{"id":"https://openalex.org/W2129142602","doi":"https://doi.org/10.1095/biolreprod65.5.1573","title":"Action of Leptin on In Vitro Luteinizing Hormone Release in the European Sea Bass (Dicentrarchus labrax)1","display_name":"Action of Leptin on In Vitro Luteinizing Hormone Release in the European Sea Bass (Dicentrarchus labrax)1","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2129142602","doi":"https://doi.org/10.1095/biolreprod65.5.1573","mag":"2129142602","pmid":"https://pubmed.ncbi.nlm.nih.gov/11673277"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod65.5.1573","doi":"https://doi.org/10.1095/biolreprod65.5.1573","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod65.5.1573","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000577803","display_name":"Pierre Peyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210097102","display_name":"Instituto de Acuicultura Torre de la Sal","ror":"https://ror.org/00xk8t981","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210097102"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pierre Peyon","raw_affiliation_strings":["Department of Fish Reproductive Physiology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre de la Sal, Castellon, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fish Reproductive Physiology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre de la Sal, Castellon, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210097102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070324202","display_name":"Silvia Zanuy","orcid":"https://orcid.org/0000-0002-8231-8260","observed_orcids":["https://orcid.org/0000-0002-8231-8260"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210097102","display_name":"Instituto de Acuicultura Torre de la Sal","ror":"https://ror.org/00xk8t981","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210097102"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Zanuy","raw_affiliation_strings":["Department of Fish Reproductive Physiology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre de la Sal, Castellon, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fish Reproductive Physiology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre de la Sal, Castellon, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210097102"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075531587","display_name":"Manuel Carrillo","orcid":"https://orcid.org/0000-0002-3342-2635","observed_orcids":["https://orcid.org/0000-0002-3342-2635"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210097102","display_name":"Instituto de Acuicultura Torre de la Sal","ror":"https://ror.org/00xk8t981","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210097102"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Manuel Carrillo","raw_affiliation_strings":["Department of Fish Reproductive Physiology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre de la Sal, Castellon, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fish Reproductive Physiology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre de la Sal, Castellon, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210097102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075531587"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210097102"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":2.3321,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.86133227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"65","issue":"5","first_page":"1573","last_page":"1578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.1298999935388565,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dicentrarchus-labrax","display_name":"Dicentrarchus labrax","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pituitary-cells","display_name":"pituitary cells","score":0.722000002861023},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fish-reproduction","display_name":"fish reproduction","score":0.6980000138282776},{"id":"https://openalex.org/keywords/sexual-development","display_name":"sexual development","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gonadotropin-regulation","display_name":"gonadotropin regulation","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2776445371","wikidata":"https://www.wikidata.org/wiki/Q905061","display_name":"Dicentrarchus","level":3,"score":0.9637783169746399},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9037514925003052},{"id":"https://openalex.org/C2780008901","wikidata":"https://www.wikidata.org/wiki/Q1248017","display_name":"Sea bass","level":3,"score":0.841907799243927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8090760111808777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7238841652870178},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6897933483123779},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.4590434432029724},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.45511630177497864},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.4530491530895233},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.32018059492111206},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.15870916843414307},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1454227864742279},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.1146840751171112},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.09124115109443665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.058299481868743896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001492","descriptor_name":"Bass","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1095/biolreprod65.5.1573","doi":"https://doi.org/10.1095/biolreprod65.5.1573","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod65.5.1573","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:11673277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11673277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.864.6555","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.864.6555","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biolreprod.org/content/65/5/1573.full.pdf","raw_type":"text"},{"id":"pmh:10.1095/biolreprod65.5.1573","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1095/biolreprod65.5.1573","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/252255","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/252255","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W30257253","https://openalex.org/W103873836","https://openalex.org/W155747232","https://openalex.org/W1486463812","https://openalex.org/W1967968809","https://openalex.org/W1974305574","https://openalex.org/W1976640392","https://openalex.org/W1981762970","https://openalex.org/W1982522479","https://openalex.org/W1989087522","https://openalex.org/W1996713062","https://openalex.org/W2001660140","https://openalex.org/W2002040778","https://openalex.org/W2009918872","https://openalex.org/W2012805490","https://openalex.org/W2013583119","https://openalex.org/W2014093920","https://openalex.org/W2014163208","https://openalex.org/W2020197424","https://openalex.org/W2033090095","https://openalex.org/W2038428130","https://openalex.org/W2042357656","https://openalex.org/W2043685918","https://openalex.org/W2048035555","https://openalex.org/W2048110559","https://openalex.org/W2054100508","https://openalex.org/W2058205882","https://openalex.org/W2060682066","https://openalex.org/W2061994480","https://openalex.org/W2078803380","https://openalex.org/W2083014754","https://openalex.org/W2083602597","https://openalex.org/W2088942059","https://openalex.org/W2099495602","https://openalex.org/W2119392964","https://openalex.org/W2119448649","https://openalex.org/W2121308229","https://openalex.org/W2126482970","https://openalex.org/W2140553785","https://openalex.org/W2144907555","https://openalex.org/W2164098477","https://openalex.org/W2184114339","https://openalex.org/W3212026698","https://openalex.org/W4245866536"],"related_works":["https://openalex.org/W7101137859","https://openalex.org/W1993048823","https://openalex.org/W3007194573","https://openalex.org/W2019693171","https://openalex.org/W4200234162","https://openalex.org/W2944488551","https://openalex.org/W2395458008","https://openalex.org/W2747426647","https://openalex.org/W2082020268","https://openalex.org/W2519103111"],"abstract_inverted_index":{"The":[0,89,188],"discovery":[1],"of":[2,10,15,20,39,48,58,86,92,117,136,171,185,191,209],"leptin":[3,16,49,61,93,118,156,172,192,205],"has":[4],"sparked":[5],"a":[6,103,207],"rapidly":[7],"growing":[8],"number":[9],"publications":[11],"concerning":[12],"the":[13,18,37,46,56,95,197,210],"role":[14,47,105],"in":[17,27,52,106,110,159,164,200,213],"regulation":[19],"body":[21],"adiposity,":[22],"feeding,":[23],"and":[24,42,64,108,124,183],"reproductive":[25,211],"system":[26,212],"mammals.":[28],"To":[29],"date,":[30],"there":[31],"have":[32],"been":[33],"no":[34],"reports":[35],"on":[36,45,62,130,145,175,180,193],"presence":[38],"leptin-related":[40],"peptide,":[41],"functional":[43],"studies":[44],"remain":[50],"limited":[51],"fishes.":[53,214],"We":[54],"investigated":[55],"effect":[57],"mouse":[59],"recombinant":[60],"basal":[63,146],"sea":[65,79,201],"bream":[66],"(sb)":[67],"GnRH-induced":[68],"LH":[69,131,147,152,177,194],"release":[70,132,153,178,195],"from":[71,76],"dispersed":[72],"pituitary":[73,198],"cells":[74],"obtained":[75],"male":[77],"European":[78],"bass":[80,202],"(Dicentrarchus":[81],"labrax)":[82],"at":[83,133,196],"different":[84,128],"stages":[85,135],"sexual":[87,137,186],"development.":[88,138,187],"potential":[90],"interaction":[91],"with":[94],"porcine":[96],"neuropeptide":[97],"Y":[98],"(pNPY),":[99],"known":[100],"to":[101],"play":[102],"dual":[104],"feeding":[107],"reproduction":[109],"vertebrates,":[111],"was":[112,142],"also":[113],"investigated.":[114],"High":[115],"doses":[116],"(10(-8)-10(-6)":[119],"M)":[120,158],"and/or":[121],"pNPY":[122],"(0.1":[123],"1":[125],"nM)":[126],"had":[127],"effects":[129,170],"various":[134],"Porcine":[139],"NPY":[140],"alone":[141],"weakly":[143],"effective":[144],"release,":[148],"but":[149,162],"it":[150],"enhanced":[151],"induced":[154],"by":[155],"(10(-6)":[157],"late":[160],"prepuberty":[161],"not":[163],"early":[165],"postpuberty.":[166],"Additive":[167],"or":[168],"inhibitory":[169],"were":[173],"observed":[174],"sbGnRH-induced":[176],"depending":[179],"sbGnRH":[181],"dose":[182],"stage":[184],"direct":[189],"action":[190],"level":[199],"suggests":[203],"that":[204],"is":[206],"regulator":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
