{"id":"https://openalex.org/W2129137689","doi":"https://doi.org/10.1248/jhs.54.493","title":"Alpha-1 Antitrypsin Genotypes in Breast Cancer Patients","display_name":"Alpha-1 Antitrypsin Genotypes in Breast Cancer Patients","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2129137689","doi":"https://doi.org/10.1248/jhs.54.493","mag":"2129137689"},"language":"fr","primary_location":{"id":"doi:10.1248/jhs.54.493","doi":"https://doi.org/10.1248/jhs.54.493","is_oa":true,"landing_page_url":"https://doi.org/10.1248/jhs.54.493","pdf_url":"https://www.jstage.jst.go.jp/article/jhs/54/4/54_4_493/_pdf","source":{"id":"https://openalex.org/S4210167946","display_name":"Eisei kagaku","issn_l":"0013-273X","issn":["0013-273X","1344-9702","1347-5207"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Health Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jhs/54/4/54_4_493/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073827734","display_name":"Zeyad Jalal El-Akawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Zeyad Jalal El-Akawi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, Jordan University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, Jordan University of Science and Technology","institution_ids":["https://openalex.org/I156983542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066711890","display_name":"Dima Sawalha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Dima Hakam Sawalha","raw_affiliation_strings":["Molecular and Diagnostic Genetics/Department of Laboratory Sciences/Faculty of Applied Medical Sciences, Jordan University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Diagnostic Genetics/Department of Laboratory Sciences/Faculty of Applied Medical Sciences, Jordan University of Science and Technology","institution_ids":["https://openalex.org/I156983542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111963707","display_name":"Mohamad Khalid Nusier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Mohamad Khalid Nusier","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, Jordan University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, Jordan University of Science and Technology","institution_ids":["https://openalex.org/I156983542"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I156983542"],"apc_list":null,"apc_paid":null,"fwci":0.4441,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.6385298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"54","issue":"4","first_page":"493","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.578000009059906},{"id":"https://openalex.org/keywords/serine-protease-inhibitors","display_name":"serine protease inhibitors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5450000166893005},{"id":"https://openalex.org/keywords/jordanian-women","display_name":"Jordanian women","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7718892097473145},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6136782169342041},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5646166801452637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5543651580810547},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5327349305152893},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5244077444076538},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.46738922595977783},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.45778951048851013},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4401707947254181},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.43234798312187195},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.401995450258255},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38085925579071045},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.274855375289917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2128315269947052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18836727738380432},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06885379552841187}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1248/jhs.54.493","doi":"https://doi.org/10.1248/jhs.54.493","is_oa":true,"landing_page_url":"https://doi.org/10.1248/jhs.54.493","pdf_url":"https://www.jstage.jst.go.jp/article/jhs/54/4/54_4_493/_pdf","source":{"id":"https://openalex.org/S4210167946","display_name":"Eisei kagaku","issn_l":"0013-273X","issn":["0013-273X","1344-9702","1347-5207"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Health Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1248/jhs.54.493","doi":"https://doi.org/10.1248/jhs.54.493","is_oa":true,"landing_page_url":"https://doi.org/10.1248/jhs.54.493","pdf_url":"https://www.jstage.jst.go.jp/article/jhs/54/4/54_4_493/_pdf","source":{"id":"https://openalex.org/S4210167946","display_name":"Eisei kagaku","issn_l":"0013-273X","issn":["0013-273X","1344-9702","1347-5207"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Health Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129137689.pdf","grobid_xml":"https://content.openalex.org/works/W2129137689.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1968664082","https://openalex.org/W2019817073","https://openalex.org/W2028780406","https://openalex.org/W2042781374","https://openalex.org/W2044331214","https://openalex.org/W2054436162","https://openalex.org/W2057518660","https://openalex.org/W2064666480","https://openalex.org/W2079330967","https://openalex.org/W2087816015","https://openalex.org/W2089695818","https://openalex.org/W2113570198","https://openalex.org/W2133651507","https://openalex.org/W2163393895","https://openalex.org/W2181678285","https://openalex.org/W2427402522","https://openalex.org/W2463297092","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1892608084","https://openalex.org/W2054436162","https://openalex.org/W2999889678","https://openalex.org/W2106692110","https://openalex.org/W1505743608","https://openalex.org/W4387979627","https://openalex.org/W21361421","https://openalex.org/W115606977","https://openalex.org/W3216694636","https://openalex.org/W7213455914"],"abstract_inverted_index":{"Proteolytic":[0],"enzymes":[1],"play":[2],"a":[3,21],"significant":[4],"role":[5],"in":[6,26,38,112,143,211],"malignancy":[7],"including,":[8],"loss":[9],"of":[10,42,53,70,74,150,172],"growth":[11],"regulation,":[12],"invasiveness":[13],"and":[14,28,59,90,107,109,126,140,146,152,187,190,206,208],"metastases":[15],"formation.":[16],"Alpha-1":[17],"antitrypsin":[18],"(A1AT)":[19],"is":[20,31,44,198],"secretory":[22],"glycoprotein":[23],"produced":[24],"mainly":[25],"liver":[27,84],"monocytes.":[29],"It":[30],"the":[32,65,101,135,138,173,180],"most":[33,66],"abundant":[34],"serine":[35],"protease":[36,60],"inhibitor":[37,56,61,184],"human":[39],"plasma.":[40],"Deficiency":[41],"A1AT":[43,76,104,202],"an":[45],"inherited":[46],"disorder":[47],"characterized":[48],"by":[49,157],"reduced":[50],"serum":[51],"level":[52],"A1AT.":[54,71],"Protease":[55,183],"Z":[57,106,139,151,205],"(PiZ)":[58],"S":[62,108,141,153,207],"(PiS)":[63],"are":[64],"common":[67],"deficient":[68,75,203],"genotypes":[69,105,192,204],"The":[72],"association":[73],"subtypes":[77],"with":[78],"several":[79],"tumors":[80],"such":[81],"as":[82],"primary":[83],"carcinoma,":[85],"lung":[86],"cancer,":[87],"bladder":[88],"cancer":[89,111,175,210],"malignant":[91],"hepatoma":[92],"was":[93,97,124,131,155],"reported.":[94],"This":[95],"study":[96],"aimed":[98],"to":[99,133],"test":[100],"relationship":[102,200],"between":[103,201],"breast":[110,174,209],"Jordanian":[113,212],"female":[114,213],"patients.":[115,122,214],"Blood":[116],"samples":[117],"were":[118,177,193],"collected":[119],"from":[120],"111":[121],"DNA":[123],"isolated":[125],"polymerase":[127],"chain":[128],"reaction":[129],"(PCR)":[130],"performed":[132,156],"amplify":[134],"regions":[136],"contain":[137],"mutations":[142],"exon":[144],"V,":[145],"III,":[147],"respectively.":[148],"Genotyping":[149],"alleles":[154],"restriction":[158,165],"fragment":[159],"length":[160],"polymorphism":[161],"technique":[162],"using":[163],"Taq1":[164],"enzyme.":[166],"Our":[167],"results":[168],"demonstrated":[169],"that":[170],"100%":[171],"patients":[176],"homozygous":[178],"for":[179],"normal":[181],"allele":[182],"MM":[185],"(PiMM)":[186],"no":[188,199],"PiZ":[189],"PiS":[191],"found.":[194],"In":[195],"conclusion,":[196],"there":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}