{"id":"https://openalex.org/W2129139440","doi":"https://doi.org/10.1093/ndt/gfp619","title":"In-hospital outcomes with thrombolytic therapy in patients with renal dysfunction presenting with acute ischaemic stroke","display_name":"In-hospital outcomes with thrombolytic therapy in patients with renal dysfunction presenting with acute ischaemic stroke","publication_year":2009,"publication_date":"2009-11-27","ids":{"openalex":"https://openalex.org/W2129139440","doi":"https://doi.org/10.1093/ndt/gfp619","mag":"2129139440","pmid":"https://pubmed.ncbi.nlm.nih.gov/19945951"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfp619","doi":"https://doi.org/10.1093/ndt/gfp619","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfp619","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026220269","display_name":"Varun Agrawal","orcid":"https://orcid.org/0000-0002-7759-2222","observed_orcids":["https://orcid.org/0000-0002-7759-2222"]},"institutions":[{"id":"https://openalex.org/I1338449461","display_name":"Baystate Medical Center","ror":"https://ror.org/01q2nz307","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1338449461"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. Agrawal","raw_affiliation_strings":["Renal Division, Baystate Medical Center, Springfield MA, USA. varunagrawal1996@yahoo.com","Renal Division, Baystate Medical Center, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Baystate Medical Center, Springfield MA, USA. varunagrawal1996@yahoo.com","institution_ids":["https://openalex.org/I1338449461"]},{"raw_affiliation_string":"Renal Division, Baystate Medical Center, Springfield, MA","institution_ids":["https://openalex.org/I1338449461"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Rai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Rai","raw_affiliation_strings":["Section of Nephrology and Hypertension, University of Oklahoma Health Sciences Center, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Nephrology and Hypertension, University of Oklahoma Health Sciences Center, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043072571","display_name":"James L. Fellows","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799370151","display_name":"Beaumont Health","ror":"https://ror.org/05g2hd893","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799370151","https://openalex.org/I4392738273"]},{"id":"https://openalex.org/I4210128757","display_name":"Corewell Health William Beaumont University Hospital","ror":"https://ror.org/03artm726","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128757","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Fellows","raw_affiliation_strings":["Division of Neurology, William Beaumont Hospital, Royal Oak MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, William Beaumont Hospital, Royal Oak MI","institution_ids":["https://openalex.org/I2799370151","https://openalex.org/I4210128757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008382551","display_name":"Peter Andrew McCullough","orcid":"https://orcid.org/0000-0002-0997-6355","observed_orcids":["https://orcid.org/0000-0002-0997-6355"]},"institutions":[{"id":"https://openalex.org/I4210128757","display_name":"Corewell Health William Beaumont University Hospital","ror":"https://ror.org/03artm726","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128757","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. A. McCullough","raw_affiliation_strings":["Divisions of Cardiology, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Cardiology, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak MI","institution_ids":["https://openalex.org/I4210128757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026220269"],"corresponding_institution_ids":["https://openalex.org/I1338449461"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":2.2882,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.87425455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"25","issue":"4","first_page":"1150","last_page":"1157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.8460000157356262},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.968999981880188},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.9729999899864197},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.9340000152587891},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.8870000243186951},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.703000009059906},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/platelet-dysfunction","display_name":"platelet dysfunction","score":0.6909999847412109},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.6679999828338623},{"id":"https://openalex.org/keywords/time-to-treatment","display_name":"time to treatment","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9826290607452393},{"id":"https://openalex.org/C3018755981","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischaemic stroke","level":3,"score":0.8226413726806641},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5719407796859741},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4740428924560547},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.465166836977005},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.41960033774375916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4177420735359192},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3626387417316437},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2758942246437073},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.20238405466079712},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020767","descriptor_name":"Intracranial Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020767","descriptor_name":"Intracranial Thrombosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ndt/gfp619","doi":"https://doi.org/10.1093/ndt/gfp619","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfp619","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:19945951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19945951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306605","display_name":"American Society of Nephrology","ror":"https://ror.org/014pcm848"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1583224488","https://openalex.org/W1637796143","https://openalex.org/W1967332017","https://openalex.org/W1967993622","https://openalex.org/W1968364422","https://openalex.org/W1970055369","https://openalex.org/W1987078398","https://openalex.org/W1987884921","https://openalex.org/W1994345903","https://openalex.org/W2004848147","https://openalex.org/W2007675941","https://openalex.org/W2020074777","https://openalex.org/W2027623711","https://openalex.org/W2027672897","https://openalex.org/W2029091816","https://openalex.org/W2030046559","https://openalex.org/W2032497047","https://openalex.org/W2040557787","https://openalex.org/W2042010853","https://openalex.org/W2045516356","https://openalex.org/W2047195246","https://openalex.org/W2054422224","https://openalex.org/W2068511447","https://openalex.org/W2076414585","https://openalex.org/W2079327962","https://openalex.org/W2085942002","https://openalex.org/W2086259640","https://openalex.org/W2086950517","https://openalex.org/W2096283301","https://openalex.org/W2098032054","https://openalex.org/W2098121633","https://openalex.org/W2103217815","https://openalex.org/W2107272221","https://openalex.org/W2113002952","https://openalex.org/W2121724843","https://openalex.org/W2125791343","https://openalex.org/W2129036957","https://openalex.org/W2130170315","https://openalex.org/W2132357532","https://openalex.org/W2134155944","https://openalex.org/W2140766694","https://openalex.org/W2141980394","https://openalex.org/W2145681280","https://openalex.org/W2154184017","https://openalex.org/W2158098319","https://openalex.org/W2159233098","https://openalex.org/W2172019253","https://openalex.org/W2292308933","https://openalex.org/W2412089950","https://openalex.org/W2594075545"],"related_works":["https://openalex.org/W1982515603","https://openalex.org/W2078715846","https://openalex.org/W1995546851","https://openalex.org/W2040868035","https://openalex.org/W3185159427","https://openalex.org/W2563019880","https://openalex.org/W4397042493","https://openalex.org/W2736813747","https://openalex.org/W4388035143","https://openalex.org/W4292702939"],"abstract_inverted_index":{"BACKGROUND:":[0],"Thrombolytic":[1],"therapy":[2,54,291],"is":[3,319],"an":[4],"effective":[5],"treatment":[6],"modality":[7],"for":[8,55,292],"acute":[9,56,293,317],"ischaemic":[10],"stroke":[11,57,155,294,318],"within":[12],"3":[13],"hours":[14],"of":[15,76,141,284,314],"symptom":[16],"onset.":[17],"Its":[18],"safety":[19],"and":[20,41,95,108,124,134,143,159,181,257],"efficacy":[21],"have":[22,37],"not":[23,296],"been":[24],"studied":[25,46,82],"in":[26,39,165,172,189,194,199,211,216,221,234,239,287,316,321],"patients":[27,48,70,129,148,174,288,322],"with":[28,120,137,149,175,265,301,323],"chronic":[29],"kidney":[30],"disease":[31,146],"(CKD),":[32],"who":[33,49],"are":[34],"known":[35],"to":[36,69,161,298],"abnormalities":[38],"coagulation":[40],"platelet":[42],"function.":[43],"METHODS:":[44],"We":[45,81],"all":[47],"consecutively":[50],"received":[51],"intravenous":[52],"thrombolytic":[53,290],"at":[58],"our":[59,278],"hospital":[60],"from":[61],"2005-2009":[62],"(n":[63],"=":[64,205,227,245,274],"74).":[65],"Alteplase":[66],"was":[67,115,208,263,295],"administered":[68],"deemed":[71],"eligible":[72],"by":[73],"National":[74],"Institute":[75],"Health":[77],"criteria":[78],"per":[79],"protocol.":[80],"associations":[83],"between":[84,254],"admission":[85],"renal":[86,324],"dysfunction":[87],"[estimated":[88],"glomerular":[89],"filtration":[90],"rate":[91],"(eGFR)":[92],"<60ml/min/1.73":[93],"m(2)]":[94],"in-hospital":[96,230,258],"outcomes:":[97],"intracranial":[98],"haemorrhage":[99],"(ICH),":[100],"poor":[101,212,266,304],"functional":[102,213,267,305],"status":[103,214,268],"(modified":[104],"Rankin":[105],"score":[106],"3-6)":[107],"death.":[109,308],"RESULTS:":[110],"Mean":[111],"+/-":[112,117],"SD":[113],"age":[114,262],"66.4":[116],"16.9":[118],"years":[119],"39":[121],"(52.7%)":[122],"men":[123],"46":[125],"(62.2%)":[126],"Caucasian.":[127],"Twenty":[128],"(27.0%)":[130],"had":[131],"eGFR":[132,150,176,195,200,217,222,235,240,255,285],"<60":[133,196,218,236,256,286],"were":[135,163],"older,":[136],"a":[138],"higher":[139],"prevalence":[140],"diabetes":[142],"coronary":[144],"artery":[145],"than":[147],">":[151,177,201,223,241],"or":[152,178,202,224,229,242,307],"=60.":[153,179],"Presenting":[154],"severity,":[156],"blood":[157],"pressure":[158],"time":[160],"alteplase":[162],"similar":[164],"the":[166],"two":[167,173],"groups.":[168],"Symptomatic":[169],"ICH":[170,183],"occurred":[171],"Asymptomatic":[180],"symptomatic":[182],"considered":[184],"together":[185],"showed":[186],"no":[187,209,252],"difference":[188,210],"these":[190],"event":[191],"rates":[192],"(20%":[193],"vs":[197,219,237],"11.1%":[198],"=60,":[203,225,243],"P":[204,226,244,273],"0.321).":[206],"There":[207],"(70.0%":[215],"57.4%":[220],"0.324)":[228],"death":[231],"outcomes":[232],"(10.0%":[233],"7.4%":[238],"0.717).":[246],"Multivariate":[247],"logistic":[248],"regression":[249],"analysis":[250],"revealed":[251],"association":[253],"outcomes,":[259],"while":[260],"increasing":[261],"associated":[264,300],"[odds":[269],"ratio":[270],"1.03":[271],"(1.00-1.06,":[272],"0.047)].":[275],"CONCLUSIONS:":[276],"In":[277],"limited":[279],"sample":[280],"size":[281],"study,":[282],"presence":[283],"receiving":[289],"found":[297],"be":[299],"increased":[302],"ICH,":[303],"outcome":[306],"These":[309],"findings":[310],"suggest":[311],"that":[312],"use":[313],"thrombolytics":[315],"appropriate":[320],"dysfunction.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
