230],"restored":[234],"sensitivity,":[236],"functional":[239],"equivalence":[240],"between":[241],"enzymes.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
