{"id":"https://openalex.org/W2129129201","doi":"https://doi.org/10.1161/hypertensionaha.108.111815","title":"Salt Excess Causes Left Ventricular Diastolic Dysfunction in Rats With Metabolic Disorder","display_name":"Salt Excess Causes Left Ventricular Diastolic Dysfunction in Rats With Metabolic Disorder","publication_year":2008,"publication_date":"2008-07-07","ids":{"openalex":"https://openalex.org/W2129129201","doi":"https://doi.org/10.1161/hypertensionaha.108.111815","mag":"2129129201","pmid":"https://pubmed.ncbi.nlm.nih.gov/18606904"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.108.111815","doi":"https://doi.org/10.1161/hypertensionaha.108.111815","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.108.111815","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111808602","display_name":"Hiromitsu Matsui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Matsui","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","Department of Nephrology and Endocrinology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Nephrology and Endocrinology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016975375","display_name":"Katsuyuki Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyuki Ando","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022848652","display_name":"Hiroo Kawarazaki","orcid":"https://orcid.org/0000-0003-2978-1261","observed_orcids":["https://orcid.org/0000-0003-2978-1261"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroo Kawarazaki","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069183953","display_name":"Ai Nagae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ai Nagae","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102801296","display_name":"Megumi Fujita","orcid":"https://orcid.org/0000-0002-8881-6367","observed_orcids":["https://orcid.org/0000-0002-8881-6367"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Fujita","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049300446","display_name":"Tatsuo Shimosawa","orcid":"https://orcid.org/0000-0002-8742-5129","observed_orcids":["https://orcid.org/0000-0002-8742-5129"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Shimosawa","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047641099","display_name":"Miki Nagase","orcid":"https://orcid.org/0000-0002-5741-578X","observed_orcids":["https://orcid.org/0000-0002-5741-578X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miki Nagase","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080266991","display_name":"Toshiro Fujita","orcid":"https://orcid.org/0000-0001-9141-7060","observed_orcids":["https://orcid.org/0000-0001-9141-7060"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiro Fujita","raw_affiliation_strings":["From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":6.5462,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.97067048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"52","issue":"2","first_page":"287","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.5342000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.5342000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.3434999883174896,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.04270000010728836,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-diastolic-dysfunction","display_name":"left ventricular diastolic dysfunction","score":0.925000011920929},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.7059999704360962},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tempol","display_name":"tempol","score":0.8640000224113464},{"id":"https://openalex.org/keywords/eplerenone","display_name":"eplerenone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/na-h-exchanger-1","display_name":"NHX1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sgk1","display_name":"SGK1","score":0.781000018119812},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.9021412134170532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.822521984577179},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8009496927261353},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.7269288897514343},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6016621589660645},{"id":"https://openalex.org/C2780072264","wikidata":"https://www.wikidata.org/wiki/Q423804","display_name":"Eplerenone","level":4,"score":0.5987851619720459},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.5721532106399536},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.5672982931137085},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5610304474830627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5557453632354736},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.5535724759101868},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.40026575326919556},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3629361391067505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24406200647354126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05917510390281677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077545","descriptor_name":"Eplerenone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006334","descriptor_name":"Heart Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013148","descriptor_name":"Spironolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013148","descriptor_name":"Spironolactone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015150","descriptor_name":"Echocardiography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016482","descriptor_name":"Urinalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/hypertensionaha.108.111815","doi":"https://doi.org/10.1161/hypertensionaha.108.111815","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.108.111815","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.509.9831","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.509.9831","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://hyper.ahajournals.org/content/52/2/287.full.pdf","raw_type":"text"},{"id":"pmid:18606904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18606904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006728112","doi":null,"is_oa":false,"landing_page_url":"https://pure.teikyo.jp/en/publications/21e59839-74a1-40a1-bedf-af93e4338860","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hypertension","raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1967964480","https://openalex.org/W1969174923","https://openalex.org/W1974033843","https://openalex.org/W1975541868","https://openalex.org/W1976239472","https://openalex.org/W1993177559","https://openalex.org/W2006659891","https://openalex.org/W2006934176","https://openalex.org/W2011977714","https://openalex.org/W2018836512","https://openalex.org/W2027306635","https://openalex.org/W2049977343","https://openalex.org/W2060449981","https://openalex.org/W2070259522","https://openalex.org/W2074110427","https://openalex.org/W2085822292","https://openalex.org/W2087968524","https://openalex.org/W2090016088","https://openalex.org/W2091360003","https://openalex.org/W2093131177","https://openalex.org/W2096073058","https://openalex.org/W2101820852","https://openalex.org/W2101948924","https://openalex.org/W2106015949","https://openalex.org/W2107319610","https://openalex.org/W2109281287","https://openalex.org/W2114109157","https://openalex.org/W2116230802","https://openalex.org/W2119789826","https://openalex.org/W2124821727","https://openalex.org/W2126085531","https://openalex.org/W2129048293","https://openalex.org/W2129223025","https://openalex.org/W2131647357","https://openalex.org/W2131715702","https://openalex.org/W2145242994","https://openalex.org/W2152094259","https://openalex.org/W2152560143","https://openalex.org/W2155905764","https://openalex.org/W2158253017","https://openalex.org/W2161484789","https://openalex.org/W2162607913","https://openalex.org/W2166874140","https://openalex.org/W2270092661","https://openalex.org/W2323458614","https://openalex.org/W4246778508"],"related_works":["https://openalex.org/W372565237","https://openalex.org/W2030595679","https://openalex.org/W2070775917","https://openalex.org/W1974920489","https://openalex.org/W2123624245","https://openalex.org/W2113511490","https://openalex.org/W2614313358","https://openalex.org/W2129223025","https://openalex.org/W7145526725","https://openalex.org/W2410873391"],"abstract_inverted_index":{"Metabolic":[0],"syndrome":[1,54,199],"is":[2,200],"a":[3,13,79,149,173,201],"highly":[4],"predisposing":[5],"condition":[6,203],"for":[7,89,204],"cardiovascular":[8],"disease":[9],"and":[10,38,59,69,103,115,126,128,164,215],"could":[11],"be":[12],"cause":[14,144],"of":[15,61,74,111,117,166,187],"excess":[16,46],"salt-induced":[17,159,205],"organ":[18],"damage.":[19],"Recently,":[20],"several":[21],"investigators":[22],"have":[23],"demonstrated":[24],"that":[25,197],"salt":[26,47,81,94,140],"loading":[27,95,141],"causes":[28],"left":[29,100,206],"ventricular":[30,101,207],"diastolic":[31,50,160,182,208],"dysfunction":[32,51,183],"associated":[33],"with":[34],"increased":[35,56,212],"oxidative":[36,57,213],"stress":[37,58,214],"mineralocorticoid":[39,62,118,167,175,217],"receptor":[40,63,168,176,218],"activation.":[41],"We,":[42],"therefore,":[43],"investigated":[44],"whether":[45],"induces":[48],"cardiac":[49,133,146],"in":[52,131,136,152,170,191],"metabolic":[53,75,198],"via":[55,211],"upregulation":[60,116,165],"signals.":[64,219],"Thirteen-week-old":[65],"spontaneously":[66,137],"hypertensive":[67,138],"rats":[68],"SHR/NDmcr-cps,":[70,93],"the":[71,132],"genetic":[72],"model":[73],"syndrome,":[76],"were":[77],"fed":[78],"normal":[80],"(0.5%":[82],"NaCl)":[83,87],"or":[84],"high-salt":[85],"(8%":[86],"diet":[88],"4":[90],"weeks.":[91],"In":[92],"induced":[96],"severe":[97],"hypertension,":[98],"abnormal":[99],"relaxation,":[102],"perivascular":[104,162],"fibrosis.":[105],"Salt-loaded":[106],"SHR/NDmcr-cps":[107],"also":[108,185],"exhibited":[109],"overproduction":[110,186],"reactive":[112,188],"oxygen":[113,189],"species":[114,190],"receptor-dependent":[119],"gene":[120],"expression,":[121],"such":[122],"as":[123],"Na(+)/H(+)":[124],"exchanger-1":[125],"serum-":[127],"glucocorticoid-inducible":[129],"kinase-1":[130],"tissue.":[134],"However,":[135],"rats,":[139],"did":[142],"not":[143,180],"these":[145],"abnormalities":[147],"despite":[148],"similar":[150],"increase":[151],"blood":[153],"pressure.":[154],"An":[155],"antioxidant,":[156],"tempol,":[157],"prevented":[158,179],"dysfunction,":[161,209],"fibrosis,":[163],"signals":[169],"SHR/NDmcr-cps.":[171,193],"Moreover,":[172],"selective":[174],"antagonist,":[177],"eplerenone,":[178],"only":[181],"but":[184],"salt-loaded":[192],"These":[194],"results":[195],"suggest":[196],"predisposed":[202],"possibly":[210],"enhanced":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
